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24 articles for “poorly water-soluble drugs”
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Distinctive Approaches for Improving the Aqueous Solubility of BCS Class II Drugs
Abstract: The most difficult feature of many novel chemical entities is their solubility behaviour, as 60 percent of new promising products suffer solubility limitations. This is the most common reason for novel medicine compounds failing to reach the market or performing to their full potential. The proportion of the aqueous phase when the solution is in equilibrium with the pure substance in its normal phase is referred to as aqueous solubility. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 3, 2023 · pp. 52–56 Read article
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Development and Characterization of Selfnanoemulsifying Drug Delivery System
Abstract: AbstractNanotechnology has presented a novel perception of human knowledge and led to innovation in the field of biological sciences including diagnostics, food, drug delivery, biomaterials for implants or prostheses, and the production of biomimetics appropriate for applications in the field of medicine. With their pinpoint accuracy and minuscule size, nanomaterials is rising in importance. Nanoscale formulations have a size range of 100–10,000 times lesser than that of the cell of …
Published in Trends in Drug Delivery · Vol. 9, Issue 3, 2022 · pp. 1–18 Read article
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Design and Development of Sustained Release Tablets using Solid Dispersion of Beclomethasone Dipropionate
Abstract: In present study an attempt was made to enhance the solubility of beclomethasone dipropionate by solid dispersion method followed by formulating sustained release matrix tablet of beclomethasone dipropionate to improve the patient compliance. Beclomethasone dipropionate has poor water solubility and short elimination half-life hence solid dispersion of beclomethasone dipropionate were prepared with β-cyclodextrin and PEG 6000 as carrier by using physical mixture, solvent evaporation and kneading method. The prepared solid …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 3, 2015 · pp. 30–41 Read article
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Comparative Study on Oro Dispersible Tablets of Candesartan Cilexetil Formulated with Natural and Synthetic Disintegrants
Abstract: Candesartan cilexetil, a BCS class II drug with low aqueous solubility and poor bioavailability (15%), poses challenges for oral delivery. To address this limitation, the present study focuses on polymer-based inclusion complexation and composite formulation strategies to enhance solubility and dissolution behavior. The drug was incorporated into β-cyclodextrin (β-CD), a cyclic oligosaccharide polymer, by the kneading method in different drug-to-carrier ratios. Among these, the 1:1 molar ratio complex exhibited the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 687–695 Read article