Search
175 articles for “Lead compound.”
-
Oxadiazole Derivatives Recent Progress in Synthesis and Bioactivity
Abstract: Over the past few decades, significant advancements have been made in the development of heterocyclic derivatives, leading to the production of numerous novel agents, both synthetic and natural in origin. Because of its numerous biological properties, including antibacterial, antiviral, and antifungal properties, thiazole is a special five-membered heterocyclic motif among heterocyclic compounds. It is utilized as a fundamental building block in many pharmaceutically significant compounds. To the best of our …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 62–67 Read article
-
Targeting Vasopressin 2 Receptor (V2R) in Renal Cystogenesis by Exploring the Nephroprotective Potential of “Terminalia arjuna”
Abstract: Objectives: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, leading to the formation of multiple cysts in the kidneys. It is a major cause of end-stage renal disease (ESRD), which often requires dialysis or a kidney transplant for survival. This research focuses on identifying potential bioactive compounds derived from natural sources that show promise for drug development targeting the V2R gene. Methods: The naturally occurred …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 14–24 Read article
-
Progress in the Chemistry of C-Glycosylation in Carbohydrates
Abstract: Glycosylation is an intricate biochemical process where a glycosyl donor and a glycosyl acceptor are combined to form a glycoside. This process involves the creation of new stereogenic centers at the anomeric site of the glycosyl donor, leading to the formation of a diverse array of products. By establishing glycosidic linkages, the synthesis of complex polysaccharides becomes possible, opening doors to the creation of analogues for further exploration of their …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 1, 2026 · pp. 87–93 Read article
-
Sources and Health Effects of Arsenic, Fluoride, and Nitrate in Water
Abstract: Arsenic, fluoride, and nitrate are major inorganic contaminants in water that pose significant risks to human health. These contaminants are introduced into water sources through both natural geological processes and human activities. Arsenic is primarily released from arsenic-bearing minerals through weathering, dissolution, and erosion, while human activities such as agriculture, mining, and fossil fuel combustion further enhance its presence in water. Fluoride contamination mainly results from the dissolution of fluoride-bearing …
Published in Journal of Water Resource Engineering and Management · Vol. 13, Issue 2, 2026 · pp. 19–25 Read article
-
Novel 1,3,4-Thiadiazole Derivatives: Design, Synthesis, Characterization and Anticancer Evaluation – A Review
Abstract: Cancer remains one of the leading causes of mortality worldwide despite significant advances in diagnosis and treatment. The clinical usefulness of many anticancer drugs is often restricted by toxicity, poor selectivity, and the emergence of drug resistance. These limitations have encouraged the search for novel heterocyclic compounds with improved therapeutic efficacy and safety. Among these, the 1,3,4-thiadiazole scaffold has gained considerable attention because of its favorable physicochemical characteristics, metabolic stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 42–49 Read article
-
Phytochemical, Pharmacological and Toxicological Studies of Solanum americanum: A Systemic Review
Abstract: Solanum americanum, a plant widely used in folk medicine, has recently gained attention in the scientific community due to its diverse therapeutic potential. The bioactive compounds found in different plant parts, such as alkaloids, flavonoids, and tannins, have significant medicinal effects. These compounds exhibit several pharmacological properties, such as antimicrobial, anti-inflammatory, anticancer, and antioxidant effects. However, despite these medicinal benefits, some compounds show significant toxicity to the human body if …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 2, 2025 · pp. 52–62 Read article
-
Green Medicines in Drug Discovery
Abstract: The process of finding new leads for medicines using natural products is challenging. It discusses bioactive composites generated from natural resources, including phytochemical analysis, characterization, and pharmacological investigation. The success of these resources in the process of discovering unique and effective pharmacological combinations that may help mortal coffers is the primary focus. Natural goods have long been employed as a source of medicinal compounds, and they have shown promising results. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 32–48 Read article
-
In Silico Molecular Docking of Indigofera tinctoria Phytocompounds to Target EGFR/ERK and FGFR/FGF Pathway Proteins Involved in Prostate Cancer
Abstract: Objective: Prostate cancer being the second major cause of cancer-related deaths in males, affects the small walnut-shaped gland below the bladder called the prostate gland. The epidermal growth factor protein (EGFR), cascade protein (ERK), and fibroblast growth factor proteins (FGFR and FGF) are involved in the different signaling pathways that lead to the formation of different products, that are responsible for the progression of cancer and thus can be considered …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 34–56 Read article
-
Removal of heavy metals from waste water treatment using composite nanomaterials – A Review
Abstract: With the rapid industrial and textile development, the increasing heavy metal ions concentration in water streams has caused serious environmental problems all over the world. Removal of heavy elements and its techniques in India of earth is a biotechnological process which has been used for more than five decades for wastewater treatment. It is generally agreed that removal of heavy metals from drinking and industries side effluent waters are important …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 9, Issue 1, 2019 · pp. 27–44 Read article
-
Growth and Impact of Artificial Intelligence Research Output in India: A Study
Abstract: The citation analysis is an essential part of an institution’s measure and evaluation of research quality. The present study is tracing the growth and impact of Computer Science Research Output in India. The study traces the growth of publication and pattern of citations. The journal observed progressive inclination in the number of publications and citations over the years. Total of 158 publications, have been published during the time span of …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 2, Issue 1, 2015 · pp. 7–14 Read article
-
Software Engineering Research Productivity and Its Visibility
Abstract: This study is tracing the growth and impact of Software Engineering research productivity in India. The study identifies the growth of publication and pattern of citations. The journal explored that progressive inclination in the no. of publications and citations over the years. Total of 119 publications have been published during time span of 7 years (i.e. from year 2008–2014). Compound Annual Growth Rate (CAGR) of publication is 49.89%. The authors …
Published in Journal of Software Engineering Tools & Technology Trends · Vol. 2, Issue 1, 2015 · pp. 1–8 Read article
-
Critical Review on Photocatalytic Polymer Nanocomposites for Indoor Air Purification in Hotels
Abstract: The indoor air quality has become a key measure of health, comfort, and customer satisfaction of a hospitality setting. The challenges that continually affect hotels especially because of volatile organic compounds (VOCs), particulate matter, and microbial pollutants that are present in cleaning agents, furnishing, and human activity. In this regard, the photocatalytic polymer nanocomposites are one of the sustainable and efficient means of purifying indoor air. These materials combine photocatalysts …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 527–541 Read article
-
Management of Warm Kabid Haad (Acute Hepatitis) by Unani Herbal Medicine
Abstract: Hepatitis, is a general term refers to inflammation of the liver, may be due to various causes mostly by the virus which leads to hepatocytes damage with subsequent cell death. Symptoms include fatigue, anorexia, nausea and right upper quadrant tenderness. In Unani system of medicine acute Hepatitis is known as Warm Kabid Haad has been described under the heading of Jaundice. For the management, several single as well as compound …
Published in Research & Reviews : Journal of Herbal Science · Vol. 6, Issue 2, 2017 · pp. 25–31 Read article
-
Therapeutic Potential of Terminalia arjuna Bark in the Management of Hemorrhoids: A Comprehensive Review
Abstract: Background: Hemorrhoids appear frequently among anorectal disorders since they create vascular swelling together with pain symptoms, while leading to bleeding and mucosal tissue tending to slide out. Though effective therapy exists, traditional treatments produce various adverse effects and lead to recurrence and inconsistent patient following of medical recommendations over the long term. Plantbased therapeutic medicines have gained rising demand, which leads experts to investigate medicinal plants with established pharmacological effects. …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 22–32 Read article
-
Biopolymer Degradation and Structure–Property Relationships in Ageing: A Polymer Science Perspective
Abstract: Ageing, as viewed from the polymer sciences perspective, is perceived as the gradual modification of the structure-property-function interrelationship of biopolymers such as proteins, polysaccharides, nucleic acids and their molecular aggregates. Such changes include structural organization, mechanical behavior, physicochemical stability and functional effectiveness. Ageing is an inevitable multifactorial polymeric process. Due to the growing aging population globally, more age-associated complications emerge, which are correlated with the molecular degeneration of biopolymeric complexes. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 479–489 Read article
-
In vitro/In vivo Study of Anti-inflammatory Effect of Cyperus rotundus on Diabetic Complications
Abstract: The reactive oxygen species (ROS) develop oxidative stress that contributes to the cause of human diseases. Radicals which enhance inflammation are nitric oxide, hydroxyl radical, hydrogen peroxide, and superoxide. Anion mediate and amplify the inflammation process, mediate vascular permeability and platelet aggregation leading to diabetic complications due to disruption of steady state of pro-oxidants and antioxidants. Cyperus rotundus plant extract was subjected to foraging radical activity with hemolysate sample to …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 24–32 Read article
-
Molecular Dynamics and Therapeutic Architectures of Cannabinoid Receptors: A Comprehensive Review
Abstract: Expanding on these foundations, recent structural biology studies using cryo-electron microscopy have provided high-resolution insights into the conformational dynamics of CB₁ and CB₂ receptors. These findings have enabled a more precise understanding of ligand–receptor interactions, particularly how agonists, antagonists, and reverse agonists stabilize distinct receptor states. Such knowledge is critical for rational drug design, allowing researchers to selectively modulate downstream signaling pathways. For instance, CB₁ receptors primarily couple to Gi/o …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 36–40 Read article
-
An Overview of Heavy-ion Collisions
Abstract: AbstractA large number of experiments have been performed to explore the heavy-ion collisions dynamics using accelerator facilities available in India. The experimental results have revealed that in reactions induced by nucleons or light particles at energies of the order of a few tens MeV, the great majority of the processes one observes are of statistical nature though they cannot be interpreted as a consequence of the decay of a fully …
Published in Journal of Nuclear Engineering & Technology · Vol. 9, Issue 2, 2019 · pp. 8–23 Read article
-
Determination of Gastric Irritation Inducing Effect of Iron-Containing Unani Compound Formulations In Animals
Abstract: AbstractBackground: Iron is the most commonly used metal for human welfare on earth and also a vital element for sustenance of life.Iron deficiency is a common affliction of human beings all over the globe and presents as iron deficiency anaemia. Most effective and preferred treatment of iron deficiency is replenishment of iron by oral administration. Successful completion of treatment depends on tolerance of the prescribed drug by a patient. Oral …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 9, Issue 3, 2022 · pp. 27–30 Read article
-
A Study on Tensile Characterization of Polypropylene Reinforced with Recycled Epoxy Particles
Abstract: Polypropylene is a thermo plastic, tensile properties of polypropylene are crucial in the real world applications as they determine structural integrity and durability. Epoxy is a thermosetting plastic finds applications in various fields like aerospace, automobile, food packing etc. A major concern is the disposal of epoxy composites after their service life, since most of the waste is sent to landfills, causing land pollution and soil infertility. In this experimental …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 221–237 Read article