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292 articles for “conclusion”
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In Silico Prediction of Multitarget Mechanism of Quinoline and Its Analogs on Phosphoinositide-3-Kinase Pathway Proteins
Abstract: Objective: Phosphoinositide 3-kinases (PI3Ks), the target of rapamycin (PI3K/Akt/mTOR, PAM), are a family of enzymes that play a role in the growth, proliferation, differentiation, motility, survival, and intracellular trafficking of cells, all of which are essential for healthy cellular function and are also connected to cancer. In this study, quinoline and its derivatives were employed to analyze its inhibition activity on the phosphoinositide-3-kinase pathway. Methods: In this work, eight phytocompounds …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 57–76 Read article
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Molecular Docking Evaluation of Cedrus deodara Secondary Metabolites as a Potent Anti-ovarian Cancer Agent
Abstract: Objective: According to the statistics for the year 2022 it was seen that cancer total cases is 14,61,427. After breast cancer, ovarian cancer is the second most frequent cancer among women. The estrogen receptor (PDB ID: 1X7E), progesterone receptor (PDB ID: 1A28), and Phosphoinositide 3-kinases (PDB ID: 4FJY) can be considered as target protein for ovarian cancer. The plant Cedrus deodara and its phytochemicals were chosen in this study to …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 77–93 Read article
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Pharmacoinformatic Based Screening Of Phytocompound Epigallocatechin Gallate To Identify As A Potential Bcl-2 Inhibitor
Abstract: Objectives: The B-cell lymphoma-2 (Bcl-2) is a protein that is particularly though to be involved in preventing apoptosis. Bcl-2 family members also essential for cancer survival, and its over expression has been linked to tumor genesis, development and resistance to anticancer treatments. The Bcl-2 family of members that inhibit apoptosis is a promising target for the creation of anticancer drugs. Methods: The study was based on computational approach using different …
Published in International Journal of Bioinformatics and Computational Biology Read article
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An Integrated Study to Extrapolate the Interaction of NMDAR with Potential Ligands for the Treatment of Alzheimer’s Disease Symptoms
Abstract: Objective: Alzheimer’s disease (AD) is the most common neurodegenerative disease affecting the health status of older adults especially those above the age of 60 years. As an outcome, two types of medications have been developed for the treatment of its symptoms which are acetylcholinesterase (AChE) and N-methyl-D-aspartate receptor (NMDAR) antagonist. This paper uses the computational approach to understand the interaction of NMDAR with four major phytocompounds (curcumin, L-epicatechin, ginsenosides, and …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 15–27 Read article
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Anti Covid-19 Drugs Suggested by Computational Methods: A Review
Abstract: Background and aims: Long COVID refers to the persistence of illness in individuals who have survived from COVID-19 infection. This article reviews long covid and the use of in silico techniques in drug development for COVID-19. Results: Many COVID-19 survivors have long COVID, which has become a burden in daily life. Various attempts have been undertaken to relieve symptoms and manage it, but there is no cure as of yet. …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 16–34 Read article
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A Study to Assess Prevalence of Tobacco Use Among Adolescents and Assess the Effectiveness of Structured Teaching Program Regarding Ill Effects of Tobacco Use and Its Prevention Among Adolescents in Selected Community of New Delhi
Abstract: Tobacco use among adolescents has become a global challenge and it is reaching pandemic levels. The objectives of the study were (a) to assess the prevalence of tobacco use among adolescents in a selected community of New Delhi, (b) To provide an organised education programme on the negative effects of tobacco smoking and how to prevent it for teenagers in a chosen New Delhi community, (c) to determine whether the …
Published in International Journal of Community Health Nursing And Practices · Vol. 1, Issue 1, 2023 · pp. 23–38 Read article
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A Study to Assess the Lived in Experience of Corona Positive Patients in Selected Community Area, Kanyakumari District
Abstract: Aim: To assess the lived-in experience corona positive parents among community people. Methodology: A Qualitative study design was used to assess the lived-in experience of corona positive patients among the community people at selected community area. There were 9 samples are selected by sampling technique. The samples shared their experience when they suffered from corona virus. Results: The study findings were said that the physical sufferings of the patients and …
Published in International Journal of Community Health Nursing And Practices · Vol. 1, Issue 1, 2023 Read article
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Review Descriptive Programme on Knowledge Regarding Diabetes Mellitus
Abstract: Context: A research study was conducted to assess the knowledge and prevalence of diabetes mellitus among elderly individuals in selected areas of Jalandhar, Punjab. The study also aimed to develop an informative guide sheet. Objectives: (1) To assess the level of understanding about diabetes mellitus among elderly individuals in the selected regions. (2) To determine the prevalence rate of diabetes mellitus among elderly individuals in the selected areas. (3) To …
Published in International Journal of Community Health Nursing And Practices · Vol. 1, Issue 2, 2023 Read article
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Youthful Students’ Perception of The Nursing Profession: A Preliminary Single-group Research
Abstract: Aim: This study had four objectives: (1) examine how adolescents perceive nursing before and after organized teaching programs; (2) examine how adolescents perceive nursing after structured teaching programs; (3) compare pre-test and post-test results to assess the efficacy of a structured teaching program; (4) relate the mean improvement in nursing image to particular demographic factors. Background: This study assists in identifying potential areas for improvement or any potential interventions to …
Published in International Journal of Community Health Nursing And Practices · Vol. 1, Issue 2, 2023 Read article
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To evaluate the effectiveness of a structured educational program on knowledge about hypoglycemia and its management among diabetes patients living in selected urban slums of Durgapur, West Bengal
Abstract: INTRODUCTION: Diabetes Mellitus (DM) is a significant global health issue characterized by chronic hypoglycemia and an imbalance in the metabolism of carbohydrates, fats, and proteins. It has multiple underlying causes. Hyperglycemia refers to high blood glucose levels, while low blood glucose levels are known as hypoglycemia. Raising awareness about the signs and symptoms of diabetes among individuals with the condition can potentially minimize complications. OBJECTIVES: 1. To evaluate the initial …
Published in International Journal of Community Health Nursing And Practices · Vol. 1, Issue 1, 2023 Read article
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Time Utilization by Hospital Attendants and Housekeeping Staffs in a Tertiary Level Hospital
Abstract: Introduction: Time management refers to the deliberate and conscious management of one's time to effectively allocate it to specific activities, with the aim of enhancing productivity and efficiency. Efficient time utilization can lead to improved employee productivity, streamlined job performance, and effective task completion. Additionally, it enables employees to accomplish necessary tasks and assists organizations in achieving their goals by effectively recording and guiding their activities. The objectives of this …
Published in International Journal of Community Health Nursing And Practices · Vol. 1, Issue 1, 2023 Read article
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Evaluation of Coping Strategies Adapted to Overcome Psychosocial Problems in Adults Residing at Residential Home: A Descriptive Study
Abstract: Coping strategies refer to intentional actions taken to address and resolve personal or interpersonal challenges, aiming to manage, reduce, or tolerate stress or conflicts. Emotional-focused techniques specifically target the reduction of negative emotional responses caused by stressors. Some examples of coping strategies focused on emotions involve participating in activities to keep oneself busy and divert attention from stressors, seeking support, encouragement, empathy, and understanding from others. Objectives: (1) to assess …
Published in International Journal of Community Health Nursing And Practices · Vol. 1, Issue 1, 2023 Read article
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Exploration of 5-Hydroxybowdichione Flavonoids As Inhibitors of Dengue Virus Ns5 RNA-Dependent RNA Polymerase Using Molecular Docking Approach
Abstract: Objectives: Human lives are now seriously threatened by dengue fever, which is brought on by the dengue virus (DENV). Aedes aegypti mosquitoes, which reproduce in still water, are the primary vectors of the arboviral virus known as dengue. It is well-recognized that phytochemicals have a high potential to eliminate bacterial, viral, and fungal infections in people. Thus, it demonstrates its inhibitory effects on the dengue virus. This study identifies some …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 1–16 Read article
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Identification of Promising Lead Compounds from Capsicum annuum Targeting BACE-1 for Alzheimer’s Disease Therapy: A Molecular Docking Study
Abstract: Background: Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions of people worldwide. Beta-secretase 1 (BACE-1) is an important therapeutic target for AD treatment. Capsicum annuum (CA) is a commonly consumed plant with potential neuroprotective properties. In this study, we aimed to identify potential lead compounds from CA that can target BACE-1 for AD therapy using molecular docking. Methods: A library of 15 compounds from CA was obtained from PubChem, …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 40–49 Read article
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Pharmacological Management of Parkinson’s Disease: Current Therapies and Emerging Treatments
Abstract: Objective: Parkinson's disease, behind Alzheimer's, is the second most common neurodegenerative ailment and a major cause of neurological morbidity worldwide. Clinical diagnosis is made, and current management is limited to symptomatic treatments, with levodopa remaining the cornerstone of pharmaceutical therapy. In certain patient groups, deep brain stimulation of specific basal ganglia targets can provide significant clinical relief. There are currently no proven disease-modifying medicines in clinical use that can halt …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 27–39 Read article
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Molecular Docking and Pharmacokinetic Profiling of the Phytocompounds of Jatropha curcas as Antagonist for Salmonella typhi
Abstract: Background: Typhoid is an infection caused by the Gram-negative bacterium, Salmonella enterica serovar typhi. The study assessed the potential use of Jatropha curcas as a typhoid fever therapy alternative to traditional medications. The ability to uncover novel drug indications for currently available medications using in silico methods has increased thanks to the wealth of pharmacological and biological knowledge that is available. Objective: In this study, we assessed the potential inhibitory …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 67–81 Read article
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Home Interior with a Vintage style
Abstract: Vintage style originated in France and is a fusion of modern and classic styles. The vintage style is distinguished using natural materials like wood and distressed wood. Furniture and decor in a vintage style can be created with artificial aged furniture or natural materials. Conclusion, Vintage interior design has always been a popular and appealing trend, as well as a fun way for people to express themselves while decorating their …
Published in International Journal of Rural and Regional Development · Vol. 1, Issue 1, 2023 · pp. 48–57 Read article
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Understanding the Level of Knowledge and Attitudes of Pregnant Women on Use of Complementary and Alternative Medicine (CAM)
Abstract: Background: The utilization of complementary and alternative medicine (CAM) among pregnant women in India is on the rise. Though the pregnant women are using these therapies, they lack adequate knowledge. It is the responsibility of the health care provider to identify the knowledge to promote healthy practices and to avoid harmful practices. Method: For this investigation, a quantitative method was used. The level of knowledge and attitude of pregnant women …
Published in International Journal of Midwifery Nursing And Practices · Vol. 1, Issue 1, 2023 · pp. 25–30 Read article
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A Study on Breast-feeding Self-Efficacy and Its Associated Factors Among Mothers
Abstract: Introduction: The process through which a kid is fed human breast milk is known as breastfeeding. Breastfeeding has a significant impact on disease prevention and health promotion. It helps to increase bonding with baby and mother. Oestrogen, progesterone, prolactin, and oxytocin are the four primary hormones that contribute to the production of breastmilk. A modifiable element that can improve breastfeeding success and duration is breastfeeding self-efficacy. Aim: To evaluate mothers' …
Published in International Journal of Midwifery Nursing And Practices · Vol. 1, Issue 1, 2023 · pp. 31–36 Read article
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A Comparative Study on Associated Factors of Hypertension Among Working Women and Non-working Women
Abstract: Background: One in four people worldwide is affected by high blood pressure, which is also the third leading cause of illness and a significant risk factor for death. Compared to non-working women, employed women had a higher prevalence of hypertension. This might be attributed to various factors such as job-related stress, lack of relaxation, and lack of physical activity. Method: Quantitative approach was adopted. To investigate the related determinants of …
Published in International Journal of Women's Health Nursing And Practices · Vol. 1, Issue 1, 2023 · pp. 09–14 Read article