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338 articles for “Cancer Cell”
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Advances in Nanoformulations for Targeted Drug Delivery Systems
Abstract: The work examines modern nanoformulations used for enhancing targeted drug delivery systems that simultaneously produce better therapeutic effects with reduced adverse effects. The pharmaceutical industry achieved deliverable drug development progress through diverse nanocarrier innovation which encompasses liposomes and nanoparticles and dendrimers and micelles. Tissue and cell-based directed delivery becomes possible via this technology to enhance the management of neurological disorders and cancer diseases. The investigation analyzes different nanoformulations by reviewing …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 01–07 Read article
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Mathematical Modeling of Tumor Growth and Immune System Interaction Incorporating Time Delays and Suppression Effects for Tumor Control
Abstract: Cancer growth is a complex biological process influenced by various factors, including the dynamic interaction between tumor cells and the host immune system. Mathematical modeling serves as a powerful tool to understand these interactions and predict the outcomes of different therapeutic strategies. This study presents a mathematical framework that captures the essential dynamics of tumor-immune interactions, specifically incorporating the effects of time delay and immune suppression mechanisms. Time delay accounts …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 3, 2025 · pp. 25–34 Read article
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In vitro Evaluation of Kigelia pinnata Leaves for Its Antioxidative and Anticancer Activity
Abstract: Previous studies suggest that the Kigelia pinnata leaves have useful effects against diseases mediated through oxidative stress and cancers. In this study, leaves of Kigelia pinnata were studied for presence of different phytochemical constituents, anti-oxidant and anti-cancer activities.Crude methane extracts of Kigelia pinnata leaves showed cytotoxic activity in vitro against non-small cell lung cancinoma (A-549) cells using the MTT assay. Phytochemical evaluation showed the existence of alkaloids, terpenoids, flavonoids, tannins …
Published in Research and Reviews: A Journal of Health Professions · Vol. 9, Issue 1, 2019 · pp. 26–30 Read article
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ABCB5 and β catenin activity for colon cancer: A review
Abstract: Colorectal malignancy (CRC) is the second most regularly analyzed disease among females and third among guys around the world. It likewise contributes fundamentally to growth related passing, regardless of the ceaseless advance in symptomatic and helpful techniques. Biomarkers as of now assume an imperative part in the recognition and treatment of patients with colorectal disease. This review gives an avant-garde synopsis on markers such as ABCB5 and β-catenin associated with …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 3, 2017 · pp. 6–18 Read article
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Extracellular Vesicle-Based Liquid Biopsies: Decoding the Tumor Microenvironment for Precision Oncology
Abstract: The tumor microenvironment (TME) plays a pivotal role in cancer initiation, progression, and therapeutic response. Decoding the TME is, therefore, essential for advancing precision oncology. Extracellular vesicles (EVs), including exosomes and microvesicles, are nanoscale lipid bilayer particles secreted by tumor and stromal cells. They transport a wide range of bioactive molecules, such as DNA, RNA, proteins, lipids, and metabolites, which reflect the dynamic state of the TME. Recent advances in …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 1, 2026 · pp. 43–62 Read article
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Clone-Specific Drug Delivery Systems: Targeted Approaches and Future Clinical Applications
Abstract: Clone-specific drug delivery systems represent a transformative frontier in personalized medicine, addressing the longstanding challenge of clonal heterogeneity within diseases such as cancer, infectious diseases, and autoimmune disorders. Traditional drug delivery platforms often fail to discriminate between pathogenic and healthy cells, leading to systemic toxicity and reduced therapeutic efficacy. In contrast, clone-specific systems aim to selectively target and eliminate disease-driving cellular clones based on unique molecular signatures, thereby improving treatment …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 21–29 Read article
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Reviewing Diagnosis and Management Strategies for Barrett's Esophagus
Abstract: Incidence of distal oesophageal carcinoma is increasing faster than that of any other visceral cancer in the western world. It is commonly known that the most, if not all, of theses tumours arise in the Barrette oesophagus through the metaplasia-dysplasia-carcinoma sequence. Which may allow for early detection; nonetheless, most of these tumours are still discovered much late in their progression. This emphasizes how far of the aim of adequate surveillance …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 12, Issue 3, 2023 · pp. 30–34 Read article
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Impact of Free Radicals and Antioxidants on Human Health
Abstract: Free radicals are atoms or groups of atoms with an odd (unpaired) number of electrons and can be formed when oxygen interacts with certain molecules. Once formed these highly reactive radicals can start a chain reaction heir chief danger comes from the damage they can do when they react with important cellular components such as DNA, or the cell membrane. Cells may function poorly or die if this occurs. To …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 3, Issue 2, 2016 · pp. 19–26 Read article
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Recent Trends in Drug Repositioning for Discovery of New Anticancer Drugs
Abstract: Drug repositioning, the process of finding new uses of existing drugs, has been gaining popularity in recent years. The availability of several established clinical drug libraries and rapid advances in disease biology, genomics and bioinformatics has accelerated the pace of both activity-based and in silico drug repositioning. Drug repositioning has attracted particular attention from the communities engaged in anticancer drug discovery due to the combination of great demand for new …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 2, 2016 · pp. 35–38 Read article
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Treatment of Korean Panax Ginseng against Cisplatin-Induced Toxicity in Rats Haematological and Histological Examination of Liver, Spleen and Kidney
Abstract: Vital goal of all anti-cancer therapies are to prevent the incidence of side effects either through more selective therapeutic methodology that target only neoplastic cells or through the use of complementary or alternative medicine. Present study investigated the effects of Panax ginseng (PG) on cisplatin-induced haematological and histopathological (liver, kidney and spleen) changes in rats. Rats were administered with PG (25, 50, 100 mg/kg) before or after an intraperitoneal injection …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 2, 2013 · pp. 35–39 Read article
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Study and Impact of COVID-19
Abstract: Recently a Novel Corona Virus has been emerged at Wuhan named as COVID-19 or SARS-CoV-2. The aim of this paper is to present a literature review of various articles which is contributing in study, prevention and control of SARS-CoV-2. We also graphically present global impact of this virus based on different criteria like; age-wise and sex-wise mortality rate, weekly and cumulative increment of infectious people, mortality rate in people suffering …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 10, Issue 3, 2020 · pp. 10–18 Read article
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Lipid Peroxidation in Postoperative Cases of Breast Carcinoma (Grade III)
Abstract: Breast cancer represents significant problem in the world. Oxidative modification of lipids is catalyzed by reactive oxygen species (ROS) which is known as lipid peroxidation (LPO); this changes the fluidity, permeability of membrane, cellular metabolic functions and causes derangement. Malondialdehyde (MDA) is a major end product and an index of LPO which crosslinks DNA, protein and nucleotides on the same and opposite strands. There are reports that LPO increased in …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 1, 2018 · pp. 16–22 Read article
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A Comprehensive Review of Antioxidant Activity of Bhringraj (Eclipta alba) : An Indian Ancient Herb
Abstract: Eclipta alba, commonly known as Bhringraj, is an herb widely utilized in traditional Indian medicine (Ayurveda) for its diverse therapeutic properties, particularly in promoting hair growth, enhancing liver function, and improving overall health. Among its numerous biological activities, the plant’s antioxidant potential has garnered significant interest in modern phytochemistry. Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and the body’s antioxidant defenses, is a key contributor to …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 1, 2025 · pp. 12–21 Read article
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Health Hazards of Nanoparticles and Environmental Pollutants
Abstract: The exponential growth in the use of nanoparticles and the prevalence of environmental pollutants have raised significant concerns regarding their health hazards. Nanoparticles, owing to their unique physicochemical properties—such as small size, high surface areatovolume ratio, and chemical reactivity—can penetrate biological barriers, including the bloodbrain barrier, and interact at the cellular and molecular levels. This can lead to oxidative stress, inflammation, and cellular dysfunction, ultimately resulting in potential toxicity. Similarly, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 1–9 Read article
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Butrin Tackles Retinoblastoma – A Clinical Hypothesis †
Abstract: Breach of association of legumain protein activities to the corresponding cellular components results in over-expression of legumain, and constitutes a key biomarker for a variety of life-taxing sicknesses like cancer, Alzheimer’s/Parkinson’s and acute kidney injury. To suppress the functions of legumain, it is hypothesized that a water soluble and edible biomolecule, namely, butrin (7, 3’, 4’-trihydroxy flavanone-7, 3’-diglucoside) may have the therapeutic potential owing to its special ability to bind …
Published in International Journal of Advance in Molecular Engineering · Vol. 2, Issue 1, 2024 · pp. 26–30 Read article
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The Risk of Second Malignant Tumors after Definitive Treatment of Nasopharyngeal Carcinoma: Three Case Reports and Literature Review
Abstract: Introduction: Patients with head and neck squamous cell carcinoma (HNSCC) have an increased incidence of developing second malignant tumors (SMTs). This may possibly be explained by the concept of “field cancerization” or “condemned mucosa syndrome”, implying the importance of other risk factors like smoking, alcohol consumption, genetic factors and viral infections. However, risk factors for SMTs have not been documented well, especially in nasopharyngeal carcinoma (NPC). Objective: Evaluate the presence …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 6, Issue 2, 2017 · pp. 15–20 Read article
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Comparative Proteomics: From Cell Lines to Clinical Samples
Abstract: Comparative proteomics is a powerful tool for understanding the molecular differences between various biological samples. It entails identifying and measuring proteins in complex biological samples to assess their abundance, modifications, and interactions under various conditions. This approach plays a crucial role in advancing biomedical research, especially in disease understanding, biomarker discovery, and therapeutic development. While cell lines are widely used for proteomic studies due to their controlled environments and reproducibility, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 30–34 Read article
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Role of Food Supplements in Premalignant Lesions: A Literature Review
Abstract: Premalignant lesions of the oral cavity are histopathological alterations in the oral epithelium linked to a higher likelihood of malignant transformation. These lesions frequently present as leukoplakia (white patches), erythroplakia (red patches), oral lichen planus, and oral submucous fibrosis. Oral cancer, categorized among head and neck malignancies, is considered the sixth most common cancer globally. While tobacco and alcohol consumption remain the primary etiological factors, increasing evidence underscores the significant …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 3, 2025 · pp. 17–26 Read article
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Recent Advances in Transition Metal Complexes with Phenyl Acetic Acid and Pseudo Halogen: Synthesis, Characterization and Applications
Abstract: A well established strategy is to introduce a biologically relevant organic molecule in coordination sphere of transition metal complexes to increase the selectivity and biocompatibility. Phenylacetic acid (PAA), an organic molecule with a phenyl functional group and a carboxylic acid functional group, is a phenylalanine that is generated from the naturally occurring auxin, which is extensively present in plants. The most promising outcomes in the battle against cancer and microbes …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 68–78 Read article
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Research and Industrial Insight: Toxicology
Abstract: Toxicology is a division of biology, chemistry, and medicine related with the study of the special effects of chemicals on breathing organisms. It also studies the injurious effects of chemical, biological and physical mediators in biological system that founds the degree of destruction in living organisms. The correlation between dose and its belongings on the exposed organism is of great importance in toxicology. A factor that inspires the chemical toxicity …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 1, 2015 · pp. 36–40 Read article