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108 articles for “Antigen”
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Review of Rasayana Therapy: An Ancient Measure of Improving Immunity
Abstract: Preventive care is need of the era; there are different measures to improve general wellbeing and increasing immunity against disease. In conventional medical system stress is given to developing immunity against specific antigen using vaccination. This system has proved its effectiveness in certain bacterial disease (especially with attenuated vaccines), but in other pathogens it has limitations. The other two varieties of vaccines i.e., dead pathogens or toxoids needs regular or …
Published in Trends in Drug Delivery · Vol. 3, Issue 2, 2016 · pp. 22–24 Read article
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Decoding Innate Immunity: Mechanisms, Components, and Clinical Implication
Abstract: Innate immunology represents the body's first line of defense against pathogens, acting as a rapid, non-specific response to a wide array of microbial invaders. This part of the immune system depends on pattern recognition receptors (PRRs) to identify pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), leading to the activation of immune cells such as macrophages, dendritic cells, and neutrophils. The innate immune system also plays a crucial role …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 2, 2025 Read article
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Nano-Materials in Vaccine Formation and Chemical Formulae’s for Vaccination
Abstract: For centuries, vaccines have been a cornerstone of public health, preventing debilitating and deadly diseases. However, the development and delivery of effective vaccines have always been met with challenges. From stability issues and limited immune response to the need for specific targeting, scientists are constantly seeking innovative approaches to improve vaccine efficacy and accessibility. Enter nanomaterials – minuscule materials with dimensions at the nanoscale – offering a powerful toolkit to …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 15, Issue 3, 2025 · pp. 27–39 Read article
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Modern Vaccines with DIVA Capability: An Overview
Abstract: DIVA vaccines are designed to achieve twin-goals of the immunological protection of the host and the immunological differentiation of the infected from the vaccinated animals (DIVA) with a companion immunodiagnostic test. The DIVA strategy is used in countries that follow the vaccination path for elimination of an infectious disease and ultimately to achieve the disease-free status for international trade. This strategy has also been advocated for and adopted in the …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 1, 2015 · pp. 1–12 Read article
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An Overview of the Human Immune Response
Abstract: This overview of the immune response provides a glimpse of the complexity of the interactions between the cells and mediators of the immune system. The recognition of the innate immune response by microbes and foreign substances leads to the induction of inflammatory and adaptive immune response. when oxidative stress increases, it affects our vital processes such as glucose homeostasis, cellular life-span and inflammation, which contributes to the pathogenesis of many …
Published in Research and Reviews : A Journal of Immunology · Vol. 11, Issue 2, 2021 · pp. 46–62 Read article
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Beyond Chemotherapy: The Promise of Immunotherapy in Cancer Care and Advancements in Cancer Therapy
Abstract: Recent advances in cancer immunotherapy harness the immune system to precisely target cancer. These include the use of immunosuppressive agents, NK cell recovery, changes in tumor microenvironment metabolic, and aging to achieve a positive tumor response The article explores how the body development of the immune system in the late 19th century, highlighting milestones such as the discovery and FDA approval of IL2. Different categories of immunology are explored, from …
Published in Research and Reviews : A Journal of Immunology · Vol. 13, Issue 2, 2023 · pp. 22–37 Read article
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Nanoparticle and Lipid-Based Vaccine Delivery Systems: A Systematic Review of Platforms, Stability, Pharmacokinetics, and Immune Modulation
Abstract: The rapid evolution of vaccine technologies over the past decade has highlighted the transformative role of nanoparticle (NP) and lipid-based delivery systems in modern immunization practices. These platforms – including polymeric nanoparticles, lipid nanoparticles (LNPs), liposomes, nanoemulsions, and solid lipid nanoparticles (SLNs) – enable enhanced antigen stability, improved cellular uptake, targeted antigen delivery, and potent immune activation. This systematic review critically examines the physicochemical foundations, manufacturing approaches, stability challenges, pharmacokinetic …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 18–36 Read article
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Mucosal Vaccines in Fish: Novel Advances in Technology and Delivery: A Review
Abstract: Vaccines rely on the acquired immune system and prime an animal to a particular antigen so that on subsequent encounter; it is recognized and quickly destroyed. The vast majority of pathogens enter the body via the mucosal surfaces of the gastrointestinal, respiratory, and urogenital tracts, where they initiate mucosal infections that lead to systemic infections. There is strong evidence that an optimum mucosal immune response can prevent systemic infection and …
Published in Research and Reviews : A Journal of Immunology · Vol. 9, Issue 1, 2019 · pp. 14–26 Read article
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A Note on Vaccine Design Using Bioinformatics Methods and Applications
Abstract: Vaccines prevent infectious diseases caused by viruses and bacteria saving millions of lives.It consists of certain agents that resemble disease causative agentsand stimulates our immune system to recognize and fight foreign antigens. Immune function or an immune response is the fundamental basis of the vaccine's mechanism. Vaccines are pharmaceutical derivatives that provide an affordable way to prevent diseases.Various bioinformatics approaches can be incorporated into vaccine design studies and development. Reverse …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 1, 2023 · pp. 1–9 Read article
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Complications with Malware Identification in IoT and an Overview of Artificial Immune Approaches
Abstract: An immunity is facilitated by lymphocyte T&B-cells that possess a wide range of T&B-cell receptors, respectively. These cells can identify and react to pathogens and diseased cells by presenting peptide antigens by means of significant histocompatibility complexes (MHCs). The amount of data on the repertoire of adaptive immune receptors has increased dramatically in recent years because to advancements in deep sequencing. Furthermore, the presentation of peptides with MHC has been …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 · pp. 54–62 Read article
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SiRNA-Based Multivalent Vaccines: A Systematic Review of Potential Risks, Benefits, and Future Applications
Abstract: Background: Small interfering RNA (SiRNA) technology represents a promising innovation in vaccine development, especially for multivalent vaccines that can target multiple pathogens or antigenic variants simultaneously. siRNA-based vaccines offer a unique mechanism to induce specific immune responses, presenting an adaptable and potentially powerful tool for tackling infectious diseases and cancer. Methods: This systematic review synthesizes recent studies on siRNA multivalent vaccines, focusing on their immunogenicity, safety, and effectiveness. We reviewed …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 43–49 Read article
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Unmasking Human Metapneumovirus: The Emerging Threat to Vulnerable Populations
Abstract: Human Metapneumovirus (HMPV) is a contagious respiratory virus that commonly spreads among individuals. It can cause serious infections, especially in high-risk groups like infants, older adults, and individuals with weakened immune systems.It is a major contributor to acute respiratory illnesses. Since its discovery in 2001, HMPV has been identified as a common cause of both upper and lower respiratory tract illnesses, with clinical presentations ranging from mild symptoms to severe …
Published in International Journal of Virus Studies · Vol. 2, Issue 1, 2025 · pp. 16–24 Read article
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Role of Pharmaceutical Software in Vaccine Development and Manufacturing Process Optimization
Abstract: Vaccine development and manufacturing have become increasingly complex due to the emergence of diverse vaccine platforms, stringent regulatory expectations, and global demand for safe and effective immunization. Across the vaccine lifecycle – from antigen design and preclinical evaluation to large‑scale manufacturing and post‑marketing surveillance – pharmaceutical software now plays a central role in handling data, optimizing processes, and ensuring regulatory compliance. Software tools support in silico antigen and epitope design, …
Published in International Journal of Vaccines · Vol. 3, Issue 1, 2026 · pp. 1–8 Read article
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Nano-Chemical Revolution in Vaccinology: A Study
Abstract: The development of traditional vaccines, reliant on attenuated pathogens or purified proteins, has historically been limited by slow development timelines, poor stability, and low immunogenicity requiring potent, often non-specific, adjuvants. This synthesis argues that the convergence of nano-material science and meticulous chemical engineering represents the next major paradigm shift in preventative medicine. Nano-materials, particularly Lipid Nanoparticles (LNPs) and various polymeric or inorganic scaffolds, have transitioned from theoretical constructs to essential …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 Read article
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Cell Membrane Immunogens of a Biofilm-producing Staphylococcus aureus Isolate Adjuvanted with Bacterial Chromosomal DNA Are Protective in a Mouse Mastitis Model
Abstract: Biofilm-forming staphylococci have been implicated in persistent bovine udder infections. Prophylactic potential of Staphylococcus aureus biofilm phenotype-associated immunogens in mouse models of systemic, but not intramammary infections has been demonstrated. In the present study, the authors observed protection in a murine model of intramammary infection by two subcutaneous injections at four-week interval of biofilm-forming S. aureus cell membrane antigens mixed with homologous chromosomal DNA as adjuvant, when challenged after eight …
Published in Research and Reviews : A Journal of Immunology · Vol. 3, Issue 3, 2013 · pp. 18–24 Read article
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Aluminum Oxide Nanoparticle-Adjuvanted Pasteurella multocida B:2 Vaccine is Potent and Efficacious and is Able with Keyhole Limpet Hemocyanin as a Marker to Differentiate Infected from Vaccinated Animals (DIVA)
Abstract: Pasteurella multocida B:2 causes hemorrhagic septicemia (HS) in bovines in Asia. For effective implementation of HS control program in India, a safe and efficacious vaccine to provide long lasting protection and allow differentiation of infected from vaccinated animals (DIVA) has to be developed. The objectives of the present study were to develop HS-DIVA vaccine with a companion immunodiagnostic test using keyhole limpet hemocyanin (KLH) as a marker, and to improve …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 2, 2015 · pp. 8–16 Read article
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Progress from the Traditional Vaccines to Novel Rational Vaccine Designs
Abstract: Vaccines are among the most valuable assets for saving human and animal lives. The vaccines discovered and designed on the Pasteurian principles laid the foundations of the traditional vaccine regime during the late-19th century. Some traditional vaccine designs proved remarkably successful, while others had safety or efficacy problems, and still others failed- particularly those against diseases caused by non-cultivable, hyper-variable or opportunist pathogens, or those requiring cellular immunity. The problems …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 3, 2016 · pp. 17–31 Read article
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Subclinical Significant High Serum Immunoglobulin E Response to 20 Allergens: Age and Gender Based Study
Abstract: Background: Antigen-immunoglobulin E (IgE) reaction is an example of immediate allergic reactions. High serum IgE levels were reported in many diseases that linked to the multiple allergens. Objectives: This study aimed to measure the serum IgE against 20 allergens in patients who had a previous history of allergy due to unidentified precipitating factors. Methods: This retrospective study was conducted at the Al Zahraa Consultant Center for Allergy and Asthma that …
Published in Research and Reviews : A Journal of Immunology · Vol. 9, Issue 3, 2019 · pp. 1–6 Read article
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A Review on Current Scenario and Update on Vaccine for Covid-19
Abstract: Background: COVID-19 pandemic is caused by SARS-CoV-2 . The SARS-CoV-2 is a beta coronavirus belonging to the family of Coronaviridae. The outbreak of novel coronavirus had a major impact on health care professionals like physicians, pharmacist, microbiologist etc. Current scenario of detection of SARS-CoV-2(COVID-19) is made through a nasopharyngeal swab based on RT-PCR technique. Some novel recent studies suggest the evidence of the possible role of fluid which is present …
Published in Research and Reviews : A Journal of Immunology · Vol. 10, Issue 3, 2020 · pp. 1–7 Read article
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Role of Natural Immunity Boosters
Abstract: Our immune system has the capacity to hit upon dangerous microorganisms and viruses that input our frame—those cells, additionally called antigens, assault them with the aid of using producing ‘antibodies’. Therefore, it is far vital to take immunity booster ingredients to reinforce the frame in opposition to COVID-19 infections. A movement or substance makes something more potent or extra effective. In scientific phrases, a booster dose is a supplementary dose …
Published in Research and Reviews : A Journal of Immunology · Vol. 12, Issue 1, 2022 · pp. 16–22 Read article