Search
558 articles for “structural modelling”
-
Integrative Structural-Functional Genomics of Fc and Fab: Precision Models for Monoclonal Antibody Stability and Anti-Aggregation Engineering
Abstract: Monoclonal antibodies (mAbs) represent the cornerstone of biotherapeutics, yet aggregation propensity compromises up to 50% of candidates during development, driven by Fab hypervariability and Fc vulnerabilities.(1,2) This review integrates functional genomics from OAS (4B+ sequences)(5) and structural databases (SAbDab: 10K+ structures)(6) with machine learning models achieving R=0.97 for SAP prediction.(11) We dissect biophysical mechanisms, benchmark predictive tools (DeepSP, ESM2), and engineering strategies (YTE, FW mutations) that enhance Tm by 5-10°C …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
-
A Comparative Study on Beam Slab and Flat Plate Building Frame under Seismic Load
Abstract: The study delves to evaluate the performance of beam slab and flat plate slab in the building frame due to seismic load. Two models of the same layout plan and story levels were compared under seismic load as per BNBC 2016—one was a typical frame structure with beam slab i.e., model 1 and another one was a frame structure with a flat slab, i.e., model 2. Frame structure with beam …
Published in Journal of Structural Engineering and Management Read article
-
Review on Computer-Aided Drug Design in RAS Inhibitor Discovery
Abstract: This review explores the utilization of computer-aided drug design (CADD) methodologies in the discovery of inhibitors targeting the RAS pathway, a pivotal signaling cascade implicated in various cancers. Through an extensive examination of computational tools, methodologies, challenges, and recent advancements, this review aims to provide insights into the role of CADD in accelerating RAS inhibitor discovery. The discovery of effective inhibitors targeting the RAS pathway is of paramount importance in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 7–14 Read article
-
Study on the Profile and Flow Field Variation of Parachute Coating by Seven-hole Probe Method
Abstract: In general, the parachute test is a long test cycle, expensive, and difficult to measure with accuracy, which makes it a very laborious and time-consuming task. Therefore, attempts have been made to overcome this by using a parachute test stand or by simulation, but in our country, there is no numerical simulation of the parachute and there is no research on it. In this paper, the variation of the shape …
Published in Journal of Aerospace Engineering & Technology · Vol. 14, Issue 1, 2024 · pp. 26–37 Read article
-
Research on Selection Method of the Optimum Alternative Using Improved AHP Method in NSDL Environment
Abstract: In this paper, we have considered the development of a decision-making tool to optimize the design of the ship-roll fin stabilizer using improved analytical hierarchy process (AHP) in a network-oriented system description language (NSDL) environment developed by combining the advantages of Petri nets and object-oriented programming languages. First, we have considered the network-oriented system description language NSDL, a new software development tool that combines the advantages of Petri nets and …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 3, Issue 1, 2025 · pp. 46–56 Read article
-
From Differential Equations to Data Science: A Survey on Analytical Methods in Contemporary Problems
Abstract: The integration of differential equations and data science methods represents a dynamic and evolving approach to solving contemporary challenges across a wide range of disciplines, including engineering, physics, biology, economics, and finance. Differential equations have long served as fundamental tools for modeling continuous systems and processes, offering powerful insights into the behavior of natural and man-made phenomena. For example, they describe how heat diffuses through materials, how populations grow in …
Published in Recent Trends in Mathematics · Vol. 2, Issue 2, 2025 · pp. 1–6 Read article
-
Remote Sensing and Atmospheric Modelling: Data, Processes, Integration and Future Directions
Abstract: Atmospheric modelling plays a central role in weather forecasting, climate projection, and air quality assessment; however, the availability, accuracy, and representativeness of atmospheric observations fundamentally constrain its reliability. Over the past two decades, rapid advances in remote sensing (RS) have transformed atmospheric observation by providing spatially continuous, multiscale measurements of key atmospheric variables, including aerosols, trace gases, clouds, precipitation, and atmospheric thermodynamic profiles. This review synthesises recent progress in integrating …
Published in International Journal of Atmosphere · Vol. 3, Issue 1, 2026 · pp. 54–67 Read article
-
Impact of Information Technology Tools and AI on Supply Chain Management of Indian Automobile Industry
Abstract: This article aims to enhance the efficiency and effectiveness of the supply chain within the Indian automotive sector through the application of innovative information technology tools and artificial intelligence. To achieve this goal, the study focuses on three main objectives: identifying key driving factors through an extensive literature review, analyzing the interrelationships among these factors, and prioritizing them based on their importance. In today's competitive environment, customer satisfaction is paramount …
Published in Journal of Advances in Shell Programming · Vol. 11, Issue 2, 2024 · pp. 19–27 Read article
-
Presenting the Model and Prioritization of Lean Production Success Drivers (Case study: Iran Khodro Company)
Abstract: The purpose of the current research is to present a model and prioritize the drivers of lean production success (case study: Iran Khodro Company). The statistical population and statistical sample of this study consists of 20 experts (managers) of Iran Khodro production department. In this research, first, the most important key success factors of lean production were determined using the validity technique of the content validity ratio, then the interpretative …
Published in International Journal of Sustainability · Vol. 1, Issue 1, 2024 · pp. 30–42 Read article
-
Aerodynamic Effects of Wind on Multi-Story Structures: A Height- and Terrain-Based Analysis
Abstract: Wind loads are a critical consideration in the structural design of buildings, with direct implications for safety and serviceability. This study investigates the aerodynamic behavior of reinforced cement concrete (RCC) buildings under varying heights and terrain conditions, in accordance with IS: 875 (Part 3): 2015. 12 structural models representing 20 m, 35 m, and 50 m tall buildings were analyzed using extended three-dimensional analysis of building system (ETABS) across four …
Published in Journal of Offshore Structure and Technology · Vol. 12, Issue 3, 2025 · pp. 1–14 Read article
-
Effects of Reels and short videos on human mind and Academic Life
Abstract: The rapid rise of short-form video platforms such as Instagram Reels, TikTok, and YouTube Shorts has fundamentally reshaped the way people consume information and entertainment. While these applications offer quick engagement and social connection, their excessive use has raised serious concerns about their psychological and academic impacts. This research investigates the relationship between short-form video addiction, mindfulness, academic anxiety, and academic engagement among university students. Drawing upon the theoretical framework …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 2, 2026 Read article
-
Integration of 5G and Low Earth Orbit (LEO) Satellite Communication for Global Connectivity
Abstract: This integration revolutionizes global connectivity by merging 5G's urban capabilities with LEO's wilderness coverage. This research examines how LEO satellite constellations can complement terrestrial 5G networks to extend high-speed, low-latency connectivity to underserved regions including rural areas, oceans, and airspace. Recent breakthroughs in LEO satellite technology and successful demonstrations of 5G-satellite integration point to a rapidly evolving ecosystem with significant market growth potential. To fully realize the potential of advanced …
Published in Journal of Thermal Engineering and Applications · Vol. 12, Issue 2, 2025 · pp. 15–32 Read article
-
AI for Cybersecurity: Deploying Machine Learning for Network Traffic Anomaly Detection
Abstract: The growing sophistication of cyberattacks and the growth of network traffic necessitate sophisticated anomaly detection methods. This study overviews the use of artificial intelligence (AI) and machine learning (ML) to counter these challenges, as noted in current studies. It analyses supervised learning (SVM, Decision Trees), unsupervised learning (K-means, DBSCAN), and deep learning (CNNs, RNNs, Auto-encoders) approaches, considering their strengths and weaknesses. The research integrates current developments in AI/ML-based network anomaly …
Published in International Journal of Computer Science Languages · Vol. 3, Issue 2, 2025 · pp. 1–10 Read article
-
Analyzing Barriers to Digital Procurement in Polymer Composites Supply Chain Using ISM for Sustainable Transformation
Abstract: The adoption of e-procurement in the polymer and composites industry presents a transformative opportunity to enhance supply chain efficiency, reduce material waste, and support sustainable engineering practices. However, industries face significant barriers in transitioning from traditional procurement to digital systems, particularly in sourcing specialized materials such as epoxy resins, bio-based polymers, and hybrid composites. This study employs Interpretive Structural Modeling (ISM) to identify, analyze, and prioritize eleven critical barriers affecting …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 512–521 Read article
-
Design of Maritime Empennage Unmanned Aerial Vehicle (UAV): A Comprehensive Study
Abstract: This project presents a comprehensive study on the design and development of a maritime empennage unmanned aerial vehicle (UAV) tailored for operations in coastal and naval environments. The primary objective is to engineer an efficient, stable, and mission-adaptable UAV with an optimized empennage configuration that enhances aerodynamic performance and control in maritime conditions. The study involves a systematic design process encompassing mission requirement analysis, conceptual and preliminary design, aerodynamic modeling, …
Published in Journal of Aerospace Engineering & Technology · Vol. 16, Issue 1, 2026 Read article
-
Differential Model of Wave Vibration on Strings and Rods
Abstract: Vibration, as a physical phenomenon, plays a multifaceted role in both natural and engineered systems. Beyond its essential contribution to communication through sound and speech, it finds critical application in various technological domains. For instance, in the design of stringed musical instruments such as violins and guitars, precise manipulation of string vibrations defines tonal quality and musical resonance. Similarly, metal rods in tuning forks exhibit vibrational properties that are finely …
Published in Research & Reviews : Journal of Physics · Vol. 14, Issue 1, 2025 · pp. 17–21 Read article
-
Experimental and Numerical Assessment of Flexural Shear Behavior of RC Beams Enhanced using Hybrid CFRP–GFRP U-Wrap System
Abstract: This study examines the Reinforced Concrete beams strengthened in Flexural-shear using a hybrid Fibre Reinforced Polymer (FRP) system that combines carbon fibre reinforced polymer (CFRP) and glass fibre reinforced polymer (GFRP) in a U-wrap configuration. Six beams totally were made and the results were tested under 4 point bending moment using LVDT, in which three beams were of control beams without strengthening and another three externally wrapped using hybrid CFRP-GFRP …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 328–338 Read article
-
Influence of Infill Density on Structural Performance of FDM-Processed PET-G Polymer: Experimental Validation through Quadcopter Flight Testing
Abstract: Polyethylene terephthalate glycol-modified (PET-G) is an amorphous thermoplastic copolymer increasingly adopted in structural applications through fused deposition modeling (FDM). However, the correlation between FDM processing parameters, especially infill density, and mechanical performance of PET-G parts remains inadequately characterized under real-life loading conditions. This study investigates how infill density (10% and 30%, grid pattern) influences the structural integrity of FDM-processed PET-G components, validated experimentally through quadcopter airframe fabrication and flight testing. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 644–656 Read article
-
Antimicrobial Peptides in Fiddler Crabs: Structural Analysis and Potential Applications
Abstract: Crustaceans represent the largest and most ecologically and economically significant group of marine and aquatic arthropods. Their biomass and critical role in ecosystems highlight their importance. Among crustaceans, decapods are frequently used as model organisms in studies of immune responses due to their significant commercial value and the need to mitigate disease outbreaks in shellfish aquaculture. Antimicrobial host-defense peptides (AMPs) are pivotal in metazoan immunity, especially for invertebrates lacking adaptive …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 26–32 Read article
-
Structural Behavior of Flexible and Semi-Rigid Beam-Column Joint Connections by FEM
Abstract: This study investigates the structural behavior of flexible and semi-rigid beam-column joint connections in cold-formed steel (CFS) structures, focusing on the use of Finite Element Modeling (FEM) to simulate their performance under various loading conditions. Traditional analysis methods often oversimplify beam-column connections, treating them as either perfectly rigid or fully flexible, which does not accurately capture real-world joint behavior. In reality, many beam-column joints exhibit semi-rigid characteristics, where the stiffness …
Published in Journal of Structural Engineering and Management · Vol. 12, Issue 3, 2025 Read article