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35 articles for “and LOQ”
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Titrimetric and Spectrophotometric Assay of Diethylcarbamazine Citrate in Pharmaceuticals using Permanganate as Oxidant
Abstract: Two titrimetric and one spectrophotometric methods are described for the determination of diethylcarbamazine citrate in bulk drug and dosage forms using permanganate as an oxidimetric agent. In method A, the drug solution in H2SO4 is titrated directly at 800C to a pink end point. DEC was treated with a measured excess of standard permanganate in H2SO4 medium, and after a contact time of 5 min, the residual oxidant back titrated …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 3, 2016 · pp. 1–11 Read article
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High-Performance Liquid Chromatographic Assay of Nateglinide and its Stability Study
Abstract: Nateglinide (NTG) is a D-phenylalanine derivative used in the treatment of type-2 diabetes mellitus. An accurate, sensitive and reproducible high-performance liquid chromatographic (HPLC) method has been developed and validated for the quantification of NTG in pharmaceutical samples. The drug was eluted from Inertsil ODS 3V (150×4.6 mm; 5 µm particle size) column at 30á´¼C with a mobile phase consisting of phosphate buffer of pH 3.3 and methanol (70:30 v/v). The …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 3, 2016 · pp. 41–52 Read article
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Two New, Useful and Facile Stability-Indicating UV Spectrophotometric Methods for the Determination of Rosiglitazone in Pharmaceuticals
Abstract: Rosiglitazone (ROS) is an antidiabetic drug belonging to the thiozolidine class. Two simple, rapid, sensitive, accurate and reproducible UV-spectrophotometric methods were developed and subsequently validated for the determination of ROS in bulk and tablet form. The methods are based on the measurement of the absorbance of the drug solution either in 0.1 M NaOH (NaOH method) or in 0.1 M HCl (HCl method) at 316 nm in both instances. The …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 2, 2017 · pp. 8–19 Read article
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Development and Validation of Simple UV-Spectrophotometric Method of Quantization of Domperidone in Solid Dosage Formulation using Mixed Solvency Concept
Abstract: Organic solvents are most frequently employed in spectrophotometric analyses. They may be the sources of pollution. Some of them may be toxic, while others may be costlier. Volatility may be a source of inaccuracy in spectrophotometric estimations. In the present investigation, it was proposed to solubilize Domperidone by the use of mixed solvency concept. Domperidone shows maximum absorbance in the concentrations range of 10–50µg/ml at 287 nm. Method of analyses …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 2, 2017 · pp. 19–23 Read article
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Method, Development and Validation of Emtricitabine and Tenofovir by Using RP-HPLC in Pharmaceutical Dosage Forms
Abstract: A new method was established for simultaneous estimation of Emtricitabine and Tenofovir by RP-HPLC method. The chromatographic conditions were successfully developed for these parathions of Emtricitabine and Tenofovir by using Xterra C185 µm (4.6*250 mm) column, flowrate was1ml/min, mobile phase ratio was phosphate buffer (0.05 M) pH4.6: CAN (55:45% v/v) (pH was adjusted with ortho-phosphoric acid), detection wavelength was 255nm. Theretentiontimewas2.399and3.907 min. for Emtricitabine and Tenofovir, respectively. The percentage purity …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 1, 2018 · pp. 37–41 Read article
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Analytical Method Development and Validation for the Simultaneous Estimation of Elvitegravir and Cobicistat by RP-HPLC Method
Abstract: A new method was established for simultaneous estimation of Elvetigravir and Cobicistat by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Elvetigravir and Cobicistat by using Xterra C18 5 µm (4.6×150 mm) column, flow rate was 1 ml/min, mobile phase ratio was phosphate buffer (0.05 M) pH 7: MEOH (30:70%v/v) (pH was adjusted with orthophosphoric acid), and the detection wave length was 270 nm. The instrument …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 2, 2018 · pp. 1–6 Read article
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Determination of RP-HPLC Method for Safinamide: Its Bulk and Tablet Dosage Form
Abstract: A new method was established for estimation of Safinamide by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Safinamide by using Agilent C18 column (4.6×150 mm, 5 µ); flow rate was 1 ml/min, mobile phase ratio was Methnol, Acetonitril (60:40), pH 3 (pH was adjusted with orthophosphoric acid), detection wavelength was 235 nm. The instrument used was WATERS HPLC Auto Sampler, Separation module 2695, photo diode …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 3, 2018 · pp. 1–6 Read article
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Simultaneous Estimation of Atenolol and Nifedipine to be incorporated in Buccal Patch: Method Development and Validation by UV-Spectrophotometric Approach
Abstract: A simple, precise, accurate and reproducible spectrophotometric method has been developed for the simultaneous estimation of Atenolol and Nifedipine. Atenolol and Nifedipine are used in combined dosage form for cardiovascular diseases. Hence, it is necessary to develop a method to analyze the two drugs simultaneously by UV-spectroscopic method. Simulated salivary fluid of pH 6.8 was used as the medium. Simultaneous equation method was developed as per ICH guidelines. The absorption …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 2, Issue 1, 2015 · pp. 28–32 Read article
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Development and Validation of RP-HPLC Method for Estimation Ertugliflozin in Its Bulk and Tablet Dosage Form
Abstract: Background: This study developed and validated a new, sensitive, appropriate, clear, accurate, and robust reversed-phase high-performance liquid chromatography (RP-HPLC) method for determining safinamide in bulk medication and tablet formulations. An HPLC procedure using a UV detector and the Openlab EZchrome workstation programme was used to separate the samples, as well as a Kromasil C18 (250 mm × 4.6 mm i.d.) 5 μm. At a flow rate of 1.0 mL/min, methanol …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 1, 2022 · pp. 8–20 Read article
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A Novel Analytical Method for the Simultaneous Estimation of Remogliflozin and Metformin Hydrochloride
Abstract: Specific and novel strategy has been improved for assessment of Remogliflozin and Metformin hydrochloride in mass and plan and cleaning tests by UPLC-PDA. The scientific method was the phosphate Buffer (pH: 4.5): Acetonitrile, (60:40%, v/v) utilizing the spherisorb C18, 5 µm, 4.6 mm×150 mm insightful segment with investigation season of 5 min. The progression of versatile stage through section was 1.0 ml/min. The test volume was 10 µl. The discovery …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 7, Issue 3, 2020 · pp. 1–15 Read article
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Simple, Direct and Stability-Indicating UV Spectrophotometric Assay of Pioglitazone Hydrochloride in Pharmaceuticals
Abstract: Pioglitazone hydrochloride (PGH) is an antihyperglycemic agent used in the treatment of type-2 diabetes mellitus. A simple and straight forward UV-spectrophotometric method is presented for the determination of PGH in bulk drug and tablets by measuring the absorbance of drug solution in 0.1M H2SO4 at 269 nm. A plot of absorbance versus concentration obeyed Beer’s law over 2–36 µg ml-1 concentration range (r = 0.9981) with a molar absorptivity of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 3, 2017 · pp. 7–16 Read article
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Analytical Method Development and Validation for Estimation of Brisoprolol Fumerate in Bulk and Pharmaceutical Dosage Form by UV Spectrometric Method
Abstract: The objective of the present work is to develop a new, rapid, simple, economical, precise, sensitive, linear and accurate, UV Spectrophotometric method has been developed. Phosphate buffer of pH 6.8 is used as solvent for the estimation of Brisoprolol Fumerate bulk and pharmaceutical formulation as per ICH guidelines. Spiked Brisoprolol Fumerate was checked over UV-visible extend for its wavelength of greatest absorbance. The wavelength of most extreme absorbance for Brisoprolol …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 1, 2022 · pp. 34–40 Read article
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Determination of the Antidiabetic Drug Miglitol in Pharmaceuticals by Ultra-Performance Liquid Chromatography
Abstract: Miglitol (MGL) is a drug used in the treatment of type-2 diabetes mellitus. A new analytical method employing ultra-performance liquid chromatography (UPLC) with UV-detection is presented for the determination of MGL in bulk drug and tablet forms. Analysis was performed in less than 3 min in isocratic mode on a reversed phase BEH C18 (100 mm × 2.1 mm; 1.7 µm particle size) column using phosphate buffer of pH 3.7-acetonitrile …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 9, Issue 2, 2018 · pp. 11–26 Read article
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Method Development and Validation for the Simultaneous Estimation of Ertugliflozin and Sitagliptin in Bulk and Tablet Dosage Form by using HPLC.
Abstract: A simple, Accurate, precise method was developed for the simultaneous estimation of the Ertugliflozin and Sitagliptin in bulk and tablet dosage form. Chromatogram was run through DIKMA Spursil C18 column (4.6 mm x 150mm, 3.0 µm). Mobile phase containing KH2PO4: Methanol (45: 55) was pumped through column at a flow rate of 1ml/min. Temperature was maintained at Ambient. Optimized wavelength for Ertugliflozin and Sitagliptin was 225 nm. Retention time of …
Published in Trends in Drug Delivery · Vol. 8, Issue 3, 2023 · pp. 40–49 Read article
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Method Development and Validation for Estimation of Brisoprolol Fumerate by UV Spectrometric Method using 0.01N HCl as Solvent
Abstract: The objective of the present work is to develop a new, simple, economical, precise, sensitive, linear, accurate, rapid UV Spectrophotometeric method has been developed, solvent used 0.1 N HCl, for the estimation of Brisoprolol Fumerate bulk and pharmaceutical formulation as per ICH guidelines. Spiked Brisoprolol Fumerate arrangement was checked over UV-visible extend for its wavelength of greatest absorbance. The wavelength of most extreme absorbance for Brisoprolol Fumerate was found to …
Published in Trends in Drug Delivery · Vol. 9, Issue 1, 2022 · pp. 69–74 Read article