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412 articles for “Gene targeting”
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Performance and Structural Analysis of Different Lithium-Ion Battery Chemistries for Electric Vehicle Applications
Abstract: Lithium-ion batteries (LIBs) stand at the forefront of electric vehicle (EV) technology and have become a driving force behind the development of advanced energy storage systems. In this study, performance and structural analysis of different lithium-ion battery (LIB) chemistries—namely Lithium Nickel Manganese Cobalt Oxide (NMC), Lithium Iron Phosphate (LFP), Lithium Cobalt Oxide (LCO) and Lithium Nickel Cobalt Aluminum Oxide (NCA)—is presented. The study explores important performance parameters like energy density, …
Published in International Journal of Advanced Robotics and Automation Technology · Vol. 3, Issue 2, 2025 · pp. 13–31 Read article
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Lab Reagents and Their Importance in Bio-chemistry
Abstract: Biochemical reagents are essential substances in the study of life at the molecular level. These reagents help scientists detect, identify, and quantify bio-molecules such as proteins, carbohydrates, nucleic acids, and enzymes in biological systems. They play a vital role in understanding metabolic reactions and physiological processes within living organisms. Biochemical reagents are generally classified into analytical, diagnostic, enzymatic, chromogenic, and buffer reagents, each serving a specific purpose in laboratory and …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 · pp. 1–4 Read article
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Phosphorescence of Carbon Nanodots – The Phenomena and the Applications
Abstract: Photoluminescence has emerged as a fundamental phenomenon in modern biomedical science, enabling advanced diagnostic, therapeutic, and theranostic applications through light–matter interactions at the nanoscale. The ability of photoluminescent materials to absorb electromagnetic radiation and emit light at distinct wavelengths has been widely exploited in bioimaging, biosensing, drug delivery tracking, and photodynamic therapy. Among various photoluminescent nanomaterials, carbon nanodots have attracted significant attention due to their strong emission intensity, tunable fluorescence, …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 1, 2026 · pp. 01–05 Read article
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Study of Radioactive Productivity in Swiss Albino Mice of Herbal Project by Plant Extract
Abstract: Use of ionising radiation for both peaceful and military purpose has increased the exposure risk to living organisms. Gamma radiation, X-Rays and various isotopes are the most common source of human exposure. Radon products, Nuclear weapons, use of atomic energy in industries, isotopes in the field of medicine institutes of research are the other sources from which man may receive radiation. Ionizing radiations generate reactive oxygen species (ROS) through radiolysis …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 2, Issue 3, 2012 · pp. 20–33 Read article
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Drug Discovery and Development: An Overview from the Regulatory Prospective
Abstract: The improvement of medication from an underlying plan to its entrance into the market is an extreme process which can take around 5–10 years and cost $1.7 billion. The thought for another advancement can originate from an assortment of sources which incorporate the flow necessities of the market, new rising infections, good clinical research, business part, and so on. Once an objective for revelation has been picked, the pharmaceutical businesses …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 1–9 Read article
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THE FACTORS THAT SHOULD INFLUENCE THE EFFECTIVENESS OF POVERTY ALLEVIATION PROGRAMS ACROSS THE GLOBE
Abstract: World is in a state of a long fight with poverty since technology advancement’s and automation came into existence, various policies and poverty alleviation programs mutually by many of the governing governments and policymakers have been put in place with the goal to eradicate poverty which however they have not yielded the expected result. The goal of this qualitative study was to investigate the claim by beneficiaries & policy lawmakers …
Published in Journal of Production Research & Management · Vol. 8, Issue 3, 2018 · pp. 1–9 Read article
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The Power of Genetic Engineering in Revolutionizing Vaccines
Abstract: Genetic engineering techniques, including recombinant subunit, viral vector, and nucleic acid vaccines have transformed the landscape of vaccine development. These novel approaches offer precise antigen design, enhanced safety profiles, and rapid adaptability to emerging pathogens. Key advantages include improved efficacy through targeted immune responses, increased safety due to the absence of live pathogens, and the ability to modify vaccines to address new variants or diseases quickly. Notable success stories, such …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 18–27 Read article
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Revolutionizing Blood Cancer Treatment: Emerging Therapies and Future Perspectives
Abstract: Blood cancer inclusive of leukemia, lymphoma and multiple myeloma poses a significant threat in the world today because of its multifactorial process and its non-amenable to standard therapies. Some of such approaches are immunotherapy, gene-editing technology and targeted small molecule inhibitors that have altered the nature of treatments. CAR T cell therapy is a molecular targeted therapy for cancers and several clinical studies have reported a huge success. Also, the …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 3, Issue 2, 2025 Read article
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Zebrafish in Drug Research: Decoding Biological Mechanisms and Finding Novel Therapeutic Targets
Abstract: The zebrafish, scientifically known as Danio rerio, is a powerful model organism in biological research because of its favorable traits, which include rapid development, genetic tractability, and transparent embryos. Zebrafish were first identified for their use in studies of vertebrate development, but they have since spread to a variety of disciplines, such as pharmacology, clinical research as a disease model, and most notably, drug development. Zebrafish have emerged as a …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 3, 2025 · pp. 1–8 Read article
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Overcoming Obstacles to an HIV-1 Cure: Advances in Genome Editing, Immune System Reprogramming, and Viral Reservoir Elimination
Abstract: Human immunodeficiency virus type-1 (HIV-1) continues to represent a major global health challenge despite the remarkable success of antiretroviral therapy (ART). Although ART effectively suppresses viral replication and prolongs survival, it cannot eradicate the virus due to the persistence of long-lived latent reservoirs. In recent years, innovative therapeutic strategies have been explored with the aim of achieving either a functional remission or complete viral elimination. Advances in genome-editing technologies, particularly …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 Read article
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2D-QSAR (Quantitative Structure Activity Relationship) Study of Probable Inhibitors for Oral and Cervical Cancers, Generation of Model for Pharmacophore Prediction
Abstract: Twenty-four analogs, conjugates and congeners of curcumin reported as inhibitors against HPV 16 E6 and E7 protein targets have been selected for generating QSAR model. The 46 descriptors were calculated using Schrodinger program version quikprop 9.2. Two alternative methods have been used to generate QSAR models. The first model generation was built on 5 descriptors namely glob, QPlogS, CIQPlogS, IP (eV), human oral absorption which were subjected to multiple linear …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 1–13 Read article
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Heterosis in Plants
Abstract: It refers to hybrid vigor or heterosis; herein, the offspring expressed better traits than one or both parent lines. This most often manifests in crop breeding as increased yield in F1 hybrids compared with their parents. Developing high-yielding hybrid cultivars across a wider range of crops represents an important strategy for addressing future food security. However, conventional hybrid breeding approaches are fraught with significant challenges in many self-pollinating crops, such …
Published in Research & Reviews : Journal of Botany · Vol. 14, Issue 2, 2025 · pp. 21–31 Read article
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Clone-Specific Drug Delivery Systems: Targeted Approaches and Future Clinical Applications
Abstract: Clone-specific drug delivery systems represent a transformative frontier in personalized medicine, addressing the longstanding challenge of clonal heterogeneity within diseases such as cancer, infectious diseases, and autoimmune disorders. Traditional drug delivery platforms often fail to discriminate between pathogenic and healthy cells, leading to systemic toxicity and reduced therapeutic efficacy. In contrast, clone-specific systems aim to selectively target and eliminate disease-driving cellular clones based on unique molecular signatures, thereby improving treatment …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 21–29 Read article
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Biological Membranes: Structure, Function, and Their Roles in Disease Pathophysiology
Abstract: Biological membranes are important structures that control cellular work, signal transmission, transport, and communication. Dysfunction of membranes has been considered in the development of many diseases, such as cancer, neurodegenerative diseases, and infections, with the distortion of lipid composition, protein activity, and cellular connections involved in the pathogenesis of the disease. The damage on membrane can be caused by oxidative stress, genetic mutation, and environmental influence to disrupt cellular homeostasis. …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 38–46 Read article
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A Brief Review On Nanoparticles Drug Delivery System Used In Cervical Cancer
Abstract: Among cervical tumor-related deaths worldwide, cervical cancer is a major cause. The limitations of traditional methods, such as chemotherapy and radiation therapy, stem from their adverse effects and increased susceptibility to medications. Despite being seen as innovative options, immune checkpoint inhibitors (ICIs) have rather low clinical response rates. Reliable treatments for patients with metastatic or recurring cervical cancer are currently lacking. Lately, nanomaterials including polymers, liposomes, and dendrimers have been …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 1, 2025 · pp. 30–40 Read article
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Nutritional Status, Bioactive Properties & Therapeutic Efficacy of Omega-3 Polyunsaturated Fatty Acids Obtained by Green Synthetic Routes
Abstract: Polyunsaturated fatty acids (PUFAs), particularly omega-3 (n-3) fatty acids like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are crucial for human health. They support structural brain development, visual acuity, and cardiovascular function, while also exhibiting potent anti-inflammatory, antioxidant, and antimicrobial properties. Historically, marine fish oil has been the primary dietary source of these essential fatty acids. However, escalating concerns regarding ecological environmental impacts, the oceanic bioaccumulation of heavy metal contaminants, …
Published in International Journal of Nutritions · Vol. 3, Issue 2, 2026 · pp. 47–65 Read article
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Molecular Detection of Mycoplasma Species from Common Respiratory Infections of Poultry in Andhra Pradesh
Abstract: The present study was undertaken to screen the common respiratory pathogens like avian mycoplasmas (Mycoplasma gallisepticum and Mycoplasma synoviae) causing respiratory infections in poultry, identification, molecular detection and differentiation of these pathogens from suspected birds and an attempt to develop suitable diagnostic tools for screening of common avian mycoplasmas (MG and MS). A total of 228 pooled cloacal swabs, 228 pooled nasal swabs, 228 pooled tracheal swabs from ailing birds …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 11, Issue 1, 2022 · pp. 4–8 Read article
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
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Integrative Network Biology Analysis of GSE6011 Uncovers Molecular Signatures in Duchenne Muscular Dystrophy
Abstract: Duchenne muscular dystrophy (DMD) is a rare, severe neuromuscular disorder demonstrated by progressive skeletal muscle deterioration and premature mortality. Despite advances in supportive care, no definitive cure exists, highlighting the need to explore novel molecular targets. The current study aimed to uncover key dysregulated genes and molecular pathways in DMD through a dataset-specific network biology approach. Publicly available microarray data (GSE6011) from DMD quadriceps muscle biopsies of 22 patients and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 3, 2025 · pp. 36–48 Read article
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Baseline Assessment of the Knowledge, Attitudes, Belief and Practices (KABP) related to HIV/AIDS in Vasai, Maharashtra, India
Abstract: Despite of decade long national effort to target prevention programs towards the general Indian population, most prevention programs have largely focused on urban populations. Information on semi-urban and rural populations is limited. This study is a baseline assessment of the Knowledge, Attitudes, Belief and Practices (KABP) related to HIV/AIDS, among participants receiving targeted awareness programmes in semi urban regions of Vasai taluka, Maharashtra state, which is identified as one of …
Published in Research and Reviews: A Journal of Health Professions · Vol. 13, Issue 3, 2023 · pp. 7–16 Read article