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494 articles for “physiological”
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Kisspeptin Modulates Reproduction in Ruminants
Abstract: AbstractKisspeptin, a neuropeptide encoded by the KiSS1 gene and its cognate, KiSS1R are the key regulators of reproduction in animals. Kisspeptin, also known as metastin, is a potent secretagogue of gonadotropin-releasing hormone (GnRH). It stimulates the GnRH neurons in the brain and generates pulses for GnRH thereby its secretion and release, and this in turn stimulates the release of LH and FSH. Owing to its importance in reproductive biology, the …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 5, Issue 1, 2016 · pp. 7–12 Read article
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Bovine Mastitis and its Treatment Strategies
Abstract: Mastitis remains a major challenge to the dairy industry in terms of economic losses occurring throughout the world. Bovine mastitis is the endemic, persistent and inflammatory reaction of the mammary gland and/or udder tissue of milch animals particularly medium to high yielding dairy cattle, usually in and around peri-parturient period caused by various infectious or non-infectious etiological agents. It is a global problem as it affects animal health, milk production …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 7, Issue 3, 2018 · pp. 11–16 Read article
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Chitosan-conjugated GnRH Nanoparticles with AFM Appearance
Abstract: Nanotechnology can provide new tools for molecular and cellular biology, biotechnology, veterinary physiology, reproduction, detection of pathogens and many more. There are several areas such as science, engineering of agriculture, animal and food systems where nanotechnology could be applied. Application of nanotechnology can be employed in the development of sustained release systems of molecules such as hormones, vitamins, antibiotics, antioxidants and nucleic acids. Longer lasting surges in Gonadotropin hormone (GtH) …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 8, Issue 3, 2019 · pp. 3–5 Read article
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Impacts of Phthalate Plasticisers—An Emerging Issues and Concerns
Abstract: Phthalates or phthalic acid esters are the esters of phthalic anhydride used to increase the flexibility and durability of plastic products including polyvinyl chloride (PVC). Based on the molecular weight, phthalates are grouped into low and high phthalates that shows diverse applications and different mode of toxicity in various animals. The enormous production and widespread applications allow them to exist in all environments including air, water, and soil; in solid, …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 9, Issue 2-3, 2020 · pp. 14–49 Read article
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Toxicity of Alpha-Cypermethrin on Fish
Abstract: Alpha-cypermethrin is a type II synthetic pyrethroid. Synthetic pyrethroids are used extensively for the control of insect pest and public health purpose. A fresh water fish was exposed to lethal concentration and sub lethal concentration of alpha-cypermethrin, respectively to observe the enzyme activity in functionally two different tissues—gills and liver. The present article focusses on non-target organism in fresh water environment and critically evaluates the toxicity of these pyrethroids in …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 10, Issue 2, 2021 · pp. 33–38 Read article
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HDAC and HDAC Inhibitors: Implication in Different Pathological Ailments
Abstract: Histone deacetylases (HDAC) and its inhibitors have been found implicated in various diseased conditions. HDACs regulate the histone tail, chromatin conformation, protein-DNA interaction, and even transcription. They have also been found to regulate the post translational modifications through deacetylation of proteins, and hence are involved in many pathophysiological conditions. Till date, USFDA has approved vorinostat, romidepsin, panobinostat, and belinostat as HDAC inhibitors for the treatment of cancer. Considering their wide …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 3, 2018 · pp. 35–40 Read article
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Synthesis and Chemical Characterization of Novel Series of Heterocyclic Compounds Containing Nitrogen and Oxygen
Abstract: The aim of this study is to synthesize some novel pyrazoline derivatives and to study their antibacterial activity. As estimated, pyrazoline derivatives exhibited significant to moderate antimicrobial activity. There is no such obsession as completely safe drug. Drugs are prevailing tool, which modify physiological processes for the enhanced or for the worse. A society, which desires to take advantage from them, it will not accomplish all the benefits open to …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 3, 2018 · pp. 24–40 Read article
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An Introduction of Glycoside- “It’s Classification, Biogenesis, Identification, Extraction and Healthful Uses”
Abstract: A glycoside is a molecule within which a sugar is absolute to another functional group through a glycoside bond. Glycosides play various vital roles in living organisms. Several plants store chemicals within the kind of inactive glycosides. It may be activated as thanks to that sugar half broken off then its creating the chemical offered to be used. In common terms, an organic compound is any molecule within which a …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 3, 2015 · pp. 4–11 Read article
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A Review on Herbal Drugs as an Analgesic
Abstract: Any group of drugs of diverse chemical structure and physiological effects which are commonly used for the relief of pain is referred to as analgesics. To qualify as an analgesic, a drug must selectively reduce or abolish pain without causing impairment of consciousness, mental confusion, in coordination or paralysis, or other derangements of the nervous system. Opium is the best-known class of narcotic alkaloid analgesics, a drug obtained by extracting …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 2, 2016 · pp. 15–22 Read article
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Effect of Polyherbal Compound (Low Cost) in Management of Insulin Dependent Diabetes Mellitus
Abstract: Diabetes mellitus is chronic ailment associated with life threating target organ damage. The present approach of treatment is to maintain glycaemic level within physiological normal level with different means, which may favour angiopathic changes even with normal blood sugar. Ayurveda believes that Medas i.e. lipid metabolism is important pathological change observed in DM that ends up presentation of elevated level of peripheral blood sugar. The quest is to come with …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 2, 2016 · pp. 31–34 Read article
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A Case Study of Laryngeal Narrowing with Glossopharyngeal Neuritis in Insulin Dependent Diabetes Patient
Abstract: Neuritis is a very common complication met in with chronic diabetics. Commonly, peripheral nerves are involved but involvement of cranial nerves is not a common phenomenon. Involvement of cranial nerves or autonomic nerves may produce serious medical emergency that requires prompt management for life saving followed by long term control management. Such a case of insulin dependent diabetes mellitus with laryngeal narrowing and glossopharyngeal neuritis was met in a clinical …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 1, 2017 · pp. 9–14 Read article
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Formulation Development of Otic In Situ Gel containing Lomefloxacin Hydrochloride
Abstract: The present study was aimed at formulation development of a sustained release otic in situ gel of lomefloxacin hydrochloride for the treatment of chronic suppurative otitis media. Poloxamer 407 was used as the thermoreversible gelling agent. Poloxamer concentration in the range of 15–20% w/v was tried. Poloxamer 407 at 16% w/v gave satisfactory in situ gel forming formulations as it gelled near physiological temperature. Poloxamer 407 with various viscosity enhancing …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 1, 2016 · pp. 20–29 Read article
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A Review on Pharmacological Activities of Leucaena leucocephala
Abstract: Experiments performed using plants have revealed tremendous beneficiary information to mankind, which has been used for treating various diseases and disorders, and it all began by studying phytochemical characteristics of the plant and its physiological behavior on animals. Leucaena leucocephala is one such plant in which various medicinal properties have been found. Thus, the current review puts an effort to give a detailed survey of all pharmacological activities of the …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 9, Issue 3, 2019 · pp. 6–9 Read article
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Impact of Free Radicals and Antioxidants on Human Health
Abstract: Free radicals are atoms or groups of atoms with an odd (unpaired) number of electrons and can be formed when oxygen interacts with certain molecules. Once formed these highly reactive radicals can start a chain reaction heir chief danger comes from the damage they can do when they react with important cellular components such as DNA, or the cell membrane. Cells may function poorly or die if this occurs. To …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 3, Issue 2, 2016 · pp. 19–26 Read article
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Metabolomics: At a Glance
Abstract: Metabolomics is the branch of science which provides the comprehensive analysis of metabolites in a biological system which in turn is useful as a marker. Metabolomics analysis is useful for ascertaining human health conditions. It will provide an insight to cellular metabolism. Since the metabolome directly reflects physiological states, it can biochemically monitor disease states and assess drug actions, improving the preclinical to clinical translation and focusing on predictability, efficiency …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 1, 2017 · pp. 23–30 Read article
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Mirabilis Jalapa Flower Extract as Natural Food Dye and Green Cellular Delivery of Nanoparticles
Abstract: Use of artificial colouring agents in sweets and packed food has become a common scenario now a day, which pose serious consequences in consumers especially children. Various studies around the globe reported the serious health hazards of artificial food dyes which include organ damage of liver, kidney and lungs thereby affecting metabolic enzymes, serum creatine and urea levels and brain damage resulting in neurotoxicity and even behavioural deficits in children. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 2, 2023 · pp. 27–34 Read article
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Pharmacological and Nonpharmacological Management of Chronic Obstructive Pulmonary Disease (COPD): An Overview
Abstract: Chronic obstructive pulmonary disease (COPD) is a composite state with many characteristics that are agreeable to treatment. A well sympathetic of the physiology of COPD and better tackles to assess consequences have led to advances in our capability to cure this disease. Pharmacological methods can progress patients’ eminence of life significantly by dipping dyspnea and limiting exacerbations. Although, none of the drugs currently obtainable for COPD are able to deduce …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 2, 2023 · pp. 45–69 Read article
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Phytochemical Screening of Coccinia indica
Abstract: It is a code of conduct that ensures the correct substances in the correct amount for the desired therapeutic effect such as safety, quality, and efficacy. There have evidence which suggest that Coccinia indica has therapeutic effects that range from antihyperglycaemic and antiureogeniceffects in diabetic, ovicidal and repellent properties. The active principles are extracted from plant drugs and purified for therapeutics. Detection of nature of adulterants carried out by various …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 6, Issue 2, 2019 · pp. 30–38 Read article
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A Review on Wound Healing: Pathophysiology, Animal Model and Role of Biomarkers
Abstract: AbstractBlood cells, extracellular matrix, parenchyma cells, and soluble mediators are all involved in the physiological process of wound healing, which is highly complex, dynamic, interactive, and well-regulated. The 4 stages of wound healing are separated out. Hemostasis b. Inflammation c. Proliferation d. Remodeling. Many animal models are employed in the examination of wound healing activities because a large variety of models have been produced for examining different components of the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 3, 2022 · pp. 29–39 Read article
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Assessment of Knowledge, Attitude and Practice of Pharmacovigilance and Adverse Drug Reaction Reporting Among Nursing Staff
Abstract: WHO characterizes adverse drug reaction (ADR) as any reaction to a medication which is harmful and unintended, and which happens at measurements typically utilized as a part of man for prophylaxis, analysis or treatment of illness or for the alteration of physiological capacity. The review reveals that nursing staffs have unfortunate information and unfortunate practice yet great in disposition towards ADR announcing. Despite the fact that they have revealed a …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 12, Issue 2, 2022 · pp. 13–27 Read article