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686 articles for “Validation”
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Exploring Glucagon-like peptide-1 as a Target Protein for Diabetes Mellitus Treatment: Molecular Docking and Pharmacokinetic Analysis of Phytocompounds from Momordica charantia
Abstract: Objective: This study aimed to use molecular docking techniques to explore the potential of GLP-1 (glucagon-like peptide-1) as a target protein for the treatment of diabetes mellitus, a chronic metabolic disease marked by elevated blood glucose levels. Given its crucial role in maintaining insulin secretion and glucose homeostasis, GLP-1 may serve as a future target for diabetes therapy. Method: The study employed a multi-phase method. Initially, protein extraction was carried …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 8–20 Read article
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Novel Laplace-domain Approach to the Electromagnetic Transients in Compensated High Voltage Power Lines
Abstract: This paper addresses the simulation of the electromagnetic transients developed in high voltage power lines, which are initiated by lightning discharges. The analysis can handle both individual and simultaneous series inductive and shunt capacitive compensation types. The sizes and locations of the compensating elements are included in the analysis. The derived Laplace s-domain mathematical model applies the concept of the ABCD transmission constants representing equivalent two-port networks. Applying the relations …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 2, Issue 1, 2024 · pp. 15–21 Read article
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RP-HPLC method for simultaneous determination of Drospirenone and Ethinylestradiol in Bulk and their Pharmaceutical dosage form
Abstract: Oral contraceptive is used to prevent the pregnancy which is contain hormones to block the release of eggs from the ovaries. Most of them contain estrogen and progesterone. Nowadays, usage of hormonal contraceptive is sharply enhancing; around 100 million of women worldwide are taking these drugs. With this drug fertility rate can be supressed as long as they want or plan their activity along with these drugs provide efficacy, reliability, …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 46–67 Read article
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Biomarkers in Cancer Research: Discovery and Future Directions
Abstract: Biomarkers have transformed the study of cancer, providing critical information regarding prognosis and therapy response and promoting earlier diagnosis. This paper discusses the different parts of cancer biomarkers, starting with their description, classification, and major types, which are the groundwork for understanding their clinical role. The discussion on the development and validation process of biomarkers is then undertaken, focusing on state-of-the-art techniques and the importance of ensuring accuracy and reproducibility. …
Published in Trends in Drug Delivery · Vol. 12, Issue 1, 2025 · pp. 22–26 Read article
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Authentication of a Rapid RP-HPLC technique for Quantification of Remogliflozin and Metformin in Medicinal Formulations
Abstract: A new, precise, and stability-assessing advanced liquid chromatography (HPLC) technique for simultaneous quantification of Remogliflozin and Metformin in fixed dose pharmaceutical formulations was designed and verified. Optimization of the technique was carried out on flowing phase composed of ethanenitrile and buffer, under isocratic conditions, the resolution of peak being sharp with retention times of 3.24 min and 4.89 min for Remogliflozin and Metformin, respectively. Technology suitability was confirmed by the …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 70–77 Read article
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Bio-Inspired FGPCs for Biomedical and Structural Applications
Abstract: Bio-inspired functionally graded polymer composites (FGPCs) represent a new class of smart materials that use gradient material distributions to enhance mechanical and biological properties, mimicking natural systems like bones, shells, and plant stems. FGPCs exhibit smooth gradient distributions across interfaces, which improves biocompatibility and reduces the risk of failure under complex loading and environmental conditions. In this study, bio-inspired FGPCs were designed, fabricated, and validated using a combined experimental and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 456–481 Read article
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DEM Simulation of Macro and Micro-scale Behavior of Granular Materials during Loading and Unloading
Abstract: The present paper aims at comparing the simulated stress-strain behavior of granular materials quantitatively with the experiment and exploring the evolution of the micro-scale behaviors during loading and unloading using the discrete element method (DEM). A numerical sample consisting of 9826 randomly generated spheres similar to the experiment was prepared. The numerically prepared isotropic sample was subjected to loading and unloading under strain controlled condition. It is noticed that the …
Published in Journal of Geotechnical Engineering Read article
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Pharmacophore mapping, 3D QSAR, docking, and ADME prediction studies of novel Benzothiazinone derivatives
Abstract: Background Tuberculosis is a major public health concern worldwide which is caused by Mycobacterium tuberculosis. DprE1 (Decaprenyl Phosphoryl Ribose 2’- Epimerase) is the most challenging target for development of novel anti- tubercular agents because it is a small protein and located into cytoplasmic membrane. So, novel anti-TB drugs did not bound effectively with it. DprE1 catalyzes the oxidation of the 2’ hydroxyl group of DPR (Decaprenyl Phosphoryl D- Ribose) …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 59–82 Read article
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Enhancing Wildlife Tourism Management Using Deep Learning and Particle Swarm Optimization (PSO) for Animal Detection in Wildlife Sanctuaries
Abstract: Wildlife tourism is one of the most thriving sectors, faced with huge challenges in terms of safeguarding protected areas. As demand for wildlife experiences accelerates, it becomes necessary to find efficient measures that are friendly to conservation. The use of these advanced techniques in this field such as YOLO and PSO algorithm presents a new dimension on managing wildlife tourism. To harness the abilities of these techniques, this research centers …
Published in Current Trends in Signal Processing · Vol. 14, Issue 3, 2024 · pp. 41–50 Read article
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Identification and Prioritization of Critical Erosion Prone and Water Potential Areas of Manandragarh Watershed Using HEC-HMS for Management
Abstract: This study was carried out at Indira Gandhi Krishi Vishwavidyalaya, Raipur (CG) on hydrological modelling and development of soil and water conservation plan for critical erosion prone and water potential sub-watersheds of Manendragarh watershed of upper Hasdeo subbasin in Chhattisgarh using Hydrological Engineering Centre-Hydrological Modelling System (HEC-HMS). The Hydrological Engineering Centre-Geo Hydrological Modelling System (HEC-Geo HMS) was utilized for developing the model setup, while the HEC-HMS model was employed to …
Published in Research & Reviews : Journal of Ecology · Vol. 14, Issue 1, 2025 · pp. 26–44 Read article
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Performance of GFRP Bars in Flexural Members: A Comparative Study with Metal Bars Using FEA and Experimental Study
Abstract: In recent years, GFRP bars have been introduced as a replacement for metal bars as reinforcement in flexural members. This study evaluates the use of GFRP bars as the main reinforcement in flexural members such as beams through computer simulations and experimental work. A 4-meter beam from a sample structure, analyzed as per IS 875 (1987) Part 2, was considered for the study. This beam was designed considering both metal …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 262–267 Read article
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Study of a Western Disturbance of 2023 Using Satellite-Based Observation, Reanalysis Data, and Numerical Simulation
Abstract: Western Disturbances (WDs) are synoptic-scale, extratropical storm systems that influence winter precipitation across northwest India. This study focuses on a specific WD event that occurred from 24– 25 March 2023, affecting Jammu & Kashmir, Himachal Pradesh, Uttarakhand, and Punjab. The analysis integrates satellite observations, ERA-5 reanalysis data, and simulations from the Weather Research and Forecasting (WRF) model to evaluate the model's performance. The novelty of this study lies in its …
Published in Journal of Remote Sensing & GIS · Vol. 16, Issue 3, 2025 · pp. 16–38 Read article
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Remote Sensing and GIS-Based Approaches for Groundwater Contamination Assessment: A Comprehensive Review of Methods, Sources, and Emerging Trends
Abstract: Groundwater contamination poses a serious threat to sustainable water resources, especially in developing regions with limited monitoring infrastructure. This review provides an in-depth analysis of remote sensing (RS) and geographic information system (GIS) techniques applied to identify, monitor, and assess groundwater contamination. The study categorizes major sources of pollution, including industrial effluents, agricultural runoff, and geogenic inputs and examines how multispectral and hyperspectral satellite data contribute to indirect mapping of …
Published in Journal of Remote Sensing & GIS · Vol. 16, Issue 3, 2025 · pp. 39–49 Read article
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A Review Paper of Automated Driving & ADAS Technologies
Abstract: Automated driving and Advanced Driver Assistance Systems (ADAS) are transforming road mobility, promising enhanced safety, improved traffic efficiency, and greater accessibility. This review presents a comprehensive synthesis of core technologies, system architectures, sensor modalities, perception and decision-making algorithms, and evaluation methodologies underpinning contemporary ADAS and automated driving. We provide a detailed discussion of the functional components—sensors (camera, radar, LiDAR, ultrasonic), localization, perception, prediction, planning, control, and human–machine interfaces—and how these …
Published in Journal of Automobile Engineering and Applications · Vol. 13, Issue 1, 2026 · pp. 1–7 Read article
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3D Printing of Polymer-Based Functionally Graded Materials: Recent Developments and Challenges
Abstract: Additive manufacturing (AM), specifically 3D printing, has become a useful technique for fabricating functionally graded materials (FGMs) because it can facilitate the spatial distribution of materials. Polymer FGMs (P-FGMs) have gained a great deal of interest due to their lightweight, customizable, multifunctional properties. In comparison to conventional fabrication, 3D printing allows better control of composition and microstructure, which results in materials with controlled mechanical, thermal, and biological properties. This review …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 338–347 Read article
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Understanding of Research Bias in Herbal Medicine: A Comprehensive Review
Abstract: Background: The communication and generation of knowledge are central to research. In herbal medicine, with its deep historical roots, research must be methodologically rigorous and unbiased to validate traditional knowledge in modern contexts. Bias, defined as any tendency preventing objective evaluation of a research question, compromises validity and reliability. Objective: To highlight types of research bias in herbal medicine and discuss strategies for minimization to ensure credible and applicable findings. …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 1, 2026 · pp. 31–35 Read article
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Role-Based Online Food Ordering and Delivery System Using Django and Restful Architecture
Abstract: Traditional food ordering processes in restaurants rely heavily on manual interactions, including in- person ordering, phone-based bookings, and unstructured coordination between customers, restaurants, and delivery personnel. These approaches lead to inefficiencies such as delayed order processing, incorrect order handling, lack of real-time tracking, and poor coordination among stakeholders. Although modern applications exist, many academic implementations lack modular architecture, role-based access control, and scalable backend design. This paper presents the design …
Published in Recent Trends in Programming languages · Vol. 13, Issue 1, 2026 Read article
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Evaluation of Safety of Unani Pharmacopieal Majoon-e-Lana in Cases of Neurasthenia
Abstract: Neurasthenia, referred to as Zof-e-Asaab in the Unani system of medicine, is a functional disorder characterized by generalized weakness of the nervous system. Individuals suffering from this condition commonly experience persistent fatigue, reduced physical and mental performance, low mood, irritability, disturbed sleep, and, in some cases, elevated blood pressure. Although various conventional treatment options are available for symptom management, no specific curative therapy has been established. Furthermore, long-term use of …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2026 Read article
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Effects of Reels and short videos on human mind and Academic Life
Abstract: The rapid rise of short-form video platforms such as Instagram Reels, TikTok, and YouTube Shorts has fundamentally reshaped the way people consume information and entertainment. While these applications offer quick engagement and social connection, their excessive use has raised serious concerns about their psychological and academic impacts. This research investigates the relationship between short-form video addiction, mindfulness, academic anxiety, and academic engagement among university students. Drawing upon the theoretical framework …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 2, 2026 Read article
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Relationship Between Mental Health, Competitive Aggression and Anger Rumination with Regard to the Role of Mental Health of Martial Arts Athletes in Gilan Province
Abstract: Due to the phenomenon of championship in sports, athletes are always very thirsty to achieve the championship and go on the podium, and this factor can cause negative behaviors by athletes, one of which is competitive aggression. Therefore, the main purpose of this study is to investigate the relationship between mental health, competitive aggression and anger rumination with regard to the role of mental health of martial artists in Gilan …
Published in Recent Trends in Sports · Vol. 1, Issue 1, 2024 · pp. 1–10 Read article