Search
118 articles for “gene regulation”
-
Assessment of Noise Pollution Level in Port Harcourt City: a Location Based Comparative Study
Abstract: Noise pollution has emerged as a significant environmental health concern in urban centers, particularly in rapidly developing cities like Port Harcourt, Nigeria. This study presents a comprehensive, location-based comparative assessment of ambient noise levels across selected zones within Port Harcourt metropolis, including residential, commercial, industrial, and traffic-dense areas. Sound level measurements were conducted in the different areas of Port-Harcourt metropolis. High-density and low-density residential neighborhoods, busy roadways, business centers, road …
Published in International Journal of Environmental Noise and Pollution Control · Vol. 3, Issue 2, 2025 · pp. 7–17 Read article
-
Next-Generation Membrane Materials: Advances, Applications, and Challenges
Abstract: Advanced membrane materials are better than regular polymers because they are more selective, permeable, and stable. New developments in nanomaterials, composite membranes, and surface engineering are making it possible to do more with water purification, gas separation, biomedical applications, and energy systems. Membrane technologies have become important tools in many areas, including biomedicine, energy systems, gas separation, and water purification. Recent progress in material science has made it possible to …
Published in International Journal of Membranes · Vol. 2, Issue 2, 2025 · pp. 19–28 Read article
-
Antibiotic Resistance in Microbes: History, Mechanisms, Therapeutic Approaches, and Strategies for Mitigation
Abstract: The global emergence of clinically significant antibiotic resistance is increasingly linked to the environment. Antimicrobials, metals, and biocides are just a few of the substances that are released into the environment through paths that are regulated by environmental regulators. Consequently, environmental regulators ought to be heavily involved in developing national and international antimicrobial resistance (AMR) measures. Antimicrobial compounds from pharmaceutical waste, agricultural runoff, and wastewater discharge contribute to the spread …
Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 1–11 Read article
-
Monoclonal Antibodies in Next Generation Animal Nutrition: Mapping Nutrient Immune Interaction Networks in Livestock Systems
Abstract: Sustainable livestock production is increasingly constrained by disease pressure, antimicrobial resistance, and declining feed efficiency under intensifying environmental stressors. Conventional nutritional strategies, while essential, remain insufficient to precisely regulate immune function and metabolic resilience. This review explores the emerging role of Monoclonal antibodies as advanced biologics in next generation animal nutrition, with a focus on mapping nutrient immune interaction networks in livestock systems. It synthesizes current knowledge on how nutrients …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
-
Effect of Mindfulness, Meditation, Yoga on Mental Health
Abstract: In the last few years to improve quality of life importance has been given to the alternative method of therapy. Yoga, Meditation and Mindfulness has a positive impact on mental well-being. These alternate therapies of healing which help in self-healing tendencies. These alternate ways are both safe and effective treatment and it helps to stimulate positive thinking, destress, resilience, improved interpersonal relationships and increased productivity. Yoga, Meditation and Mindfulness has …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 1, 2026 · pp. 73–78 Read article
-
New-Age E-voucher Utility: Redefining Peer-to-Peer Transactions in the Digital Economy
Abstract: This system introduces an innovative new-age e-voucher utility designed to facilitate peer-to-peer (P2P) intake through a person-pleasant cell platform. This revolutionary answer empowers people to create and list e-vouchers for numerous services, experiences, or bodily goods, circumventing conventional channels and fostering an extra direct financial machine. Operating on a decentralized architecture, the utility guarantees stable transactions through fee gateways and contains a recognition machine to set up acceptance as true …
Published in International Journal of Computer Science Languages · Vol. 2, Issue 2, 2024 · pp. 36–46 Read article
-
Gene Therapy in Modern Medicine: Promises and Challenge in Treating Genetic Diseases
Abstract: Gene therapy is a medical approach that focuses on altering or adjusting an individual’s genes to treat or prevent illnesses. The aim is to repair faulty genes or insert new ones into the body to combat diseases. Gene therapy can involve directly introducing modified or new genes into a patient’s cells or altering the genes already present in the patient’s body. This approach shows potential for treating a range of …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 27–32 Read article
-
QSAR Modeling Techniques: A Comprehensive Review of Tools and Best Practices
Abstract: Quantitative Structure–Activity Relationship (QSAR) modeling has become an essential tool in drug discovery, toxicity assessment, and environmental chemistry. By correlating chemical structure with biological activity or toxicity, QSAR enables the prediction of compound behavior without extensive experimental testing. This approach not only saves time and resources but also supports ethical practices by reducing reliance on animal studies. The evolution of QSAR from basic linear models to advanced machine learning and …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 56–63 Read article
-
Differential Gene Expression Analysis of Human Atrial Fibroblasts Reveals Dysregulation of RNA Metabolism and Translational Machinery in Atrial Fibrillation
Abstract: Atrial fibrillation (AF) is a complex cardiac arrhythmia characterized by extensive structural remodeling and the activation of atrial fibroblasts, which drive the progression of fibrosis. To identify the underlying transcriptomic alterations, we analyzed six human atrial fibroblast RNA-Seq datasets (three control and three AF) retrieved from the Sequence Read Archive. After performing rigorous quality control and adapter trimming, we aligned the reads to the GRCh38 human reference genome using a …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 · pp. 15–25 Read article
-
A Comprehensive Study of various Multi-Area Hybrid Power Systems for Generation Control
Abstract: This paper is a detailed examination of multi-area hybrid power systems in the control of the generation taking into consideration the two area up to five area connected networks. As renewable energy sources are more and more integrated, and modern grids become more and more complex, the stability of the system itself and the frequency regulation have risen to a major issue. The study highlights the significance of Automatic Generation …
Published in International Journal of Electrical Power and Machine Systems · Vol. 3, Issue 2, 2025 · pp. 28–42 Read article
-
Integrating Biotechnology, Physiology, and Agroecological Practices for Sustainable Crop Production and Protection
Abstract: Global agriculture is currently confronting a wide range of complex challenges, including a rapidly growing population, climate change, increasing pest and disease pressures, soil degradation, water scarcity, and the urgent need for sustainable intensification of crop production. Addressing these issues requires integrated strategies that combine crop improvement (through modern breeding and biotechnology), precision agronomic practices related to soil, irrigation, and nutrition, as well as advancements in plant physiology, molecular biology, …
Published in International Journal of Trends in Horticulture · Vol. 2, Issue 2, 2025 · pp. 1–6 Read article
-
Gene Editing in Dairy Cows: Advancing Milk Yield, Health, and Resilience for Sustainable Dairy Development
Abstract: Gene editing has emerged as a transformative tool in dairy science, offering unprecedented opportunities to enhance productivity, improve animal health, and bolster resilience against environmental challenges. This study explores the potential of gene editing technologies, including CRISPR-Cas9, in advancing milk yield, optimizing milk composition, and addressing genetic disorders in dairy cows. Specific applications include targeting genes associated with mastitis resistance, improving feed efficiency, and introducing heat tolerance traits to adapt …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
-
The Power of Genetic Engineering in Revolutionizing Vaccines
Abstract: Genetic engineering techniques, including recombinant subunit, viral vector, and nucleic acid vaccines have transformed the landscape of vaccine development. These novel approaches offer precise antigen design, enhanced safety profiles, and rapid adaptability to emerging pathogens. Key advantages include improved efficacy through targeted immune responses, increased safety due to the absence of live pathogens, and the ability to modify vaccines to address new variants or diseases quickly. Notable success stories, such …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 18–27 Read article
-
The Renaissance and Resilience of CB1 Reverse Agonists: From Central Liabilities to Peripheral Promise
Abstract: Building upon these foundational insights, current research has increasingly focused on refining the pharmacological profile of CB1 reverse agonists to maximize therapeutic benefit while minimizing central adverse effects. The adverse neuropsychiatric outcomes associated with first-generation agents such as Rimonabant including anxiety, depression, and suicidal ideation highlighted the critical role of central CB1 receptors in mood regulation. Consequently, drug development strategies have shifted toward peripherally restricted CB1 reverse agonists that exhibit …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 30–35 Read article
-
An AAV Vector for Inducible Gene Expression Preferentially in Muscles
Abstract: Adeno associated viral (AAV) vectors has been used widely in gene therapy and efforts have been made to improve their utility by adding genetic elements that would enable targeting transgene expression to particular cells or tissues of interest and permitting on/off regulation of expression. In this study, we designed a recombinant AAV9 variant PHP.eB vector with muscle creatine kinase (Mck)-derived enhancers, a synthetic muscle-expression promoter, in combination with a third-generation …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 46–61 Read article
-
Yoga and Neural Health: Enhancing Brain Function Through Postural Alignment
Abstract: Correct posture significantly influences neural function and brain health by ensuring optimal alignment of the spine and nervous system. Poor posture disrupts neural communication, impairs blood flow, and affects cerebrospinal fluid (CSF) circulation, leading to adverse effects on cognitive performance, emotional regulation, and overall brain health. This study examines the physiological connection between posture and neural health, emphasizing its impact on cognitive function, mood, and neuroplasticity. Using a mixed-methods approach, …
Published in Recent Trends in Sports · Vol. 2, Issue 1, 2025 · pp. 24–28 Read article
-
Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
-
Microalgae Based Wastewater Treatment: A Sustainable Approach
Abstract: The global water crisis and strict environmental policies demand advanced wastewater treatment techniques that combine pollution control with resource recovery. Microalgae-based wastewater treatment has emerged as a sustainable biotechnological solution that aligns with circular economy principles by simultaneously eliminating contaminants and producing valuable biomass that can be converted into useful products. This review paper provides an in- depth assessment of the application of microalgae in treating municipal, industrial, and agricultural …
Published in International Journal of Sustainability · Vol. 3, Issue 2, 2026 · pp. 1–15 Read article
-
Self-Help Group and Rural Women’s Socioeconomic Empowerment in India: An SDG Perspective
Abstract: This research examines the impact of Self-Help Groups (SHGs) on rural women in Khurda District, Odisha, and their contribution to achieving the United Nations’ Sustainable Development Goals (SDGs). The central aim of the study is to understand whether participation in SHGs helps women improve their socioeconomic conditions and move closer to global development goals, such as poverty reduction, food security, better health, improved education, and gender equality. To assess this, …
Published in International Journal of Rural and Regional Development · Vol. 4, Issue 1, 2026 · pp. 38–48 Read article
-
Advancing Cancer Vaccine Development through CRISPR/Cas9 Technologies and Future Opportunities
Abstract: The advent of CRISPR/Cas9 genome editing has revolutionized the cancer immunotherapy market, offering unprecedented precision and versatility in the development of next-generation cancer vaccines. This review examines how CRISPR technologies are being integrated into various stages of cancer vaccine development including neoantigen discovery, dendritic cell engineering, cancer cell reprogramming, and tumor microenvironment modulation. In the area of neoantigen discovery, CRISPR enables rapid identification and validation of tumor-specific mutations, thereby supporting …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 Read article