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30 articles for “Mycobacterium tuberculosis”
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Breakthroughs in Biotechnology for the Regulation of Infectious Diseases
Abstract: Infectious diseases have a heavy impact on both public health and the world’s economies. In most diseases, antibiotic resistance has become widespread over time. A variety of diseases comprising pneumonia, tuberculosis, and gonorrhea go through the same evolutionary processes, which include the formation of drug-resistant pathogens in response to selection pressure from medications and their potential extinction when drug use is ceased. Since the occurrence of drug resistance in serious …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 1, 2025 · pp. 1–25 Read article
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Bedaquiline: An In-Depth Exploration into Its Antitubercular Significance
Abstract: Tuberculosis is still a leading infectious disease and a major threat to public health. Although there has been a slow decrease in the incidence over years, its “hard to kill nature” is responsible of about 2 million deaths in HIV infected individuals annually. Bedaquiline, a Diaryl-Quinoline drug was fast-track approved as an orphan drug to combat drug resistance. It shows potent activity against Mycobacterium tuberculosis by interfering with the production …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 06–14 Read article
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Host-Pathogen Coevolution: Implications for Immune Evasion and Pathogen Fitness
Abstract: The interaction between hosts and pathogens represents a continuous evolutionary struggle, shaping both microbial virulence and host immunity. Pathogens employ diverse strategies to evade immune surveillance, ranging from antigenic variation and molecular mimicry to hijacking of host immune checkpoints. Simultaneously, hosts refine innate and adaptive immune mechanisms to counteract infection and limit damage. This reciprocal adaptation, known as host–pathogen coevolution, influences pathogen persistence, transmission, and fitness, while also sculpting immune …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 6–10 Read article
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Understanding Airborne Pathogens: Pathways, Risks, and Control Strategies
Abstract: Airborne transmission is the transfer of germs through the air, mostly by respiratory droplets and aerosols that come out when you cough, sneeze, talk, or breathe. These particles can stay in the air for a long time and move a long way, especially in small or poorly ventilated places. Mycobacterium tuberculosis, measles virus, varicella-zoster virus (chickenpox), influenza virus, and more recently, SARS-CoV-2 are all infections that can be spread through …
Published in International Journal of Pathogens · Vol. 2, Issue 2, 2025 Read article
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Vaccines Through Time: Conventional Foundations and Next-Gen Innovations–Part 1
Abstract: Vaccination serves as a critical pillar of global public health, markedly decreasing infection rates and associated mortality. Traditional vaccine platforms such as live attenuated, inactivated, toxoid, and subunit vaccines have demonstrated effectiveness against pathogens like Mycobacterium tuberculosis and Plasmodium spp., yet they are constrained by antigenic variability, limited immune persistence, and complex production processes. Breakthroughs in synthetic biology, structural antigen design, and computational vaccinology have driven the development of advanced …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 16, Issue 1, 2026 · pp. 53–70 Read article
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Host Invasion to Immune Evasion: Emerging Concepts in Pathogen Virulence Strategies
Abstract: The interaction between hosts and pathogens represents a continuous evolutionary struggle, shaping both microbial virulence and host immunity. Pathogens employ diverse strategies to evade immune surveillance, ranging from antigenic variation and molecular mimicry to hijacking of host immune checkpoints. Simultaneously, hosts refine innate and adaptive immune mechanisms to counteract infection and limit damage. This reciprocal adaptation, known as host–pathogen coevolution, influences pathogen persistence, transmission, and fitness, while also sculpting immune …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 Read article
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Bacteriological and Yeast Profile in Clinical Samples from Immunocompromised Persons (Especially in HIV and Cancer Patients) and Their Antimicrobial Susceptibility Pattern
Abstract: AbstractImmunocompromised host describes a patient who is on increased risk to acquire infection due to congenital or acquired abnormality of the immune system. In the past few decades, the population of immunocompromised hosts has expanded enormously, due to the increased use of immunosuppressive conditions like HIV, cancer, etc. This study was planned to know the spectrum of organisms and trend of antimicrobial susceptibility pattern in immunocompromised patients. All hospitalized patients …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 7, Issue 1, 2017 · pp. 1–8 Read article
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Comparative Genomics of Heat Shock Protein in Pathogenic Bacteria
Abstract: Genome comparison has recently become a common research topic in computer science. The development of computer-assisted mathematics (using products such as Mathematica or Matlab) has helped engineers, mathematicians, and computer scientists to start operating in this domain, and a public collection of case studies and demonstrations is growing, ranging from whole genome comparisons to gene expression analysis. This has increased the introduction of different ideas, including concepts from systems and …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 1, Issue 2, 2014 · pp. 19–34 Read article
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A Study to Evaluate Nurse Led Intervention Regarding Home Care Management Among Tuberculosis Patients Attending Chest and TB OPD at PGIMS Rohtak
Abstract: Introduction: Tuberculosis is an infectious bacterial pathogen caused by the bacillus called Mycobacteriumtuberculosis, an acid-fast rode shaped bacillus 0.8–5 μm in length and 0.2–0.6 μm in thickness. Tuberculosis (TB) primarily impacts the lungs (pulmonary TB), but it can also affect other parts of the body (extra-pulmonary TB). It spreads through the air and causes damage to the lungs and various other organs. TB is a significant public health issue in …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 31–36 Read article
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Molecular Characterization of Environmental and Clinical Non Tuberculous Mycobacteria Isolates from Copper Mines and Miners in Zambia
Abstract: Background: The active and ex-miners have high risk factors for Non Tuberculous Mycobacteria (NTM) disease due to the high burden of Human Immunodeficiency Virus (HIV) infection, tuberculosis and silicosis through extensive use of aerosolised water for dust control in the mining environment. The study aimed at the isolation and characterization of nontuberculous mycobacteria from the miners and ex-miners in Zambia. Methods: Sputum samples were collected from 85 miners and ex-miners132 …
Published in Research and Reviews : A Journal of Immunology · Vol. 13, Issue 3, 2023 · pp. 30–39 Read article