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109 articles for “Mediation Effect”
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Impact of Grape Seed Extract on Liver Function against Cadmium Chloride-Induced Toxicity
Abstract: The present study was designed to evaluate the antioxidant activities of grape seed and to benefit from the impact of grape seed on hepatotoxicity mediated by cadmium chloride (CdCl2). Gas liquid chromatography (GC-MS) was used to assay the chemical profile. A total of 40 male rats (10 rats per group) were divided into four groups: (1) control group, (2) grape seed group: rats treated with grape seed extract (GSE) at …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 7, Issue 3, 2020 · pp. 30–39 Read article
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Studies on the Self-Assembly of Steroids and DNA Mediated by Naphthalene-Based Amphiphilic Block Copolymer
Abstract: Amphiphilic block copolymers have attracted considerable interest in pharmaceutical and biomedical applications, including controlled drug release, gene delivery, and biomolecular sensing. In this study, fluorescent amphiphilic block copolymers were designed to facilitate interactions with biological molecules, such as DNA and antiviral agents, enabling their behavior to be monitored through fluorescence spectroscopy. Two novel block copolymers, poly(methyl methacrylate)-b-poly(dimethylaminoethyl methacrylate-co-naphthyl methacrylate) [PMMA-b-P(DMAEMA-co-NMA)] and poly(styrene)-b-poly(tert-butyl acrylate-co-naphthyl methacrylate) [PS-b-P(t-BA-co-NMA)], were synthesized successfully via atom …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 · pp. 183–196 Read article
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Evaluation of Anti-inflammatory Activity of Zornia gibbosa Span (Samyojaki)
Abstract: 93% of wild medicinal plants used for making Ayurvedic medicines in the country are endangered. Hence the usage of drugs which are common and abundantly available should be encouraged to control the extensive overuse of few classical drugs. An Ayurveda states that every drug possesses medicinal property, so it’s our prime duty to scrutinise those drugs which are abundantly available & cost-effective for their medicinal value. The herb Zornia gibbosa …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 4, Issue 1, 2014 · pp. 5–8 Read article
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A Comprehensive Review of Guillain-Barré Syndrome (GBS)
Abstract: The rare but potentially life-threatening immune-mediated condition dubbed Guillain-Barré syndrome (GBS) impacts the peripheral nerves and nerve roots and is generally brought on by infections. As was the scenario during the Zika virus outbreaks in Latin America (2015) and French Polynesia (2013), the incidence of GBS may consequently escalate during influenza outbreaks. Considering GBS’s clinical features and ailments course are multiple and there are currently no global clinical guidelines, the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 3, 2025 · pp. 1–5 Read article
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Interaction of Cardiotoxin with Calmodulin and its EF Hand Peptides
Abstract: Calmodulin is a ubiquitous protein having EF hand peptide(helix-loop-helix sstructural domain), which is found in all the eukaryotic cells. Calmodulin functions as a multipurpose intracellular receptor, mediating much calcium regulated processes and undergoes conformational change upon binding to calcium. These activated calmodul in then bind to a number of different target proteins, including a family of calcium/calmodul in-dependent protein kinases which then phosphorylatedserine’s or threnodies on other proteins. Cardiotoxin, snake …
Published in Trends in Drug Delivery · Vol. 4, Issue 3, 2017 · pp. 9–13 Read article
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ISGylation: A Key Host Cellular Defense Mechanism
Abstract: ISGylation, a crucial process of the innate immune response, has garnered increasing attention for its involvement in host's defense against pathogenic infections as well in cancer progression. The key player of ISGylation, ISG15, is stimulated by type I interferons (IFNs). ISG15 covalently binds with viral (influenza NS1A and nucleoproteins) and host (Nedd4, filamin B and CHMP5) target proteins and this interaction inhibits the viral replication process and release of viral …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 2, 2024 · pp. 68–80 Read article
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Study of Polycystic Ovary Syndrome (PCOS) with Special Reference to Candidate Genes
Abstract: The PCOS (polycystic ovary syndrome) has become a worldwide concern as progression of PCOS in the age group of adolescence to postmenopausal women is increasing. In India, sudden rapid growth in PCOS is observed in the range of 3.7–22.5%. Effects of PCOS are not only on the reproductive and metabolic systems, but the whole body’s metabolism gets affected; ultimately, it leads to different life- style diseases like type 2 diabetes …
Published in Research and Reviews: A Journal of Health Professions · Vol. 13, Issue 1, 2023 · pp. 49–55 Read article
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MicroRNAs in Animal Behavior: Regulation of Memory and Decision-Making in Mammals
Abstract: MicroRNAs are small, non-coding RNA molecules that play a crucial role in post-transcriptional regulation of gene expression. In recent years, their significance has extended beyond cellular development and disease regulation, as emerging evidence suggests they are critical mediators in complex behavioral processes, including learning, memory, and decision-making. This article explores the role of miRNAs in regulating neural plasticity and cognitive functions in mammals, emphasizing their involvement in memory formation and …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 13, Issue 3, 2024 · pp. 21–25 Read article
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Grid based docking study of some 2-(4-methylsulfonyl phenyl) pyrimidine derivatives (designed after QSAR studies) with Cyclooxygenase
Abstract: Molecular docking helps in studying drug/ligand or receptor/ protein interactions by identifying the suitable active sites in protein, obtaining the best geometry of ligand-receptor complex and calculating the energy of interaction for different ligands to design more effective ligands. In Grid based docking, after unique conformers of the ligand are generated, the receptor cavity of interest is chosen and a grid is generated around the cavity. Cavity points are found …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 23–41 Read article