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1222 articles for “design and development”
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Development and Fabrication of Biohydrogel for Targeted Delivery of Delafloxacin for Bacterial Skin Infections
Abstract: The escalating challenge of bacterial resistance necessitates innovative drug delivery systems to enhance the efficacy of antibiotics. This study focuses on the development and optimization of a biohydrogel formulation for the targeted delivery of Delafloxacin, aiming to improve its therapeutic outcomes against resistant bacterial strains. Utilizing a 3² factorial design, biohydrogel formulations incorporating Poly(N-isopropylacrylamide) (PNIPAM) and Genipin were synthesized. The optimization process was guided by Design Expert software, focusing on …
Published in Research & Reviews: A Journal of Drug Design & Discovery Read article
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Impact of Adaptive Learning, LMS, and Personalized Skill Development on Industry Recruitment Alignment
Abstract: This paper discusses the impact of adaptive learning on the development of skill and self-learning, and it portrays a methodology framework to design an adaptive learning system that works with industry recruitment objectives. The paper distinguishes different approaches to learning, namely teacher-centric and student-centric, rigid and adaptive, competitive and collaborative, and explains that each learner has their own learning style, preference, and level of knowledge and skill acquisition. The paper …
Published in Journal of Software Engineering Tools & Technology Trends · Vol. 12, Issue 1, 2025 Read article
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Restructuring of Sanitation Structures: Reviewing Technological Changes
Abstract: This paper comprehensively reviews the latest technological advancements in rural sanitation systems, focusing on developing urinals and toilets. In many rural areas, improper toilet waste disposal directly into water bodies has led to environmental contamination. In addressing this issue, biological processes are used to degrade fecal matter. However, contemporary challenges include bacterial infections from unhygienic toilets, persistent foul odors, and poorly designed toilet pans. Additionally, more community engagement is needed …
Published in Journal of Polymer & Composites · Vol. 11, Issue 12, 2023 · pp. 67–80 Read article
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Integrating Human-Centric Principles into Machine Design: Ergonomic and Safety Enhancements in Mechanical Systems
Abstract: The integration of human-centric design (HCD) principles into mechanical systems has become increasingly critical in contemporary machine design. As machines become more complex and operate within high-interaction environments, the need for design strategies that prioritize human safety, usability, and comfort has intensified. This review explores how ergonomic insights, safety standards, and user experience (UX) considerations influence the physical configuration, control mechanisms, and operational safety of mechanical systems across industrial, healthcare, …
Published in Trends in Machine design · Vol. 12, Issue 2, 2025 · pp. 33–37 Read article
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Wear and Tribological Characteristics of Novel Metal Matrix Composites
Abstract: The development of advanced metal matrix composites (MMCs) with enhanced tribological performance has become increasingly important due to the premature failure of critical engineering components operating under severe wear conditions in automotive, aerospace, marine, defense, and power generation systems. Conventional composites such as Copper–Alumina and Aluminium–Silicon Carbide have demonstrated improved mechanical and wear characteristics; however, their widespread application is often limited by issues including particle agglomeration, non-uniform reinforcement distribution, porosity …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1326–1346 Read article
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Hydroenergen: A Piezoelectric-Based Raindrop Energy Harvesting System for Sustainable Power Generation and Monitoring
Abstract: The Raindrop Energy Conversion System represents a groundbreaking approach to renewable energy generation by harnessing the kinetic energy of raindrops and water flow from outlets of dams and reservoirs. By utilising innovative piezoelectric transducer plates, the system efficiently converts the impact energy of raindrops into electrical power. Robust insulation and sealing techniques ensure the durability and reliability of the transducer plates, making the system suitable for operation in diverse environmental …
Published in Trends in Electrical Engineering · Vol. 15, Issue 1, 2025 · pp. 35–43 Read article
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Light-Matter Interactions in Molecular Photochemistry
Abstract: Molecular photochemistry explores the ways of molecules interaction with light, absorb photons, and excited‐state processes, and ultimately conversion of photon energy into chemical change. Core concepts of this innovative and relevant field are matter interaction like electronic, vibrational, and rotational transitions; non‐adiabatic couplings; energy & electron transfer; and light–matter coupling in weak and strong regimes. This article briefly surveys the multiplicity of these interactions, from the fundamentals of photon absorption …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 3, Issue 2, 2025 · pp. 33–42 Read article
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Computational Biomodeling: Transforming Drug Design with Advanced Simulations
Abstract: Computational biomodeling has emerged as a transformative approach in the field of drug discovery, significantly enhancing the efficiency and precision of identifying and optimizing potential drug candidates. This article explores the various computational techniques utilized in drug design, including molecular docking, molecular dynamics (MD) simulations, free energy calculations, and virtual screening, and examines how these methods collectively contribute to the drug development process. The integration of these advanced simulations allows …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 24–29 Read article
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Power Estimation Approach for Artix 7 FPGA using Machine Learning Technique
Abstract: This paper presents the power estimation approach using a suitable machine learning technique. Artix7 FPGA has been chosen as the target FPGA (Field Programmable Gate Arrays) platform for understanding the methodology of power estimation. There are various approaches of power estimation for FPGAs that have been given in the literature viz. probabilistic, statistical, and LUT- based, etc. In the past few years, the demand for hand-handled devices like smartphones, tabs, …
Published in Research & Reviews: A Journal of Embedded System & Applications Read article
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Wearable Devices Incorporating Nanostructured Biosensors: Enabling Real-Time Monitoring and User-Friendly Interfaces
Abstract: Wearable devices incorporating nanostructured biosensors have emerged as a revolutionary technology, enabling real-time monitoring of various physiological parameters and biomarkers. These devices leverage the unique properties of nanostructured materials, such as high surface-to-volume ratio, enhanced sensitivity, and improved electrical and optical characteristics, to achieve exceptional performance in terms of sensitivity, selectivity, and response time. This chapter explores the recent advancements in wearable devices with nanostructured biosensors, highlighting their applications in …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 14, Issue 1, 2024 · pp. 13–21 Read article
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A Review Paper on Friction Stir Processing on Aluminium Alloys
Abstract: Friction stir processing is a step from friction stir welding, targeted at surface modification through improving the local microstructure via localized plastic deformation. The tool consists of a rotating mechanism incorporating a shoulder and pin that are inserted into the material, traversing the designated area. When the tool's shoulder and the workpiece make contact, friction develops, generating heat that produces plastic deformation. This localized plastic deformation and heat impact result …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 2, Issue 1, 2024 · pp. 1–8 Read article
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Leveraging Origami for Space Efficiency: A Comprehensive Review of Its Role in Aerospace
Abstract: Originating in East Asia, origami has developed beyond its original artistic medium to play a significant role in the design of adjustable systems, especially in the sector of space engineering. Due to tight weight and space constraints, these structures which are essential for aviation and spacecraft make effective use of the geometric qualities of origami. This study provides a summary of recent research, emphasizing the benefits, technical applications, and uses …
Published in Journal of Aerospace Engineering & Technology · Vol. 14, Issue 3, 2024 · pp. 43–50 Read article
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Epilert: Epilepsy Tracker and Detector
Abstract: Epilepsy, affecting over 50 million individuals worldwide, necessitates innovative solutions for effective monitoring and intervention. Current systems face challenges such as inaccuracy, limited accessibility, and discomfort, leaving patients and caregivers vulnerable. Epilert, a wearable device, addresses these gaps by employing advanced sensors and machine-learning algorithms for real-time epilepsy detection and monitoring. The device integrates electromyography (EMG) and motion sensors to capture and analyze physiological and movement data. Preprocessing techniques ensure …
Published in Recent Trends in Sensor Research & Technology · Vol. 12, Issue 1, 2025 · pp. 1–8 Read article
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Design and Structural Evaluation of a Dual-Axle Trailer Frame with a Focus on Increasing Strength While Aiming to Reduce Overall Weight
Abstract: The primary objective of this project is to evaluate various cross-sections and materials for the structural frame. The frame includes elongated side components and a central longitudinal member, which is connected to several cross-supports. The design focuses on optimizing both the cross-support layout and the choice of materials, incorporating composites to enhance performance. Load conditions are also altered to achieve improved efficiency. Static simulations are performed using ANSYS, while CATIA …
Published in Journal of Experimental & Applied Mechanics · Vol. 16, Issue 2, 2025 · pp. 9–17 Read article
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Computational Study of Sombor Index on Generalized Abid–Waheed Graphs for Polymer Modeling
Abstract: This study investigates the topological properties of generalized Abid Waheed graphs. Development of theoretical models in chemistry, reducing computational complexity while analysing large molecules or networks Abid Waheed graphs play a significant role. Motivated by these findings, the research was extended to encompass generalized Abid Waheed graphs, characterized by r cycles of order s. A notable similarity between Abid Waheed graphs and Jahangir graphs was observed. The potential applications of …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 267–274 Read article
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Assessment of Factors Affecting Telebirr (Mobile Money) Project Implementation in the Case of Ethio Telecom Sector
Abstract: Background: Mobile money services facilitate financial transactions through mobile devices, reducing dependence on physical cash and promoting financial inclusion. The Telebirr Mobile Money project by Ethio Telecom is a key initiative in this domain. Objective: This study aims to examine the factors influencing the successful implementation of the Telebirr Mobile Money project within Ethio Telecom. Methods: A census survey was conducted among 75 project team employees at the Lebu and …
Published in International Journal of Mobile Computing Technology · Vol. 3, Issue 2, 2025 · pp. 13–19 Read article
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Polymer Nanocomposites As Emerging Platforms in Pharmaceutical Nanotechnology
Abstract: Nanotechnology allows the handling of materials in the 1–100 nm range, where distinct physicochemical phenomena, including quantum effects and higher surface-to-volume ratio, enable disruptive uses in pharmaceuticals and biomedicine. Significant challenges in solubility, stability and targeted biodistribution of therapeutics can be overcome by incorporating nanostructured polymers and polymer-based composites into drug delivery systems. PLGA nanoparticle and other nanocarriers, such as PLGA micelles, dendrimers, and hydrogels, have revealed promising effects on …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 268–278 Read article
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Metagenome-Informed Engineering of Monoclonal Antibodies: Mining Microbial Immunoglobulin-Like Domains for Ultra-Stable Therapeutics
Abstract: Metagenome-informed engineering represents an emerging strategy for improving the stability and functionality of monoclonal antibodies (mAbs) by leveraging the vast diversity of microbial immunoglobulin-like (Ig-like) domains (10,24). These domains, derived from uncultured bacteria and bacteriophages, exhibit exceptional thermostability, protease resistance, and structural resilience due to adaptation to extreme environments (29,30). This review highlights advances in metagenomic mining, structural characterization, and protein engineering that enable the integration of microbial Ig-like scaffolds …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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Use of AI Tools to Create New Drugs
Abstract: The emergence of artificial intelligence in pharmaceutical research [in drug discovery] is a revolution in pharmaceutical research, often combining computational methods with traditional research methods to solve problems. This review article describes various applications of artificial intelligence at various stages of drug development and highlights significant advances and approaches. He explores the critical role of intelligence in drug design, polypharmacology, drug synthesis, drug repurposing, and prediction of drug properties, such …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 2, 2024 · pp. 22–49 Read article
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Quantum-Fuzzy Tensor Operators for Multi-Qubit Conjunction, Disjunction, and Symmetry-Preserving State Discrimination
Abstract: The integration of fuzzy logic and quantum information theory raises a fundamental mathematical question: how can degrees of truth be encoded in multi-qubit amplitudes while preserving the unitary dynamics and symmetry structure of quantum state spaces? This paper develops a tensor-operator framework for implementing quantum-fuzzy logical operations on finite qubit registers. Fuzzy truth values are represented by normalized quantum amplitude pairs, enabling logical information to be embedded directly into quantum …
Published in Emerging Trends in Symmetry · Vol. 2, Issue 1, 2026 · pp. 16–21 Read article