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478 articles for “ADME”
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Pharmacological Management of Parkinson’s Disease: Current Therapies and Emerging Treatments
Abstract: Objective: Parkinson's disease, behind Alzheimer's, is the second most common neurodegenerative ailment and a major cause of neurological morbidity worldwide. Clinical diagnosis is made, and current management is limited to symptomatic treatments, with levodopa remaining the cornerstone of pharmaceutical therapy. In certain patient groups, deep brain stimulation of specific basal ganglia targets can provide significant clinical relief. There are currently no proven disease-modifying medicines in clinical use that can halt …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 27–39 Read article
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Molecular Docking and Pharmacokinetic Profiling of the Phytocompounds of Jatropha curcas as Antagonist for Salmonella typhi
Abstract: Background: Typhoid is an infection caused by the Gram-negative bacterium, Salmonella enterica serovar typhi. The study assessed the potential use of Jatropha curcas as a typhoid fever therapy alternative to traditional medications. The ability to uncover novel drug indications for currently available medications using in silico methods has increased thanks to the wealth of pharmacological and biological knowledge that is available. Objective: In this study, we assessed the potential inhibitory …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 67–81 Read article
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Fitness and Aesthetics Hostel Gym Management
Abstract: Fitness & Aesthetics’ mission is to help people achieve their fitness objectives by offering training regimens and healthy living plans, as well as assistance with managing a club. By automating the current manual method with the use of digitized equipment and comprehensive computer software, it will provide the information of the Trainer, Gym, Facility, Workout Routines, and Time Slot and proceed into the administrative position, satisfying their requirements, in order …
Published in International Journal of Computer Science Languages · Vol. 1, Issue 1, 2023 · pp. 21–27 Read article
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Extrapolations of Periwinkle Secondary Metabolites as Multitarget Inhibitor of Breast Cancer Proteins
Abstract: Objective: Breast cancer is considered one of the most common and dangerous forms of cancer. It is a significant public health issue on a global scale. The study estimates that 10.0 million people will die from cancer this year, and 19.3 million people will develop the disease overall (BC). In this computation approach, nowadays emphasizes new drug discovery, the target protein epidermal growth factor receptor (EGFR) (5UGB), estrogen receptor (ER) …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 36–49 Read article
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The Power of the Shell: A Deep Dive into Shell Programming Techniques
Abstract: Shell programming is a fundamental skill in Unix/Linux environments, enabling users to automate tasks, streamline workflows, and enhance system efficiency. This paper, “The Power of the Shell: A Deep Dive into Shell Programming Techniques,” explores the core concepts, commands, and strategies that make shell scripting a powerful tool for both novice and advanced programmers. By examining key elements such as control structures, file manipulation, process management, and error handling, the …
Published in Journal of Advances in Shell Programming · Vol. 11, Issue 3, 2024 · pp. 41–50 Read article
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Enhanced Shell Script Optimization Techniques for Low-latency Automation in DevOps Environments
Abstract: Shell scripting remains a foundational component in system administration and DevOps automation, providing a straightforward yet powerful method for automating tasks, managing system configurations, and integrating seamlessly within continuous integration and continuous delivery (CI/CD) pipelines. These scripts serve as the backbone for many repetitive and complex tasks, enabling IT teams to execute workflows efficiently without manual intervention. As organizations continue to scale their infrastructure and adopt more complex architectures, the …
Published in Journal of Advances in Shell Programming · Vol. 11, Issue 3, 2024 · pp. 1–5 Read article
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Computational Investigation of Withania somnifera Compounds Targeting S. pombe SMN YG-Dimer in Spinal Muscular Atrophy: Insights from Molecular Docking Analysis
Abstract: Objectives: The primary objective of this study is to determine the potential of phytochemical constituents of Withania somnifera in treating spinal muscular atrophy, an autosomal recessive genetic neurodegenerative disorder, through computational techniques. To investigate the binding affinity of phytocompound to the target protein S. pombe SMN YG-Dimer through molecular docking. Besides, evaluating the pharmacological attributes of phytochemical constituents to assess their ability as an ideal prospect for developing therapeutic medication. …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 39–52 Read article
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A Design and Development of Online Ticket Reservation System
Abstract: The purpose of this case study is to develop and demonstrate various facilities and features available in Full Stack Development using Django by considering a simple example of an Online Ticket Reservation System (OTRS). The concepts of Django Models, Views, Templates, Admin Interfaces, and Forms are used to ensure this case study utilizes all features of the framework to make it the complete miniature product. In addition, a well-documented report …
Published in International Journal of Computer Science Languages · Vol. 2, Issue 2, 2024 · pp. 54–63 Read article
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Resilience Building through Disaster Risk Reduction
Abstract: A catastrophe is a serious disruption to a society's functioning that causes mortal, material, profitable, and environmental losses beyond a community's capability to manage. It results from the admixture of hazards, surroundings of exposure, and lack of volume or measures to lower the implicit negative results of threat. Hence, catastrophe control may be delineated as the arranging and administration of effects and the responsibility for handling all philanthropic angles of …
Published in International Journal of Environmental Planning and Development Architecture · Vol. 2, Issue 2, 2024 · pp. 32–45 Read article
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Exploring the Therapeutic Potential of Grapeseed Phytoconstituent Through Molecular Docking Analysis for Multiple System Atrophy Treatment
Abstract: Objective: Alpha-synuclein (α-Syn) aggregates are a common neurodegenerative disorder associated with Parkinson’s disease and multiple system atrophy (MSA). As a fruit that is extensively grown, grapes have several pharmacological advantages when it comes to reducing oxidative stress. Research has indicated that grape seed phytoconstituents have a major effect on α-Syn. The objective of this study is to inquire into the pharmacological characteristics and potential therapeutic applications of grape seed derivatives …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 14–26 Read article
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Materials, Mechanism and Mechanical Properties of Self-curing Concrete: A Review
Abstract: Concrete, a key construction material with high demand for infrastructure development, necessitates an increased water input both during production and curing. This poses a challenge in areas facing acute water scarcity, highlighting the importance of research to reduce water consumption in the process. The process of hydration of the cement within concrete, without outside source, such as water for curing is referred to self curing. Improper curing will cause self …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 185–194 Read article
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Screening Phytocompounds of Tinospora cordifolia to Find Potential Drug Targets for Cystic Fibrosis
Abstract: This study aimed to evaluate the therapeutic potential of phytocompounds derived from Tinospora cordifolia in treating cystic fibrosis (CF), a genetic disorder caused by mutations in the CFTR gene that lead to severe respiratory and digestive complications. Phytocompounds were retrieved from the IMPPAT database and subjected to molecular docking simulations using PyRx to assess their binding affinity to the CFTR protein. The top-scoring compounds – sterol, magnoflorine, tembetarine, kaempferol, and …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 16–24 Read article
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Molecular Pharmacokinetics and Structural Docking of Phenolic Acids for Targeting NF-κB Pathway Components in Inflammation and Fibrosis: A Computational Approach Toward Therapeutic Discovery
Abstract: Inflammation and Fibrosis are critical pathological processes associated with various chronic diseases, often mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. This study investigates the therapeutic potential of phenolic acids as modulators of the NF-κB pathway, aiming to identify novel ligands that can effectively interact with key components of this signaling cascade. A comprehensive computational approach was employed, utilizing molecular docking, pharmacological screening, and post-docking …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 14–31 Read article
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Evaluating the Optimal Alccofine-1203 Replacement Ratio in M20 Grade Concrete
Abstract: The primary objective of this research is to investigate the potential of partially replacing cement with Alccofine 1203 in M20 grade control concrete and to evaluate the resulting effects on the mechanical properties of the concrete. Alccofine 1203, a high-performance mineral admixture known for its ultrafine particle size and high reactivity, was used as a partial cement substitute at varying replacement levels of 5%, 10%, and 15% by weight of …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 294–299 Read article
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Drug Repurposing of Anticancer Agents JP-8g and REDX05358 Against the Target Protein Plectin 1a in Epidemolysis Bullosa Simplex with Muscular Dystrophy (EBS-MD)
Abstract: Epidermolysis Bullosa Simplex with Muscle Dystrophy is a genetic disease affecting the skin and muscles which can be seen at birth or start at adulthood due to the mutation in the protein Plectin 1a (PLEC gene) causing skin blisters and muscle weakness. This protein is seen in sarcolemma, Z disks in skeletal muscles, hemidesmosomes in skin and cardiac muscles giving stability to cytoskeleton, playing a crucial role in neuromuscular transmission …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 22–34 Read article
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Molecular Docking Analysis of Berberis aristata Phytocompounds as Potential Growth Factor Receptor Blockers in Cancer Therapy
Abstract: Middle-aged and older women are susceptible to breast cancer (BC), a potentially fatal condition. When breast cancer is diagnosed, the median age is 62. Breast cancer diagnoses in women under 45 are comparatively uncommon, whereas the bulk of breast cancer diagnoses occur in women 62 and older. Growth factor receptors are interesting therapeutic targets because of their critical role in the pathophysiology of cancer. Vascular endothelial growth factor receptors (VEGFR-2) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 1–10 Read article
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Molecular Docking Studies of Nyctanthes arbor-tristis Phytochemicals for Targeting TNF Receptor in Arthritis
Abstract: Rheumatoid Arthritis is an autoimmune disorder which results in inflammation. Tumor necrosis factor-alpha (TNF-α) is responsible for the progression of inflammatory arthritis by promoting immune cell activation and cytokine release. The present study explores the potential of bioactive compounds derived from Nyctanthes arbor-tristis (Parijat) in modulating TNF receptor activity through molecular docking. Computational methods were employed to evaluate the binding affinity of selected phytocompounds from N. arbor-tristis against the extracellular …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 11–21 Read article
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Advances in Shell Programming: Techniques, Tools, and Emerging Trends
Abstract: Shell programming has undergone a significant transformation, shifting from simple command-line interactions to a mature, versatile scripting environment that supports modern computing needs. Over time, shells such as Bash, Zsh, and PowerShell have expanded far beyond basic task execution, evolving into powerful tools capable of handling complex automation workflows, system configuration tasks, and cross-platform orchestration. These environments now offer improved error handling, stronger security features, integrated performance-monitoring options, and more …
Published in Journal of Advances in Shell Programming · Vol. 12, Issue 3, 2025 Read article
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Immunological Biomarkers and Epidemiological Evaluation of Lymphatic Filariasis Elimination Efforts in Osun State, Nigeria
Abstract: Lymphatic filariasis (LF) remains a neglected tropical disease affecting millions globally, despite extensive elimination efforts. While the interruption of transmission is a key goal, the long-term immunological effects on individuals with existing complications like elephantiasis remain poorly understood. This study assessed the current transmission status of LF and the haematological profiles of infected individuals across selected Local Government Areas (LGAs) in Osun State, Nigeria. A total of 7,388 individuals from …
Published in International Journal of Tropical Medicines · Vol. 3, Issue 1, 2026 · pp. 22–30 Read article
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A Computational Study to Elucidate the Phytochemicals as An Antagonist Against Pruritis in Psoriasis
Abstract: Objective: Psoriasis is a chronic, non-contagious, auto-immune skin disorder that causes inflammation, pain, and itching in the affected areas. The etiology of this condition is not entirely understood, and while there are treatments available to manage the symptoms, there is currently no cure. The Transient receptor potential cation channel, subfamily Vanillin, member 3 (TRPV3), present in keratinocytes, allegedly had a part in the development of psoriasis-related pain and itching. Specifically, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 49–61 Read article