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25 articles for “cirrhosis”
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Modified Nucleosides “(ProTide)†as Potential Anti-HCV Therapeutics
Abstract: Hepatitis C virus (HCV) is among the most common causes of cirrhosis and chronic liver disease worldwide. As a result, many researchers are interested in designing and synthesis of a clinical treatment for HCV. Nucleoside monophosphates and monophosphonates play such an important role for treatments of incurable diseases such as hepatitis. For example, 2'-C-methyladenosine and 2'-C-methyl guanosine have shown activities against HCV in the replicon assay as well as against …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 1, 2017 · pp. 32–39 Read article
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Diagnostic Methods for Hepatitis-C Virus and Tuberculosis Coinfection among HIV Infected Individuals: A Review
Abstract: HIV is the chronic viral infection documented worldwide. HIV virus infects and destroys helper T cells (CD4) leading to a number of immunological deficiencies among which Hepatitis-C Virus (HCV) and Tuberculosis (TB) are the major. HCV is a RNA virus that infects the liver leading to cirrhosis, hepatocellular carcinoma and is a leading cause of deaths in HIV/HCV co-infected patients. Tuberculosis, the most common opportunistic infection in HIV positive patients, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 6, Issue 3, 2016 · pp. 38–41 Read article
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SGOT (Serum Glutamic Oxaloacetic Transaminase)—Its Role (A Review Article)
Abstract: Aspartate transaminase (AST) is an important liver enzyme which catalyses reversible transfer of an alpha amino group between aspartate and glutamate. It has an important role in amino acid metabolism. AST is predominantly found in the liver, skeletal muscle, kidneys, brain and red blood cells. AST is measured as a part of diagnostic liver function test, but AST reflects pathology in organs other than liver. Elevation in AST is found …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 9, Issue 3, 2019 · pp. 1–5 Read article
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Phytochemical and Neuroprotective Activity of Annona reticulata Leaf Extract in Gentamicin-Induced Nephrotoxicity in Wistar Rats
Abstract: Natural products are an important source of bioactive compounds and have potential for the development of novel therapeutics. Natural products and their derivatives represent more than 50% of all drugs in clinical use in the world. Herbal plants contain and produce a variety of chemical substances that are used as a remedy for treating diseases. Annona reticulata contain different chemical constituents but does not contain glycosides, alkaloids and phytosterols. Various …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 3, 2019 · pp. 30–38 Read article
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A Review of Medicinal Plants against Drug-Induced Nephrotoxicity
Abstract: Kidney is an excretory organ as it regulates chemical balance and releases waste products from the human body. It is primarily associated with filtration of blood, maintaining level of hormones (mainly vitamin D and erythropoietin) to regulate blood pressure, mineral balance and production of red blood cells. The kidney is more susceptible to drug induced toxicity due to the constant exposure to drug and chemicals present in blood. Over-consumption of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 1, 2025 · pp. 16–26 Read article