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142 articles for “Inhibitory”
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Extrapolations of Periwinkle Secondary Metabolites as Multitarget Inhibitor of Breast Cancer Proteins
Abstract: Objective: Breast cancer is considered as one of the most common and dangerous forms of cancer. It is a significant public health issue on a global scale. The study estimates that 10.0 million people will die from cancer this year, and 19.3 million people will develop the disease overall (BC). In this computation approach nowadays emphasises for new drug discovery, the target protein EGFR (5UGB), ER (2QGT), and PI3KA (4OYS) …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 3, 2022 · pp. 22–36 Read article
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Brain GST Inhibition, An Additional Mode of Action Following Beta-Cyfluthrin Intoxication in Albino Rat
Abstract: The aim of the study was to reveal the neurotoxic effect of an orally administered beta-cyfluthrin, a type-II pyrethroid in albino rats on the basis of activity of brain GST (Glutathione-s-transferase), AChE (acetylcholinesterase) and of total proteins level at different doses 35.48 and 5.06, 2.53, 1.68, 1.27 mg/kg body weight, for acute (1 day) and sub-acute (7, 14, 21 and 28 days) treatments respectively. Results reveal that beta-cyfluthrin administration inhibits …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 3, 2014 · pp. 30–36 Read article
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Effects of Sub Chronic Dermal Exposure of Gasoline Blended with Varying Concentration of Benzene on Hepatic Mixed Function Oxidases in Rats
Abstract: Interaction of chemicals in a mixture, their biotransformation and adverse impact, if any, on environment and workroom atmosphere needs to be evaluated to identify the nature of potential toxic effects elicited by constituent chemical(s) in a mixture. The nature of chemical interaction(s) through which an individual chemical in a mixture undergoes metabolism and/or biotransformation in the target tissue could be helpful in evaluation of its toxic potential. Gasoline is a …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 1, 2013 · pp. 1–5 Read article
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Literature Review of Irsal-e-Alaq (Leech Therapy) in Unani and Modern Science
Abstract: The Unani system of medicine is based on the humoral theory (Nazriya Akhlat) postulated by Buqrat. According to this theory, all illness is caused by an imbalance of one of the four body humors that is, blood, phlegm, yellow bile and black bile. Irsal-e-alaq is one of the oldest and widely practiced means of Ilaj-bit-tadbeer for local evacuation of morbid humours. It is a procedure of treatment with the use …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 6, Issue 3, 2019 · pp. 21–29 Read article
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Clinical Fusariosis in India: Taxonomy, Pathogenesis, and Therapeutic Challenges
Abstract: Fusarium species are emerging opportunistic pathogens in humans, responsible for a wide spectrum of infections ranging from superficial keratitis and onychomycosis to life-threatening disseminated disease in immunocompromised hosts. Historically regarded as plant pathogens and environmental saprophytes, these hyaline moulds have become clinically relevant with the increasing use of intensive chemotherapy, haematopoietic stemcell and solidorgan transplantation, and widespread use of broadspectrum antibiotics and corticosteroids. In India, Fusarium assumes particular importance due …
Published in International Journal of Pathogens · Vol. 3, Issue 2, 2026 Read article
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Antimicrobial Activity of Alcoholic and Aqueous Extracts of Tinospora cordifolia
Abstract: 1024x768 Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} The success of chemotherapy lies in the continuous search for new drugs to counter the challenge posed by resistant strains. Ethanolic and aqueous extracts of plant Tinospora …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 2, Issue 1, 2011 · pp. 1–6 Read article
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Fluconazole Resistance among Candida species Causing Vulvovaginitis
Abstract: Yeasts have emerged as a prominent cause of vaginal infections in community and hospitalized patients. Majority of cases of Vulvovaginal candidiasis (VVC) are caused by Candida albicans however, episodes due to non-albicans Candida appear to be increasing in the recent years leading to increase medical concern. Most non-albicans Candida species have higher minimum-inhibitory concentration (MIC) to fluconazole and infections caused by these species are often difficult to treat. This study …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 2, Issue 2, 2012 · pp. 1–3 Read article
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Combined Antibacterial Effects of Honeybee (Apis mellifera) and Garlic (Allium sativum) Extracts against Standard and Clinical Pathogenic Bacteria
Abstract: Normal 0 false false false EN-US X-NONE X-NONE Among natural antimicrobial substances, honey and garlic were widely used and investigated separately. But their synergistic antibacterial effect was not studied. The objective of this study was to investigate synergistic antimicrobial effect of combination of honey and garlic against pathogenic bacteria. The antimicrobial activity of mixture of honey and garlic, honey and garlic extract alone against Salmonella NCTC 8385, Listeria monocytogenes (ATCC …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 3, Issue 1, 2013 · pp. 1–8 Read article
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Microbial Profile and Dynamics of Metata ayib
Abstract: Although metata ayib is widely consumed, there is no scientific report about microbial profile, role of microbes and spices during fermentation. The objective of this study is to investigate microbial profile, role of spices and lactic acid bacteria in metata ayib fermentation. Metata ayib was prepared from ayib and different spices. Ayib without spice and sterilized ayib with spices were used as controls. Samples were taken periodically within four days …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 3, Issue 3, 2013 · pp. 15–21 Read article
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Synthesis of Silver Nanoparticles by Biological Method and its Application in Protection of Wood from Ganoderma Species
Abstract: The major advancement in the field of nanotechnology during the last decade have resulted in the wide spread application of nanomaterials in the field of science and technology. Nanoparticles were synthesised biologically, which is a pure green chemistry and completely toxic free compared to chemical synthesis. The property of the reductases present in the E. coli culture filtrate reduces silver nitrate to silver oxide and also serves as a capping …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 3, Issue 1, 2013 · pp. 37–43 Read article
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3D-QSAR and Molecular Docking Studies of Triazol-Cycloalkanol Derivatives Used as Potent 3-Dehydroquinase II Inhibitors Against Mycobacterium tuberculosis
Abstract: Tuberculosis is a life threatening infectious disease caused by gram positive bacteria mycobacterium tuberculosis. Emergence of drug resistance, multi drug resistance and extensively drug resistance strain of mycobacterium make the situation more worst. It increases the mortality rate of tuberculosis patient, time duration and cost of treatment. Various inhibitors and drug molecules are designed to combat this fatal disease. Enzymes of shikimate pathway are responsible for production of essential amino …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 5, Issue 3, 2015 · pp. 18–28 Read article
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3D-QSAR Studies, Molecular Docking and Adme Property Prediction of Mannosyl Triazoles Used as Potent Antiadhesives of Uropathogenic E. coli
Abstract: Urinary tract infections (UTIs) are among the most common infectious diseases, accounting for almost five million cases annually and causing considerable morbidity and mortality. Escherichia coli is a commensal inhabitant of the mammalian large intestine and the most common cause of UTIs in humans. Increasing incidence of antibiotic-resistant E. coli causing up to 95% of these infections, calls for additional therapeutic considerations. In this study, 3D-quantitative structure-activity relationship (3D-QSAR) analysis …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 6, Issue 1, 2016 · pp. 26–33 Read article
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In Vitro Screening of Antibacterial Potentiality of Some Important Flowers’ Extracts Against Some Pathogenic Bacteria
Abstract: Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 The present investigation was carried out to screen and evaluate the antibacterial activities of different flowers, namely, Calendula officinalis, Rosa damacena, Hibiscus rosa-sinensis, Datura stramonium, Bougainvillea stabilis, and Vinca rosea. These flowers were screened for potential antibacterial activity against some important bacterial Gram negative and Gram positive bacteria strains, namely Escherichia coli, Salmonella typhi, Staphylococcus aureus, and E. faecalis. Dried leaf …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 1, Issue 3, 2011 · pp. 9–19 Read article
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Biochemical and Kinetic Investigations of Partially Purified Thermostable Acid Phosphatases from Solanum tuberosum and Citrus limonium
Abstract: Biochemical and kinetic properties of partially purified thermostable acid phosphatases from Solanum tuberosum and Citrus limonium involving ammonium sulphate fractionation have been investigated. The maximum specific activity in Solanum tuberosum and Citrus limonium was found in 40–80% (ACP I) and 0–40% (ACP II) fractions, respectively. The specific activities of ACP I and ACP II were 46.01 and 48.00 units mg − 1 with Km values of 1.00 and 2.50 mM, …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 2, Issue 1, 2012 · pp. 1–10 Read article
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An in Silico Study of Selected Compounds from Garcinia spp. to Fight against Multidrug Resistant Bacteria
Abstract: AbstractBackground: Antibiotic resistant bacteria have emerged as a global threat. They have limited the number of available treatment options. New Delhi Metallo-beta-lactamase-1 (NDM-1) mediated drug resistance and efflux pump mediated drug resistance are among the major mechanisms associated with multidrug resistance.Objective: In our study, potential NDM-1 inhibitors as well as efflux pump inhibitors were identified through reverse chemogenomics from Garcinia spp. to deal with multidrug resistant bacteria. Method: Selected compounds …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 4, Issue 2, 2017 · pp. 1–4 Read article
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In vitro Antibacterial Activity of Averrhoa carambola Leaf Extracts
Abstract: The aim of the present study was to determine the phytochemical constituents and antimicrobial potential of Averrhoa carambola leaf extracts against three gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus and Streptococcus mutans) and three gram-negative bacteria (Klebsiella pneumoniae, Proteus vulgaris and Pseudomonas aeruginosa) which are some of the infectious bacteria. The A.carambola leaves were extracted in three different solvents of increasing polarities (hexane, ethyl acetate, and acetone). The phytochemical analysis showed …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 8, Issue 2, 2018 · pp. 27–32 Read article
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In Silico Identification of Small Molecules as Novel Coronavirus Protease Enzyme Inhibitors
Abstract: AbstractThe novel corona virus 2019 (COVID-19) is one of the global threats to the human civilization as it causes serious respiratory infection and multi-organ failure. Because of the absence of appropriate treatment protocol for 2019 novel corona virus, different methodologies are being tried in China, including drug repurposing. Recent discovery revealed the structure of novel corona virus main protease enzyme (Mpro) containing HIS41 and CYS145 amino acid residues present in …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 7, Issue 2, 2020 · pp. 33–43 Read article
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Integrated Effect of Bioagents along with FYM on Pokkah Boeng Disease of Sugarcane
Abstract: AbstractSugarcane production in various regions of the country is affected by different biotic and abiotic stresses. Among the biotic constraints, there are many diseases such as red rot, wilt, grassy shoot, pineapple disease, smut, leaf scald and pokkah boeng disease. Amongst the foliar diseases, the pokkah boeng disease is becoming a major disease of sugarcane. Pokkah boeng is frequently associated with sett rot or stem rot disease as both are …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 8, Issue 3, 2019 · pp. 8–13 Read article
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Allelopathic Nature of Cucumis Prophetarum Linn.
Abstract: ABSTRACTCucumis prophetarum Linn. is perennial, monoecious climber, commonly growing weed, belonging to family Cucurbitaceae. The whole plant of C. prophetarum is medicinally important. Plant pacifies vitiated dysentery, diarrheic diseases, flatulene, skin diseases, antivenin and general debility. Dispending medicinally uses, our study has found that this weed is allelopathic in nature. To check the allelopathic activity, C. prophetarum was assessed for the effects of their extracts on the growth of mature …
Published in Research & Reviews : Journal of Botany · Vol. 1, Issue 1, 2012 · pp. 16–21 Read article
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Screening of Allelopathic Activity of Momordica dioica and Mukia maderaspatana
Abstract: ABSTRACTAllelopathy is a chemical process which a plant uses to keep other plants from growing too close or away from it. Allelopathy refers to the chemical inhibition of one species by another. The “inhibitory” chemical releases into the environment where it affects the development and growth of neighboring plants. In the present investigation to check the allelopathic activity, two plants of family Cucurbitaceae were selected, i.e., Momordica dioica Roxb. ex …
Published in Research & Reviews : Journal of Botany · Vol. 1, Issue 3, 2012 · pp. 1–7 Read article