Search
1363 articles for “Pre-clinical”
-
Early Pregnancy Levels of Fasting Glucose, HbA1c, and Adiponectin as Predictors of Gestational Diabetes Mellitus Among Pregnant Women in Tamil Nadu, India
Abstract: Background: Gestational diabetes mellitus (GDM) is rapidly becoming a major public health issue across India, and Tamil Nadu continues to report some of the country’s highest incidence figures. Identifying women at elevated risk during the first trimester allows health workers to intervene early and improve outcomes for both mothers and babies. This research, therefore, examines whether fasting plasma glucose, glycated haemoglobin, and adiponectin measured at that initial visit can reliably …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 2, 2026 · pp. 10–18 Read article
-
A Computational Study to Elucidate the Phytochemicals as An Antagonist Against Pruritis in Psoriasis
Abstract: Objective: Psoriasis is a chronic, non-contagious, auto-immune skin disorder that causes inflammation, pain, and itching in the affected areas. The etiology of this condition is not entirely understood, and while there are treatments available to manage the symptoms, there is currently no cure. The Transient receptor potential cation channel, subfamily Vanillin, member 3 (TRPV3), present in keratinocytes, allegedly had a part in the development of psoriasis-related pain and itching. Specifically, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 49–61 Read article
-
Complex Tuberculous Meningitis: A Case Series Highlighting Rare Co-infections and Severe Complications
Abstract: This case series presents two complex cases of tuberculous meningitis (TBM) with different complications, illustrating the diverse clinical presentations and management challenges of this disease. Case 1 involves an 18-year-old female with TBM complicated by cryptococcal co-infection, while Case 2 describes a 64-year-old female with TBM complicated by obstructive hydrocephalus and secondary bacterial infections. Both patients had been on anti-tubercular therapy before presentation. Diagnostic approaches included cerebrospinal fluid analysis, cultures, …
Published in International Journal of Pathogens · Vol. 1, Issue 2, 2024 · pp. 1–7 Read article
-
Disease Prediction Using Ensemble Learning Models: A Comprehensive Approach
Abstract: In recent years, ensemble learning techniques have become pivotal in advancing predictive analytics within healthcare, particularly for early disease detection. The inherent variability and complexity of medical data, often characterized by high dimensionality, class imbalance, and noise, make it challenging for standalone classifiers to maintain high predictive accuracy. Ensemble learning, by integrating multiple models through bagging, boosting, or stacking, offers a more robust and generalizable approach. This study explores the …
Published in Journal of Communication Engineering & Systems · Vol. 15, Issue 3, 2025 · pp. 26–33 Read article
-
Effect of Snehpana (Lipid Based Drug Delivery System) with Shatpala Ghrit in Non-Alcholic Fatty Liver Diseases
Abstract: Among all the Drug Delivery Systems, Snehpana (~Lipid Based Drug Delivery System) is being widely used because this facilitates uniform distribution and absorption of fat and water-soluble chemical constituents. Due to their effective size-dependent properties and challenges related to the solubility and bioavailability of water-soluble drugs, this system holds a significant advantage. Numerous studies have highlighted the potential of lipid-based formulations in managing chronic and life-threatening diseases. Shatpala ghrit (SG) …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 1, 2025 · pp. 1–11 Read article
-
Pharmacogenetics: A Marvel!
Abstract: Normal 0 MicrosoftInternetExplorer4 Pharmacogenetics is a new paradigm in the field of medical research and therapeutics which is set to revolutionize the current scenario of drug prescribing in health care. It can identify the genetic variations responsible for differences in drug efficacy and safety among individuals by employing pharmacogenomic tools and hence result in lowering of the chances of therapeutic failures and adverse effects. Clinical practitioners will also need to …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 2, Issue 2, 2012 · pp. 12–20 Read article
-
Role of Trikatu Churna and Purana Gurrh (Jaggery) in Treatment of Sutika Makkal shoola
Abstract: In Ayurveda, the term Sutika (Puerperal Woman) can be used only after expulsion of placenta. After delivery, woman becomes weak and also empty bodied due to unsteadiness or indolence of Dhatus, labour pains and excretion of Kleda (moisture) and blood. Mithyaachar (inappropriate physical and mental behavior) in this period definitely results in incurable diseases or diseases which are difficult to cure. Sutika Makkal is a common complaint met with obstetrics …
Published in Research & Reviews : Journal of Herbal Science · Vol. 10, Issue 1, 2021 · pp. 35–46 Read article
-
Randomized Clinical Study on Dissolution of Urinary Catheters and Stents Encrustation by an Ayurvedic Compound
Abstract: Encrustation, a crust or hard coating on the surface of urinary catheter and stents, is developed due to the formation of biofilm. Encrustation causes blockage of urinary catheter and leads to reflux of urine, increases renal pressure and ultimately damages renal parenchyma tissues. Present clinical study was designed to evaluate the dissolution activity of an Ayurvedic compound on catheter and stent encrustation and to study the changes seen in serum …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 2, Issue 3, 2013 · pp. 12–24 Read article
-
Marchiafava Bignami Syndrome: A Review
Abstract: Marchiafava-Bignami syndrome (MBS) is a rare neurological disorder characterized by demyelination and necrosis of the corpus callosum, which is the main bundle of nerve fibers connecting the two hemispheres of the brain. MBS primarily affects individuals with chronic alcoholism, although cases unrelated to alcohol consumption have also been reported. The corpus callosum is affected in almost a pathognomonic way. The clinical presentation is based on neurological impairment, motor abnormalities, seizures, …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 14, Issue 1, 2024 · pp. 21–25 Read article
-
Polymeric Microfluidic Chips for Rapid Point-of-Care Diagnostic Testing
Abstract: Polymeric microfluidic chips have emerged as promising platforms for rapid point-of-care (POC) diagnostic testing by integrating sample preparation, fluid manipulation, biochemical reactions, and signal detection within compact and potentially low-cost devices. Their compatibility with materials such as polydimethylsiloxane (PDMS), polymethyl methacrylate (PMMA), cyclic olefin copolymer (COC), polystyrene (PS), polycarbonate (PC), and polymer–paper composites provide considerable flexibility in device design and manufacturing. Advances in soft lithography, injection moulding, hot embossing, laser …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
-
Impact of Clinical Pharmacist in Evaluating Drug–Drug Interactions in Outpatients of a Tertiary Care Hospital: An Observational Study
Abstract: Background: In patients receiving multi-drug therapy, drug–drug interactions (DDIs) are of extensive concern. The term drug–drug interaction is used when the effect of one drug is altered by the concomitant use of another drug. Aim: To analyze the impact of clinical pharmacist in evaluating drug–drug interactions in outpatients of a tertiary care hospital in various departments in a tertiary care hospital. Objectives: To assess the prevalence of drug–drug interactions and …
Published in Trends in Drug Delivery · Vol. 7, Issue 1, 2020 · pp. 10–16 Read article
-
Nutritional Management of Dwarfism
Abstract: Early childhood PROTEIN-CALORIE malnutrition is the most prevalent nutritional condition, especially in emerging nations and among disadvantaged people. The primary issue appears to be dietary intake of insufficient good quality protein to meet requirements for growth, resistance, and repair, as well as a low or disproportionately high intake of calories from carbohydrates, despite the possibility of many different synergistic factors influencing its occurrence and manifestations. For many years, the most …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 14, Issue 2, 2023 · pp. 35–41 Read article
-
Signal Drift Compensation in Polymer-Based Wearable Biosensors Using Data Processing Techniques
Abstract: Polymer-based wearable biosensors have emerged as promising platforms for continuous physiological monitoring due to their mechanical flexibility, low operating voltage, and compatibility with soft biological interfaces. However, their long-term deployment remains challenging because of signal drift caused by polymer ageing, hydration–dehydration cycles, ionic trapping, and environmental variations. These effects introduce baseline fluctuations and sensitivity degradation, which compromise the reliability and interpretability of physiological measurements. This study proposes a data-processing–driven framework …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 197–207 Read article
-
What Does Location of Abdominal Pain Say, Anatomically and Homoeopathically
Abstract: Background and justification for the study: Every symptom is an indication of bodily derangements which a patient feels when sick. The medical personal has to recognize these derangements only by symptomatic study of the disease without making any hypothetical theories. Therefore, examining symptoms is the sole correct method for determining the presentation of a disease.In Homoeopathy, a complete symptom is that which covers location, sensation, modalities and concomitant symptoms. The …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 1, 2024 · pp. 14–19 Read article
-
An Open Clinical Study to Evaluate the Efficacy of Shirobasti and Nasya with and without Levodopa in the Management of Kampavata w.s.r. to Parkinson’s Disease (PD)
Abstract: Background: Kampavata (Parkinson’s disease), considered as Vata Nanatamaja disorder, is the most common progressive neurodegenerative disorder characterized by bradykinesia, resting tremors, muscular rigidity, shuffling gait and flexed posture accompanied by a variety of non-motor symptoms, including autonomic, sensory, sleep, cognitive and psychiatric disturbances. Aim and Objectives: To study the effect of Shirobasti and Nasya in the management of Kampavata (PD) with levodopa and without levodopa. Materials and Methods: The present …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 8, Issue 3, 2021 · pp. 15–28 Read article
-
Bacterial Spectral in UTI in a Hospital Environment
Abstract: Urinary tract infections (UTIs) represent a significant public health issue, primarily caused by a variety of pathogens such as Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis, and Staphylococcus saprophyticus. UTIs contribute substantially to illness and complications in individuals with pre-existing health conditions and account for a large portion of hospital visits globally. UTIs are usually self-limiting in people with no structural or functional problems, but they do tend to …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 2, 2024 · pp. 1–11 Read article
-
Exploration and Advancement of Drugs Within the Field of Bioinformatics: A Review
Abstract: After selection, research objectives fall under the supervision of either the pharmaceutical industry or pertinent academic institutions. The initial approach involves identifying drug molecules possessing the essential qualities necessary for the synthesis of targeted medications. Drug development constitutes the subsequent phase following the discovery of a drug and unfolds as a meticulous process aimed at introducing novel pharmaceuticals to the market. This intricate journey from discovery to market availability encompasses …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 10, Issue 3, 2023 · pp. 15–21 Read article
-
Management of Warm Kabid Haad (Acute Hepatitis) by Unani Herbal Medicine
Abstract: Hepatitis, is a general term refers to inflammation of the liver, may be due to various causes mostly by the virus which leads to hepatocytes damage with subsequent cell death. Symptoms include fatigue, anorexia, nausea and right upper quadrant tenderness. In Unani system of medicine acute Hepatitis is known as Warm Kabid Haad has been described under the heading of Jaundice. For the management, several single as well as compound …
Published in Research & Reviews : Journal of Herbal Science · Vol. 6, Issue 2, 2017 · pp. 25–31 Read article
-
A Case study of Parapharyngeal Space Tumor with Unusual Presentation
Abstract: Aim: To study and treat the parapharyngeal space tumors presenting with swelling on left side of neck. Result: presenting a case of 25 year old male with swelling on left side of neck, FNAC revealed the diagnosis of a pleomorphic adenoma of parapharyngeal space. Tumor was intraorally excised. HPR revealed pleomorphic adenoma which concluded the diagnosis of benign parapharyngeal tumor from deep lobe of parotid gland. Conclusion: Tumor of parapharyngeal …
Published in Research and Reviews : Journal of Surgery · Vol. 6, Issue 2, 2017 · pp. 16–21 Read article
-
A Study on Ekakushtha (Psoriasis) With Its Ayurvedic Management
Abstract: The skin, the delicate outer layer of vertebrates, often reflects internal imbalances and stress-related conditions within the body. In Ayurveda, the skin (Tvak) is considered a mirror of internal health, revealing various abnormalities or disorders. All skin diseases are collectively categorized under the term "Kushtha" in Ayurvedic texts. The ancient Acharyas explain that Kushtha involves the imbalance of all three doshas, with the specific type of Kushtha determined by the …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 1, 2025 · pp. 15–18 Read article