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1046 articles for “Regulations”
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An AAV Vector for Inducible Gene Expression Preferentially in Muscles
Abstract: Adeno associated viral (AAV) vectors has been used widely in gene therapy and efforts have been made to improve their utility by adding genetic elements that would enable targeting transgene expression to particular cells or tissues of interest and permitting on/off regulation of expression. In this study, we designed a recombinant AAV9 variant PHP.eB vector with muscle creatine kinase (Mck)-derived enhancers, a synthetic muscle-expression promoter, in combination with a third-generation …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 46–61 Read article
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Driving Digital Transformation with Robotic Process Automation
Abstract: Compared to conventional administration methods, robotic process automation (RPA) has a number of advantages. Without a less intrusive mechanical hurdle, it allows for cost savings and resource liberation. Other benefits include more output, greater precision (and fewer errors), the potential to streamline regulatory compliance, quicker service (and hence higher customer satisfaction), and more uniformity. A description of business and digital transformation using procedure technology.The creation and use of computer-generated robots …
Published in International Journal of Advanced Robotics and Automation Technology · Vol. 1, Issue 1, 2023 · pp. 27–31 Read article
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Nutraceutics: Opening the Debate for a Framework for the Safety and Efficacy of Nutraceuticals Formulations
Abstract: As of right now, there is no precise definition for nutraceuticals that distinguishes them from other food-based categories such herbal products, dietary supplements, pre- and probiotics, functional foods, and fortified foods. Several studies have shed light on the possible mechanisms of action of pharmaceutically active ingredients in food, emphasizing their ability to improve health, lower the risk of disease, and promote general wellbeing. However, Nutraceuticals confront difficulties in substantiating safety …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 1, 2024 · pp. 27–33 Read article
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In vivo Modulatory Effect of Clerodendrum Splendens (Glory Blossom) in Aluminum Induced Alzheimer Diseases and Lonchocarpus Sericeus in Rotenone Induced Parkinson’s Disease on Na+/K+ Atpase (Sodium Pump) in the Cerebral Tissues of Male Albino Wister Rats
Abstract: Elegant research has shown that plants are useful for both curative and preventive purpose on the humans populous. Prevalent among diseases associated with humans are neurological diseases which affect a large sector of the population especially the elderly. The most common neurological diseases are Parkinson and Alzheimer disease which affect a large sector of the brain and also cause an imbalance in brain electrolyte. Among such electrolytic mechanisms of the …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 2, 2023 · pp. 31–36 Read article
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Navigating the Depths of Cancer Stem Cells: Unraveling Resistance Mechanisms and Emerging Therapeutic Strategies
Abstract: In the past few decades, comprehensive evidence has convincingly established the presence of cancer stem cells (CSCs) as a minor subset within tumors, contributing to an unusually elevated level of cellular diversity within the malignancy. CSCs are functionally identified by their capacity for self-renewal and differentiation, frequently influenced by signals from their surrounding microenvironment. The interconnected transcriptional, post-transcriptional, metabolic, and epigenetic regulatory networks govern the biological characteristics of CSCs. CSCs …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 14–18 Read article
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Designing a Novel Insider Threat Model for Enhanced Cybersecurity
Abstract: Designing a novel insider threat model is a critical imperative in the realm of cybersecurity. As organizations face an ever-expanding threat landscape, insider threats, whether deliberate or inadvertent, present a formidable challenge to the safeguarding of sensitive data and critical assets. This abstract encapsulates the significance, challenges, and innovations inherent in crafting an effective insider threat model for enhanced cybersecurity. The necessity for novel insider threat models arises from the …
Published in International Journal of Information Security Engineering · Vol. 1, Issue 2, 2023 · pp. 24–27 Read article
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Evaluating the Efficacy of a Self-instructional Teaching Module on Home Care Management Knowledge for Renal Failure Patients Undergoing Hemodialysis in a Selected Hospital in Ambikapur, Chhattisgarh
Abstract: The kidneys, with their remarkable organization and precision in regulatory functions, exhibit a level of sophistication that can be likened to a divine quality. In a conducted study, a substantial correlation was identified between the pre-test knowledge scores of participants and specific demographic factors, particularly educational qualifications. The chi-square values calculated for educational qualifications were 18.85, and for previous knowledge, it was 6.56. In both instances, the calculated values surpassed …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 1–8 Read article
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Event Tent: A Hall Booking Communication Website
Abstract: We designed this project to help Hall business to provide extra functionality and to make the work go faster and to decrease the pressure on the owner as well as the customer. In addition, this project will help owners, staff, and other people to select any hall they want, and they can book the hall from anywhere via Event Hall Website, and there will be no need to visit the …
Published in International Journal of Electrical and Communication Engineering Technology · Vol. 1, Issue 1, 2023 · pp. 29–35 Read article
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A Study to Assess the Effectiveness of Home-based Stretching Exercises on Joint Pain Among Clients with Osteoarthritis in Selected Old Age Home, Rajkot City, Gujarat
Abstract: Osteoarthritis (OA) is a commonly encountered condition in middle-aged and older individuals, marked by its slow development. Strengthening exercises targeting the quadriceps muscles, situated in the front thigh, can mitigate knee pain, and reduce disability associated with OA. The musculoskeletal system encompasses the bones of the skeleton, the joints where these bones connect, and the muscles responsible for enabling and regulating movement. The knee, the largest and most complex joint, …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 24–28 Read article
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Sole mate-Electronic Shoes to Assist Visually Challenged
Abstract: Making daily living easier has always been a goal of technological development. Everyone in today's fast-paced world uses technology to their advantage, except for some regions. Society. One of them is visually impaired and must contend with many difficulties on a regular basis. One of their biggest issues is getting around, such as crossing roads, taking trains, or going to public places, all of which frequently require human help. Occasionally, …
Published in International Journal of Optical Innovations & Research · Vol. 1, Issue 1, 2023 · pp. 1–7 Read article
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Evaluation of Fly Ash/ZrO2 Reinforced AZ91E Hybrid Composites Based on Wear and Friction Characteristics
Abstract: In the current study the compo-casting Al alloy MMCs' wear resistance was examined under a variety of abrasive circumstances, including coefficient friction, wear rate and it’s sliding distance. The AZ91E matrix composite was made by the liquid metallurgy process and reinforced with aluminum plated zirconium dioxide (ZrO2) particles. Designers examined the characteristics of matrix alloys along with created composites. friction and wear from dry sliding experiments had been performed on …
Published in Journal of Polymer & Composites · Vol. 11, Issue 8, 2023 · pp. 324–338 Read article
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The Role of Automation in Modernizing Irrigation Practices and Smart Farming: A Comprehensive Review
Abstract: The development of a "Smart Farming Using Automation" system that functions in three modes—timer, soil moisture, and PH sensor—for the farmer's advantage is the focus of this study. An automated drip irrigation system with a PLC is described in this paper. Using sensors for soil moisture and pH. The soil moisture sensor's function is to calculate how much water is required for irrigation. A PLC uses the solenoid valve to …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 1, Issue 1, 2023 · pp. 36–42 Read article
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CFD Analysis of Six-Flow Microchannel Heat Sink Using the Different Nanofluid
Abstract: In this study, we compare the heat-conveying capabilities of ordinary water with those of cooling fluids such as Ag-Water, TiO2-water, and Al2O3-water nanofluid at a volume percentage of 0.50%, and we also examine the six flow micro-channels of the fin-equipped heat sink. Hardware like microprocessors and integrated circuits are not used in the comparison. To evaluate the effectiveness of different cooling fluids, a number of thermal metrics are used, such …
Published in Journal of Polymer & Composites · Vol. 11, Issue 11, 2023 · pp. 1–11 Read article
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Rheumatoid Arthritis and its Relationship with Vitamin D, ESR, and Obesity
Abstract: Recent years have seen a rise in the prevalence of rheumatoid arthritis (RA), a disease marked by the destruction of articular cartilage and ankylosis of the joints, as well as other complications such as diffuse lung inflammation, sclera, pleura, pericardium, and nodular lesions, which are also common in subcutaneous tissue. Reviewing RA symptoms, diagnosis, treatment, and associations with vitamin D, ESR, and obesity was the aim of the study. Even …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 06–12 Read article
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A Case Report of Advanced Periampullary Carcinoma: Palliative Chemotherapy Following Whipple’s Surgery
Abstract: This case report delves into the complex management of a 60-year-old female patient diagnosed with Stage 4 periampullary carcinoma, encompassing the pancreatic head. Presenting with difficulty in eating, diagnostic investigations, including ERCP, confirmed the diagnosis, leading to Whipple's surgery. Postoperatively, liver metastasis was identified, prompting palliative intervention through stenting and the initiation of a GEMOX chemotherapy regimen. The patient responded favorably to the initial chemotherapy cycle, leading to a planned …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 1–6 Read article
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Development and Validation of a Robust RP-HPLC Method for Rufinamide Quantification in Pharmaceutical Dosage Forms
Abstract: The creation and validation of a simple, precise, and targeted reverse phase high-performance liquid chromatographic (RP-HPLC) approach allowed for the quantification of rufinamide in pharmaceutical dosage forms. With a mobile phase of methanol and water (50:50, v/v), the technique used a gradient mode Symmetry Qualisil gold C18 column (4.6 x 150mm, 5 μm). For the detection method, a flow rate of 1 mL/min was employed at 220 nm. During a …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 25–32 Read article
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Biomaterials and its Role in Dentistry–A Review
Abstract: Increasing success through modern techniques in implantology brought a new transformation in dentistry field to successfully replace missing teeth. To inflate the success rate, regular and continuous attempts are done to improve the materials, techniques for comprehensive understanding of implant behavior to the biological system. Biomaterials used for implants and brought in contact with the biological environment play the most symbolic role in the success of treatment modality. This has …
Published in Journal of Polymer & Composites · Vol. 11, Issue 8, 2023 · pp. 339–352 Read article
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Harnessing the Medicinal Potential of SwertiaChirata: A Phytochemical Strategy for Controlling Coronavirus Symptoms Like High Fever and Anxiety
Abstract: The current investigation focuses on exploring the therapeutic capacities of SwertiaChirata, colloquially known as Chirata, in managing the symptomatic displays of coronavirus infections. Chirata, a member of the Gentianaceae family, is a distinguished herb extensively used in Ayurvedic and Unani medicinal traditions, acknowledged for its myriad of healing qualities. In addition to its regular use in combating fever and loss of appetite, its prominent antioxidant traits position it as an …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 1, Issue 2, 2023 · pp. 27–31 Read article
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Assessing Vitamin D Levels in Fortified Foods and Supplements for Infants and Its Impact: A Review
Abstract: In this study, the vitamin D levels in fortified foods (including follow-on formula, baby porridge, and curd cheese dessert) and dietary supplements designed for infants were examined. Analytical assessments uncovered variations in vitamin D concentrations compared to the labeled values, fortified foods contain anywhere from 50% to 153% for supplements 8% to 177%. Instant follow-on formula and oil-based supplements typically aligned with or surpassed the labeled values, whereas ready-to-eat baby …
Published in International Journal of Nutritions · Vol. 1, Issue 1, 2024 · pp. 19–24 Read article
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IoT-Enabled Authentic Ration and Material Distribution Systems
Abstract: A home Ration Certificate is an essential item. The largest retailer system in India is Public Distribution System (PDS). A ration card is provided by the public distribution network, which is run by the state administration. All people have ration cards for purchasing essential consumers material like wheat, rice, kerosene, and oil. The present ration distribution system has many problems such as authentication problems, waste of time in queues, lots …
Published in International Journal of Solid State Innovations & Research · Vol. 1, Issue 1, 2023 · pp. 26–34 Read article