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111 articles for “path discovery”
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Pathophysiology Reimagined: Integrating Systems Biology and AI for Disease Understanding
Abstract: Pathophysiology, the study of disease mechanisms at molecular, cellular, and systemic levels, has traditionally relied on reductionist approaches that often fail to capture the complex, dynamic, and interconnected nature of biological systems. Diseases such as cancer, neurodegenerative disorders, and infectious diseases arise from intricate interactions among genetic, epigenetic, metabolic, and environmental factors, necessitating integrative, data-driven methodologies for a deeper understanding. Systems biology has emerged as a powerful approach by leveraging …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 63–71 Read article
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Recent Developments in Structural Genomics: Uncovering Cellular Functions
Abstract: Structural genomics has become a groundbreaking field for understanding cellular functions by revealing the three-dimensional structures of proteins and other biomolecules. This field combines advanced methods like X-ray crystallography, nuclear magnetic resonance spectroscopy, cryo-electron microscopy, and computational modeling to explore the molecular structure and behavior of cellular components. Recent advances have significantly accelerated the pace of structure determination, bolstered by high-throughput methods and artificial intelligence tools like AlphaFold. These developments …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 30–35 Read article
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Impact of PPAR-γ2 pro12Ala Gene Polymorphism and Susceptibility of Type 2 Diabetes Mellitus in Patients Visiting Gondar University Teaching Hospital
Abstract: Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that can occur through mechanisms such as; impaired insulin secretion, insulin resistance in peripheral tissues and increased glucose output by liver. Type 2 diabetes clearly represents a multifactorial disease, and several findings indicate that multiple genetic and environmental factors are important contributing factor involved in the pathogenesis of this disease. Recently great emphasis has been given to genetical factors to combat …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 2, 2015 · pp. 21–28 Read article
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Decoding the Mycobacterium tuberculosis–Macrophage Interplay: From Immune Defense to Pathogen Persistence
Abstract: Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (Mtb) and has been responsible for over one billion deaths worldwide over the past two centuries, remaining a major global health challenge despite advances in diagnosis and treatment. The barriers that make tuberculosis difficult to treat and eliminate are inextricably tied to its intracellular habitat. However, a research gap lies in understanding the molecular mechanisms of its survival and …
Published in International Journal of Pathogens · Vol. 3, Issue 2, 2026 Read article
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Modulation of Receptor Proteins: A Recent Paradigm in Drug Discovery and Target
Abstract: The main aim in drug discovery is to design different ligands those work on specific drug targets. However, various effective drugs work through the modulation of many proteins than single target. Advancement in system biology are establishing a phenotypic strength and a network structure, which suggests that, the excellent selective compounds may be performed less than desired clinical efficacy in comparison to multi-target drugs. In this new appreciation of the …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 14–24 Read article
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Epstein-Barr virus A Review
Abstract: The unravelling of the molecular pathogenesis of malignancy that had its beginnings in the last third of the twentieth century was, in many ways, sparked by the discovery of virus-associated tumors and oncogenic viruses. Epstein Barr virus (EBV) and other viruses that soon followed were not only exciting stories in themselves but provided models with starting points and outcomes, which, since they were specific, could be dissected and generalized. In …
Published in Research and Reviews : A Journal of Immunology · Vol. 1, Issue 1-3, 2011 · pp. 10–15 Read article
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Data Maneuvering Identification
Abstract: Copy-move forgery detection (CMFD) is unquestionably one of the most active research areas in the field of blind image forensics. Most existing algorithms rely on block and key-point strategies, either separately or jointly. Recent applications of deep convolutional neural network (CNN) techniques include image forensics, image hashing retrieval, and picture classification. These techniques have outperformed more conventional techniques in many areas. In this study, a brand-new convolutional neural network based …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 10, Issue 1, 2023 · pp. 99–104 Read article
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Secondary Metabolites in Drug Development: Tracing Their Historical and Therapeutic Impact
Abstract: Secondary metabolites, also known as natural products, exhibit a level of structural and chemical diversity unmatched by synthetic small molecule libraries. These compounds, which have evolved to possess drug-like properties, continue to be a primary source for new medications and drug leads. Their discovery has significantly impacted advancements in chemistry, biology, and medicine, influencing drug development and therapeutic strategies throughout history. Derived from primary metabolic pathways such as photosynthesis, glycolysis, …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 51–55 Read article
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Integrating Network Pharmacology and Molecular Docking to Assess Rutin’s Pharmacological Properties
Abstract: Objectives: In the present research, the network pharmacology process was applied to determine the underlying mechanism of the pharmacological properties of Rutin. Network pharmacology was utilized to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The identification of diverse drug-target interactions using network pharmacology may be utilized to discover novel medications for difficult conditions like …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 20–33 Read article
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Exploring Pharmacological Mechanism Of Pteridines And Its Derivatives Against Neurodegenerative Disorders Using Network Pharmacology And Molecular Docking Techniques
Abstract: Objectives: Pteridines have been identified via various research and shown therapeutic efficacy in Neurodegenerative disorders(ND) preclinical models. In the current study, a network pharmacology technique was applied to determine the underlying mechanism of the pteridines' protective effects on ND. Network pharmacology was utilised in order to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 1–13 Read article
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Design and Fabrication of Electric Car Jack
Abstract: Humans have always been enthralled by new scientific discoveries and technological advancements. The desire to produce something better in order to address the shortcomings of the prior iteration paved the path for ever-increasing technological demands. The automobile industry is another industry where new ideas or inventions are proposed on a daily basis to aid the industry's growth in all ways possible. With new innovations comes the obligation of constantly monitoring …
Published in Journal of Automobile Engineering and Applications · Vol. 8, Issue 3, 2021 · pp. 29–32 Read article
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Bioenergy and Biomass Conversion for Sustainable Energy Production
Abstract: This study delves deeply into the essential role that bioenergy derived from biomass conversion plays in achieving sustainable energy production. The primary aims of this research encompass exploring a diverse range of biomass resources, and their availability, evaluating different biomass conversion technologies (including both thermochemical and biochemical processes), analyzing the sustainability of these conversion methods, and elucidating their significant contribution towards realizing renewable energy targets. This investigation relies on an …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 13, Issue 2, 2023 · pp. 1–16 Read article
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Study of Platelet Count in Dengue Fever, Function and Their Importance in Hemostasis
Abstract: Dengue infection is a major vector-borne disease. Compatible hematological discovery comprises of vasculopathy, thrombocytopenia, and coagulopathy. The study comprises of 60 patients and all the cases were studied in the Department of Pathology, Kachchhi laboratory, Amreli, Gujarat, India. In this study, out of 60 cases, there were 12 cases of IgG positive and 31 cases of IgM positive. In which seven males had IgG infection and 18 males had IgM …
Published in Research and Reviews : A Journal of Immunology · Vol. 9, Issue 1, 2019 · pp. 1–3 Read article
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Marine Fungi – An Expandable Source for Production of Novel Bioactive Metabolites: A Comprehensive Review
Abstract: The marine environment, representing the largest and most extreme biome on Earth, serves as an unparalleled reservoir of biodiversity. Within this vast ecosystem, marine fungi have emerged as a prolific source of structurally diverse and pharmacologically active secondary metabolites. Dwelling in habitats characterized by extreme high salinity, high hydrostatic pressure, and low temperatures, these microorganisms have evolved unique biochemical and metabolic pathways to synthesize novel compounds, including pyrrole-imidazole alkaloids, cyclic …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 30–37 Read article
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Risk & Opportunities in Development of new Drugs: A New Perspective
Abstract: The procedures of drug discovery and development are briefly described in this article. Our goal is to assist researchers whose work may be pertinent to the discovery and/or development of new drugs in framing their research reports in a way that appropriately situates their findings within the drug discovery and development process and supports the efficient translation of preclinical research to humans. One overarching theme of our article is the …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 19–28 Read article
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Lactoferrin for the Treatment of Rheumatoid Arthritis
Abstract: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder characterized by synovial hyperplasia that can lead to cartilage and bone erosion and is associated with decreased life expectancy and quality of life. In the last decade, various RA management strategies has been revolutionized which has led to discovery of specific treatments targeted against cytokines. Despite all available therapeutic approaches, only 20% of patients have reached remission and still many questions …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 8, Issue 1, 2019 · pp. 6–9 Read article
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Personalised Cancer Vaccination Strategies: Bridging Genomics, Bioinformatics, and Immunotherapy
Abstract: Immunotherapy has revolutionized cancer treatment by harnessing the body’s immune system to detect and destroy cancer cells. Personalised cancer vaccines are one of the most promising options because they could allow treatment to be based on the specific tumour profile of each person. The goal of these vaccines is to make the immune system recognise and fight cancer-specific antigens, which will lead to strong and long-lasting anti-tumor responses. However, moving …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 3, 2025 Read article
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The use of Genetics and Proteomics in the Finding of Therapeutic Targets
Abstract: Gene medicine is overcoming long-standing health issues that have confounded humanity. To fully comprehend and apply gene medicine, it is vital to grasp how it works at the molecular level. Currently, various technologies may be utilized to find pharmacological targets; the two most prominent are genomic and proteomic methods. In this paper, we go over how to use genomic and proteomic approaches to find pharmacological targets in depth. These materials …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 1, 2022 · pp. 9–12 Read article
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Detection and Comparative Analysis of Uber-operons of FabZ gene Responsible for Fatty Acid Biosynthesis in Nostoc Punctiforme Cyanobacterium
Abstract: The increasing price of petroleum products has necessitated the development of alternative fuel energy. The long alkyl chains that represent nature’s ‘petroleum’, are today isolated from microbes, plant and animal oils by amore scalable, controllable and economic routes.Hence, in this perspective, the present study was aimed at exploring the uber-operons of FabZ gene responsible for the synthesis of fatty acid in an aquatic nitrogen-fixing and filamentous cyanobacterium called Nostoc punctiforme. …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 1, Issue 1, 2014 · pp. 23–35 Read article
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article