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248 articles for “Inhibitor”
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Cardiotoxicity Associated with Tyrosine Kinase Inhibitors in Philadelphia Chromosome-Positive Leukemias: An Overview of Mechanisms, Clinical Implications, and Management Strategies
Abstract: Tyrosine kinase inhibitors have greatly enhanced the outlook for individuals diagnosed with Philadelphia chromosome-positive leukemias, including chronic myeloid leukemia and acute lymphoblastic leukemia. However, these therapeutic agents are associated with Cardiotoxicities and can manifest as left ventricular dysfunction, which may progress to heart failure, along with electrocardiographic abnormalities, dysrhythmias, hypertension, myocardial ischemia, and thromboembolic events. The unclear frequency of drug-induced cardiovascular complications, coupled with uncertainties regarding their reversibility and long-term …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 18–24 Read article
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Guanidine as a Starting Material for Preparing a Scale Inhibitor
Abstract: Oilfield scale inhibition, which can obstruct fluid flow in pipelines, valves, and pumps during oil production and processing, is critical for preventing scale formation. Effective scale inhibitors (SIs) minimize downtime and enhance productivity by preventing the build-up of insoluble crystals in water systems. In oil processing, scale formation results from the precipitation of salts due to incompatible aqueous phases, leading to equipment blockage. Phosphonates are highly effective chelating agents for …
Published in Journal of Petroleum Engineering & Technology · Vol. 16, Issue 1, 2026 · pp. 15–28 Read article
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Molecular Docking Studies for the Identification of Mycobacterial Adenosine Triphosphate (ATP) Synthase Inhibitors Using Active Phytocompounds from Plants Curcuma longa, Curcuma zedoaria and Galipea officinalis
Abstract: Objective: Tuberculosis (TB), known in human history for several decades, remains the second leading infectious disease after COVID-19. Still, the occurrence of TB increases due to the bacterium’s greater survival nature. They can survive in extreme conditions by being in long latency and adapting to the host. This study seeks to identify potential inhibitors from Curcuma longa, Curcuma zeodaria, and Galipea officinalis based on ancient folklore and compare them against …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 16–26 Read article
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Exploring the Potential of Allium sativum Phytocompounds as B-Cell Leukemia 2 Inhibitors in Acute Lymphoblastic Leukemia: Molecular Docking Study
Abstract: Objective: Acute lymphoblastic leukemia (ALL) is a lymphoid progenitor cell malignancy that could be treated with plant-based drugs, thus alleviating the off-target effects caused by conventional chemotherapy. Since ancient days, Allium sativum has been an integral part of traditional medicine and an excellent antimicrobial, antioxidant, and antiproliferative agent. Hence, this study aims to assess the anti-leukemic potential of A. sativum phytoconstituents as the B-cell leukemia 2 protein (Bcl-2) natural inhibitor …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 53–80 Read article
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Corrosion Inhibition of Mild Steel in Acidic Medium using Essential Oil of Clove (Syzygium aromaticum) as Inhibitor
Abstract: This research work deployed a weight loss technique in evaluating the feasibility and efficiency of using essential oil of clove as corrosion inhibitor due to its anti-oxidant properties. Prepared sample of mild steel was exposed to acidic medium in the absence of inhibitor and the corrosion rate was evaluated. Subsequently, other samples of the same mild steel were exposed to acidic environment in the presence of varied concentrations of the …
Published in Journal of Catalyst & Catalysis · Vol. 4, Issue 1, 2017 · pp. 30–36 Read article
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Eco-friendly Corrosion Inhibitors for N80 Steel in Hydrochloric Acid
Abstract: An important method of protecting metallic materials against deterioration due to acid corrosion is by the use of corrosion inhibitors. In the present investigation, corrosion inhibition study of two compounds,1-(2-hydroxyethyl)-2-ethylimidazoline(Inh I) and 1-(2-hydroxyethyl)-2-decylimidazoline (Inh II) have been performed for oil-well tubular steel (N80) in 15% HCl using weight loss, electrochemical polarization, AC impedance and SEM. The inhibition efficiencies of the inhibitors follow the sequence, Inh II > Inh I. The …
Published in Journal of Materials & Metallurgical Engineering · Vol. 2, Issue 1-3, 2012 · pp. 71–83 Read article
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Computational Identification of Protein Tyrosine Phospatase-1B (PTP-1B) Inhibitors for Checking Type II Diabetes
Abstract: Protein tyrosine phosphatases (PTPs) are a family of enzyme that comprises of about 100 proteins which catalyze dephosphorylation of phosphotyrosine residues in protein substrates. Phosphotyrosine is a central element in cell signaling, and its activity is essential for cellular homeostasis and for appropriate responses to extracellular signals. PTP-1B antagonizes insulin signaling by reducing the activation state of the insulin receptor kinase, thereby inhibiting post-receptor signaling in insulin responsive tissue. The …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 6, Issue 3, 2017 · pp. 21–25 Read article
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Exploration of 5-Hydroxybowdichione Flavonoids As Inhibitors of Dengue Virus Ns5 RNA-Dependent RNA Polymerase Using Molecular Docking Approach
Abstract: Objectives: Human lives are now seriously threatened by dengue fever, which is brought on by the dengue virus (DENV). Aedes aegypti mosquitoes, which reproduce in still water, are the primary vectors of the arboviral virus known as dengue. It is well-recognized that phytochemicals have a high potential to eliminate bacterial, viral, and fungal infections in people. Thus, it demonstrates its inhibitory effects on the dengue virus. This study identifies some …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 1–16 Read article
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Synthesis and Study of Different Thioamides as Corrosion Inhibitors
Abstract: Many organic compounds having electron rich atoms in their structures, such as nitrogen, and sulphur are widely use in lubricating additives, in the oil industry to minimize corrosion. The presence of electron rich atoms in the molecules increases its ability to form coordinate covalent bonds with the metal atoms, involved in the corrosion environment. Compounds based on fatty amines, aromatic amines, imidazoline, diamidazoline, and fatty amides are now, uses as …
Published in Journal of Catalyst & Catalysis · Vol. 3, Issue 3, 2016 · pp. 18–25 Read article
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Studies of Environmental Effect of Aluminium-2014 Alloy in 1m Acetic Acid using Extratcted Inhibitor
Abstract: AbstractThis examination considers distinctive natural elements influencing consumption under marine inundation conditions and proposes a scientific model consolidating their impacts on erosion corruption through the boat life. The examination receives a nonlinear capacity of time as the reference erosion model aligned with operational consumption information at long haul normal conditions to speak to the erosion conduct under standard natural conditions.Based on recently acquired field information, an erosion disintegration model is …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 10, Issue 2, 2020 · pp. 19–26 Read article
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Bio Solvent EOR: Performance Assessment of Plant Extracts as Asphaltene Inhibitor
Abstract: Changes in pressure and temperature during oil production and transportation most notably during CO2 injection for enhanced recovery could lead to changes in the oil composition and deposition of asphaltene. Deposition of asphaltene near the wellbore region, production tubing and production facilities could cause severe flow assurance problem. Physical removal of asphaltene is costly and in most cases it is not preferred. A more favorable option is to prevent the …
Published in Journal of Petroleum Engineering & Technology · Vol. 5, Issue 1, 2015 · pp. 9–24 Read article
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Corrosion Inhibition Effect of 1-(4-Methoxy-phenyl)-3-(5-phenyl-1,3,4-oxadiazol-2-yl) propan-1-one Inhibitor for Mild Steel in 1 M HCl Solution
Abstract: The environmental friendly 1-(4-Methoxy-phenyl)-3-(5-phenyl-1,3,4-oxadiazol-2-yl) propan-1-one (A1) inhibitor is synthesized and their corrosion inhibition for Mild Steel in a 1 M HCl solution was studied using weight loss methods, electrochemical measurements, and the surface morphology of mild steel with and without inhibitor were studied using scanning electron microscopy (SEM) analysis. As the concentration of the inhibitor was increased the inhibition efficacy of 1-(4-Methoxy-phenyl)-3-(5-phenyl-1, 3, 4-oxadiazol-2-yl) propan-1-one was also enhanced and on …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 8, Issue 2, 2021 · pp. 31–37 Read article
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Performance Evaluation of Green Walnut Husk Waste Extract for Inhibiting Aluminium 8088 Corrosion in Acidic Solution
Abstract: The cumulative call for environmental and supportable corrosion inhibitors has obsessed curiosity in exploiting plant-based agronomic surplus resources. Presented research work discovers the corrosion inhibition probable of green walnut husk extract(GWH)—a normal and plentiful agro-waste—on Aluminium 8088 alloy in an acidic medium. Aluminium 8088, however identified for its corrosion resistance, is vulnerable to squalor in highly acidic settings, affectation trials in several industrial claims. GWH extract act as an ecologically …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 1, 2026 · pp. 44–60 Read article
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Inhibitory Potentials of Datura Metel to Prevent Mild Corrosion
Abstract: The resistance of mild steel to corrosion was evaluated by immersing it in well water and determining the weight it lost after being allowed to return to room temperature after the submersion. The effectiveness of mild steel's ability to withstand corrosion was evaluated using this approach. A reduction in total body mass has an influence that is connected to and helps play a role in the prevention of rusting from …
Published in Journal of Polymer & Composites Read article
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Evaluating the Influence of Temperature on the Efficacy of Capparis Decidua Extract as a Corrosion Inhibitor for Aluminium in Acidic Media
Abstract: The study investigates the anti-corrosive properties of the ethanolic extract of Capparis decidua fruit on aluminum corrosion in a 2N HCl acid solution, using a weight loss technique at temperatures ranging from 303 to 343 K. At a concentration of 0.45%, the inhibition efficiency (η%) is notably high, reaching 63.15% at 303 K. The inhibitor's adsorption behavior on the aluminum surface is consistent with the Langmuir adsorption isotherm, suggesting that …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 3, 2024 · pp. 58–65 Read article
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In Silico Analysis and Molecular Docking Studies of COX-2 Inhibitors for Anti-Inflammatory Activity
Abstract: Although nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to treat pain, lower fevers, and control inflammation, they frequently cause gastrointestinal side effects because they inhibit the COX-1 and COX-2 enzymes. Despite their effectiveness and lack of gastrointestinal side effects, selective COX-2 inhibitors have been linked to cardiovascular risks. To find new COX-2 inhibitors that are safer and more effective, this study uses in silico techniques, such as molecular docking and …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 38–55 Read article
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Nitrosamine Accumulation, Processing Variables, and Indigenous Plant Inhibitors in Nigerian Traditionally Processed Meats
Abstract: N-nitrosamines are classified as probable or possible human carcinogens by the International Agency for Research on Cancer. Carcinogenic N-nitrosamines — principally N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) — are formed in abundance during the preparation of widely consumed Nigerian traditional processed meats including suya, kilishi, and balangu. This original investigation combined a six geopolitical zone of Nigerian market survey with laboratory-controlled model system experiments, effects of processing parameters on N-Nitrosamine formation …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 1, 2026 · pp. 61–72 Read article
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Evaluating Novel Inhibitor Pigment Blends using Electrochemical Scanning Techniques (EIS, SVET and SKP)
Abstract: AbstractOne of the main applications coming to the fore for scanning vibrating electrode technique (SVET) and scanning Kelvin probe (SKP) systems is ability to look at inhibitor combinations, which could be used to replace chromates in coil-coated galvanized steels. The results are very promising using the SVET system and results with the SKP system also show results to be comparable with the SVET system. Electrochemical impedance spectroscopy (EIS) is also …
Published in Journal of Polymer & Composites · Vol. 1, Issue 1, 2013 · pp. 6–16 Read article
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Effect of Temperature on Inhibitory Efficacy of Tamarindus indica fruit extract on acid corrosion of Aluminium
Abstract: An attempt has been made to investigate the anti-corrosive propensity of ethanolic extract of Tamarindus indica fruit at elevated temperature between 303 to 343 K, so as to replace the exploitation of toxic chemicals as corrosion inhibitors. Inhibition efficiency has been observed significantly high (84.06%) at room temperature at concentration 0.45 %. The inhibition efficiency is found to increase with increasing concentration of extract and decrease with rise in temperature. …
Published in Recent Trends in Fluid Mechanics · Vol. 10, Issue 3, 2023 · pp. 42–50 Read article
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In Silico Identification of Antimalarial Drug Targets and Screening of Potential Inhibitors in Plasmodium vivax
Abstract: AbstractMalaria is an infectious disease caused by the protozoan of the genus Plasmodium. It is a major problem in third-world countries, with hundreds of millions of infections and millions of fatalities annually. Plasmodium vivax is the most frequent and widely distributed cause of recurring (Benign tertian) malaria. Due to emergence of drug-resistance, one has to explore new dimensions in order to curb the menace. We propose a two-step strategy—first step …
Published in Research and Reviews : Journal of Computational Biology · Vol. 9, Issue 1, 2020 · pp. 52–75 Read article