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1363 articles for “Pre-clinical”
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Hairy Cell Leukemia: A Morphological Dilemma in Case of Low Peripheral Blood Hairy Cell Count
Abstract: Hairy cell leukemia (HCL) is a lympho-proliferative neoplasm of mature B cells with an indolent course, representing 2 to 3% of all leukemias. It clinically presents as bicytopenia and splenomegaly. We here present a case report where peripheral blood smear showed few lymphoid cells with hairy projections. A suspicion of hairy cell leukemia was given which was confirmed later on bone marrow aspiration and biopsy followed by flow cytometry which …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 2, 2018 · pp. 18–21 Read article
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Rectal Polyp may turn out to be Rectal Adenocarcinoma—Case Report Emphasize Histopathology as a Routine Measure
Abstract: AbstractAdenocarcinoma is a commonest type of colorectal cancer. For the primary care physicians, a review of the pathophysiology and clinical presentation are important in its diagnosis. In India the annual incidence rate of rectal cancer in men is 4.1 per 100000 populations. Colon cancer in women is 3.9 per 100000 populations. Causes of colorectal cancer include genetic and environmental factors or lifestyle-related factors. Some previous studies confirm colonoscopy as a …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 2, 2020 · pp. 19–23 Read article
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Production, Characterization and Toxicological Evaluation of Eco-Friendly Flavolipid Biosurfactant
Abstract: At present majority of surfactants are chemically synthesized. Nevertheless, in recent years, much attention has been directed towards biosurfactants due to their broad range of functional properties, there are cheaper as they can be produced from alternative sources. They have applications in the fields, such as: oil recovery process, as an additive in food processing industry, pharmaceuticals preparations, energy saving technologies etc. As they are being microbial derivatives, it is …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 1, 2014 · pp. 16–21 Read article
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Therapeutic Approach for the Management of Bawaseer (Hemorrhoid)
Abstract: Varicosities of the veins of anal canal are known as hemorrhoids. Hemorrhoids or piles are a common ailment among adults. More than half of men and women aged 50 years and older will develop hemorrhoid symptoms during their lifetime. It occurs in the anal canal and causes both discomfort and embarrassment to the sufferers. Direct costs to the health care system and indirect cost through absence from work are high. …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 5, Issue 1, 2018 · pp. 1–5 Read article
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A Conceptual Review of Qillate Ifraze Darqia (Hypothyroidism) and Its Correlation with Sue Mizaj Barid
Abstract: Qillate Ifraze Darqia (Hypothyroidism) is the most common disease of thyroid gland. Iodine deficiency continues to be a major contributor to hypothyroidism worldwide. The condition is the most common, impacting up to 40/10 000 women and 6/10 000 men annually. In traditional Unani literature, Qillate Ifraze Darqia is not explicitly described. However, ancient Greco– Arab scholars have given ample description of Sue Mizaj Barid and mentioned its Asbab, Alamaat wa …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 10, Issue 1, 2023 · pp. 23–28 Read article
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Locomotion Inhibitory Activity of Lagerstroemia speciosa Hydroalcoholic Root Extract
Abstract: Presently, it has been found from the medical databases such as PubMed, Scopus, Google Scholar, etc. that no locomotion inhibitory activity has been explored by any research group so far for the hydroalcoholic extract of Lagerstroemia speciosa (Family: Lythraceae) root. The present study involved filling the above gap by exploring the locomotion inhibitory activity (actophotometer-based) in Swiss albino rats. The investigation showed promising therapeutic perspectives (as compared to standard drug …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 11, Issue 1, 2021 · pp. 8–11 Read article
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Molecular Docking Study of Curcumin-Sugar Conjugates as Cholesterol Biosynthesis as well as Staphylococcus Aureus Virulence Inhibitor
Abstract: Methicillin resistant Staphylococcus Aureus infections are the major concern in both, communities as well as in clinics. Presqualene diphosphate is the key molecule obtained from farnesyl diphosphate for the biosynthesis of staphylophyloxanthin which is responsible for the virulence of Staphylococcus Aureus as well as for cholesterol biosynthesis in humans. We designed some natural curcumin-sugar conjugates that binds to the protein associated with the formation of presqualene diphosphate and inhibit it, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 1, 2017 · pp. 15–21 Read article
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Anti-Escherichia coli Potentials of a Novel Chemical Compound 1-(2-hydroxy-1, 2-diphenylethylidene)-3-phenylthiourea
Abstract: Inspiration from the anti-infective excellence (anti-bacterial, anti-fungal, anti-viral, and anti-malarial) of Schiff’s base molecules as well as knowing the rising importance of low-molecular-weight ligands (LMWL), the present research involved the development of novel Schiff’s base compound utilizing very basic laboratory components; 1-phenylthiourea and benzoin using the conventional synthesis technique. The compounds were comprehensively characterized through sophisticated instruments and further screened for anti-microbial activity against pathogenic Escherichia coli (E. coli, MTCC …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 1, 2020 · pp. 9–12 Read article
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Carbon Nanotubes: Revolutionizing Noval Drug Delivery Approach for Alzheimer's Disease
Abstract: The objective of the review was to comprehensively study the application of nanotechnology and investigate the potential of carbon nanotubes in serving as a drug delivery system to improve the condition of Alzheimer's disease. Alzheimer's disease, characterized as an irreversible and progressive cerebral disorder, presents clinical manifestations such as dementia, cognitive decline, altered personality, impaired motor function, confusion, and diminished cognitive planning. The neurodegenerative processes inherent in Alzheimer's disease stem …
Published in Trends in Drug Delivery · Vol. 10, Issue 3, 2023 · pp. 10–15 Read article
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Utility of Abbreviated Burn Scoring Index in Predicting Mortality in Burn Patients – Our Experience
Abstract: The prediction of the outcome of patients presenting with severe burns is crucial in guiding clinical judgments. There are multiple models for predicting burn mortality that have been developed over a period of time. Advancements in burn management over the past few decades have led to a remarkable reduction in burn-related morbidity and mortality worldwide. Improvements in critical care, fluid resuscitation protocols, infection control measures, nutritional support, early wound excision …
Published in Research and Reviews : Journal of Surgery · Vol. 15, Issue 2, 2026 · pp. 49–53 Read article
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Systolic-Predominant Hypertension and the Aging Heart: A Cross-Sectional Study on LVH and Cardiovascular Riskss
Abstract: Background: Systolic-predominant hypertension, defined as a systolic blood pressure ≥140 mm Hg with diastolic pressure <90 mm Hg, is the most prevalent form of hypertension in the elderly. It arises primarily due to age-related arterial stiffening and baroreceptor dysfunction. Once considered a benign outcome of aging, systolic-predominant hypertension is now recognized as a major risk factor for cardiovascular morbidity and mortality. Aim and Objective: To evaluate the cardiac status and …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 13–24 Read article
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Liquid Biopsy in Solid Tumor: An Ultimate Source for Molecular Landscaping, Biomarker Discovery and Clinical Management
Abstract: Presently, work in the liquid biopsy field showed a great prospect utility in the diagnosis and stratification of cancer patients and furthermore personify an adaptive method for monitoring treatment response when compared to the tissue biopsy approach. Analysis of cell free DNA (cfDNA), circulating tumor cells (CTCs) and exosomes, all conjointly referred to as “liquid biopsies,” are not only a modality to monitor treatment efficacy, disease progression, and emerging therapy …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 8, Issue 3, 2019 · pp. 25–36 Read article
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Prevalence of Mucocutaneous Manifestation and Associated Factors Among Adult HIV Positive Patients Attending Art Clinic in Mekelle Zonal Hospital
Abstract: Mucocutaneous disorders are among the first recognized clinical manifestation of HIV/AIDS and they help as a visual marker in assessing the progression of HIV/AIDS. More than 90% of HIV-positive patients may develop mucocutaneous problems at one stage of the disease or the other with significant morbidity and mortality and the magnitude of mucocutaneous manifestation is not known in Mekelle. The objective of this study was to determine the magnitude and …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 4, Issue 2, 2015 · pp. 21–30 Read article
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Comparative Proteomics: From Cell Lines to Clinical Samples
Abstract: Comparative proteomics is a powerful tool for understanding the molecular differences between various biological samples. It entails identifying and measuring proteins in complex biological samples to assess their abundance, modifications, and interactions under various conditions. This approach plays a crucial role in advancing biomedical research, especially in disease understanding, biomarker discovery, and therapeutic development. While cell lines are widely used for proteomic studies due to their controlled environments and reproducibility, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 30–34 Read article
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Advances in Deep Learning for Medical Image Analysis in the Era of Precision Medicine
Abstract: Medical imaging is fundamental to modern healthcare but analyzing the high-dimensional data requires advanced techniques. Manual image interpretation is time-consuming, subjective and limited in detecting complex patterns and minute details. Recent breakthroughs in Deep Learning offer transformative advances for unlocking clinically relevant information from medical images. This paper provides a comprehensive 6000+ word review of the current state-of-the-art Deep Learning techniques for medical image analysis including detailed coverage of key …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 2, 2023 · pp. 10–23 Read article
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European Regulatory Perspective on Super-Generics: Antacid Orally Disintegrating Tablets (ODT)
Abstract: Super-generic is the general form of nomenclature for hybrid medicinal product in European Union (EU). The super-generic form of the medicinal product is one that considers changes in the form of active substance, therapeutic indications, strength, pharmaceutical form or route of administration. They rely partly on results of preclinical tests and clinical trials of an innovator product and also on new data with appropriate bioavailability and bioequivalence studies. Marketing authorization …
Published in Trends in Drug Delivery · Vol. 3, Issue 1, 2016 · pp. 31–37 Read article
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"Onychomycosis in the Indian Subcontinent: Clinical, Microbiological and Therapeutic Perspectives,”
Abstract: Onychomycosis is a chronic fungal infection of the nail unit involving the plate, bed, and matrix, accounting for a substantial proportion of nail disorders encountered in dermatology practice worldwide. In South Asia—particularly India, Pakistan, Bangladesh, and Nepal—the burden is amplified by a convergence of climatic, socioeconomic, and healthcare-related factors. Hot and humid environmental conditions, widespread dermatophytosis, occlusive footwear practices, chronic wet work, and limited access to specialized mycological diagnostics contribute …
Published in International Journal of Tropical Medicines · Vol. 3, Issue 2, 2026 Read article
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Review of the Antifungal Drug Luconazole for the Treatment of Skin Infections
Abstract: Many U.S. researchers are still working on a broad-spectrum imidazole antifungal called Luliconazole to treat dermatophytic skin and nail infections. The in vitro activity of luliconazole against filamentous fungi, including dermatophytes, is among the highest of any antifungal drug tested to date. The unique molecular characteristics of a 10% solution of Luliconazole make it possible for the drug to quickly reach fungicidal concentrations in the nail unit, allowing it to …
Published in Journal of Catalyst & Catalysis · Vol. 9, Issue 2, 2022 · pp. 13–19 Read article
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Bioinformatics and Medicine: Bringing Data to the Bedside
Abstract: From being an empirical and experience-based practice, modern medicine has transformed into a codified and research-based discipline, known as Evidence-Based Medicine (EBM). Though EBM has greatly enhanced the quality of medical practice through population-scale clinical trials, it still has limitations in managing biologically diverse patient populations, especially when dealing with clinical outliers who respond in an unusual way to standard treatments. With the rapid progress in genomics, proteomics, and high-throughput …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 · pp. 41–46 Read article
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Molecular Diagnosis of Rifampicin Antibiotic Resistance in Mycobacterium Avium Subspecies Paratuberculosis Isolated from Sheep Clinical Samples
Abstract: The present study was conducted to identify parts of the rpoB gene in MAP of Indian sheep isolates. The rpoB gene (Beta sub unit of RNA polymerase) is involved in conferring the rifampicin antibiotic resistance in MAP bacteria. The resistance is due to the presence of mutations in the 81 bp variable region of the rpoB gene including C1367T and T1442C mutations identified by several workers. The study was further …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 12, Issue 3, 2022 · pp. 35–56 Read article