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31 articles for “DNA damage”
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Aquatic Ecosystems: A Review on Prospecting of Anticancer Molecules from Fungi & Other Microbes
Abstract: Marine biota; namely, actinomycetes, bacteria, fungi, microalgae, green algae, oceanic weeds, mangroves, and other extremophiles constitute about 90% of the oceanic biomass. The organisms are taxonomically diverse, biologically productive/active, and biochemically unique. These unique biochemiques may act as a great source for the discovery of new bioactive molecules, including anticancer drugs. The marines produce medicinally potent biochemicals; namely, sulfated saccharides, polyphenols, and, sterols. Only a few of these alkaloids have …
Published in International Journal of Fungi · Vol. 1, Issue 2, 2024 · pp. 1–22 Read article
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Rotenone Beyond Just An Insecticide: A Review
Abstract: Pesticides have received the most attention due to their global application and widespread implications on human health. In recent years, both epidemiological and toxicological studies have provided evidence that pesticides have the potential to act as toxicants contributing to the development of pathogenesis such as neuronal degenerations as well as may be utilized to induce signalling for reversal, suppress or prevent carcinogenic progression. Rotenone, an isoflavones naturally found in the …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 2, 2014 · pp. 8–13 Read article
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Black Tea: Leveraging Human Health from Indian Perspective
Abstract: Tea, the most preferred drink in the world after water, has been under intense research in recent years due to its fascinating chemical composition. Major polyphenolic compounds— theaflavins (TF), residual catechins, thearubigins as well as theanine and caffeine—present in black tea (BT) contribute to color, distinctive flavor and play significant roles both for quality of tea and act as a safeguard against many ailments. Antioxidants present in BT act against …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 2, 2018 · pp. 53–60 Read article
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Nitric Oxide Synthase (NOS) in Breast Carcinoma
Abstract: Breast cancer is the most alarming problem of the current time. Nitric oxide, a free radical gas is synthesized by isoenzymes called nitric oxide synthase. Nitric oxide synthase consists of three isoforms; Nitric oxide produced is cytotoxic which is known to inhibit the DNA synthesis causing its damage. Keeping this in mind, nitric oxide synthase was determined in breast cancer and normal breast tissue. For this tissue from 60 breast …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 1, 2018 · pp. 23–28 Read article
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Concept of Free Radical Theory in Ayurveda
Abstract: A free radical can be defined as any molecular species capable of independent existence that contains an unpaired electron in an atomic orbital. Free radical is produced as an intermediate product during metabolism of fat, carbohydrates and protein in body. Free radicals are known to attack the structure of cell membranes which then create metabolic waste products. Free radicals are capable of damaging biological entities (due to their unstable and …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 4, Issue 2, 2015 · pp. 36–38 Read article
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Health Implications of Electromagnetic Wave Exposure
Abstract: From low-frequency radio waves to high-frequency gamma rays, electromagnetic waves have a wide range of effects on human health. This diverse subject includes an extensive spectrum of waves. The non-thermal effects of low-frequency waves, such as microwaves, are not completely understood despite the fact that they predominantly represent thermal dangers, which could potentially lead to tissue heating and damage similar to those caused by heating. High-frequency radiation, such as gamma …
Published in Research & Reviews : Journal of Physics · Vol. 13, Issue 1, 2024 · pp. 9–13 Read article
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Development of Antioxidant Based Therapeutics in Unani System of Medicine
Abstract: During the last decades, several studies have examined the potential role of oxidative stress in the development of various diseases like cancer, Parkinson's disease, Alzheimer's disease, atherosclerosis, myocardial infarction, chronic fatigue syndrome etc. Oxidative stress can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Unani system of medicine has a wealth of antioxidants that can …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 5, Issue 3, 2018 · pp. 1–4 Read article
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A Technical Survey on Nanotechnology in Nanorobots
Abstract: Nanotechnology, the manipulation of matter at the atomic and molecular scale, has given rise to a revolutionary frontier: nanorobots – microscopic machines capable of interacting with biological systems and environments with unprecedented precision. This study explores the design, functionality, and application of nanorobots in medicine, environmental remediation, and materials science. By integrating principles from materials engineering, biotechnology, and robotics, nanorobots are engineered to perform tasks such as targeted drug delivery, …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 16, Issue 1, 2026 · pp. 14–21 Read article
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Molecular Docking Studies of Wildtype P53 with Damnacanthal and Scopoletin- Phytochemicals Derived from Morinda Citrifolia
Abstract: Cancer is a prominent cause of mortality globally, and it has the potential to impact any region of the body. The tumor suppressor protein P53 plays a significant role in inhibiting tumor growth by regulating DNA repair, inducing cell cycle arrest, promoting senescence, and triggering apoptosis when confronted with genotoxic stress. P53 is found mutated in 50% of cancers where it loses its tumor suppressive properties and gains oncogenic properties …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 20–31 Read article
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Pyrethroid Mediated Some Macromolecular and Biochemical Changes in Freshwater Teleost
Abstract: Abstract In present investigation, a freshwater fish Channa punctatus was exposed for 21 days to synthetic pyrethroid malathion at sublethal concentrations of 0.007mg L−1 and 0.093 mg L−1 that represented 10% of the 96 h LC50 of the pesticide for this fish. Tissue samples were collected at the end of the experiment and analyzed to determine oxidant/antioxidants status (catalase, LDH, DNA content, protein content, cortisol, etc.) of the fish. Enzyme …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 2, 2020 · pp. 14–21 Read article
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An Integrating Multimodal Technologies and Ethical Frameworks in Addressing Challenges in Modern Wildlife Monitoring
Abstract: Wildlife monitoring plays a crucial role in understanding and conserving biodiversity, but traditional methods often have limitations in scope, accuracy, and ethical impact. Advances in multimodal technologies such as drones, acoustic sensors, environmental DNA (eDNA), and camera traps offer new avenues for gathering rich, non-invasive data. However, the integration of these technologies comes with a range of challenges, particularly in terms of ethical concerns related to animal welfare, data management, …
Published in Journal of Aerospace Engineering & Technology · Vol. 15, Issue 1, 2025 · pp. 1–7 Read article