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373 articles for “t-test”
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Biomimetic Approaches to Damage Tolerance: Lessons from Natural Materials
Abstract: Biomimicry has emerged as a powerful and innovative strategy for designing materials with enhanced damage tolerance by drawing inspiration from biological systems found in nature. Various natural materials, such as bone, nacre (mother-of-pearl), and spider silk, display exceptional mechanical properties, including high toughness, superior strength, and inherent self-healing capabilities. These remarkable attributes arise from their complex hierarchical architectures and adaptive mechanisms, which have been refined over millions of years through …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 3, Issue 1, 2025 · pp. 11–16 Read article
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Functional Recovery Among Stroke Survivors Following Targeted Nursing Interventions: Evidence from a Quasi-Experimental Study
Abstract: Background: Stroke rehabilitation is crucial for reducing disability and improving functional independence. However, in India, nursing-led rehabilitation interventions remain underexplored. This study evaluates the effectiveness of nursing-led rehabilitation programs in improving mobility, ADL independence, and psychological well-being among stroke survivors. Methods: A quasi-experimental study was conducted at Index Medical College, Hospital & Research Center, involving 200 stroke survivors. Participants were divided into two groups: (1) Intervention Group (n = 100): …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 3, Issue 2, 2025 Read article
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QSAR Modeling Techniques: A Comprehensive Review of Tools and Best Practices
Abstract: Quantitative Structure–Activity Relationship (QSAR) modeling has become an essential tool in drug discovery, toxicity assessment, and environmental chemistry. By correlating chemical structure with biological activity or toxicity, QSAR enables the prediction of compound behavior without extensive experimental testing. This approach not only saves time and resources but also supports ethical practices by reducing reliance on animal studies. The evolution of QSAR from basic linear models to advanced machine learning and …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 56–63 Read article
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Synthesis, Molecular Docking and Biological Evaluation of Novel Chlorobenzenesulfonamide Analogues of Ibuprofen as Anti-Bacterial, Anti-Diabetic and Anti-Alzheimer Agents
Abstract: In this work, we have synthesized novel chlorobenzensulfonamide tertiary amide based analogues of Ibuprofen (Ibu) and investigated them for their anti-bacterial, anti-diabetic and anti-Alzheimer activities. In the first step, Ibu was converted to amide derivatives by incorporating different aromatic amines. These were further converted into sulfonamide analogues (Sul-Ibu, 1-9) by treating it with p-chlorobenzensulfonyl chloride. Sul-Ibu (1-9) were screened against S. aureus, B. subtilis, S. mutans, E. coli, P. aeruginosa, …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 41–55 Read article
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The Role of Adaptive Physical Education in Improving Quality of Life for Disabled Individuals
Abstract: The purpose of this paper is to analyze the effectiveness of Adaptive Physical Education (APE) in enhancing the quality of life of disabled students at Punjabi University, Patiala. APE refers to an interface that is mainly aimed at the person with disabilities’ physical and psychological characteristics, which enable the original physical activities to be adapted to the disabled person's nature and rounded by conductive physical health examinations, fitness tests, and …
Published in Recent Trends in Sports · Vol. 2, Issue 2, 2025 · pp. 1–9 Read article
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Pharmacokinetic Profiling and Molecular Docking of Carvacrol and Structural Analogs: Targeting Quorum Sensing Proteins to Disrupt Biofilm-Mediated Antimicrobial Resistance in Multidrug-Resistant Bacterial Pathogen
Abstract: Antibiotic resistance, particularly in Pseudomonas aeruginosa, has become a major global health threat, exacerbated by the organism's ability to form biofilms and regulate virulence through quorum sensing (QS). The LuxR and LasR receptors are key regulators in this process, influencing both pathogenicity and antibiotic resistance. This study investigates potential QS inhibitors targeting these receptors as a strategy to mitigate antibiotic resistance. The primary objective was to identify novel ligands that …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 43–61 Read article
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Role of Fatigue and Creep in Structural Damage: A Comprehensive Review
Abstract: Fatigue and creep are two critical degradation mechanisms that significantly influence the structural integrity and longevity of engineering materials. These phenomena arise due to different loading and environmental conditions but often coexist in various industrial applications, leading to severe material degradation over time. Fatigue primarily results from cyclic loading, where repeated stress variations induce microstructural damage and crack initiation, ultimately causing catastrophic failure. Conversely, creep occurs under sustained stress at …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 3, Issue 1, 2025 · pp. 22–26 Read article
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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Machine Learning Approach to Predict the Performability and Emissions of Diesel Engine Fueled with Doped Biodiesel Blend
Abstract: Enhancing the performability and emission characteristics of diesel engines has been a difficult task in light of growing concerns about global warming and other negative effects, as diesel accounts for 70% of global energy demand. In this study, engine performance and exhaust emissions for various fuel blends were thoroughly evaluated using machine learning techniques to predict engine emission and performance behavior. We focused on biodiesel blend and nanoparticle additive concentration …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 3, Issue 1, 2025 · pp. 1–12 Read article
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The Influence of Self-Efficacy on Anxiety and Perfectionism among Dancers
Abstract: The world of dance, while driven by creativity, often imposes significant psychological demands on performers. This study explored how self-efficacy influences anxiety and perfectionism—both adaptive (excellencism) and maladaptive—among dancers, with a focus on gender differences. A sample of 120 dancers (60 males, 60 females) was assessed using standardized scales. Relationships and predictive effects were assessed using statistical techniques, such as regression, Pearson correlation, and t-tests. Findings revealed no significant gender …
Published in International Journal of Behavioral Sciences · Vol. 2, Issue 2, 2025 Read article
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Development, Optimization and Evaluation of Polyherbal Gel Comprising of Azadirachta Indica, Calendula Officenalis, Turmeric and Aloe-vera for Treatment of Wound
Abstract: Azadirachta indica, Calendula officinalis, Turmeric (Curcuma longa), and Aloe-vera are known to possess numerous medicinal properties. These herbs have been traditionally used across various cultures for the treatment of a wide range of ailments due to their potent therapeutic effects. Individually, they have demonstrated efficacy in addressing conditions such as acne, diabetes, wound healing, gastric ulcers, first-degree burns, psoriasis, arthritis, and pneumonia. Additionally, they are known for their antimicrobial, anti-inflammatory, …
Published in Recent Trends in Cosmetics · Vol. 2, Issue 2, 2025 · pp. 41–53 Read article
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Innovative Antifungal strategies: Terbinafine hydrochloride in Niosomal carriers
Abstract: Onychomycosis, an infection caused by fungi that affects fingernails or toenails, causes the nails to grow, separate from the nail bed, and become discoloured. While anybody can get, those with weakened immune systems, children and the elderly are especially susceptible. Present study was related to formulate an effective nail lacquer that would treat onychomycosis by utilizing Terbinafine hydrochloride. In this study, niosomes of a medication called terbinafine hydrochloride, an antifungal …
Published in International Journal of Fungi · Vol. 2, Issue 2, 2025 · pp. 1–16 Read article
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Pelvic Floor Muscle Strengthening in Antenatal Period Among Primigravida Cases at Jorhat, Assam
Abstract: Aim: The study aimed to evaluate the effectiveness of pelvic floor muscle (PFM) strengthening exercises during the antenatal period among primigravida women in Jorhat, Assam, with a focus on improving pelvic floor muscle strength and its impact on pregnancy outcomes. Purpose: To assess whether pelvic floor muscle exercises (specifically Kegel exercises) can enhance PFM strength in pregnant women, using the Modified Oxford Grading Scale (MOS), and to compare these effects …
Published in International Journal of Midwifery Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 35–42 Read article
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Prevalence and Risk Factors of Neglected Tropical Diseases Among Women and Children in Rural Liberia: A Regional Perspective
Abstract: Neglected Tropical Diseases (NTDs) remain a critical public health challenge in Liberia, disproportionately affecting women and children in rural regions due to systemic inequities in water, sanitation, and healthcare access. This cross-sectional study assessed the prevalence and risk factors of NTDs among 1,000 participants (600 children above 15 years and 400 women aged 15–49) in rural Liberia using stratified and cluster sampling. Laboratory diagnostics, including Kato-Katz stool analysis, urine filtration, …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 1–7 Read article
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COVID-19 Resurgence in 2025: India’s Continuing Public Health Challenge
Abstract: The year 2025 has witnessed the resurgence of COVID-19, reigniting concerns at both global and national levels regarding the persistent threat posed by SARS-CoV-2. In early 2025, India witnessed a moderate resurgence of COVID‑19, characterized by the emergence of Omicron sub-variants and a rise in mild-to-moderate infections. As of mid-June, active COVID‑19 cases in India totaled approximately 6,000–7,400, with hotspots in Kerala (~2,100 cases), Delhi (~600), Maharashtra (~500), and several …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 2, 2025 · pp. 16–23 Read article
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Advancing Cancer Vaccine Development through CRISPR/Cas9 Technologies and Future Opportunities
Abstract: The advent of CRISPR/Cas9 genome editing has revolutionized the cancer immunotherapy market, offering unprecedented precision and versatility in the development of next-generation cancer vaccines. This review examines how CRISPR technologies are being integrated into various stages of cancer vaccine development including neoantigen discovery, dendritic cell engineering, cancer cell reprogramming, and tumor microenvironment modulation. In the area of neoantigen discovery, CRISPR enables rapid identification and validation of tumor-specific mutations, thereby supporting …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 Read article
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Hybrid Material Systems for Flexible Electronics Electro-Mechanical Performance and Future Prospects
Abstract: Flexible electronics are transforming the landscape of modern electronic systems, enabling devices that are lightweight, stretchable, and adaptable to complex surfaces. These technologies are particularly impactful in applications such as wearable health monitors, soft robotics, energy harvesting systems, and implantable biomedical devices. At the heart of this evolution are hybrid material systems—engineered composites that combine organic polymers and inorganic nanomaterials to achieve synergistic electro-mechanical properties. These materials address the limitations …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 3, Issue 1, 2025 · pp. 7–12 Read article
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In silico Molecular Docking Analysis of Stephania glabra phytocompounds Targeting Thymidylate Kinase for potential Antituberculosis Activity
Abstract: Tuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis. It mainly affects the lungs and spreads through the air when a person with active TB in their lungs coughs, sneezes, or spits. This study investigates several bioactive compounds derived from plants to forecast how effective plant-based ligands will be at preventing tuberculosis. The purpose of the study was to use computational techniques to assess the effectiveness of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 Read article
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Impact of Anxiety and Affect on Quality of Life among Youth
Abstract: Youth well-being is an important phenomenon comprising physical, psychological, and social health, where the psychological factors such as anxiety and affect play an essential role in determining Quality of Life (QOL). Young people experience multiple transitions and they are at risk of anxiety disorders that in turn can have adverse effects on academic achievement, physical health, emotional well-being and relationships. Furthermore, affect has a role in the management of emotions …
Published in International Journal of Education Sciences · Vol. 3, Issue 1, 2026 · pp. 1–13 Read article
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Unveiling the Relationship Between Anxiety and Self-Esteem in Adult Populations
Abstract: The purpose of this study was to investigate the intricate connection between anxiety and self-esteem in adult Delhi National Capital Region (NCR) residents. A purposive sample approach was employed to select seventy people from this region. The study measured participants' self-worth and gathered pertinent background data using the Rosenberg Self-Esteem Scale (RSES) and a sociodemographic data form. In the data analysis, a t-test was employed to assess significant differences between …
Published in International Journal of Children · Vol. 2, Issue 2, 2025 · pp. 35–44 Read article