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1375 articles for “Pre-clinical”
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STRUCTURAL–EPIGENOMIC ATLAS: CNV/SV- DRIVEN PROGNOSTIC REFINEMENT ACROSS CANCERS
Abstract: Structural genomic alterations, including copy number variations (CNVs) and structural variants (SVs), play a central role in cancer initiation and progression. These alterations extend beyond gene dosage effects and interact dynamically with epigenomic mechanisms such as DNA methylation, histone modifications, and three-dimensional chromatin organization. Recent pan-cancer studies have demonstrated that CNV burden and SV signatures reflect key oncogenic processes including chromothripsis, homologous recombination deficiency, enhancer hijacking, and extrachromosomal DNA (ecDNA) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 1, 2026 · pp. 35–43 Read article
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
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A Descriptive study to assess the prevalence of Nomophobia among Nursing students in Chirayu College of Nursing Bhopal (MP).
Abstract: Nomophobia, defined as the fear or anxiety of being without access to a mobile phone, has emerged as a growing behavioral concern in the digital age, particularly among young adults. Nursing students are especially vulnerable due to their extensive reliance on smartphones for academic, clinical, and social purposes. The present descriptive study was conducted to assess the prevalence of nomophobia among nursing students at Chirayu College of Nursing, Bhopal (Madhya …
Published in Journal of Nursing Science & Practice · Vol. 16, Issue 1, 2026 · pp. 36–41 Read article
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Episiotomy in Nellore Brown Ewe Successfully Relieved Dystocia Due to Vulvo Vestibular Constriction
Abstract: A full term pregnant, primiparous ewe was presented to the Department of Veterinary Clinical Complex, College of Veterinary Science, Proddatur with the history of non-progressive straining persisting for the past 24 hours. The owner reported that attempts had previously been made by local quacks to assist in the delivery, but all the efforts proved unsuccessful, and the condition remained unresolved. The ewe had not shown any signs of improvement following …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 2, 2025 · pp. 30–34 Read article
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Necrotizing Enterocolitis (NEC): A Devastating Neonatal Gastrointestinal Disorder
Abstract: Necrotizing enterocolitis (NEC) represents a formidable challenge in neonatal medicine, particularly afflicting premature infants with its characteristic features of severe intestinal inflammation and necrosis. Despite advancements in neonatal care, NEC continues to exact a heavy toll, standing as a prominent cause of morbidity and mortality in this vulnerable population. Its multifaceted etiology, encompassing prematurity, enteral feeding practices, alterations in microbial colonization, and episodes of intestinal ischemia, underscores the complexity of …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 2, 2024 · pp. 78–83 Read article
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Role of ABCDE Rule in Wound Assessment
Abstract: The diagnosis of chronic wounds poses an interdisciplinary and interprofessional challenge. In routine clinical practice, the appropriate diagnostic workup is frequently carried out insufficiently. In addition to financial obstacles, those involved in the process often lack the required knowledge, a circumstance that must be overcome. Today, the treatment of patients with chronic wounds is thus, commonly, merely symptomatic and frequently not accompanied by determination of the exact cause. The ABCDE …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 3, 2024 Read article
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Comprehensive Evaluation of Quercetin from Bauhinia purpurea for Its Anti-Acne and Anti-Inflammatory Potential, Including Advances in Quercetin-Loaded Nanogel Formulation
Abstract: Acne vulgaris is among the most prevalent chronic inflammatory dermatoses in clinical dermatology, afflicting a substantial proportion of the global adolescent and adult population. Conventional pharmacotherapies — including topical retinoids, benzoyl peroxide, and systemic antibiotics — remain the therapeutic mainstay; however, their long-term utility is progressively undermined by adverse cutaneous reactions, systemic toxicity, and the rising prevalence of antibiotic-resistant Cutibacterium acnes strains. These limitations have intensified scientific interest in plant-derived …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 · pp. 34–46 Read article
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Phyto-pharmacological Review of Banafsha (Viola odorata) with Special Reference to Unani Uses
Abstract: Viola odorata Linn. known as banafshan in Unani medicine is being used in different systems of medicine since very old time. Vast description of this herb is present in Unani literature regarding its therapeutic uses in various ailments. Phytochemical analyses have also shown presence of different alkaloids and chemicals in this herb proving its medicinal importance. Also parts of this herb have been studied in animals for its pharmacological properties …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 7, Issue 3, 2018 · pp. 21–29 Read article
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A Review: Electrical Impedance Tomography System and Its Application
Abstract: Nowadays, the objective of medical research is to improve the diagnostic tools and instruments such as to develop new assessment methods, non-invasive and long-term monitoring method. Currently, the non-invasive technique is used for during pregnancy and labor due to its standard clinical approach. Such as ultrasound and MCG, CTG is also used during pregnancy because of its sensitivity to the mother and fetal movement but it is not used during …
Published in Journal of Control & Instrumentation · Vol. 7, Issue 2, 2016 · pp. 14–22 Read article
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A Practical Approach to Clinical Trials: Concepts and Methodologies
Abstract: AbstractClinical trial is a research study that is conducted on human volunteers to collect safety and efficacy data for health interventions (e.g., drugs, diagnostics, devices, therapy protocols). Clinical trial is intended to produce knowledge valuable for understanding human disease, preventing and treating illness and promoting health. Clinical trials can only be conducted after gathering satisfactory information on the quality and non-clinical safety of the product, and after taking Ethics Committee …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 3, Issue 1, 2014 · pp. 35–40 Read article
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Effect of Abdominal Compression on Blood Pressure of Patients with Postural Hypotension Receiving Antipsychotics/Antidepressants
Abstract: Postural hypotension is caused due to neurogenic and cardiogenic origin is given more attention, but postural hypotension is very commonly seen among patients receiving antipsychotics and antidepressants. Getting the side effects of the medications is one of the factors leading for poor compliance of the treatment. This study aims to investigate effectiveness of Abdominal Compression in managing the patients with postural hypotension receiving antipsychotics /antidepressants. The methodology adopted for the …
Published in Journal of Nursing Science & Practice · Vol. 2, Issue 1, 2012 · pp. 50–57 Read article
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Effect of Abdominal Compression on Blood Pressure of Patients with Postural Hypotension Receiving Antipsychotics/Antidepressants
Abstract: Postural hypotension is caused due to neurogenic and cardiogenic origin is given more attention, but postural hypotension is very commonly seen among patients receiving antipsychotics and antidepressants. Getting the side effects of the medications is one of the factors leading for poor compliance of the treatment. This study aims to investigate effectiveness of Abdominal Compression in managing the patients with postural hypotension receiving antipsychotics /antidepressants. The methodology adopted for the …
Published in Journal of Nursing Science & Practice · Vol. 2, Issue 1-3, 2012 · pp. 50–57 Read article
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Lobulated Tongue- A Rare Devlopmental Anomaly
Abstract: Lobulated tongue is a relatively uncommon congenital anomaly characterized by one or multiple elevations and/or indentations on the edge or surface of the tongue, resulting in an irregular contour. This condition is considered a rare occurrence in the spectrum of human congenital anomalies, and it may present as an isolated case or be associated with syndromes, co-existing with hamartomas or teratomas.Various syndromes have been identified in association with lobulated tongue, …
Published in Research and Reviews: A Journal of Dentistry · Vol. 14, Issue 3, 2023 · pp. 31–34 Read article
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MIRDcalc & OLINDA/EXM Dosimetry Software Analysis by SPECT/CT Scan Data of Lu-177 DOTATATE Radionuclide Therapy of NET Patients
Abstract: Accurate dosimetry is essential in nuclear medicine for optimizing radionuclide therapies and ensuring patient safety. In Radiopharmaceutical dosimetry the Medical Internal Radiation Dosimetry (MIRD)Society is the pioneer in organ-level dosimetry providing the fundamental basis for commonly used clinical and research dosimetry software like MIRDOSE and OLINDA/EXM. Recently, in MIRD Pamphlet No. 28, Part 1, the MIRD committee of the Society of Nuclear Medicine and Medical Imaging presented a new Software …
Published in Journal of Nuclear Engineering & Technology · Vol. 15, Issue 2, 2025 · pp. 48–63 Read article
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High-Definition Electroencephalography: A New Horizon in Neurological Pathology Research
Abstract: The advent of high-density electroencephalography (HD-EEG) has catalyzed a paradigm shift in the exploration of neurological pathologies. This editorial underscore its transformative potential in elucidating brain dynamics and refining diagnostic approaches for a spectrum of conditions, spanning from epilepsy and dementia to cognitive impairments in preterm infants. Our objective is to optimize the utility of HD-EEG by emphasizing the imperative for methodological homogenization and fostering collaborative endeavors. The remarkable spatial …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 14, Issue 2, 2024 · pp. 15–21 Read article
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Exploring the Relationship Between Disseminated Intravascular Coagulation and Waterhouse–Friderichsen Syndrome
Abstract: Waterhouse–Friderichsen syndrome was first identified as a distinct clinical entity by Little in 1901. He described four cases from his own observations and, after examining existing literature, identified eight additional cases that he considered previously unclassified. One case in his report may have involved purpura resulting from a different cause. The knowledge of this unusual disorder developed slowly from several significant clinical observations and case reports during the first two …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 2, 2026 · pp. 45–49 Read article
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Study of Pattern of Orthopedic Injuries by Road Traffic Accident Victims in Northern Indian Population
Abstract: Road Traffic Accident (RTA) is a current global development epidemic. The World Health Organization (WHO 2010: 5) estimates that road traffic crashes cause over 1.24 million deaths and about 50 million people are injured per year. In India, the problem of road traffic accidents has been a public health issue. The present study aims to study the clinical profile of road traffic accident victims with orthopedic injuries admitted in a …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 4, Issue 3, 2015 · pp. 9–12 Read article
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Patient Profile and Antimicrobial Susceptibility Testing of Clinically Isolates In E. coli
Abstract: Escherichia coli, commonly known as E. coli, is a prevalent bacterium capable of causing infections in humans. The development of antimicrobial resistance in E. coli poses a significant public health issue. This study aimed to determine the patient profile and antimicrobial susceptibility patterns of clinically isolated E. coli. A retrospective study was carried out on E. coli samples collected from clinical specimens within a hospital environment. Patient profiles, including age, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 1, 2024 · pp. 32–47 Read article
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Effectiveness of Planned Teaching Programme Regarding Tracheostomy Care on Knowledge among Staff Nurses in a Selected Hospital at Kollam District
Abstract: A Quantitative study was conducted to assess the effectiveness of planned teaching programme regarding tracheostomy care on knowledge among staff nurses in a selected hospital at Kollam District. The objectives of the study were to assess, knowledge of staff nurses regarding tracheostomy care, to evaluate effectiveness of planned teaching programme on knowledge of staff nurses regarding tracheostomy care, to find out the association between knowledge of staff nurses regarding tracheostomy …
Published in Research and Reviews: A Journal of Health Professions · Vol. 12, Issue 1, 2022 · pp. 23–31 Read article
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The Quiet Intruder: An Insidious Presentation of Primary Plasma Cell Leukemia and a Literature Review on Current Treatment Strategies
Abstract: Introduction: Primary plasma cell leukemia (pPCL) is a rare and aggressive plasma cell dyscrasia, defined by ≥5% circulating plasma cells, with poor prognosis and rapid progression. Case Presentation: A 66-year-old African–American female with no prior medical history presented with one week of fatigue, dehydration, and polydipsia. Laboratory evaluation revealed leukocytosis, severe thrombocytopenia, acute kidney injury (creatinine 4.03 mg/dL), and hypercalcemia (13.0 mg/dL) with suppressed PTH. Imaging showed intra-abdominal lymphadenopathy without …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 2, 2026 · pp. 1–5 Read article