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70 articles for “pathophysiology”
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Cancer Chemotherapy-Induced Cachexia: Bridging Mechanisms, Management, and Future Therapies
Abstract: Involuntary weight loss, skeletal muscle atrophy, adipose tissue depletion, anorexia, and systemic inflammation are all symptoms of chemotherapy-induced cachexia, a complex illness. Although it is common, it remains poorly understood and is often referred to as an "orphan disease." This study covers the epidemiology, pathophysiology, clinical symptoms, diagnosis, treatment, and emerging treatment options for chemotherapy-induced cachexia. To comprehend the causes, clinical results, and therapeutic approaches, a literature-based synthesis of recent …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 17–26 Read article
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Gene Expression Profiling in Autism Spectrum Disorder: A Microarray Analysis Using Gse42133
Abstract: Autism Spectrum Disorder (ASD) is a diverse neurodevelopmental disorder characterized by difficulties in social interaction, communication impairments, and restricted or repetitive patterns of behavior. Despite its increasing prevalence, the underlying molecular mechanisms remain poorly understood. Advances in transcriptomics offer opportunities to investigate the gene expression changes that may contribute to ASD pathophysiology. In this study, the microarray dataset GSE42133 was analyzed, which comprises gene expression profiles from peripheral blood samples …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 37–48 Read article
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The Hidden Struggle: Premenstrual Depression its Impact on Women’s Health and Management Strategies: A Narrative Review.
Abstract: Background: Premenstrual depression, including Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD), represents a significant yet underrecognized contributor to women’s mental health burden. Hormonal fluctuations during the luteal phase interact with neurotransmitter systems, particularly serotonin and GABA, leading to affective and somatic symptoms that impair daily functioning. Objective: This systematic review synthesizes evidence on the prevalence, pathophysiology, psychological impact, and management strategies of premenstrual depression among reproductive-aged women, with particular …
Published in International Journal of Nutritions · Vol. 3, Issue 1, 2026 · pp. 21–32 Read article
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Contribution of Dalak (Massage) in the Treatment of Waja-uz-Zohar (Back Pain): A Review
Abstract: Classical Unani literature presents a detailed understanding of Waja-ul-Mafasil (diseases of bones and joints) among which Waja-uz-Zohar (low back pain) has received extensive attention. Distinguished Unani physicians meticulously described its etiology, clinical features, complications, and treatment modalities. According to Unani theory Waja-uz-Zohar is defined as pain originating from the muscles, ligaments, and connective tissues surrounding the lumbar and lumbosacral regions. Prominent scholars, such as Ibn Sina and Zakariya Razi, attributed …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 1, 2026 · pp. 1–6 Read article
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Jaundice: Etiology, Clinical Manifestations, Diagnosis, Management, Nursing Care, and Prevention
Abstract: Jaundice is a significant clinical condition marked by a yellow discoloration of the skin, sclera, and mucous membranes resulting from increased bilirubin levels in the bloodstream. Rather than being a disease itself, jaundice represents an underlying disorder involving the liver, biliary system, or hematological processes. Hyperbilirubinemia develops when there is excessive bilirubin production, impaired hepatic uptake, defective conjugation, or obstruction in bile excretion. Jaundice remains a major global health concern …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 32–39 Read article
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A Study on High-Risk Pregnancy and Its Management: Role of Obstetric Nurses in Improving Maternal and Fetal Outcomes
Abstract: High-risk pregnancy is a major challenge in maternal and neonatal healthcare and is associated with increased morbidity and mortality among mothers and new-borns, particularly in developing regions where access to quality healthcare services remains uneven, this article examines the concept, classification, risk factors, pathophysiology, and management of high-risk pregnancy with a strong focus on the role of obstetric nurses in improving maternal and fetal outcomes, obstetric nurses play a central …
Published in International Journal of Midwifery Nursing And Practices · Vol. 4, Issue 1, 2026 · pp. 26–43 Read article
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Lemon Sign: The Diagnostic Indicator for Spina Bifida
Abstract: The “lemon sign” is a distinctive ultrasonographic finding that serves as a diagnostic indicator for spina bifida, a congenital neural tube defect characterized by incomplete closure of the spinal cord. This sign is observed in fetal imaging and is considered an early and reliable marker for detecting spina bifida, particularly when combined with other prenatal diagnostic tools such as the “banana sign.” The lemon sign is characterized by a flattened, …
Published in International Journal of Midwifery Nursing And Practices · Vol. 4, Issue 1, 2026 · pp. 1–6 Read article
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Child Friendly Innovation: A New Era in Pediatrics Drug Delivery Systems
Abstract: Pediatric formulations are becoming more and more popular as a result of advancements in pharmaceutical delivery technology. For young patients, there isn't a safe and effective drug delivery system in place. Since children's pharmacokinetics and pathophysiologic profiles differ from those of adults, it is imperative to design and develop an innovative and appropriate delivery system to provide accurate and dependable medicine administration to pediatric patients. Discussions will be held under …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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Managing Chronic Diseases: Diabetes Mellitus
Abstract: Diabetes mellitus is one of the most prevalent chronic non-communicable diseases worldwide and represents a major public health challenge due to its long-term complications, increasing prevalence, and economic burden on individuals and healthcare systems. It is distinguished by chronic hyperglycemia brought on by deficiencies in either insulin action or secretion, or both. Diabetes causes increasing harm to several organ systems, including the kidneys, eyes, neurological system, and cardiovascular system, if …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 Read article
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Schizophenia – An Ayurvedic Review and Treatment – A Case study
Abstract: Schizophrenia is a complex, heterogeneous disorder. It is neuro developmental disorder characterized by problems with thinking (cognition),behavior- not focused on goals, negative symptoms, suicidal thoughts This means having a reduced or impaired ability to function normally and having noemotions(notmakingeyecontact,notchangingfacialexpressions,orspeakinginamonotone).Additionally, the person may lose interest in daily activities, withdraw from relationships, or be unable to sustain and reflection often associated with hearing or speech disorders, extreme confusion and associated functional impairments. …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 11, Issue 1, 2024 · pp. 40–48 Read article