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441 articles for “functionalization”
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Revitalizing São Cristóvão: Integrating Industry, Commerce, and Community for a Sustainable Urban Future
Abstract: This paper introduces a comprehensive framework for the sustainable regeneration of São Cristóvão, a historically industrial district in Rio de Janeiro, South America, which presently demonstrates significant urban deterioration, socio-economic instability, and increasing environmental hazards. Through an interdisciplinary methodology integrating spatial analysis, ethnographic profiling, environmental assessment, and stakeholder engagement, the study develops a phased master plan aimed at transforming the neighborhood into a resilient, inclusive, and economically diverse urban environment. …
Published in International Journal of Urban Design and Development · Vol. 4, Issue 1, 2026 · pp. 58–68 Read article
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Mapping A Contextualized Southern Africa's Innovation Ecosystem: The Emerging Role of Higher Education in Promoting Inclusive Innovation and Rural Industrialization
Abstract: Higher education institutions (HEIs) are increasingly recognized as strategic actors in shaping innovation ecosystems that can respond to persistent socio-economic inequalities in the Global South. In Southern Africa, where rural underdevelopment, youth unemployment, weak industrial bases, and uneven innovation capacities remain pressing concerns, universities are under growing pressure to move beyond their traditional teaching and research mandates and contribute more directly to inclusive development. This paper examines the emerging role …
Published in International Journal of Rural and Regional Development · Vol. 4, Issue 1, 2026 · pp. 14–27 Read article
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Pharmacoepigenomics of Replication Timing: How Anti- Cancer Drugs Reshape Chromatin Domains and Mutational Landscapes.
Abstract: DNA replication timing serves as a fundamental epigenetic feature that organizes genome function during the cell cycle (3), while anti-cancer drugs profoundly alter this process to disrupt tumor growth(4). These agents target chromatin architecture, shifting replication domains and reshaping mutational patterns critical for cancer evolution (1,5). DNA replication timing (RT) domains serve as dynamic epigenetic organizers, partitioning the genome into early- and late-replicating regions that correlate with chromatin states, gene …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Monoclonal Antibodies in Next Generation Animal Nutrition: Mapping Nutrient Immune Interaction Networks in Livestock Systems
Abstract: Sustainable livestock production is increasingly constrained by disease pressure, antimicrobial resistance, and declining feed efficiency under intensifying environmental stressors. Conventional nutritional strategies, while essential, remain insufficient to precisely regulate immune function and metabolic resilience. This review explores the emerging role of Monoclonal antibodies as advanced biologics in next generation animal nutrition, with a focus on mapping nutrient immune interaction networks in livestock systems. It synthesizes current knowledge on how nutrients …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Status and Distribution of Major Invasive Plant Species in the Dehradun Region of the Uttarakhand Himalaya
Abstract: Invasive alien plant species are widely recognized as one of the major threats to global biodiversity and ecosystem stability. Their rapid spread and ability to adapt to different environmental conditions allow them to dominate natural habitats and disrupt ecological balance. The present study examines the status and distribution of major invasive plant species in the Dehradun region of Uttarakhand, which is situated in the Himalayan foothills of northern India. Field …
Published in International Journal of Trends in Horticulture · Vol. 3, Issue 1, 2026 · pp. 17–23 Read article
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The Role of English Language in Communication: Multidisciplinary Perspectives
Abstract: The English language performs an essential role in communication, serving as the universal medium through which people exchange data, express feelings, and build relationships. This research explores the importance of language in communication, examining its role in human interactions, the dynamics of effective communication, and the socio-cultural impact of language. Communication is a skill that involves a systematic and continuous process of speaking, listening, and understanding. We are also taught …
Published in Emerging Trends in Languages · Vol. 3, Issue 1, 2026 · pp. 1–7 Read article
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Revolutionizing Gender Justice: The Intersection of AI and Third-Gender Rights in Indian Legal Systems
Abstract: Artificiаl intеlligеncе (AI) аnd third-gеndеr rights in Indiа convеrgе аt а рivotаl juncturе for аdvаncing еquitаblе justicе systems. A trаnsformаtivе cараcity emеrgеs whеn аlgorithmic tools аrе strаtеgicаlly alignеd with lеgаl frаmеworks, раrticulаrly in reducing systemic bаrriеrs through еnhаncеd judiciаl аccеssibility. This аnаlysis еvаluаtеs AI’s duаl rolе аs both cаtаlyst аnd chаllеngе within Indiа’s evolving рolicy lаndscаре, focusing on thrее domains: lеgislаtivе dеsign, рredictivе jurisрrudеncе, аnd rights-bаsеd govеrnаncе structurеs. Currеnt rеsеаrch …
Published in Recent Trends in Social Studies · Vol. 3, Issue 1, 2026 · pp. 25–31 Read article
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Quasar: Quantum-Accelerated Sustainable Anomaly Recognition in Climate Systems
Abstract: Accurate detection of climate anomalies is vital for disaster alleviation and policy making in a sustainable manner, but customary detection methods face the challenges of computational inefficiency and physical inconsistency. In this study, we propose a novel approach called Quantum-Optimized Fuzzy Physics-Informed Neural Networks (QFuzzy-PINNs), which integrates quantum computing, fuzzy logic, and physics-informed deep learning. As a first step, we employ quantum annealing for conventional optimization to adjust multiple Gaussian …
Published in International Journal of Climate Conditions · Vol. 2, Issue 2, 2025 · pp. 18–27 Read article
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The Renaissance and Resilience of CB1 Reverse Agonists: From Central Liabilities to Peripheral Promise
Abstract: Building upon these foundational insights, current research has increasingly focused on refining the pharmacological profile of CB1 reverse agonists to maximize therapeutic benefit while minimizing central adverse effects. The adverse neuropsychiatric outcomes associated with first-generation agents such as Rimonabant including anxiety, depression, and suicidal ideation highlighted the critical role of central CB1 receptors in mood regulation. Consequently, drug development strategies have shifted toward peripherally restricted CB1 reverse agonists that exhibit …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 30–35 Read article
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Digital Payments as a Driver of Sustainable Consumption: A Consumer-Based Study of Perceived Challenges and Opportunities in FinTech Ecosystems
Abstract: The Digital Payment Systems evolved remarkably fast, and so, have transformed the way in which the consumer makes purchases for products and services as well as the way in which they function economically, i.e., how they consume things. Beyond convenience and efficiency, digital payments are increasingly viewed as a potential driver of sustainable consumption by reducing cash dependency, improving transaction transparency, and supporting responsible spending practices. This study examines digital …
Published in International Journal of Optical Innovations & Research · Vol. 4, Issue 1, 2026 · pp. 1–12 Read article
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A Study on AI-Driven Multi-Layered Defense in 6G Ecosystems
Abstract: The 6G networks bring about new degrees of possible functions related to connectivity, latency, data throughput, and integration with artificial intelligence (AI). This enables advances within healthcare, autonomous systems, and smart cities. The positive impact of rapid advancements must also be balanced with heightened risks due to the sheer volume of gaps that can be exploited, and the complex nature of the alignments and breaches. This results in the breaches …
Published in International Journal of Radio Frequency Innovations · Vol. 4, Issue 1, 2026 Read article
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Silicon Symphony: The Science of Semiconductors Circuits
Abstract: Modern electronics are built on the foundation of semiconductor circuits, which precisely and efficiently control the flow of electrical impulses. This article takes a look at the underlying physics of semiconductor materials and how their unique electrical properties allow the design and functioning of diodes, transistors and integrated circuits. This study links microscopic scientific principles to the behaviour of real circuits. It considers essential concepts such as charge carriers, doping …
Published in International Journal of Solid State Innovations & Research · Vol. 4, Issue 1, 2026 Read article
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Effect of Skin Barrier Damage on Absorption and Action of Cosmeceuticals
Abstract: The skin acts as a primary defensive barrier protecting the human body against environmental aggressors, microbial invasion, and chemical exposure. The integrity of the skin barrier, particularly the stratum corneum, plays a crucial role in regulating the permeation of substances applied topically. Cosmeceuticals, a hybrid category between cosmetics and pharmaceuticals, are designed to deliver biologically active ingredients into the skin to exert therapeutic or beneficial effects. However, the condition of …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 2, 2026 · pp. 1–19 Read article
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Fracture Analysis of Laminated composite plates using Extended Finite Element Method: A Review
Abstract: Laminated composite plates are used in aerospace, automotive, and marine industries. They feature great durability against fatigue, a high strength-to-weight ratio, and mechanical attributes that may be altered. However, they are prone to fracture and delamination under complex loading, requiring accurate fracture analysis for structural integrity. Traditional finite element methods (FEM) need extensive mesh refinement for modelling crack propagation which increases the computational costs. The Extended Finite Element Method (XFEM) …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 4, Issue 1, 2026 · pp. 16–25 Read article
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Differential Gene Expression Analysis of Human Atrial Fibroblasts Reveals Dysregulation of RNA Metabolism and Translational Machinery in Atrial Fibrillation
Abstract: Atrial fibrillation (AF) is a complex cardiac arrhythmia characterized by extensive structural remodeling and the activation of atrial fibroblasts, which drive the progression of fibrosis. To identify the underlying transcriptomic alterations, we analyzed six human atrial fibroblast RNA-Seq datasets (three control and three AF) retrieved from the Sequence Read Archive. After performing rigorous quality control and adapter trimming, we aligned the reads to the GRCh38 human reference genome using a …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 · pp. 15–25 Read article
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Structure–Property Correlation of Infill Topology and Density on Tensile and Flexural Performance of FDM-Printed PLA and ABS
Abstract: Additive Manufacturing (AM), particularly Fused Deposition Modeling (FDM), has become a widely adopted manufacturing technology due to its design flexibility, low cost, and capability for rapid prototyping. However, the mechanical performance of FDM-printed components is strongly influenced by internal structural parameters such as infill pattern and infill density, in addition to the intrinsic material behaviour. This study investigates the structure–property relationship between infill topology, density, and mechanical performance of PLA …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 4, Issue 1, 2026 · pp. 26–37 Read article
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An Overview on VLSI based Hardware Security in IoT Node
Abstract: In the coming era, security will not be a feature we add to an IoT device; it will be a property inherent to its transistor-level design. By encoding security into the VLSI architecture, we move away from the fragile "software-only" paradigm and toward a future where the identity of the device is as immutable as the laws of physics. The rapid proliferation of Internet of Things (IoT) devices has transformed …
Published in International Journal of VLSI Circuit Design & Technology · Vol. 4, Issue 1, 2026 Read article
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Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
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Diabetes Risk Prediction from Survey Data Using Machine Learning Algorithms
Abstract: Diabetes mellitus represents one of the most significant global health challenges, affecting millions worldwide and leading to severe complications if left undiagnosed or poorly managed. Early detection and risk assessment are crucial for preventing the progression of this chronic condition. This research presents a comprehensive machine learning approach for predicting diabetes risk using survey-based health parameters. The study implements and compares four prominent classification algorithms: Logistic Regression, K-Nearest Neighbors (KNN), …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 Read article
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Mass Spectrometry–Based Phosphoproteomic Markers to Predict Kinase Inhibitor Response in Solid Tumors
Abstract: Mass spectrometry-based phosphoproteomics has emerged as a powerful tool for predicting kinase inhibitor responses in solid tumors, offering direct functional insights into signaling pathways that surpass traditional genomic profiling by capturing dynamic kinase activities and adaptive resistance mechanisms. Technological breakthroughs, including data- independent acquisition (DIA), trapped ion mobility spectrometry (timsTOF), and efficient enrichment methods like TiO2 or IMAC, now enable comprehensive profiling of over 40,000 phosphorylation sites from limited clinical …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 Read article