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478 articles for “ADME”
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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3D-Printed Polymeric Drug Delivery Systems for Personalized Medicine
Abstract: Personalized medicine has revolutionized healthcare by tailoring treatments to individual patient needs. Among the emerging technologies, 3D printing has demonstrated immense potential in fabricating polymeric drug delivery systems with precise control over drug release, dosage, and bioavailability. These systems offer customized therapeutic solutions, improving efficacy while reducing adverse effects. This paper provides an overview of 3D-printed polymeric drug delivery systems, discussing the types of polymers used, fabrication techniques, applications in …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 313–325 Read article
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Vaccines in the Fight Against COVID-19: Mechanisms, Efficacy, and Global Challenges
Abstract: The SARS-CoV-2 pandemic has created an unparalleled public health problem, necessitating comprehensive prevention. This page discusses COVID-19's evolution, scientific understanding, and quick vaccine production and implementation. It compares the mechanisms, efficacy, and safety profiles of the four major types of COVID-19 vaccines—namely mRNA, viral vector, protein subunit, and inactivated virus vaccines. Each type is evaluated in terms of how it stimulates the immune response, its effectiveness in preventing infection or …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 34–48 Read article
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Prevalence and Risk Factors of Neglected Tropical Diseases Among Women and Children in Rural Liberia: A Regional Perspective
Abstract: Neglected Tropical Diseases (NTDs) remain a critical public health challenge in Liberia, disproportionately affecting women and children in rural regions due to systemic inequities in water, sanitation, and healthcare access. This cross-sectional study assessed the prevalence and risk factors of NTDs among 1,000 participants (600 children above 15 years and 400 women aged 15–49) in rural Liberia using stratified and cluster sampling. Laboratory diagnostics, including Kato-Katz stool analysis, urine filtration, …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 1–7 Read article
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Quality Sustainability Of Recycled High Density Polyethylene (HDPE)
Abstract: The main way to reduce the generated large amounts of polymer waste is their recycling, their return to the processes of processing and reuse. The main and most commonly used method is mechanical recycling, in which some of the characteristics of the processed material deteriorate. It is known that the properties of the recyclate are most significantly affected by the homogeneity and the degree of aging of the end-of-life plastic …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 28–37 Read article
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Judicial Oversight of Biometric Evidence and The Role of Polymer and Composite Technologies in Indian Criminal Trials
Abstract: This paper critically looks at changes that have taken place in the role of forensic science in the remodeled Indian criminal justice system and how the modern law has deviated since the colonial laws. With the changing of reformatory model of justice to a more balanced one that suggests fairness and due process, the study lends weight to the increasing cases of clarity, consistency and control in the field of …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 141–152 Read article
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Harnessing Polymer Chemistry for Pharmaceutical Technology
Abstract: Polymer chemistry has emerged as a cornerstone of modern pharmaceutical technology, offering unprecedented control over drug formulation, delivery, and therapeutic performance. This review highlights the pivotal role of polymers—both synthetic and natural—in revolutionizing drug delivery systems across various routes, including oral, parenteral, transdermal, ocular, nasal, and pulmonary administration. Special emphasis is placed on the structural and functional versatility of polymers, which allows for tailored drug release profiles, enhanced bioavailability, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1–6 Read article
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Exploring Oroxylum indicum Phytochemicals as VEGFR-2 Inhibitors: A Molecular Docking Approach for Cancer Management
Abstract: Cancer is still a major health problem around the world and is one of the top causes of death. A protein called VEGFR-2 (vascular endothelial growth factor receptor 2) is important because it helps blood vessels grow by supporting the survival, movement, and growth of certain cells. This process is essential for tumors to grow and spread to other parts of the body. This study focused on evaluating the binding …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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A study on Public Perception and self-medication practices with Over-the-counter (OTC) Drugs
Abstract: Over-the-counter (OTC) medications are commonly used by individuals for self-medication due to their easy availability and the general belief that they are safe. However, misuse can lead to negative health outcomes such as adverse reactions, drug interactions, and delays in seeking professional medical care. In a country like India, where enforcement of drug regulations can vary and socioeconomic factors play a major role, the practice of self-medication is especially widespread. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 01–07 Read article
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Review article on Quality Control in Clinical Trials
Abstract: Quality control (QC) is a critical component in the conduct of clinical trials, ensuring the accuracy, reliability, and credibility of data collected throughout the study. It encompasses a systematic set of procedures designed to monitor trial conduct and data integrity, thus safeguarding the rights, safety, and well-being of participants. This review explores the principles, implementation, and evolving practices of quality control in clinical trials, highlighting its importance across all phases …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 01–07 Read article
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A Study on Smart Healthcare Innovations
Abstract: The desire for effective, patient-centred solutions and the rapid growth of technology are driving forces in the healthcare industry. The term "smart healthcare innovation" refers to a broad category of approaches, tools, and procedures that are intended to improve patient outcomes, optimize resource use, and enhance overall healthcare delivery. These innovations integrate cutting-edge technologies such as artificial intelligence (AI), the Internet of Things (IoT), wearable devices, big data analytics, and …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 2, 2025 · pp. 63–68 Read article
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In silico Molecular Docking Analysis of Stephania glabra phytocompounds Targeting Thymidylate Kinase for potential Antituberculosis Activity
Abstract: Tuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis. It mainly affects the lungs and spreads through the air when a person with active TB in their lungs coughs, sneezes, or spits. This study investigates several bioactive compounds derived from plants to forecast how effective plant-based ligands will be at preventing tuberculosis. The purpose of the study was to use computational techniques to assess the effectiveness of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 Read article
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Carboxymethyl Cellulose-Based Spray-Dried Microspheres: Recent Advances and Applications in Targeted Drug Delivery Systems
Abstract: Microspheres are spherical particles ranging from 1 to 1000 μm, made from natural or synthetic polymers and inorganic materials. Their structure allows precise drug delivery, improving targeted release and minimizing off-target effects. Natural polymers such as starch, chitosan, and alginate are favored for their biodegradability, adhesion, and compatibility, enhancing mucosal interaction and residence time. Microspheres are widely used in site-specific drug delivery, gene therapy, and vaccine administration, improving immunogenicity, extending …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 251–268 Read article
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Artificial Intelligence and the Future of Education
Abstract: Artificial Intelligence (AI) refers to the capability of a computer system to mimic human intelligence by performing tasks such as learning, reasoning, problem-solving, and decision-making. As a rapidly evolving and emerging technology, AI holds the potential to transform a wide range of sectors, including healthcare, transportation, business, and notably, education. Its application in the educational domain is gaining momentum, aiming to create more efficient, engaging, and personalized learning environments. Incorporating …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 3, 2025 · pp. 39–44 Read article
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Role of Artificial Intelligence in Transforming Personalized Learning in Education
Abstract: Artificial Intelligence (AI) is revolutionizing personalized education by tailoring learning experiences to meet each student's unique needs. Through advanced algorithms, AI can adapt educational content to align with individual learning speeds, preferences, and styles. Technologies such as adaptive learning systems, smart tutoring tools, and AI-powered assessments offer instant feedback and assist teachers in quickly identifying areas where students may be struggling. Additionally, predictive analytics help anticipate student outcomes, enabling early …
Published in Journal of Multimedia Technology & Recent Advancements · Vol. 12, Issue 3, 2025 · pp. 27–32 Read article
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A Comprehensive Review of Guillain-Barré Syndrome (GBS)
Abstract: The rare but potentially life-threatening immune-mediated condition dubbed Guillain-Barré syndrome (GBS) impacts the peripheral nerves and nerve roots and is generally brought on by infections. As was the scenario during the Zika virus outbreaks in Latin America (2015) and French Polynesia (2013), the incidence of GBS may consequently escalate during influenza outbreaks. Considering GBS’s clinical features and ailments course are multiple and there are currently no global clinical guidelines, the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 3, 2025 · pp. 1–5 Read article
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Agra’s Taj Mahal
Abstract: The Taj Mahal, situated in Agra, India, stands as one of the most iconic monuments in the world, a testament to Mughal architecture, art, and cultural legacy. Built in the 17th century by Emperor Shah Jahan in memory of his wife Mumtaz Mahal, the mausoleum exemplifies the zenith of Indo-Islamic architectural design. This article explores the historical, architectural, and symbolic significance of the Taj Mahal, delving into its intricate craftsmanship, …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 15, Issue 3, 2025 · pp. 11–19 Read article
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Adaptive Routing Protocol to Optimize the Quality of Service of MANET Using Neural Network
Abstract: A MANET is a group of mobile nodes that create a temporary network without relying on centralized administration or standard supporting devices, often functioning as a conventional network. These dynamic environments present significant challenges for traditional routing and switching protocols, particularly in delivering Quality of Service (QoS) benchmarks such as bandwidth, latency, packet delivery ratio, and robustness. This study proposes an Adaptive Routing Protocol (ARP) leveraging Neural Network (NN) techniques …
Published in Journal of Mobile Computing, Communications & Mobile Networks · Vol. 12, Issue 3, 2025 · pp. 01–09 Read article
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DR. REVIVE: An AI-Powered Medical Recommendation System for Optimised Resources and Improved Patient Care
Abstract: Dr. Revive is an AI-powered medical recommendation system designed to enhance virtual healthcare interactions by connecting patients, doctors, and healthcare stakeholders. Leveraging advanced machine learning algorithms, it analyses user-reported symptoms to provide initial medical recommendations, serving as a reliable first point of guidance. With access to a comprehensive medical database, the platform delivers accurate and timely advice, empowering patients while supporting healthcare professionals with data-driven decision-making. By offering a complete …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 3, 2024 · pp. 1–10 Read article
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Exploring Recent Advancements in Nanomedicine for Tumor Microenvironmental Tissue Engineering
Abstract: The combination of tissue engineering and nanomedicine is transforming cancer treatment by offering creative ways to get around problems with conventional therapies. Recent developments in nanomedicine are examined in this review, with an emphasis on how they might be used to comprehend and control the tumor microenvironment (TME), a dynamic and complex environment that has a major impact on the course of cancer and the effectiveness of treatment. Targeted interactions …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 122–136 Read article