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336 articles for “genetic study”
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The Ames Test in Twenty-first Century
Abstract: Since the 19th century, industrial development has increased exposure to mutagens and possible carcinogens. In order to avoid these health risks, several techniques have been developed to recognize genotoxins. In the 1970s, Dr. Bruce Ames and colleagues, studying the histidine operon of Salmonella typhimurium, observed that histidine (−) auxotroph mutants were reverted to histidine (+) upon exposure to a mutagen. The researchers further observed that known carcinogens were mutagenic to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 1, 2012 · pp. 23–37 Read article
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Impact of PPAR-γ2 pro12Ala Gene Polymorphism and Susceptibility of Type 2 Diabetes Mellitus in Patients Visiting Gondar University Teaching Hospital
Abstract: Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that can occur through mechanisms such as; impaired insulin secretion, insulin resistance in peripheral tissues and increased glucose output by liver. Type 2 diabetes clearly represents a multifactorial disease, and several findings indicate that multiple genetic and environmental factors are important contributing factor involved in the pathogenesis of this disease. Recently great emphasis has been given to genetical factors to combat …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 2, 2015 · pp. 21–28 Read article
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Evaluation of Jackfruit (Artocarpus heterophyllus Lam.) Germplasm
Abstract: AbstractThe experiment was conducted with the existing bearing trees of different jackfruit genotypes at Jamalpur region during the year 2014–2015. Twenty-three jackfruit germplasm viz., AHJ-01, AHJ-02, AHJ-03, AHJ-04, AHJ-05, AHJ-06, AHJ-07, AHJ-08, AHJ-09, AHJ-10, AHJ-11, AHJ-12, AHJ-13, AHJ-14, AHJ-15, AHJ-16, AHJ-17, AHJ-18, AHJ-19, AHJ-20, AHJ-21, AHJ-22 and AHJ-23 were selected for the study to identify superior ones. The recorded age of the selected tress ranged from 8 to 29 years. …
Published in Research & Reviews : Journal of Botany · Vol. 7, Issue 1, 2018 · pp. 38–53 Read article
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Evolutionary History of Endemic Species of Bihar
Abstract: Bihar, a state known for its history and rich cultural heritage, is also a refuge of clearly defined species that are unique to the world and are found no place else. The present study involving the history of these species by using genetic analysis, fossil evidence, and ecological studies, investigates the situation. Through initial and secondary explanation, we can realistically infer some of them locked in so closely with their …
Published in Research & Reviews : Journal of Ecology · Vol. 14, Issue 2, 2025 · pp. 1–10 Read article
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From Ancient DNA to Modern Livestock: Paleogenomics
Abstract: Paleogenomics, an interdisciplinary blend of paleontology and genomics, has revolutionized our understanding of ancient DNA and its applications across various fields. In Animal Genetics and Breeding, this field has emerged as a pivotal tool providing invaluable insights into the historical genetics of domesticated animals. By reconstructing and analyzing the genomes of long-extinct organisms, paleogenomics sheds light on genetic diversity, evolutionary dynamics, and adaptations of ancient species. Paleogenomics significantly impacts animal …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 1–6 Read article
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Homology Modeling and in silico Characterization of a Hypothetical Protein of Arabidopsis lyrata ssp. Lyrata
Abstract: Arabidopsis lyrata, a plant belonging to brassicaceae, is a model organism for studying evolutionary and ecological genetics. Most of the proteins of this plant have remained uncharacterized and their functional roles are still to be elucidated. In this investigation, we have attempted to characterize one such hypothetical protein in terms of its physico-chemical properties, secondary and tertiary structure features by in silico study. The protein was classified under glycoside hydrolase …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 3, Issue 2, 2013 · pp. 1–5 Read article
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
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GenChrome-ML: A Machine Learning Framework for Early Detection of Chromosomal Disorders Using Genomic Data
Abstract: The increasing burden of chronic disease and cancer demands innovative, more rapid and effective diagnostic tools in the field of healthcare. The majority of current diagnostic tools are dependent upon clinical symptomology and manual evaluation, leading to delays in early detection and treatment. The development of artificial intelligence (AI) and machine learning (ML), in recent years, has offered opportunities for the enhancement of disease prediction, diagnosis and personalization of treatment …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 Read article
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Zebrafish in Drug Research: Decoding Biological Mechanisms and Finding Novel Therapeutic Targets
Abstract: The zebrafish, scientifically known as Danio rerio, is a powerful model organism in biological research because of its favorable traits, which include rapid development, genetic tractability, and transparent embryos. Zebrafish were first identified for their use in studies of vertebrate development, but they have since spread to a variety of disciplines, such as pharmacology, clinical research as a disease model, and most notably, drug development. Zebrafish have emerged as a …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 3, 2025 · pp. 1–8 Read article
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Outcome of the Ayurvedic medication on a patient with Sickle cell anaemia – A single case study
Abstract: Sickle cell disease is caused by genetic modification of β-globin (HBB). The result of clinical syndromes is characterized by chronic hemolytic anemia and can be complicated by vaso-occlusion and vasculopathy which can lead to severe and chronic organ damage and premature death. A 17-year-old female patient was diagnosed with sickle cell anemia with symptoms of severe weakness, shortness of breath, loss of appetite, constipation, severe calf pain, chest pain, abdominal …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 11, Issue 3, 2022 · pp. 1–8 Read article
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CRISPR-Cas9: Revolutionizing the Genetic Frontier
Abstract: The rapid development of CRISPR/CRISPR-associated enzyme (Cas) technology has enabled truly customised treatment of human genetic disorders, paving the way for recent developments in the field of gene therapy. Because CRISPR/Cas can accurately target and edit individual genes within a genome, it has established itself as a formidable tool for genetic manipulation. CRISPR/Cas9 technology allows for precise editing of specific DNA sequences in an organism's genome. This method uses three …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
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Collection and Evaluation of Ber Germplasm
Abstract: An experiment to identify suitable ber germplasm was conducted at Horticulture Research Centre (HRC) fruit orchard, Regional Agricultural Research Station (RARS), Bangladesh Agricultural Research Institute (BARI), Jamalpur, Bangladesh during the fruiting season of 2016-2017. Fifty-eight accessions collected from different parts of Bangladesh were included in the study. The scion of the collected germplasm was grafted on 10 years old ber plant and the age of grafted branches was 3 years …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 6, Issue 3, 2017 · pp. 24–39 Read article
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Extended Spectrum Beta-Lactamase Production By Acinetobacter baumannii Isolated From Hospital Environment
Abstract: Extended spectrum β-lactamases production was determined by Double Disc synergy test for twenty one bacterial isolates of Acinetobacter bumannii isolated from the hospital environment. This study investigates the prevalence, genetic mechanisms, and clinical implications of ESBL production by A. baumannii. We employed molecular techniques to identify and characterize ESBL genes in clinical isolates, alongside evaluating their susceptibility profiles against a range of antibiotics. These resistant strains were notably associated with …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 71–78 Read article
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Molecular Mechanisms of Drug Metabolism in Anesthesia: A Pharmacogenomic Perspective
Abstract: Pharmacogenomics studies how a person’s genetic profile affects their reaction to drugs, which is vital in anesthesia. Anesthetic pharmacology depends significantly on drug metabolism, which involves complex biochemical processes that manage the absorption, distribution, metabolism, and excretion (ADME) of anesthetic drugs. The cytochrome P450 (CYP) enzyme family plays a critical role in the metabolism of various anesthetic drugs, with genetic polymorphisms leading to inter-individual variability in drug responses. Specific CYP …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 90–95 Read article
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Evaluation of Genetic Variation in Endangered Tree Species of Boswellia serrata with the Help of Genetic Markers
Abstract: Salai (Boswellia serrata) is the most valuable medicinal tree. It has many medicinal properties like anti-inflammatory agent extensively used in ayurvedic formulations for relieving ache and pain, particularly associated with arthritis. In this study, identification of potential pockets of the designated species in different agro-climatic zones of Madhya Pradesh and evaluation of genetic variation with help of RAPD markers of Boswellia serrata is done, so as to produce elite genotype …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 7, Issue 1, 2017 · pp. 22–26 Read article
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Single Nucleotide Polymorphism in CYP17 and CYP19 in Breast Cancer
Abstract: A single T > C change at the 5’ promoter region of the CYP17 and CYP19 genes are reported to be associated with increased risk of breast cancer. This study evaluates the influence of genetic polymorphism of CYP17 and CYP19 on breast cancer susceptibility. Ten patients with histopathologically confirmed breast cancer and 30 age-matched controls were included in study. A polymerase chain reaction – single nucleotide polymorphism (PCR-SSCP) method was …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 1, Issue 2, 2014 · pp. 8–11 Read article
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Genetic Diversity and Characterization of Ocimum sanctum Collected from Anand, Central Gujarat Region, by PCR-based RAPD Markers
Abstract: Genetic relationships were examined among thirty germplasm accessions belonging to ten Ocimum species using RAPD markers. A very high degree of polymorphism (98.92%) was observed. UPGMA cluster analysis of genetic similarity indices grouped all the accessions into two major clusters corresponding to previously reported botanical sections. Intra-clustering within the two clusters precisely grouped the accessions belonging to one species in onesub-cluster as expected from their genetic background. Results of this …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 3, Issue 2, 2013 · pp. 6–12 Read article
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Practical Strategies to Mitigate Acidosis in Dairy Cattle: Implications of Nutritional, Genetic, and Management Practices
Abstract: Acidosis in dairy cattle remains a critical concern, adversely affecting rumen health, milk production, and overall animal welfare. This study investigates practical strategies to mitigate acidosis through integrated nutritional, genetic, and management approaches. Nutritional strategies emphasize balancing forage-to-concentrate ratios, providing adequate fiber, and utilizing feed additives such as buffers, probiotics, and yeast cultures to stabilize rumen pH. The importance of gradual dietary transitions and monitoring total mixed ration (TMR) composition …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 2, 2025 · pp. 27–44 Read article
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Study of DFIG with Rotor Excited Through Inverter and Method of Efficiency Maximization
Abstract: AbstractIn order to extract maximum power output from a DFIG or Doubly fed Induction Generator, maximum mechanical power must be extracted from wind turbine and the losses must be minimized. As the wind speed is not fixed, in order to get maximum power and minimum losses, the d-axis and q-axis rotor currents I*dr and I*qr are controlled according to the changes in wind speed. In this research, Genetic Algorithms are …
Published in Research & Reviews : Journal of Physics · Vol. 9, Issue 1, 2020 · pp. 51–56 Read article
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Genetic Authentication of Acacia Senegal (L.) Wild
Abstract: A study was carried out to ascertain the taxonomic identity and phylogenetic lineage of three presumed Acacia senegalensis using molecular markers. Three (3) varieties of seeds presumed to belong to Acacia spp. were collected from the Rubber Research Institute of Nigeria (RRIN) Benin City and three BP haplotypes (A, B, and C) was used as control for the analysis. These seeds were processed at the Applied Biotech International Laboratory Nigeria …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 33–39 Read article