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1363 articles for “Pre-clinical”
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Breast Cancer at Community Level in Bangladesh
Abstract: Background: Breast cancer is an issue of gaining concern in Bangladesh that causes high mortality and morbidity. Lack of screening and surveillance programme contributes to this. Almost no baseline data were found in this issue, though Government of Bangladesh launched a breast cancer surveillance programme based on clinical breast examination (CBE). This research was an effort to produce some baseline data to strengthen the programme of Government of Bangladesh. Methods: …
Published in Research and Reviews : Journal of Surgery · Vol. 8, Issue 2, 2019 · pp. 4–7 Read article
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Stiff Person Syndrome: Advances in Understanding, Diagnosis, and Treatment of a Rare Autoimmune Disorder
Abstract: Stiff Person Syndrome (SPS) is a rare and complex autoimmune neurological disorder characterized by progressive muscle stiffness, rigidity, and painful spasms. This chapter provides a comprehensive overview of SPS, exploring its pathophysiology, clinical presentation, diagnostic challenges, and current treatment approaches. We discuss the latest research findings, including the role of autoantibodies, genetic factors, and environmental triggers in the development of SPS. The chapter examines various diagnostic methods, emphasizing the importance …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 35–43 Read article
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Evaluation of the Effect of Manyabasti and Sarvangatailadhra in Manyagata vata (Cervical Spondylosis)
Abstract: Present clinical study was designed to assess the efficacy of Manyabasti and Sarvangatailadhara in reducing the sign and symptoms of cervical spondylosis. Total 11 patients of cervical spondylosis were registered in the OPD and IPD of Samadhan Panchakarma Hospital, Nagpur, India. They were subjected to the treatment schedule of 15 days. During this period Manyabasti was done for 15 min and Sarvangatailadhara for 30 min by the mixture of Arogya …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 1, Issue 3, 2014 · pp. 1–5 Read article
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Understanding the Cervical Spine Disorder: A Cross-sectional Survey Study
Abstract: Cervical spine disorders encompass a spectrum of conditions including degenerative spondylosis, disc herniation, traumatic injuries, and myelopathy that impair quality of life through chronic pain, neurological deficits, and functional limitations. Globally, neck pain affects over 200 million individuals, with an age-standardized prevalence of 2666 per 100000 population and an incidence of 816 per 100000 person-years, contributing to significant years lived with disability (YLDs). Economic analyses estimate annual direct healthcare costs …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 80–97 Read article
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CRISPR, Recombinant DNA, and LAMP-Based Platforms for Monkeypox: Emerging Tools for Diagnosis and Therapeutic Development
Abstract: Monkeypox, a zoonotic viral infection caused by the Monkeypox virus of the Orthopoxvirus genus, has recurred as a worldwide public health concern after recent outbreaks outside of its classical endemic areas in Central and West Africa. The resurgence has demanded a thorough reassessment of its epidemiology, mode of transmission, and clinical presentation. In light of these challenges, recombinant DNA technology (rDNA) has emerged as a candidate for developing vaccines, diagnostics, …
Published in International Journal of Virus Studies · Vol. 3, Issue 1, 2026 · pp. 7–28 Read article
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A Comprehensive Review on Male Infertility
Abstract: The failure to attain a clinical pregnancy naturally after one year of unprotected intercourse is termed as infertility. Some of the factors that contribute to Infertility are late marriages, advanced age, genetics and lifestyle to name a few. To tackle this scenario, infertile and sub fertile couples take the aid of assisted reproductive technology. Intra uterine insemination (IUI), In vitro fertilization (IVF), Intra cytoplasmic sperm injection (ICSI), surgical sperm retrieval …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 3, 2025 · pp. 95–103 Read article
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The Evaluation of the Light Parameters and Pleural Fluid Cholesterol to Determine the Differences Between Exudative and Transudative Pleural Discharge
Abstract: Background: Pleural effusion occurs when an imbalance between pleural fluid production and absorption leads to the accumulation of excess fluid in the pleural cavity. Pleural effusions are commonly classified into two types: transudative or exudative, depending on the underlying mechanism of fluid formation. While transudates typically result from systemic factors like heart failure or liver cirrhosis, exudates are usually caused by local factors such as infection, malignancy, or inflammation. Differentiating …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 30–35 Read article
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Basal Cell Adenocarcinoma of Submandibular Gland: A Case Report
Abstract: Basal cell adenocarcinoma (BCAC) of the salivary gland is a rare neoplasm that commonly occurs in major salivary glands, most likely in parotid gland. BCAC was included in the 1991 World Health Organization (WHO) classification of salivary gland neoplasms. In 2005 WHO classification; BCAC has been added to the subtypes of salivary gland carcinoma and is classified as a low grade malignancy. Histologically, BCAC is divided on the basis of …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 4, Issue 1, 2015 · pp. 18–22 Read article
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Thyroid Disorders in Regard to Aetiology, Clinical Patterns, Management
Abstract: Thyroid disorders are one of the important and common endocrine problems encountered in clinical and occupational practice in all age groups more frequently in women and in adult population. Amongst all the functional thyroid disorders, hypothyroidism is far more common than hyperthyroidism. Recognition of this condition at an early stage can delay the progression to overt disease. Appropriate use of biochemical test, i.e., thyroid function test can delineate practically all …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 6, Issue 3, 2016 · pp. 34–42 Read article
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Stretching Boundaries: A Comprehensive Review of Ehlers-Danlos Syndrome and its Subtypes
Abstract: The Ehlers-Danlos syndromes (EDS) encompass 13 inheritable disorders affecting connective tissue. These conditions arise from genetic alterations impacting the structure of connective tissue. Every variant of Ehlers-Danlos syndrome (EDS) exhibits distinct features and has specific diagnostic criteria. While certain traits such as joint hypermobility, skin hyperextensibility, and tissue fragility are common across all types of EDS. The range of clinical presentations spans from minor skin and joint looseness to severe …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 44–57 Read article
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Subacute Intestinal Obstruction: Clinical Profile and Short-term Follow up in a Tertiary Care Hospital in Bangladesh
Abstract: Background: Subacute intestinal obstruction (SAIO) implies incomplete, intermittent, or recurrent obstruction. The diagnosis of SAIO is usually delayed and several patients continue to suffer from symptoms for weeks and months due to the waxing and waning nature of the disease. Objective: To see the clinical presentation, aetiology, type of management and short-term outcome of the patients of SAIO. Method: This prospective cohort study was performed in the Department of Gastroenterology, …
Published in Research and Reviews : A Journal of Immunology · Vol. 8, Issue 3, 2018 · pp. 19–23 Read article
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Identification of Diabetic Foot Ulcer by Using Filter and Pixel Classification Methods
Abstract: Ulceration of the foot in diabetes is common and disabling and frequently leads to amputation of the leg. Mortality is high and healed ulcers often recur. The pathogenesis of foot ulceration is complex, clinical presentation variable, and management requires early expert assessment. Interventions should be directed at infection, peripheral ischaemia, and abnormal pressure-loading caused by peripheral neuropathy and limited joint mobility. Despite treatment, ulcers readily become chronic wounds. Diabetic foot …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 1, 2015 · pp. 22–31 Read article
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Multiple Sclerosis: A Systematic Review of a Neurological Disorder
Abstract: The inflammatory illness known as multiple sclerosis (MS) is brought on by outside influences that affect a biologically vulnerable host. It has 3 separate diagnostic phases: the pre-clinical phase, which can only be discovered by MRI; the relapsing-remitting (RRMS) phase, which again is defined by bouts of neurological malfunction accompanied by remission; and the progressing phase, which often develops from either the relapse phase. Unfortunately, the majority of relapse MS …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 53–71 Read article
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Role of Carbohydrates and Herbal Plants in the Management of Diabetes Mellitus
Abstract: This extensive review explores the intricate relationship between carbohydrates and diabetes mellitus, integrating historical perspectives, biochemical foundations, and modern therapeutic approaches. The article delves into the chemistry of carbohydrates, elucidating their structural diversity and metabolic significance in relation to diabetes pathophysiology. It traces the evolution of diabetes, understanding from ancient civilizations to contemporary molecular insights, highlighting pivotal discoveries such as insulin’s identification. They critically examined various forms of diabetes, including …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 34–60 Read article
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Comprehensive Approaches to Seizure Control: Home Care & Hospital Care
Abstract: Seizures show up as sudden, uncontrollable brain electrical abnormalities. Those afflicted by this health issue can suffer greatly and usually call for quick and thorough treatment. Examining several facets of seizure control, including disease epidemiology, etiology, clinical presentation, categorization, as well as acute and long-term therapy techniques, this review. Furthermore, emphasized in the review are several new trends that might help with seizure control. Factors including CNS infections, metabolic abnormalities, …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 1, 2024 · pp. 30–34 Read article
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Chronic Obstructive Pulmonary Disease (COPD) in Younger Adults: Challenges and Considerations – A Review
Abstract: Chronic Obstructive Pulmonary Disease (COPD) phenomenon rapidly converting into chronic significant health issues for many young adults. A disease calculated for older age gives way to early-onset COPD, which creates new issues for diagnosing and treating the illness and even interacts with the quality of life. The article reviews the epidemiology, risk factors, pathophysiology, clinical presentation, and treatment considerations related to this set of conditions. From those risk factors, early-onset …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 3, 2025 · pp. 08–19 Read article
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Effects of Trayodashang Guggulu and Janu Basti in Janu Sandhigata Vata
Abstract: AbstractHuman body is composed of seven dhatus. The fifth one is asthi dhatu sequentially. Whole body resides on asthi dhatu. Vata is situated in asthi as ashraya-ashrayi (interrelated) bhava. Vitiation of vata and kapha dosha in joints produces sandhigatavata. It is an abnormal stage. It is a degenerative disorder in which degeneration of asthi dhatu in the joints occurs normally in the fourth or fifth decade. The treatment comprises of …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 2, Issue 3, 2013 · pp. 43–50 Read article
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Study on the Effect of Rohitaka Sharapunkha Churna and Kunjal Kriya on Mukhadushika
Abstract: The present clinical trial was conducted to evaluate the efficacy of Kunjal Kriya and Rohitaka Sharapunkha Churna in the management of Mukhadushika (Acne Vulgaris). The subjects were randomly divided into three groups. A total 30 patients were selected for the study and all the patients completed the study. The efficacy was determined by finding out the difference between the base line data of parameters with the after treatment data. The …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 3, Issue 2, 2014 · pp. 48–57 Read article
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Unicystic Ameloblastoma: Mural Variant—A Rare Case Report
Abstract: According to the recent literatures, ameloblastoma is a benign tumour of jaw bones with locally invasive capacity. It is a true neoplasm of enamel-organ type of tissue which does not undergo differentiation to the point of enamel formation. It belongs to the group of tumors arising from odontogenic epithelium with mature fibrous stroma without odontogenic ectomesenchyme as per according to the World Health Organization (WHO) Classification of Odontogenic Tumors in …
Published in Research and Reviews: A Journal of Dentistry · Vol. 7, Issue 3, 2016 · pp. 7–12 Read article
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A Clinical Review of Aphasia
Abstract: Aphasia is a very commonest clinical presentation of stroke. Aphasia is a disturbance of comprehension and formulation of language caused by dysfunction in specific brain regions. It can be caused by virtually and neurologic insult that affect cerebral hemisphere. Most cases are caused by stroke, head injury, cerebral tumours, or degenerative dementias such as Alzheimer’s disease.
Published in Research and Reviews: A Journal of Neuroscience · Vol. 11, Issue 3, 2021 · pp. 1–8 Read article