Search
550 articles for “HIV-1 Integrase” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
Nothing matched all of your words, so these match any of them.
-
Gut Microbial Metabolites in Inflammatory, Metabolic, and Neurologic Disorders.
Abstract: The human gut microbiota transforms dietary and hostderived substrates into a diverse array of metabolites—including shortchain fatty acids (SCFAs), hydrogen sulfide (H₂S), bile acid derivatives, indoles, trimethylamine Noxide (TMAO), branchedchain amino acid (BCAA) derivatives, and lipopolysaccharide (LPS)—that act as key signaling mediators along epithelial, immune, endocrine, and neural axes. These metabolites regulate barrier integrity, energy homeostasis, inflammation, and gut–brain communication and are increasingly implicated in the pathogenesis of inflammatory bowel …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 58–64 Read article
-
Plant Bioactive Metabolites and Their Role in the Prevention and Control of Dental Diseases and Infections.
Abstract: The oral diseases, including dental caries and periodontitis, affect masses worldwide, and have historically been managed with synthetic antimicrobials that cause deleterious side effects, leading to mounting bacterial resistance. Consequently, contemporary dentistry is rapidly shifting toward phytomedicine using plant bioactive molecules, such as polyphenols, terpenes, anthraquinones (berberin, eugenol, curcumin, catechins, allicin, and azadirachtin. These compounds offer potent antimicrobial, anti-inflammatory, and tissue-regenerative properties that are crucial for preventing and curing dental …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 47–66 Read article
-
The Mycobiome Frontier – Pre & Post 2020 Status: Integrating Fungal Bioactive Compounds, Probiotics, and Antimicrobial Peptides in Modern Therapeutics and Biotechnology.
Abstract: The fungal kingdom represents an indispensable resource in modern therapeutics and biotechnology, offering a diverse array of bioactive compounds, probiotics, and antimicrobial peptides (AMPs). Functional fungal polysaccharides (FFPs), such as beta-glucans, chitin, and mannans, are centrally involved in modulating the human gut microbiota, providing novel therapeutic avenues for chronic conditions including diabetes, neurodegenerative disorders, and cancer. These compounds act as prebiotics, nourishing beneficial bacteria and enhancing metabolic parameters such as …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article
-
Integrative Structural-Functional Genomics of Fc and Fab: Precision Models for Monoclonal Antibody Stability and Anti-Aggregation Engineering
Abstract: Monoclonal antibodies (mAbs) represent the cornerstone of biotherapeutics, yet aggregation propensity compromises up to 50% of candidates during development, driven by Fab hypervariability and Fc vulnerabilities.(1,2) This review integrates functional genomics from OAS (4B+ sequences)(5) and structural databases (SAbDab: 10K+ structures)(6) with machine learning models achieving R=0.97 for SAP prediction.(11) We dissect biophysical mechanisms, benchmark predictive tools (DeepSP, ESM2), and engineering strategies (YTE, FW mutations) that enhance Tm by 5-10°C …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
-
Reactivity of Monochlorotetrakis2-Isopropylphenoxoniobium(V), [NbCl(OC6H4CH(CH3)2-2)4] towards Chelating Ligands
Abstract: The niobium(V) complexes with the formula [NbCl(OC₆H₄CH(CH₃)₂-2)₄] were successfully synthesized in high yields through the reaction of niobium pentachloride with four equivalent amounts of 2-isopropylphenol in carbon tetrachloride. The synthesized complexes were characterized and confirmed by elemental analysis, molar conductance measurements, infrared (IR) spectroscopy, ^1H and ^13C NMR spectroscopy, as well as mass spectrometric analysis. The spectroscopic studies have shown these to exhibit dimeric structures bridging through isopropylphenoxo groups. The …
Published in International Journal of Minerals · Vol. 3, Issue 1, 2026 · pp. 37–45 Read article
-
A Descriptive Cross-Sectional Study to Assess the Knowledge and Practice of Antenatal Mothers Regarding Maternal Diet Including Macronutrients and Micronutrients in Selected Hospitals of Indore (M.P.) in the Year 2022–2023
Abstract: A balanced and adequate diet is most important during pregnancy to meet the mother's increased needs and prevent nutritional stress. Maternal nutrition during pregnancy plays a crucial role in lowering both maternal and infant mortality rates. This study aimed to evaluate the level of knowledge and the dietary practices of antenatal mothers concerning maternal nutrition, including both macronutrients and micronutrients. A descriptive cross-sectional research design was used, involving 100 pregnant …
Published in International Journal of Women's Health Nursing And Practices · Vol. 4, Issue 1, 2026 · pp. 41–46 Read article
-
A Study on Cancer Related Fatigue and Quality of Life (QOL) among Women Undergoing Treatment for Various Cancers in Selected Tertiary Care Hospitals of Ludhiana, Punjab
Abstract: Cancer is a collection of illnesses marked by irregular cell proliferation that has the potential to infiltrate or metastasize to different areas of the body. Gynecological cancer specifically refers to the abnormal cell growth in the female reproductive tract, including various organs such as the endometrium, fallopian tubes, ovaries, uterus, cervix, vagina, and breast. These cancer cells have a tendency to multiply uncontrollably. The majority of individuals diagnosed with cancer …
Published in International Journal of Oncological Nursing and Practices · Vol. 1, Issue 1, 2023 · pp. 6–11 Read article
-
A Study to Assess the Awareness of the Breast Cancer Screening Among Teacher Training Students in Selected Teacher Training Institutions at Mysuru with the View to Conduct Educational Program
Abstract: Background: Cancer is one of the major causes of death both in developed and developing countries. Breast cancer is defined by the uncontrollable proliferation of cells within the breast, encompassing different forms of cancer that impact the breast tissue. The majority of breast cancer cases manifest as painless lumps, while a smaller percentage may exhibit additional symptoms. Breast cancer is amenable to almost complete care if detected in its early …
Published in International Journal of Oncological Nursing and Practices · Vol. 1, Issue 1, 2023 · pp. 17–31 Read article
-
Assessment of Knowledge and Estimated Burden of Life Style Diseases in a Rural Community
Abstract: Although rapid human evolution has brought about advancement, it has also caused several lifestyle ailments. People’s daily routines have drastically changed as a result of emerging technologies, and it paved the way for numerous life style disorders. According to reports, lifestyle diseases are a major cause of increased mortality globally. Our study highlights the prevalence of life style diseases in the rural community and the need for early identification and …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 1, Issue 1, 2023 · pp. 33–38 Read article
-
Impact of Education on Knowledge and Perception of Antenatal Care Among Primigravida Mothers, Residing in Farasan, Kingdom of Saudi Arabia: A Community-based Interventional Study
Abstract: Pregnancy is one of the most cherished phases in the life of a woman. This timeframe holds immense importance for both the mother and the infant. Offering appropriate prenatal care during pregnancy is crucial for the health of the mother and the growth of the foetus. It provides a chance to promote sound parenting techniques and healthful conduct. The quality of prenatal care contributes to sustaining overall well-being throughout an …
Published in International Journal of Women's Health Nursing And Practices · Vol. 1, Issue 2, 2023 · pp. 6–13 Read article
-
Studies on Extraction of Flavonoids from the Peel of Pisum Sativum
Abstract: Pisumsativum is commonly known as Pea plant and belongs to Fabaceae family. It is an herbaceous annual plant. Pea pods not only yield an adequate quality of dietary fibre but provide a substantial amount of proteins, sugars, and minerals. Globally, significant quantities of pea residue are generated, an enormous amount of which is used as animal feed. The pea pods consist of an appreciable amount of polyphenols, including phenolic acids …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 2, 2023 · pp. 17–22 Read article
-
Bioactive Compounds in Ethanolic Extract of Strychnos innocua Root Using Gas Chromatography and Mass Spectrometry (GC-MS)
Abstract: Medicinal plants are of great relevance with endless pharmaceutical and therapeutic properties. They are source of wide array of secondary metabolites or bioactive compounds/phytochemicals (phenols, alkaloids, flavonoids, terpenoids, tannins, steroids and saponins) which can discharge numerous biological functions (antimicrobial, antioxidant, antiviral, antifungal, anti-fibrotic, immune-modulatory, cytotoxic, antipyretic, antitumor, antihelminthic, antiprotozoal, antibacterial, and so on). The use of gas chromatography and mass spectrometry analysis in identifying the bioactive compounds in the ethanolic …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 9–14 Read article
-
Effectiveness of Sensitization Program on Knowledge of School Children Regarding Refractive Errors
Abstract: The human eyes are portals of absorbing divine knowledge from the surrounding world. These two precious pearls need to take proper care throughout to taste life. The eye care starts right from birth onward and becomes keenly required in children's school age as they use these gifts for intense learning. The neglected care in the initial years may trouble them with various visual disorders and disturb their studies too. Well-structured …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 1, 2024 · pp. 13–20 Read article
-
Knowledge and Practice of Rural Population Regarding Mosquito Control Measures: A Descriptive Study
Abstract: The research aimed to evaluate the understanding and implementation of mosquito control strategies among the rural inhabitants in specific wards of the Athirampuzha panchayath. The study aimed to achieve the following objectives: evaluate the understanding of mosquito control measures among the rural population, analyze the implementation of mosquito control measures by the rural population, and investigate potential correlations between the rural population's knowledge of mosquito control measures and various demographic …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 1, Issue 2, 2023 · pp. 14–18 Read article
-
Chaya Plant Extract Jatropha tanjorensis: The Concepts of Bioremediation of Contaminated Soil Evaluation
Abstract: This research was carried out to study the performance of sun-dried and room dried Chaya plant extract on the remediation of crude oil contaminated soil samples from Obele Community. The parameters under investigation were Total Petroleum Hydrocarbon degraded((TPHD), pH, amount of Nitrogen, Phosphate, and Potassium, Total organic carbon. Twenty-two (22) batch reactors were used for this research with each reactor containing 1kg of soils samples contaminated with 100ml of crude …
Published in International Journal of Advance in Molecular Engineering · Vol. 1, Issue 1, 2023 · pp. 31–48 Read article
-
Knowledge and Attitude of Women Regarding Mammogram and Other Screening Modalities for Breast Cancer in a Selected Hospital, Kottayam
Abstract: The present study was conducted at Caritas Hospital, to assess the knowledge and attitude of women (30–50 years) regarding mammogram and other screening modalities. The study aimed to evaluate women's understanding of mammograms and various breast cancer screening methods, gauge their attitudes toward mammograms and other screening options, investigate the relationship between women's knowledge and attitudes regarding these screening methods, explore any associations between knowledge and certain demographic factors, and …
Published in International Journal of Oncological Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 36–44 Read article
-
Optimizing Antibiotic Analysis: A Comprehensive Guide to HPLC Process of Assessment and Quantification
Abstract: The history and uses of chromatography are thoroughly covered in this work, with an emphasis on the use of High-Pressure Liquid Chromatography (HPLC) in pharmaceutical analysis. Since its discovery by Russian botanist Mikhail Tswett in the 19th century, chromatography has undergone tremendous developments that have given rise to a variety of chromatography types and applications. The story follows the evolution historically, emphasizing Tswett's groundbreaking breakthrough in plant color classification and …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 27–44 Read article
-
Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
-
The Evolution and Development of travel, travel blogs
Abstract: Over time, there have been substantial advances in the development of travel and the ways in which memories and experiences can be preserved. Jorn Barger initially used the term "weblog" on December 17, 1997. Peter Merholz introduced the acronym "blog" by amusingly combining the words "web" and "log" on his blog. By developing the "Blogger" platform, Pyra Labs' Evan Williams helped to popularize the term even further. Despite a sluggish …
Published in International Journal of Rural and Regional Development · Vol. 2, Issue 1, 2024 · pp. 06–10 Read article
-
Lower Genital Tract Infections in Pregnant Women: Epidemiology and Risk Factors Associated in Dakar, Senegal
Abstract: Vaginal infections are responsible for many problems in women of childbearing age and significantly influence pregnancy outcomes. This study sought to ascertain the prevalence of lower genital tract infections and the risk factors associated with them in pregnant women under observation at the Nabil Choucair Health Centre in Dakar, Senegal. This nine-month cross-sectional study, which involved women between 34 and 38 weeks gestation (WG), was carried out from July 2020 …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 47–59 Read article