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24 articles for “route discovery”
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Synthesis, Characterization and Biological Evaluation of Some Novel Phenazine Derivatives
Abstract: Novel phenazine analogues (PZ1‑PZ6) were synthesized, characterized by the spectral analysis and screened for anti-arthritis activity by bovin serum and egg albumin protein denaturation method. The synthetic route involves the equimolar mixture of ortho-phenylenediamine and ammonium persulphate which were dissolved in 1 M HCl to give 2,3-diaminophenazine(I). Different substituted aromatic aldehydes were added to the 2,3-diaminophenazine(I) and dissolved in methanol. The reaction mixture was stirred for 1‑2 h and then …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 3, 2019 · pp. 31–37 Read article
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Simultaneous Estimation of Prazosin and Polythiazide in Bulk and Fixed Dose Combination (Tablets) by RP-HPLC
Abstract: Objective:A New method was established for simultaneous estimation of Prazosin and Polythiazide by RP-HPLC method. Methods:Chromatographic separations were carried using HPLC equipped with Auto Sampler and PDA Detector, Discovery (150 x 46 mm, 5mm) column with a mobile phase composition of Buffer and ACN: taken in the ratio 60:40 (60:40 v/v) have been delivered at a flow rate of 1ml/min and the detection was carried out using waters HPLC auto …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 3, 2025 · pp. 66–74 Read article
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Artificial Intelligence -Driven in Clinical Pharmacy Practice: Transforming Medication Management and Patient-Centred Care
Abstract: Artificial intelligence (AI) is transforming clinical pharmacy practice by enhancing the safety, accuracy, and efficiency of medication management while supporting evidence-based clinical decision-making. Recent advances in machine learning, deep learning, natural language processing, and predictive analytics have enabled the integration of AI into various aspects of pharmacy practice, including drug discovery, pharmacovigilance, clinical decision support, personalized medicine, medication adherence, and patient counselling. The objective of this review is to provide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 3, 2026 Read article
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UV Method of Development and Validation of Olaparib
Abstract: An analytical method must be developed and validated in the discovery, development, and production of pharmaceuticals to ensure the identification, purity, potency, and performance of drug commodities. Quality control laboratories use official test protocols that emerge from the processes. A simple ultraviolet spectrophotometric approach was designed and validated using various characteristics, including linearity. Precision, reproducibility, accuracy, robustness, ruggedness, limit of detection, and limit of quantification are among the measuring criteria. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 20–27 Read article