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555 articles for “media”
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Carcinoma Ovary Metastasis to Breast
Abstract: Ovarian cancer commonly metastasises to lymph nodes, lung and liver. Primary ovarian carcinoma metastasising to breast is a very unusual and very few cases are described. Literature reports only 39 cases till date. Most common histological variety of Primary ovarian cancer metastasising to breast is papillary serous adenocarcinoma. Metastasis to breast suggests distant spread of the tumour and hence poor prognosis with median age of survival being 6 months from …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 2, 2016 · pp. 6–10 Read article
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Serum Advanced Oxidation Protein Products (Aopp) in Oral Squamous Cell Carcinoma (Oscc): Possible Markers of Diagnostic Significance
Abstract: The aim of this study was to measure the concentrations/levels of serum, total proteins and advanced oxidation protein products as the markers of oxidant mediated protein damage in the sera of patients with oral cancers. The study consisted of the sera analysis of serum total protein, albumin and advanced oxidation protein products’ levels in 30 age and sex-matched controls, 60 patients with reported pre-cancerous lesions and/or conditions and 60 patients …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 1, Issue 1, 2012 · pp. 16–29 Read article
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Induction of Apoptosis using Gene Therapy in the Treatment of Cancer
Abstract: Gene therapy is the treatment of a genetic disease through the insertion of normal or genetically altered genes into cells in order to replace or make up for the non-functional or missing genes. A major application of gene therapy is the induction of apoptosis to inhibit metastases or cure cancer. Besides the identification of the target site, the choice of a suitable vector system for gene delivery is also critical …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 2, Issue 3, 2013 · pp. 6–10 Read article
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The Risk of Second Malignant Tumors after Definitive Treatment of Nasopharyngeal Carcinoma: Three Case Reports and Literature Review
Abstract: Introduction: Patients with head and neck squamous cell carcinoma (HNSCC) have an increased incidence of developing second malignant tumors (SMTs). This may possibly be explained by the concept of “field cancerization” or “condemned mucosa syndrome”, implying the importance of other risk factors like smoking, alcohol consumption, genetic factors and viral infections. However, risk factors for SMTs have not been documented well, especially in nasopharyngeal carcinoma (NPC). Objective: Evaluate the presence …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 6, Issue 2, 2017 · pp. 15–20 Read article
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Role of Nitric Oxide in Platelets of Breast Carcinoma
Abstract: Breast cancer is a disease of multifactorial origin; it is seen frequently in women of older age, having family history, affluent society, late age of marriage and first childbirth, early menarche, late menopause, and nulliparity. Oxidative stress results when balance between reactive oxygen species (ROS) production and antioxidant defence is lost which result in mutations, sister chromatid exchanges, cytotoxicity, carcinogenesis etc. Clinical, experimental and epidemiological studies suggest that free radicals …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 8, Issue 2, 2019 · pp. 25–29 Read article
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Current Tumour Immunotherapy strategies and their molecular basis
Abstract: AbstractStudying cancer and devising techniques to combat the deadly disease has witnessed a paradigm shift, from conventional toxic treatments of radiation and chemotherapy, to a more specific, and biologically significant immunotherapy and molecular targeted therapy. This can be seen in the global immunotherapy market, which is dominated by North America region valued about $45.9 billion in 2017 that is estimated to reach about $115.9 billion by 2025, and is closely …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 2, 2020 · pp. 1–18 Read article
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To Develop Self-instructional Module on ‘Umbilical Cord Stem Cell Collection, Preservation and Utilization’ and Evaluate its Effectiveness on Improving the Knowledge of Operational Level Nurses
Abstract: Umbilical cord stem cell based regenerative and cellular medicine has now become a fascination for all. The umbilical cord blood, donated by mothers after the birth of newborn, has become an accepted source of hematopoietic stem cells for bone marrow reconstitution. They play an important role in the treatment of blood and immune system related genetic diseases, cancers, and blood disorders. This study is aimed to assess the knowledge of …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 3, 2020 · pp. 10–22 Read article
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Thrombotic thrombocytopenic purpura: A Narrative Review of Diagnosis and Treatment by drugs and novel agents.
Abstract: Thrombotic thrombocytopenic purpura (TTP) is an infrequent but fatal disease, is primarily caused by autoantibodies against the von Willebrand factor (VWF) cleaving metalloprotease ADAMTS13. Overall, severe deficiency of plasma ADAMTS13 action (< 10 IU dL-1) with or without noticeable inhibitory autoantibodies counter to ADAMTS13 supports the diagnosis of TTP. The International Working Group for TTP released a consensus statement on the standardization of terminology in these disorders which we use …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 10, Issue 1, 2021 · pp. 40–55 Read article
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Treatment Modalities of Planter Fasciitis: A Two Years’ Experience
Abstract: Back-ground: Plantar fasciitis causes soreness or tenderness of the sole of the foot under the heel, which sometimes extends into the medial arch. Objective: A study was conducted to ascertain which treatment modality provides the best results for heel pain patients. Method: The therapies included orthoses, stretching, ultrasonic therapy and local infiltration with a combination of a local anaesthetic and corticosteroid injection. These were included based on the availability of …
Published in Research and Reviews : Journal of Surgery · Vol. 7, Issue 3, 2018 · pp. 21–25 Read article
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Protective Role of Sulforaphane against Multiorgan Toxicity in Rats: An In-vivo and In-vitro Review Study
Abstract: Sulforaphane [1-isothiocyanate-(4R) -(methylsulfinyl) butane] is a natural dietary isothiocyanate produced by the enzymatic accomplishment of the myrosinase on glucopharanin, a 4-methylsulfinylbutyl glucosinolate contained in cruciferous vegetables such as broccoli, brussel sprouts, and cabbage. Exploring of this compound against various oxidative degenerative diseases such as hepatic, nephro and cardiac diseases is growing because of its anticarcinogenic and cytoprotective properties. In several invivo and invitro experimental paradigms proved SFN and its compounds …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 1, 2018 · pp. 1–8 Read article
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Acute Toxicity, Morphological Changes and Behavioral Responses Induced by Sodium Perfluorooctanoate in Indian Major Carp Labeo rohita (Ham.)
Abstract: Sodium perfluorooctanoate (NaPFO) is an anthropogenic ubiquitous environmental pollutant mainly used in textile, paper and ink industries, for specialized usage as emulsifiers, firefighting foam, lubricants etc. It finds entry into aquatic ecosystem through effluents from these industries. Static renewal bioassay test was conducted to determine 96 h LC50 of NaPFO on Indian major carp, Labeo rohita. The behavioral and morphological alterations in fingerlings were observed critically during the whole experiment …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 3, 2018 · pp. 1–8 Read article
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Arsenic Induced Oxidative Stress and Its Possible Reversal by Chelation Therapy
Abstract: Arsenic (As) is a metalloid listed in group Va of the periodic chart. It exists in nature in the oxidation states +V (arsenate), +III (arsenite), 0 (arsenic) and −III (arsine). In the aqueous environment inorganic arsenic appears commonly in the oxidation states +V and +III as arsenous acid (As (III)), arsenic acid (As (V)), and their salts. Chronic and acute exposures of arsenic leads to cancer, cardiovascular disease (hypertension and …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 2, 2012 · pp. 16–37 Read article
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Production, Characterization and Toxicological Evaluation of Eco-Friendly Flavolipid Biosurfactant
Abstract: At present majority of surfactants are chemically synthesized. Nevertheless, in recent years, much attention has been directed towards biosurfactants due to their broad range of functional properties, there are cheaper as they can be produced from alternative sources. They have applications in the fields, such as: oil recovery process, as an additive in food processing industry, pharmaceuticals preparations, energy saving technologies etc. As they are being microbial derivatives, it is …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 1, 2014 · pp. 16–21 Read article
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The Acute Toxicological Effects of Paraquat on Male Reproductive Hormones (Testosterone, Luteinizing Hormone and Follicle Stimulating Hormone) of Intoxicated Rats
Abstract: Paraquat (PQ) a contact herbicide widely used to control weeds in agricultural, recreational, or industrial sites has been linked in various studies as a contributory agent to high male infertility in regions of most use. The current study investigated the acute toxicity effect of PQ administered intraperitoneal (ip.) on reproductive hormones; luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone (Te) of male rats. 24 rats, grouped four per group …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 3, 2015 · pp. 13–16 Read article
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Isolation and Identification of Bacteria Inhabiting in the Digestive Tract of Tetrodon cutcutia Collected from the River Brahmaputra, Assam, India
Abstract: The Tetrodon cutcutia found in the river Brahmaputra were dissected and its intestinal contents were examined for the presence of bacterial strains. In situ culture of bacteria inhabiting the intestine of Tetrodon cutcutia was conducted in the media followed by biochemical analysis. A novel bacterial strain was confirmed by NCBI after 16S rRNA sequencing. Keywords: Tetrodon cutcutia, 16S rRNA sequencing, novel bacterial strainCite this ArticleJ.K. Nath, S. Khound, T.G. Devina. …
Published in Research and Reviews: A Journal of Toxicology · Vol. 6, Issue 2, 2016 · pp. 13–16 Read article
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Effects of Intraperitoneal Administration of ATRA on the Testis of Elastase Induced Emphysematous Rats
Abstract: Emphysema is the pathological manifestation primarily associated with lungs. However, there are evidences of extra-pulmonary manifestations related to emphysema. The inflammation developed during emphysema triggers the release of several inflammatory mediators, which affects the proximal as well as distal organs. The present study was designed to determine the effect of inflammatory spillage on testicular tissue of male Sprague dawley rats; moreover, the main focus was to assess the potential role …
Published in Research and Reviews: A Journal of Toxicology · Vol. 6, Issue 3, 2016 · pp. 1–12 Read article
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Molecular Mechanism of Fluoride Induced Oxidative Stress and Its Possible Reversal by Chelation Therapy
Abstract: Fluorine (Fl) a member of the halogen family is the most electronegative and reactive of all the elements of the Periodic table. Chronic and acute exposures of fluoride leads to cardiovascular disease (hypertension and atherosclerosis), neurological disorders, gastrointestinal disturbances, liver disease, renal disease, reproductive effects, other health disorders and also affects the antioxidant system in the body. Furthermore, reactive oxygen species (ROS)-mediated oxidative damage is a common malady in fluoride …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 2, 2013 · pp. 7–34 Read article
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Effects of Smoking on Respiratory System
Abstract: Smoking is whispered to exacerbate respiratory diseases by harming respiratory defense mechanisms. Specifically, smoking damages mucociliary function, which impairs clearance of inhaled substances even in smokers who have no respiratory symptoms promotes bacterial adherence to airway epithelial cells. The devastating health impact of cigarette smoking is well known, Cigarette and its components produce structural changes in the respiratory tract include peri-bronchiolar inflammation and fibrosis, augmented mucosal permeability, destruction of the …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 3, 2013 · pp. 5–8 Read article
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Radon Monitoring in Underground Water of Punjab State and Thermal Springs of Himachal Pradesh
Abstract: The source of Radon gas is generally within the rock strata in the form of an intermediate decay product of the U/Th radioactive series. It migrates from the earth’s crust to atmosphere by diffusion in the aqueous media. Radon monitoring is carried out to study health hazard effects. Scintillometry technique was used for measurement of Radon concentration in groundwater of Gurdaspur district and Parbati valley of HP. Radon concentration values …
Published in Research and Reviews: A Journal of Toxicology · Vol. 11, Issue 1, 2024 · pp. 16–20 Read article
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Toxicity of Copper Sulphate on Behaviour, Hematological and Biochemical Parameters of Mrigal Cirrhinus mrigala
Abstract: The present study deals with the toxicity of copper sulphate on behavior, hematological and biochemical parameters of Mrigal Cirrhinus mrigala. Copper sulphate was prepared and characterized by using SEM, FTIR and XRD. The physic-chemical characteristics of water sample were analyzed before the experiment. The sub-lethal analysis on Cirrhinus mrigala in different concentrations such as 10–40 and 50 ppm of copper sulphate were used for a period of 96 h. Based …
Published in Research and Reviews: A Journal of Toxicology · Vol. 11, Issue 1, 2024 · pp. 26–32 Read article