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61 articles for “Malignancies”
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Sustainable Advances in Oral Pathology: The Impact of Artificial Intelligence
Abstract: Oral cavity cancers constitute about 4% of all malignant neoplasms. More than 9,900 new cases are reported from the developed countries yearly, and the 5-year mortality rate is higher than 39%. In Europe, the highest rates occur in Hungary, Croatia, and other Central and Eastern European countries; high levels are also seen in India, Pakistan, and Bangladesh. The management of endosseous pathologies presents considerable challenges because they often exhibit no …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 1, 2025 · pp. 24–27 Read article
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Pharmacogenomics in Anesthesia: Case Studies and Clinical Applications for Personalized Care
Abstract: Pharmacogenomics, the study of how genetic variability influences individual responses to medications, is transforming anesthetic practice by enabling personalized care. This case study collection explores the integration of pharmacogenomic insights into anesthesia management, highlighting its impact on safety, efficacy, and patient outcomes. Adverse reactions to anesthetics often arise from genetic polymorphisms that alter drug metabolism or sensitivity. For instance, patients with RYR1 mutations are susceptible to malignant hyperthermia (MH) when …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 85–91 Read article
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Blood Cell Saver Machine
Abstract: Intraoperative Cell Salvage (ICS) is a crucial technique in modern surgical practice aimed at minimizing the need for allogeneic blood transfusions. By collecting, filtering, washing, and re-infusing a patient’s own blood lost during surgery, ICS provides a safer and cost-effective alternative to donor transfusion, reducing the risk of transfusion-related infections and immunologic reactions. Initially conceptualized in the early 19th century, ICS technology evolved significantly with the introduction of the Cell …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 2, 2025 · pp. 51–59 Read article
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Mandible reconstruction following resection of gingival squamous cell carcinoma with peroneal artery perforator based fibular osteocutaneous free flap
Abstract: Reconstructing soft tissue defect resulting from resection of malignant tumor in face is crucial in esthetic and functional point of view. To address this condition, various surgical flaps are used, including the free vascularized osteocutaneous flap. In this case, we used a free fibular osteocutaneous flap to reconstruct both the bone (osseous) and soft tissue (mucosal) defects. These defects were caused by the removal (resection) of a lesion in a …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 2, 2025 · pp. 12–18 Read article
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Advances in Multiclass Oral Cancer Detection Using Spectroscopic and AI Techniques
Abstract: Oral cancer, primarily OSCC, is still a major health issue worldwide, especially in low-HDI countries. Early diagnosis is essential since survival rates for early detection are much higher than for late-stage detection. However, traditional methods like visual inspection and biopsy are time-consuming, invasive, and rely on the clinician's skill, which is a limitation in accessibility and efficiency. Oral cancer detection has just been revolutionized by recent advances in spectroscopic techniques, …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 3, 2025 · pp. 39–48 Read article
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Computer Aided Diagnosis of Breast Cancer using Machine Learning Techniques
Abstract: Breast cancer is one of the significant health problems that lead to early mortality in women, especially those between 40 and 55 years of age all over the world. In recent years, the number of breast cancer cases among women has risen significantly, making early and accurate diagnosis more important than ever. Computer-aided diagnostic (CAD) tools have become valuable in supporting radiologists by enhancing the precision of breast cancer detection. …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 2, 2025 · pp. 1–11 Read article
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Melanoma Skin Cancer Detection Using Deep Learning
Abstract: Melanoma, a fatal type of skin cancer, is a major global health concern. For better patient outcomes, early and precise detection is essential. A branch of artificial intelligence called deep learning has demonstrated encouraging outcomes in medical image analysis, particularly the identification of skin cancer, in recent years. We present a new method for detecting melanoma skin cancer in this paper by utilizing the ResNet-50 architecture, a deep convolutional neural …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 · pp. 1–9 Read article
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Comparative Study of Machine Learning Algorithms for Detection of Breast Cancer
Abstract: Breast cancer continues to be the most commonly diagnosed cancer among women, with more than 2.3 million new cases diagnosed yearly worldwide. It is stated as the leading cause of cancer-related deaths. Therefore, this emphasizes the dire necessity for early diagnosis with a view to improving survival. Early diagnosis elevates the effectiveness of prediction and treatment. This research carries out a structured and analytical evaluation of various machine learning algorithms, …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 12, Issue 2, 2025 · pp. 113–129 Read article
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Comprehensive Review of Adenoid Cystic Carcinoma: Pathogenesis, Diagnosis, and Emerging Therapeutic Approaches
Abstract: Adenoid cystic carcinoma (ACC)is an infrequent neoplasm, highly malignant, that develops mainly in the salivary glands with the potential to exist in any secretory glandular sites, including the lacrimal glands, breast, and respiratory tract. ACC usually has a benign initial course, but conversely, it is notoriously aggressive in behavior with high incidence of perineural invasion, local recurrence, and distant metastasis, mostly to the lungs. The tumor’s molecular features are characterized …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 1–17 Read article
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Magnetic and Radioactive Nanoparticles for Improved Theranostics and AI Assisted Radiation Therapy
Abstract: Nanoparticles based therapeutic and theranostics technique is becoming an active area of research in nanomedicine. The sensitivity, biocompatibility, and stability of magnetic and radioactive nanoparticles determine their functionality. This research highlights the impacts of magnetic and radioactive nanoparticles on therapeutic techniques namely, cell therapy, gene therapy, and tissue regeneration. Then, it is intended to brief a principal role of these therapeutic techniques to envisage theranostics medicine and radiation therapy using …
Published in International Journal of Advance in Molecular Engineering · Vol. 3, Issue 2, 2025 · pp. 10–21 Read article
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A Review on Unmasking Merkel Cell Polyomavirus: From Discovery to Cancer Driver
Abstract: Merkel cell polyomavirus (MCPyV) is a small, non-enveloped, circular double-stranded DNA virus belonging to the Polyomaviridae family, first characterized in 2008. Epidemiological data suggest widespread exposure, with seroprevalence rates approaching 80% in adults. While primary infection is typically asymptomatic, rare integration events in Merkel cells can initiate oncogenesis, yielding Merkel cell carcinoma (MCC), a neuroendocrine skin cancer with a five-year survival rate under 60%. This review integrates findings from six …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 6–11 Read article
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Advancing Gene Therapy: Next-Generation Viral Vector Engineering for Precision, Safety, and Scalability
Abstract: Gene therapy has emerged as a paradigm-shifting modality for the treatment of genetic disorders, malignancies, and rare diseases through the delivery of therapeutic nucleic acids aimed at correcting or modulating dysfunctional gene expression. Among the various delivery systems, viral vectors including adeno-associated viruses (AAVs), lentiviruses, adenoviruses, retroviruses, and herpes simplex viruses have proven indispensable owing to their high transduction efficiencies and adaptability. This review offers a comprehensive assessment of viral …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 37–55 Read article
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The Role of Helicobacter pylori in Stomach Cancer Incidence: A Study in Rural Communities in Rajasthan
Abstract: Background: Stomach cancer remains a major global health challenge, with a particularly high burden in developing regions. Helicobacter pylori (H. pylori) infection is a known risk factor for gastric malignancy. In India, especially in rural states like Rajasthan, there is limited data on the prevalence of H. pylori and its association with stomach cancer, despite the high incidence of gastric diseases. Methods: This cross-sectional study was conducted among rural communities …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 3, 2025 · pp. 45–50 Read article
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Artificial Intelligence in Diagnostics: Advancements, Challenges, and Future Prospects
Abstract: AI is changing (and will change) healthcare as we know it, and diagnostics might be the specialty that feels the most discomfort. Artificial intelligence-based analytical systems are facilitating the detection, diagnosis, and treatment of a variety of diseases, with better accuracy, speed, and results. Now, this abstract investigates the role of AI in diagnostics, scouring its elements, landmark techniques, transformative impact and future overview. This article explains AI and discusses …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 3, 2025 · pp. 8–17 Read article
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Extra Philadelphia in CML Due to Isodicentric 22: A Case Report
Abstract: Introduction: Chronic Myelogenous Leukemia is a malignancy that affects the hematopoietic stems cells (HSC) of the bone marrow, leading to the rapid and continual proliferation of granulocytes and precursor blast cells. This is caused due to a reciprocal translocation that occurs between chromosomes 9 and 22, leading to the formation of derivative 22 also called as Philadelphia (Ph) chromosome. The Ph chromosome then encodes a fusion oncoprotein that functions as …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 18–22 Read article
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Breast Cancer Screening Awareness and Participation Among Women in North India
Abstract: Breast cancer is the most prevalent malignancy among Indian women, accounting for 25% of all female cancers (ICMR, 2020). Significant urban-rural disparities in screening persist across North India due to socioeconomic, cultural, and healthcare access barriers. This study evaluates these disparities to inform targeted interventions. A cross-sectional study was conducted among 1,500 women (750 urban, 750 rural) in Delhi, Uttar Pradesh, Punjab, and Haryana, using stratified random sampling. Data were …
Published in International Journal of Women's Health Nursing And Practices · Vol. 3, Issue 2, 2025 · pp. 43–50 Read article
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The Impact of Nanotechnology in Transforming Neuro-oncology - A Comprehensive Review
Abstract: The treatment of central nervous system (CNS) tumours, including aggressive malignancies like glioblastoma, faces significant challenges. The blood–brain barrier (BBB) blocks nearly 98% of small-molecule drugs from achieving therapeutic levels in the brain, and the heterogeneity of these tumours frequently contributes to treatment resistance and poor outcomes. Traditional approaches, including chemotherapy and radiotherapy, are hindered by systemic toxicity and inadequate drug penetration. Nanotechnology provides a promising alternative, as nanoparticles (NPs) …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 627–637 Read article
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Cellular Mechanisms of Autophagy in Carcinogenesis: A Narrative Review
Abstract: Autophagy is a highly conserved lysosomal degradation pathway essential for cellular homeostasis, metabolic adaptation, and survival under stress. In the context of carcinogenesis, autophagy exhibits a paradoxical and stage-dependent role. During early tumor development, autophagy acts as a tumor-suppressive mechanism by limiting genomic instability, oxidative stress, and chronic inflammation. Conversely, in established malignancies, cancer cells exploit autophagy to sustain growth, survive hostile tumor microenvironments, and resist anticancer therapies. Increasing evidence …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 1, 2026 · pp. 23–28 Read article
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Jaundice: Etiology, Clinical Manifestations, Diagnosis, Management, Nursing Care, and Prevention
Abstract: Jaundice is a significant clinical condition marked by a yellow discoloration of the skin, sclera, and mucous membranes resulting from increased bilirubin levels in the bloodstream. Rather than being a disease itself, jaundice represents an underlying disorder involving the liver, biliary system, or hematological processes. Hyperbilirubinemia develops when there is excessive bilirubin production, impaired hepatic uptake, defective conjugation, or obstruction in bile excretion. Jaundice remains a major global health concern …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 32–39 Read article
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A Knowledge Graph Approach for Breast Cancer Diagnosis and Data Sharing Platform Implementation in the Context of Human Papillomavirus Infection
Abstract: Background: Breast cancer remains among the most prevalent malignancies in women worldwide, and effective diagnosis and data integration continue to challenge clinical practice. Diagnostic reports from mammography and ultrasound contain rich clinical information that is often under-utilised due to heterogeneous formats and limited data-sharing infrastructure. In the context of human papillomavirus (HPV) infection, which may influence oncogenic pathways and data complexity, advanced computational methods offer new solutions to this problem. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 1, 2026 Read article