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109 articles for “Pathway analysis”
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CB₁ Reverse Agonists: A Cheminformatic and Patent Landscape Study
Abstract: The endocannabinoid system plays a crucial role in numerous physiological functions, making cannabinoid receptor 1 (CB1) an attractive target for therapeutic development. This review provides a systematic analysis of patent filings from 2019 to 2023 that focus on small-molecule CB1 reverse agonists. It begins with an overview of the endocannabinoid system, highlighting CB1’s involvement in energy balance, pain regulation, and neuroinflammatory processes The main section of the review examines fifteen …
Published in International Journal of Cheminformatics · Vol. 3, Issue 2, 2025 · pp. 33–36 Read article
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A Knowledge Graph Approach for Breast Cancer Diagnosis and Data Sharing Platform Implementation in the Context of Human Papillomavirus Infection
Abstract: Background: Breast cancer remains among the most prevalent malignancies in women worldwide, and effective diagnosis and data integration continue to challenge clinical practice. Diagnostic reports from mammography and ultrasound contain rich clinical information that is often under-utilised due to heterogeneous formats and limited data-sharing infrastructure. In the context of human papillomavirus (HPV) infection, which may influence oncogenic pathways and data complexity, advanced computational methods offer new solutions to this problem. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 1, 2026 Read article
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Comparison Analysis of Transformer Boosting and Induced Degeneration Topology Design of LNA for Millimeter Wave Frequency Range Using Polymeric Substrates
Abstract: In this study, a comparison between transformer boosting and source degeneration LNA topologies is conducted using two polymeric substrates—Polyimide (PI) and Liquid Crystal Polymer (LCP)—for millimeter-wave (mmWave) applications. With growing interest in flexible and high-frequency electronics, polymeric materials offer unique advantages such as low dielectric constants, mechanical flexibility, and thermal stability. The analysis explores gain, return loss, and noise figure performance while evaluating the influence of dielectric properties on the …
Published in International Journal of Electrical and Communication Engineering Technology · Vol. 3, Issue 2, 2025 · pp. 1–24 Read article
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Electoral Engagement and Political Representation: An Analytical Study of Women’s Participation in India’s Democratic Process
Abstract: This study investigates the persistent disconnect in women’s political participation in India, where their consistently high voter turnout stands in stark contrast to their minimal presence in Parliament. Although constitutional provisions guarantee equality and women demonstrate strong engagement as voters, their representation within formal political structures remains disproportionately low. Using the 2024 Lok Sabha elections as a primary reference point, the research interrogates core questions surrounding this imbalance: Why does …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 15, Issue 3, 2025 · pp. 1–23 Read article
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The Role of DevOps in Financial Network Security
Abstract: This study provides a comprehensive analysis of the significance of Development and Operations (DevOps) in ensuring the security of financial networks. With an ever-increasing need for speed, efficiency, and quality in the Fintech sector, integrating DevOps methodologies into operational workflow has become critical. Adopting DevOps practices not only expedites the software delivery cycle, but also ensures comprehensive security. The study explores the adoption of Secure DevOps strategies, the importance of …
Published in Recent Trends in Programming languages · Vol. 11, Issue 1, 2024 · pp. 21–28 Read article
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Thermo-Hydraulic Enhancement of Annular Finned Shell-and-Tube Heat Exchangers Using Epoxy-Based Polymer Composites: A Material–Geometry Coupled CFD Investigation
Abstract: Shell-and-tube heat exchangers remain a backbone of industrial thermal systems, yet their performance is often limited by relatively low shell-side heat transfer and the weight and cost associated with conventional metallic components. In this context, the integration of polymer composite materials offers a promising pathway toward lightweight, corrosion-resistant, and performance-tunable heat exchanger designs. The present study investigates the thermo-hydraulic performance of a straight-tube shell-and-tube heat exchanger equipped with annular fins, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 669–684 Read article
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Histological Effects of the Antibiotic Gentamicin on the Ovarian Tissue of Female White Laboratory Rats
Abstract: This study aimed to evaluate the histological alterations induced by Gentamicin in the ovarian tissue of white laboratory rats. A total of 12 adult female rats were used and randomly divided into two groups, with each group consisting of six animals. The experimental group received Gentamicin at a dose of 120 mg/kg body weight administered as an injection once daily, while the control group received an equivalent volume of normal …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 1–8 Read article
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A comprehensive study on elemental analysis and sustainable integration of CETP (common effluent treatment plant) sludge as a substitute to sand in concrete
Abstract: This study examines the utilization of sludge from common effluent treatment plants (CETP) as a fractional substitute for sand in M20 concrete mixtures. Its aim is to address disposal challenges associated with CETP sludge while promoting sustainable use of natural resources. The research assesses the structural and microstructural attributes of concrete mixes containing varying percentages of CETP sludge (0%, 10%, 20%, 30%, 40%, and 50%). Tests conducted include compressive, flexural, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 49–59 Read article
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Evaluation of the Emission and Engine Operability of Biodiesel and Biodiesel Blends Produced from Alkali-Catalyzed Esterification and Transesterification of Jatropha Oil Feedstock
Abstract: This study reports on the engine performance analysis of biodiesel and blends produced from jatropha-based bio-oil feedstock via combined esterification and transesterification process, the physiochemical of the bio-oil, and subsequent biodiesel produced. Jatropha bio-oil was characterized to determine its fuel properties. A liquid phase transesterification reaction at 60 min reaction time, 50°C temperature, using a methanol-oil molar ratio of 40:1 and 0.35 g of sodium hydroxide (NaOH) catalyst was carried …
Published in Journal of Petroleum Engineering & Technology · Vol. 15, Issue 1, 2025 · pp. 9–21 Read article