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240 articles for “binding”
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Drug Repurposing of Anticancer Agents JP-8g and REDX05358 Against the Target Protein Plectin 1a in Epidemolysis Bullosa Simplex with Muscular Dystrophy (EBS-MD)
Abstract: Epidermolysis Bullosa Simplex with Muscle Dystrophy is a genetic disease affecting the skin and muscles which can be seen at birth or start at adulthood due to the mutation in the protein Plectin 1a (PLEC gene) causing skin blisters and muscle weakness. This protein is seen in sarcolemma, Z disks in skeletal muscles, hemidesmosomes in skin and cardiac muscles giving stability to cytoskeleton, playing a crucial role in neuromuscular transmission …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 22–34 Read article
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Theoretical Study of Z = 122 Nuclei
Abstract: We used atomic nuclei with proton number Z = 122 to calculate bulk properties within the relativistic mean field (RMF) theory. We utilized the force parameters recognized as NL3 in our calculations. We extend our calculation to isotopic series of Z = 122 and analyses the theoretical outcomes. A whole isotopic chain of nuclei with atomic number 𝑍 = 122 Z=122 is included in our inquiry, enabling a methodical examination …
Published in Journal of Nuclear Engineering & Technology · Vol. 16, Issue 1, 2026 · pp. 1–9 Read article
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Recent Developments in Polymer Concrete: Considerations for Materials, Performance, and Sustainability
Abstract: In modern infrastructure Growing need of durability and environmental has driven interest in polymer concrete (PC) as an alternative to conventional cement-based materials. This review critically evaluates recent developments in polymer concrete with emphasis on material innovations, performance characteristics, and sustainability aspects. Demonstration of Advanced polymer binders (e.g. epoxy, polyester and vinyl ester resins) shown significant improvements in mechanical strength, adhesion and chemical resistance. Investigation indicates that use of nanomaterials …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 910–920 Read article
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Description & Prevention of Omicron
Abstract: November 9, 2021, Botswana becomes the first country to recognise it (Nov 11 2021). The new variant (B.1.529) has been represented in 77 countries. Omicron presents 32 changes in spike protein Scribd, restricting the point of interaction with the ACE2 receptor protein. Computational shows and components’ recreation has been applied to investigate the collaboration between the SARS-CoV-2 RBD and the ACE2 receptor. The receptor-binding domain (RBD), which more barely joins …
Published in Research & Reviews: A Journal of Pharmacognosy Read article
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Prediction of Molecular Targets for Anthraquinone and Its Analogs for Treatment of Good Pasteur Syndrome
Abstract: Objective: In order to find prospective molecular targets for the treatment of Good Pasteur Syndrome (GPS), a rare autoimmune disease that affects the kidneys and other organs, computational methods and network pharmacology were applied in this work. The goal of the study is to identify particular human proteins that might interact with anthraquinone and its analogues as well as to uncover potential mechanisms of action by which these drugs might …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Melanogenic Inhibitory Effects of Sesamum indicum Phytocompounds Towards CDK 2, c-KIT, and BRAF.
Abstract: Objective: Melanoma is thought to be the fifth most frequent cancer in the US population, despite cancer being the most common cause of death in the globe. BRAF, CDK2, and c-KIT proteins are regarded as potential therapeutic agents since mutations in these proteins are the primary cause of melanoma. For the investigation of their pharmacological properties and therapeutic activities against the target proteins, Sesamum indicum L. and its phytocompounds were …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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Computational Exploration of Bhrijraj-derived Phytochemicals as Potential Anti-inflammatory Agents: A Molecular Docking Study with Cyclooxygenase-II Complex
Abstract: The molecular docking analysis was meticulously conducted using state-of-the-art computational tools, notably Chimera and Python. These tools were employed to unravel the complex interactions between the identified phytochemicals from Bhrijraj and the target protein, COX-II. The 3D structures of the phytochemicals were prepared with precision using ChemSketch, ensuring accuracy in the subsequent molecular docking simulations. This rigorous approach enhances the reliability and validity of the findings. This research aims to …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 31–37 Read article
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Improving Polymer Composite Properties Through Reinforcement Learning Guided Prototyping A Novel Approach for Material Engineering
Abstract: Innovative approaches integrating reinforcement learning (RL) and machine learning (ML) into the fields of polymer composite prototyping and soft actuator manufacturing for applications. This new an algorithm utilizing RL optimizes polymer composite fabrication parameters to enhance material properties efficiently. By iteratively adjusting parameters based on predefined objectives, the RL agent guides the prototyping process, promising to revolutionize polymer composite engineering. A finest control method for locked loop control of Shape …
Published in Journal of Polymer & Composites · Vol. 12, Issue 4, 2024 · pp. 208–218 Read article
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A Review on Phytochemistry and Pharmacological Properties of Curcuma amada (Zingiberaceae)
Abstract: Plant has been employed in traditional medicine since ancient times. Curcuma amada Roxb. (Mango ginger), is a member of Zingiberaceae family and the Curcuma genus. It is a distinctive spice that shares a similar appearance with ginger but provides a raw mango taste. It is considered as a valuable plant in traditional medicine which plays a crucial function in both the food and pharmaceutical industries. Ayurveda and Unani medicinal traditions …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 3, 2024 · pp. 10–20 Read article
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Commercialization of Smart Polymers in Advanced Composite Structures for Industrial Applications
Abstract: The commercialization of smart polymers in advanced composite structures represents a significant rise in material science, particularly for industrial applications. These smart polymers show unique properties such as self-healing, shape memory, & responsiveness to environmental disturbances, making them ideal for a wide range of applications. In this paper, the researcher explores the advancements in developing and applying smart polymers within composite structures, focusing on their potential. Revolutionize industries like atmosphere, …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 70–81 Read article
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Understanding Cervical Cancer Screening: An Overview
Abstract: This study aimed to evaluate women's knowledge of cervical cancer screening in relation to specific demographic factors and to create an informational pamphlet on the topic. A total of 190 women aged 20 to 50 participated, selected using convenience sampling. A descriptive quantitative research design was employed, with data gathered through a structured questionnaire assessing socio-demographic factors and knowledge levels. Analysis was conducted using descriptive statistics and SPSS software. Results …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 1–5 Read article
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Super Ni 718 Machinability Investigation on Electrical Discharge Machining Using Hybrid Al 7(075+178) Electrode Under Abrasive Assisted Dielectric
Abstract: As aluminum alloy is the lightest metal and has the best mechanical qualities among metal, it has proven to be a perfect choice for strututal industry, particularly in the aerospace sector.7xxx alloys from the Al alloy family are widely used in aviation constructions due to their outstanding processing, welding efficiency, great specific strength & stiffness, and high toughness. The two aluminum alloys that are most frequently used in airplane structures …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1–17 Read article
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Enhancing Wildlife Tourism Management Using Deep Learning and Particle Swarm Optimization (PSO) for Animal Detection in Wildlife Sanctuaries
Abstract: Wildlife tourism is one of the most thriving sectors, faced with huge challenges in terms of safeguarding protected areas. As demand for wildlife experiences accelerates, it becomes necessary to find efficient measures that are friendly to conservation. The use of these advanced techniques in this field such as YOLO and PSO algorithm presents a new dimension on managing wildlife tourism. To harness the abilities of these techniques, this research centers …
Published in Current Trends in Signal Processing · Vol. 14, Issue 3, 2024 · pp. 41–50 Read article
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Microstructural Characterisation and Analysis of Mechanical Behaviour of Hybrid AA 7075/7178 Fabricated Using Die Casting Technique
Abstract: AA are being increasingly used in the field of structural engineering owing to their desirable mechanical properties coupled with their recyclable and sustainable nature, thus contributing significantly towards reduction of carbon footprints and development of circular economy. Till date numerous research projects have been prompted to investigate the structural performance of aluminium alloy structures and develop alternatives with enhanced performance parameters. AA 7xxx (Al-Zn-Mg-Cu) are being widely used in variety …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 441–451 Read article
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In Silico Analysis and Molecular Docking Studies of COX-2 Inhibitors for Anti-Inflammatory Activity
Abstract: Although nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to treat pain, lower fevers, and control inflammation, they frequently cause gastrointestinal side effects because they inhibit the COX-1 and COX-2 enzymes. Despite their effectiveness and lack of gastrointestinal side effects, selective COX-2 inhibitors have been linked to cardiovascular risks. To find new COX-2 inhibitors that are safer and more effective, this study uses in silico techniques, such as molecular docking and …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 38–55 Read article
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Application Henderson's Need Theory on a Case of Esophageal Cancer
Abstract: Cancer is a broad term that refers to the uncontrolled growth of abnormal cells, which can invade or spread to other areas of the body. Cancer encompasses over 150 different types, each presenting unique challenges. Patients with cancer often require specialized healthcare to manage their condition and the treatments involved. This case report discusses a 55-year-old female diagnosed with esophageal cancer, who was admitted for chemotherapy. Throughout her treatment, nursing …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 1, 2025 · pp. 12–17 Read article
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Combustion Characteristics of Waterlily (Nymphaea lotus Linn.) Briquettes
Abstract: The effect of binder types (bananas, yams, and cassava) and binders proportion on thermal properties of waterlily (Nymphaea lotus Linn.) briquettes were investigated. Peels from bananas, yams, and cassava were collected from agro processing cottage industry. The peels were washed, sun-dried, and ground using a disk mill and Tyler sieves to a particle sizes of 0.50 mm. The waterlily plants were collected from the river using a drag net, sun-dried, …
Published in Journal of Petroleum Engineering & Technology · Vol. 15, Issue 2, 2025 · pp. 12–21 Read article
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Serum Magnesium, Iron, TIBC, and Hormonal Imbalances in Hypertensive Pregnant Women: A Comparative Study
Abstract: Pregnancy-induced hypertension (PIH), including gestational hypertension and preeclampsia, is a leading cause of maternal and fetal complications. The regulation of blood pressure and overall pregnancy health is influenced by micronutrients and hormones. This study aimed to evaluate serum magnesium, serum iron, total iron binding capacity (TIBC), thyroid profile, and quadruple marker levels in hypertensive pregnant women and compare them to normotensive controls. Methods: A total of 1056 hypertensive pregnant women …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 2, 2024 · pp. 41–45 Read article
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Enhanced Mechanical and Tribological Performance of Magnesium–Boron Carbide Composites Fabricated via Stir Casting for Lightweight Structural Applications
Abstract: This study investigates the fabrication and evaluation of properties of magnesium (Mg) matrix composites reinforced with boron carbide (B₄C) for lightweight structural applications. Stir casting was employed to incorporate B₄C particles at varying weight fractions (0%, 3%, 6%, and 9%) into the magnesium matrix. The influence of B₄C on density, porosity, hardness, tensile strength, and wear resistance was systematically examined. Theoretical density increased from 1.74 g/cm³ (pure Mg) to 1.88 …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 29–39 Read article