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1959 articles for “Disc” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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A Review on Anesthetic Drug Discovery with Computer Aided Drug Design
Abstract: In contemporary medicine, anaesthesia is essential for enabling surgical procedures, pain control, and patient comfort. Finding and creating safe and efficient anaesthetics is crucial to enhancing patient outcomes and developing the medical field. In this review, we provide a comprehensive overview of anesthetic drug discovery with a focus on the integration of computer-aided drug design (CADD) methodologies. Beginning with an exploration of anesthesia mechanisms and targets, we delve into the …
Published in International Journal of Antibiotics Read article
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Biomarkers in Cancer Research: Discovery and Future Directions
Abstract: Biomarkers have transformed the study of cancer, providing critical information regarding prognosis and therapy response and promoting earlier diagnosis. This paper discusses the different parts of cancer biomarkers, starting with their description, classification, and major types, which are the groundwork for understanding their clinical role. The discussion on the development and validation process of biomarkers is then undertaken, focusing on state-of-the-art techniques and the importance of ensuring accuracy and reproducibility. …
Published in Trends in Drug Delivery · Vol. 12, Issue 1, 2025 · pp. 22–26 Read article
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A Review on Unmasking Merkel Cell Polyomavirus: From Discovery to Cancer Driver
Abstract: Merkel cell polyomavirus (MCPyV) is a small, non-enveloped, circular double-stranded DNA virus belonging to the Polyomaviridae family, first characterized in 2008. Epidemiological data suggest widespread exposure, with seroprevalence rates approaching 80% in adults. While primary infection is typically asymptomatic, rare integration events in Merkel cells can initiate oncogenesis, yielding Merkel cell carcinoma (MCC), a neuroendocrine skin cancer with a five-year survival rate under 60%. This review integrates findings from six …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 6–11 Read article
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Dr. Somenath Dutta, Discoverer of Micro-RNA (MiRNA) Therapeutic to Prevent Harmful Zika Virus for Liver Cancer: A Scientometric Portrait
Abstract: Dr. Somenath Dutta allies Rahul is a global recognized scientist for his outstanding recent discovery of “miRNA therapeutics for the Zika virus” at the age of 26 years, which can be cured Liver Cancer and allied health problems due to Zika virus disease. This study covers his 12 publications in variety of forms including 07 journal articles (59%), 03 conference papers (25%), 01 dissertation, and 01-chapter paper during 2019-2024. All …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 22–36 Read article
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Optimization of Machining Parameters of EN-27 Material Using Wire Electric Discharge Machining (WEDM)
Abstract: The optimization of Wire Electrical Discharge Machining (WEDM) parameters for EN-27 alloy steel, a high-strength material widely utilized in mechanical and structural applications, is the subject of this study's methodical analysis. Due to its hardness and poor machinability by conventional methods, WEDM is preferred for achieving precise dimensional accuracy and surface integrity. The primary objective of this work is to enhance machining performance by identifying optimal process parameters influencing Material …
Published in Journal of Production Research & Management · Vol. 16, Issue 1, 2026 · pp. 32–36 Read article
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Quantum-Fuzzy Tensor Operators and Uncertainty-Band Bifurcation for Symmetry-Preserving State Discrimination
Abstract: A tensor-operator framework is developed for fuzzy conjunction, fuzzy disjunction, and symmetry-preserving state discrimination in multi-qubit quantum systems. In this formulation, fuzzy membership and non-membership degrees are represented through expectations of effect operators acting on density matrices, providing a natural bridge between fuzzy logic and quantum measurement theory. Conjunction and disjunction operations are extended to the quantum domain via tensorised channels, constructed using projective measurements and unitary transformations, enabling logical …
Published in Emerging Trends in Symmetry · Vol. 2, Issue 1, 2026 · pp. 08–15 Read article
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Intuitionistic Fuzzy Hypergraph Laplacians and Dominating Transversals for Resilient Discrete Network Design
Abstract: This manuscript develops a discrete mathematical framework for resilience analysis on networks whose interactions are polyadic, uncertain, and partially conflicting. Classical graphs compress multi-way coordination into pairwise edges, while ordinary fuzzy graphs often ignore the non-membership information that becomes critical in emergency logistics, infrastructure interdependence, and cyberphysical coordination. We therefore formulate an intuitionistic fuzzy hypergraph in which each vertex hyperedge incidence carries membership, non-membership, and hesitation, and we construct a …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 13, Issue 2, 2026 · pp. 15–21 Read article
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Neuro-Symbolic Agentic AI for Autonomous Scientific Discovery: Integrating Deep Reinforcement Learning, Quantum Simulation, and XAI-Audited LLM Hypothesis Generation in Drug Target Identification
Abstract: The exponential growth of multi-omics data and the increasing complexity of disease-associated protein interactomes have rendered conventional drug target identification pipelines computationally and epistemologically inadequate. This paper presents the Neuro-Symbolic Agentic AI for Scientific Discovery (NS-AASD) framework, a unified architecture that cohesively integrates deep reinforcement learning (DRL) exploration strategies, variational quantum simulation (VQS) of protein conformational dynamics, and XAI-audited large language model (LLM) hypothesis generation within an autonomous scientific discovery …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 2, 2026 · pp. 15–24 Read article
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Spectral Intuitionistic Fuzzy Hypergraph Operators and Dominance Kernels for Resilient Discrete Network Design
Abstract: A new discrete-mathematical framework is developed for resilient network design on intuitionistic fuzzy hypergraphs, where uncertainty is explicitly represented through membership, non-membership, and hesitation degrees associated with both vertices and hyperedges. These three components are systematically integrated into an effective incidence operator that captures the underlying uncertain relationships within complex hypergraph structures. Based on this operator, both un-normalised and normalized Laplacian matrices are formulated to characterize the spectral properties and …
Published in Recent Trends in Mathematics · Vol. 3, Issue 2, 2026 · pp. 41–48 Read article
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An Experimental Study to Determine Optimum Machining Conditions for Electrical Discharge Machining of the Heat Treatable Steel 42CrMo4 (Din 1.7225)
Abstract: Electric discharge machining (EDM) is a well-established machining option and a non-traditional machining process, in many manufacturing-related industries worldwide. It is found to be capable of machining geometrically complex or hard material components, which are specific and difficult-to-machine. In this study, the electrical discharge machining of 42CrMo4 with different electrode materials namely, copper, aluminum and tungsten carbide and process parameters was performed to explore the influence of EDM parameters on …
Published in Journal of Mechatronics and Automation · Vol. 2, Issue 2, 2015 · pp. 23–32 Read article
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Experimental Investigation of Influence of Key-shape Variation on Discharge Capacity of Piano Key Weir
Abstract: The piano key weir is a nonlinear free flow type weir with small foundation width. There are many geometrical parameters which influence the discharge capacity of the piano key weir. As in Labyrinth weir, the piano key weir is zigzagged in a plan to increase the crest length. Overhanging on both sides reduces the foundation width of such weir. To investigate the effects of key-shape variation of piano key weirs …
Published in Journal of Water Resource Engineering and Management · Vol. 3, Issue 3, 2016 · pp. 44–49 Read article
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Emerging Therapeutic Discovery Against Escherichia coli Infection by Rational Inhibition of Fatty Acid Responsive Transcription Factor: Theoretical Molecular Investigations of Some Metabolites as Inhibitors of Fatty Acid Metabolism Protein
Abstract: For the discovery of effective agent for overcoming resistance against Escherichia coli (E. coli) bacteria by modulating Fatty Acid Metabolism Protein (FadR)—a Fatty Acid Responsive Transcription Factor. The present study involved discovery of some metabolites of furan, furan-2-yl, macrolactin, and chromene scaffold via in silico structure-based drug design (SBDD) technique by utilizing the Maestro 9.1 software. The study will provide clues, motivate, and throw light on imperative aspects for the …
Published in Research and Reviews : Journal of Computational Biology · Vol. 7, Issue 3, 2018 · pp. 1–7 Read article
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Boundary Localization of Optic Disc using Pixel Level Deviation in Retinal Fundus Image
Abstract: In automated computer-aided diagnosis (CAD) approach for Diabetic retinopathy (DR) detection and monitoring, optic disc (OD) localization is the first and fundamental task for further processing of retinal fundus image. Identification of OD area is complex, as it attains the similar pathological blood vessels characteristics such as intensity variations and texture pattern. This paper presents a simple approach for the outer boundary localization of OD based on pixel level variations, …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 2, 2018 · pp. 14–18 Read article
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Analysis of Discrete Wavelet Transform for Denoising of Breast CT Image
Abstract: During acquisition of medical images noise gets induced in the digital image by various effects. The state of art devices used for capturing the images introduces complex type of addition noise in the images. No medical imaging devices are noise free. The most commonly used medical images are acquired from MRI (Magnetic Resonance Imaging), CT (Computed Tomography) and X-ray equipment’s. Additive noise into medical image decreases the visual quality that …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 7, Issue 1, 2018 · pp. 27–31 Read article
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Improvised Rapid Antibiotic Sensitivity Test by Disc Dispersion Method
Abstract: Multidrug resistance is the one of vital issue globally, there are several causes for multidrug resistance, like improper utilization of antibiotics and selection of suitable antibiotics are the one of the predominant reasons for multidrug resistance gaining. To enable physician to select the suitable antibiotics, appropriate antibiotic sensitivity shall be performed in shortest time period. A method has been developed to get the antibiotic sensitivity test in 2–3 hours for …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 3, 2018 · pp. 44–57 Read article
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Discovery of Curcumin: Miraculous Activity as Anticancer
Abstract: AbstractCancer is the second most life-threatening disease and one of the main public health problems worldwide now a day. Despite the great advances in cancer therapy, the incidence and mortality rates of cancer remain high. Therefore, the quest for more efficient and less toxic cancer treatment strategies is still at the forefront of current research. Curcumin is an active ingredient of the Curcuma longa plant, has received great attention over …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 2, 2020 · pp. 29–38 Read article
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
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Eco-Adventures: Discovering the Planet Responsibly in Himachal Pradesh
Abstract: Himachal Pradesh, settled in the Himalayas, is a great location for eco-undertakings, offering a rich mix of regular excellence and social legacy. This paper explores the concept of eco-adventures and their significance in promoting sustainable tourism in the region. Key eco-adventure activities such as trekking, river rafting, paragliding, wildlife safaris, and camping are discussed, along with guidelines for minimizing environmental impact and supporting local communities. Emphasizing the importance of responsible …
Published in Research & Reviews : Journal of Ecology · Vol. 13, Issue 3, 2024 · pp. 6–12 Read article
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The Role of Natural Products in Antiviral Drug Discovery: Insights into Mechanisms and Therapeutic Potential
Abstract: Drug discovery has always relied heavily on natural sources, especially when it comes to creating antiviral medications. This review explores the therapeutic potential of various natural products, including plant extracts, marine compounds, and microbial metabolites, in the fight against viral infections. We examine the mechanisms of action by which these natural compounds exert their antiviral effects, including direct inhibition of viral replication, modulation of host immune responses, and interference with …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 36–47 Read article
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Study of Strength of Composite Laminates with Ply- Discontinuities Using FEM
Abstract: Present research work attempts to understand the effect of ply-discontinuities on the strength of the FRP Composite. Finite Element Analyses have been performed for specimen undergoing four-point bend loading condition using ABAQUS software. Three specimens consisting of different ply sequences, same resin pocket size and location have been considered for the present analysis. Cohesive zone modelling technique is implemented to simulate and predict crack propagation pattern during failure of composite …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 89–98 Read article