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1037 articles for “severity”
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Pathways in Drug Discovery and Development: From Molecular Targets to Market Approval
Abstract: A complicated, multidisciplinary, and resource-intensive process, the discovery and development of new pharmacological drugs is essential to the advancement of contemporary medicine. Finding and optimising lead chemicals comes after a disease-relevant biological target has been identified and validated. Through preclinical research in animal models, these leads are thoroughly assessed for toxicity, pharmacokinetics, safety, and efficacy. Clinical trials, which are carried out in several stages to evaluate safety, efficacy, ideal dosage, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 01–04 Read article
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Quick Service: A Scalable Multi-Service Web Platform—A Microservices Approach for Seamless Integration
Abstract: This study proposes a model designed to save both time and cost for individuals seeking convenient access to a variety of services. In today’s fast-paced lifestyle, people often require quick and reliable solutions that can be tailored to their immediate needs. Our approach focuses on delivering multiple on-demand services that can cater to both individuals and businesses, ensuring that essential tasks are completed efficiently and on time in many emerging …
Published in Journal of Open Source Developments · Vol. 12, Issue 3, 2025 · pp. 26–45 Read article
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Comparison Of Postoperative Sore Throat Following Endotracheal Intubation With Or Without Water Based Lubricating Jelly
Abstract: Background: Water-soluble lubricant gel (X-Y jelly) was evaluated for its ability to lessen the common throat pain that follows tracheal intubation under general anesthesia. Materials and Methods: scheduled for elective surgery under general anesthesia requiring endotracheal intubation, Were enrolled in a prospective, randomized, double-blind comparative study. They were split evenly into two -member cohorts. One cohort received 3 mL of water-soluble X-Y gel smeared from the cuff tip to 15 …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 3, 2025 · pp. 1–7 Read article
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Enhancing Protection and Monitoring in Modern Distribution Systems Using Smart Meter: A Review
Abstract: Emerging distribution systems are witnessing a significant increase in the deployment of smart meters (SMs). Though, some remain hesitant about adopting SMs due to concerns related to health risks from radio wave exposure, fire hazards, and the privacy of user data. Additional key issues are high cost for energy suppliers, with perceived less advantages, as highlighted in detailed cost-benefit analyses. In some instances, existing SM applications have failed to justify …
Published in International Journal of Electrical Power and Machine Systems · Vol. 3, Issue 2, 2025 · pp. 20–27 Read article
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Nuclear Reactor Safety Using Fuel Pallet: A Study
Abstract: Nuclear power stands as a vital source of low-carbon electricity, but its widespread acceptance hinges critically on unwavering safety. While public perception often focuses on massive containment buildings, intricate cooling systems, and redundant backup power, a less visible yet fundamentally crucial component plays a paramount role in safety. There is much more to these tiny, cylindrical ceramic pellets than just fissionable material. As an essential part of a reactor's defense-in-depth …
Published in Journal of Nuclear Engineering & Technology · Vol. 15, Issue 3, 2025 · pp. 16–23 Read article
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In-Silico Repurposing of Antipsychotic Drugs Against Novel Protein Targets in Multidrug-Resistant Mycobacterium tuberculosis
Abstract: Multidrug-resistant TB is a growing worldwide health concern, particularly in high-burden areas. Resistance to frontline drugs like isoniazid and rifampicin is caused by mutations in key Mycobacterium tuberculosis proteins. Given the difficulty of developing new antibiotics, medication repurposing offers a good alternative. The potential use of molecular docking to target resistance-associated TB proteins with FDA-approved antipsychotic drugs is investigated in this work. Three proteins were selected: InhA (PDB ID: 5W07), …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 49–63 Read article
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Securing the Internet of Things: A Survey on Lightweight Blockchain Framework for Enhancing Security and Privacy
Abstract: Modern technologies, supported by the Internet of Things (IoT), have imparted great speed in data sharing between connected devices across several domains of the economy. The Internet of things transformed data collection activities with its creation of smart homes and cities, healthcare, transportation environments, and industrial automation. The fact that there are multiple resource-limited devices, and continuous data transfer of sensitive information has turned the IoT devices less secure and …
Published in International Journal of Data Structure Studies · Vol. 3, Issue 2, 2025 · pp. 6–14 Read article
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Predictive Maintenance Strategies for Safety-critical Mechanical Systems
Abstract: Ensuring the reliability and safety of industrial systems is essential, especially in high-risk sectors such as aerospace, manufacturing, and energy. Predictive maintenance (PdM) has become a crucial approach for minimizing operational failures and improving maintenance efficiency. This research introduces an advanced PdM framework that enhances industrial safety by integrating Internet of Things (IoT) technology, machine learning (ML), and big data analytics. By enabling real-time monitoring and predictive fault detection, this …
Published in Journal of Industrial Safety Engineering · Vol. 12, Issue 1, 2025 · pp. 12–17 Read article
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Identification of Hazards and Evaluation of Risks in Flyover Construction Site
Abstract: Indore, a rapidly growing city in Madhya Pradesh, India, faces significant traffic congestion challenges. Constructing flyovers has been suggested as an effective measure to resolve this problem. This project of Reti mandi flyover which is 1199.65 long and 37 km wide having six lanes. This review aims to evaluate the feasibility and sustainability of flyover construction in Indore, considering urban infrastructure development, traffic management, environmental impact, and socio-economic factors. The …
Published in Journal of Industrial Safety Engineering · Vol. 12, Issue 2, 2025 · pp. 17–16 Read article
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Neurotoxic Effects of Chronic Arsenic Exposure Among Leather Tannery Workers in Kanpur
Abstract: Chronic arsenic exposure is a known health risk, with potential neurotoxic effects. In industrial settings like leather tanneries, workers are particularly vulnerable due to prolonged exposure to chemicals, including arsenic. This study aims to investigate the neurotoxic effects of chronic arsenic exposure among leather tannery workers in Kanpur, focusing on symptoms of neurological damage and related health outcomes. To evaluate the prevalence of neurotoxic symptoms among leather tannery workers in …
Published in Journal of Industrial Safety Engineering · Vol. 12, Issue 2, 2025 · pp. 39–46 Read article
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Extra Philadelphia in CML Due to Isodicentric 22: A Case Report
Abstract: Introduction: Chronic Myelogenous Leukemia is a malignancy that affects the hematopoietic stems cells (HSC) of the bone marrow, leading to the rapid and continual proliferation of granulocytes and precursor blast cells. This is caused due to a reciprocal translocation that occurs between chromosomes 9 and 22, leading to the formation of derivative 22 also called as Philadelphia (Ph) chromosome. The Ph chromosome then encodes a fusion oncoprotein that functions as …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 18–22 Read article
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Integrating Plant Selection, Planting Design, and Landscape Construction for Sustainable Site Development
Abstract: This paper explores the interrelationship between plant selection, planting design, and landscape construction in achieving ecologically sustainable and aesthetically pleasing outdoor environments. Plant selection involves choosing species that are well adapted to site conditions, ecological functions, maintenance regimes, and visual preferences. Planting design refers to the arrangement, composition, and spatial organization of plant materials to meet functional, aesthetic, and environmental objectives. Landscape construction encompasses implementation—from site preparation and planting through …
Published in International Journal of Trends in Horticulture · Vol. 2, Issue 2, 2025 · pp. 7–12 Read article
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Unlocking Novel Drug Targets and Therapeutic Advancements Against RNA Viruses: Insights from HMPV and SARS-CoV-2
Abstract: Re-emerging RNA viruses pose a significant epidemiological welfare threat due to their high mutation rates, potential for zoonotic transmission, and capacity to cause widespread outbreaks such as Human Metapneumovirus (HMPV), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Influenza, etc. The rapid evolution and re-emergence of these viruses necessitate the development of novel drug targets and therapeutic strategies to combat existing and future outbreaks. This study focuses on structural as well …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 3, 2025 · pp. 54–86 Read article
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A Study on Innovations in Primary Containment Technology for Safer Nuclear Power
Abstract: Nuclear power is a powerful carbon-free energy source that balances enormous potential with widespread public fear. Fear of radioactive leakage, a catastrophic catastrophe that might have long-lasting effects on the environs and human health, is at the core of this anxiety. The future of nuclear energy depends on finding a solution to this issue, and at the heart of that debate is the idea of primary containment, a technological marvel …
Published in Journal of Nuclear Engineering & Technology · Vol. 15, Issue 3, 2025 · pp. 37–44 Read article
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Integration of Multispectral Satellite data with Ensemble Machine Learning Models for Wetland Classification: a new Ramsar Site in Central India
Abstract: For biodiversity conservation, several wetlands in India have been classified as Ramsar sites, and Sirpur Lake is a recent addition to the list. The objective of this paper is to use Sentinel optical data with 10-meter resolution to prepare a robust and accurate classified map which will be crucial for further analysis. The data on thirteen spectral bands along with four essential spectral indices, Normalized Difference Vegetation Index (NDVI), Normalized …
Published in Journal of Remote Sensing & GIS · Vol. 16, Issue 3, 2025 Read article
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Revolutionizing Blood Cancer Treatment: Emerging Therapies and Future Perspectives
Abstract: Blood cancer inclusive of leukemia, lymphoma and multiple myeloma poses a significant threat in the world today because of its multifactorial process and its non-amenable to standard therapies. Some of such approaches are immunotherapy, gene-editing technology and targeted small molecule inhibitors that have altered the nature of treatments. CAR T cell therapy is a molecular targeted therapy for cancers and several clinical studies have reported a huge success. Also, the …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 3, Issue 2, 2025 Read article
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Green Medicines in Drug Discovery
Abstract: The process of finding new leads for medicines using natural products is challenging. It discusses bioactive composites generated from natural resources, including phytochemical analysis, characterization, and pharmacological investigation. The success of these resources in the process of discovering unique and effective pharmacological combinations that may help mortal coffers is the primary focus. Natural goods have long been employed as a source of medicinal compounds, and they have shown promising results. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 32–48 Read article
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Heavy Metal Exposure in Industrial Workers of Punjab
Abstract: Background: Particularly for those in sectors such textiles, metallurgy, and electronics, heavy metal exposure in industrial environments is a major health issue. A range of negative health effects can result from metal exposure including lead (Pb), cadmium (Cd), chromium (Cr), arsenic (As), and nickel (Ni), including neurological, pulmonary, and renal ones. There is little information available on the degree of heavy metal exposure industrial workers in Punjab, India experience. Objective: …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 3, 2025 · pp. 1–7 Read article
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Design and Development of Mini-Groundnut Oil Extraction Machine for Domestic Purpose
Abstract: A machine is designed to extract various types of oil from groundnuts. The primary purpose of this machine is to facilitate the extraction of oil using a mechanical extraction method, specifically employing a screw press mechanism to crush the seeds and extract the oil. The design prioritizes portability, ease of use, and high extraction efficiency. It comprises several components, including the frame, hopper, gear reduction unit, pulleys, bearings, and power …
Published in Journal of Materials & Metallurgical Engineering · Vol. 15, Issue 2, 2025 · pp. 31–38 Read article
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Histological Effects of the Antibiotic Gentamicin on the Ovarian Tissue of Female White Laboratory Rats
Abstract: This study aimed to evaluate the histological alterations induced by Gentamicin in the ovarian tissue of white laboratory rats. A total of 12 adult female rats were used and randomly divided into two groups, with each group consisting of six animals. The experimental group received Gentamicin at a dose of 120 mg/kg body weight administered as an injection once daily, while the control group received an equivalent volume of normal …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 1–8 Read article