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620 articles for “Pharma”
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
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Advancements in Nanostructured Membranes for Gas Separation: A Comprehensive Review
Abstract: Gas separation is vital in petrochemical, pharmaceutical, and environmental industries, yet traditional methods like distillation and cryogenic separation are energy-intensive and inefficient. Nanostructured membranes present a promising alternative, utilizing nanomaterials such as titanium dioxide, silica, carbon nanotubes, zeolite, and metal-organic frameworks to enhance separation efficiency and selectivity while reducing energy consumption. These membranes fall into various categories: polymeric nanostructured membranes, including mixed matrix and thin-film composites; inorganic membranes, such as …
Published in International Journal of Membranes · Vol. 1, Issue 1, 2024 · pp. 31–36 Read article
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Chompound contaning oxadiazole derivatives and their potential therapeutic uses.
Abstract: Derivatives of oxadiazole or furadi azole rings constitute a significant class of heterocyclic substances. Oxadiazole is a heterocyclic, five-membered ring with two carbons, one oxygen atom, two nitrogen atoms, and two double bonds. They are produced by substituting two nitrogen (-N =) atoms for two methylene groups (= CH) in furan. The furan ring's aromaticity was significantly decreased by substituting these groups, resulting in a conjugated diene character. There were …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 68–74 Read article
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Nanotechnology’s Emerging Frontiers
Abstract: Nanotechnology holds significant promise across diverse sectors, including agriculture, food processing, energy, transportation, and communication systems. This swiftly evolving domain revolves around the development of groundbreaking materials and devices that tackle intricate engineering and scientific hurdles across various sectors. In agriculture and food processing, nanotechnology unfolds a myriad of potentialities. Its potential extends to the development of various products such as nano-fertilizers, nano-herbicides, nano-pesticides, and nano-scale carriers. Additionally, it plays …
Published in Journal of Petroleum Engineering & Technology · Vol. 14, Issue 1, 2024 · pp. 14–23 Read article
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Using Multitarget Molecular Docking to Examine the Antiviral Potential of Clerodendrum Phlomidis against Measles
Abstract: Objective: Measles, a viral disease caused by a member of the Paramyxoviridae virus family, is highly contagious and characterized by a respiratory illness and a maculopapular rash on the skin. Children are the main victims of the illness. In the context of drug development, this study investigates the efficacy of phytocompounds derived from Clerodendrum phlomidis against the target protein of the measles virus. Methods: The 7SKS protein was retrieved from …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 32–42 Read article
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Advancements in Solubility Enhancement Through Liquisolid Compact Technology: A Comprehensive Review
Abstract: The study examines Liquisolid Compact Technology as an innovative approach for improving the bioavailability and solubility of drugs that are poorly soluble in water. Liquisolid systems, comprising solid carriers and liquid drugs, offer advantages such as improved drug release and bioavailability, reduced manufacturing costs, and controlled drug delivery. The technique involves dissolving or suspending the drug in non-volatile solvents, adding carrier materials, super disintegrants, and coating materials, and then compressing …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 2, 2024 · pp. 25–34 Read article
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Formulation And Evaluation of Vyadhikshamatva Vardhak Giloy Ghanvatis
Abstract: The product of Kalka Kalpana, one of the five essential ayurvedic medicinal preparations, is vati Kalpana. Because of its many advantages, such as its tasty nature, ease of administration, ease of dispensing, and ease of transportation, vati kalpana is a vital part of the ayurvedic formulation. A pharmaceutical technique called vati kalpana uses powder of unprocessed medications (herbal or herbo minerals) and is triturated using juice, honey, or kassayam, and …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 2, 2024 · pp. 7–13 Read article
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Diversity of Agaricaceae (Basidiomycota: Agaricales) in Dharampur and Kaprada Taluka, Valsad District: A Taxonomic Study
Abstract: The fungal diversity of Dharampur and Kaprada Taluka in Valsad District, Gujarat, India, particularly within the Agaricaceae family, has been extensively studied. According to a standard reference text, the Agaricaceae contains 85 genera and 1340 species. Agaricaceae fungi, categorized as macrofungi, are prevalent in this region and are notably utilized by local tribal communities for culinary purposes due to their edibility. The life cycle of Agaricus is cyclic beginning with …
Published in International Journal of Fungi · Vol. 1, Issue 1, 2024 · pp. 51–62 Read article
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In Silico Investigation of 2,3-Dihydrobenzofuran from Centella asiatica: A Possible Pioneer in the Management of Tetanus
Abstract: Objective: Tetanus toxin (TeNT) is a neuroprotein toxin, the most toxic known. They have three functional domains and are structurally similar. They possess an N-terminal catalytic section (light chain), an internal domain for heavy-chain translocation (HN domain), and a C-terminal receptor binding domain for the heavy chain (Hc domain or RBD). Tetanus, an acute nerve-affecting disease, is provoked by a toxin-producing bacterium called Clostridium tetani. This bacterium is environmental, Gram-positive, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 19–30 Read article
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Computer Aided Drug Designing for Targeted Drug Delivery Systems
Abstract: The discovery and development of a contemporary sedate is widely acknowledged as an extremely difficult task that requires significant resources and effort. Therefore, computer-aided medication design techniques are widely utilized today to increase the productivity of the drug discovery and development process. Among structure-based and ligand-based drug design approaches, both recognized for their efficiency in drug discovery and development, various CADD (Computer-Aided Drug Design) techniques are evaluated based on specific …
Published in Trends in Drug Delivery · Vol. 11, Issue 2, 2024 · pp. 34–41 Read article
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
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Recovery of Mycelial Biomass of Agaricus Bisporus, Pleurotus Ostreatus, Ganoderma lucidum, Hieracium Erinaceus: A comparative Study
Abstract: Mushrooms are the spore-bearing fruiting body of fungi which has a significant potential for numerous applications like pharmaceuticals, textile industry, bioremediation, soil management, alternative to toxic packaging materials and environment sustainability. Mushrooms generally belongs to the class Basidiomycota or Ascomycota. They are typically made of hyphae, the tiniest threads which comprises most fungi. Mycelia are tiny thread like structure which help in making vegetative part of fungus. In this study, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 2, 2024 · pp. 12–18 Read article
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A Blockchain Technology Application In Supply Chain Management: Hindrances & Prospects
Abstract: Traditional supply chain management faces limitations in transparency, traceability, and security. Blockchain technology, characterized by its unchangeable and secure attributes, presents promising remedies for these issues. It has emerged as a transformative advancement with the capacity to overhaul supply chain management. This study emphasizes on the potential of blockchain to transform existing supply chain practices while acknowledging the challenges hindering its widespread adoption. It further explores the applications of blockchain …
Published in Current Trends in Information Technology · Vol. 14, Issue 2, 2024 · pp. 16–22 Read article
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Towards Intelligent Healthcare: Artificial Intelligence’s Impact on Healthcare
Abstract: Artificial Intelligence (AI) stands as a transformative force within healthcare, offering multifaceted support to various processes and medical professionals. This comprehensive study investigates the extensive array of AI applications and its potential to reshape the healthcare landscape. Specifically, it examines the utilization of deep-learning methodologies in harnessing vast medical datasets to enhance healthcare provision. Expanding beyond theoretical discussions, this study scrutinizes AI's role in breast cancer, seizure, and tumor detection, …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 11, Issue 2, 2024 · pp. 77–83 Read article
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Phytochemical Profile & Therapeutic Potential of Clematis Terniflora: A Comprehensive Review
Abstract: Clematis terniflora is a plant comes under the family Ranunculaceae, which is folk medicinal plant which is found widely in China, according to the Chinese medical system, Clematis terniflora is a widely distributed folk remedy that is used to cure rheumatoid arthritis, asthma, syphilis, gout, malaria, dysentery and used as analgesic, antitumor, anti-inflammatory, diuretic, antibacterial, antioxidants and anti-inflammatory etc. It is distributed around the world like China, Japan, Korea, Mongolia, …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 2, 2024 · pp. 16–24 Read article
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Practical approach for Type 2 Diabetes: Role of DPP4 Inhibitors
Abstract: Dipeptidyl peptidase-4 inhibitors (DPP-4Is) have become essential in managing type 2 diabetes mellitus (T2DM) due to their ability to enhance incretin hormone activity, which promotes insulin secretion and inhibits glucagon release. These agents effectively lower HbA1c levels by 0.5–1.0%, are weight-neutral, and have a low risk of hypoglycemia, making them suitable for a broad patient population, including the elderly. The antidiabetic market in India is vast. Gliptin as group row …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 20–26 Read article
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Unlocking The Bioactivity Potential: Molecular Insights and Predictions of Salen, Salophen, Allicin, Curcumin, and Piperine
Abstract: In this work, the prediction of the biological activity of several significant molecules, including salen, salophen, allicin, curcumin, and piperine, are discussed. Using Molinspiration software, the molecular properties of these compounds were calculated. These molecules are highly significant due to their extensive potential in medical applications. Salen and salophen, for instance, play crucial roles in cancer chemotherapy and act as inhibitors of angiogenesis. Curcumin is renowned for its antioxidant properties, …
Published in International Journal of Cheminformatics · Vol. 1, Issue 2, 2023 · pp. 14–21 Read article
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Quantitative Structure-activity Relationship in Computer-aided Drug Design: A Review
Abstract: Quantitative Structure-Activity Relationship stands at the forefront of Computer-Aided Drug Design, providing a systematic framework for understanding the relationship between the chemical structure of molecules and their biological activity. The present review delves into the multifaceted realm of quantitative structure-activity relationship methodologies within the landscape of drug discovery. Through an exploration of diverse quantitative structure-activity relationship models, molecular descriptors, validation techniques, and recent advancements, the present article aims to elucidate …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 55–63 Read article
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Role of Gastric Receptors in Gastrointestinal Disorder
Abstract: The established and potential roles of cholecystokinin1 and cholecystokinin2 receptors in gastrointestinal and metabolic diseases are analyzed, along with findings from human studies involving agonists and antagonists. While there is considerable evidence implicating cholecystokinin1R in various diseases such as pancreatic disorders, motility disorders, tumor growth, satiety regulation, and cholecystokinin-deficient states, its specific role in these conditions remains ambiguous. Conversely, the role of cholecystokinin2R in physiological (e.g., atrophic gastritis) and pathological …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 2, 2024 · pp. 37–49 Read article
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Effect of Valsalva Maneuver Prior to Cannulation on Pain Among Patients Undergoing Peripheral Venous Cannulation
Abstract: Peripheral venous canulation is the common nursing procedure carried out which cause soreness to the recipient. Previous experience of peripheral venous cannulation may result in negligence or delay in need of medical care. Valsalva Maneuver is a non-pharmacological and cost- effective method to decrease intensity of pain during peripheral venous cannulation. Aim: To assess the effect of Valsalva Maneuver prior to cannulation on pain among patients undergoing peripheral venous cannulation. …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 2, 2024 · pp. 1–6 Read article