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1882 articles for “CRISPER cas-9” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Formulation and Evaluation of an Antifungal Emulgel Containing Carbopol 940 as Gelling Agent
Abstract: Emulgels have emerged as one of the most intriguing topical distribution systems as they have dual release control system, i.e., gel and emulsion. The main purport of the present study was to develop and evaluate topical emulgel system for Fluconazole, antifungal agent, utilizing different polymers namely carbopol 940. In addition, light liquid paraffin as oil, Tween-20 and Span-20 as emulsifiers and propylene glycol and methyl alcohol as co-surfactant were culled …
Published in Trends in Drug Delivery · Vol. 2, Issue 1, 2015 · pp. 28–37 Read article
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Comparative Investigation on Mechanical Properties of AMCs Fabricated through Liquid and Solid-State Fabrication Process
Abstract: This current research work is primarily focused on comparative experimental study on effect of two distinct fabrication process routes i.e. liquid state and solid state process and their corresponding parameters on microstructure and micro-hardness properties of Aluminium matrix composites (AMCs). In this work, AMCs were fabricated by reinforcing Al2O3 powder materials of 5, 10 and 15 wt.% into pure Aluminum (Al) matrix phase through two distinct processes; liquid state (stir …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 202–215 Read article
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A Case Report of Advanced Periampullary Carcinoma: Palliative Chemotherapy Following Whipple’s Surgery
Abstract: This case report delves into the complex management of a 60-year-old female patient diagnosed with Stage 4 periampullary carcinoma, encompassing the pancreatic head. Presenting with difficulty in eating, diagnostic investigations, including ERCP, confirmed the diagnosis, leading to Whipple's surgery. Postoperatively, liver metastasis was identified, prompting palliative intervention through stenting and the initiation of a GEMOX chemotherapy regimen. The patient responded favorably to the initial chemotherapy cycle, leading to a planned …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 1–6 Read article
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Effect of Vamanadhauti Along with Diet and Lifestyle Modification as per Ayurveda in Ajeerna w.s.r. Dyspepsia–A Case Study
Abstract: Introduction: In present era, Ajeerna is a very common health issue and has resemblance with dyspepsia. Ajeerna denotes improper functioning of Agni leading to lots of other diseases. Unhealthy & sedentary lifestyle, increasing intake of fast food and faulty eating habits play important role in pathogenesis of Ajeerna. In the context of Ajeerna, Sadyovamana Chikitsa is described which can be correlated with a Yogic cleansing procedure-Vamanadhauti. Vamanadhauti mainly acts on …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 11, Issue 2, 2024 · pp. 24–35 Read article
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A Screening Study on Occurrence and Distribution of Urinary Tract Infections Among Suspected Cases (Pyuria, With or Without Symptoms) During Pregnancy
Abstract: Background: Urinary tract infection is one of the most frequently seen medical complications in pregnancy. Methods: Ethical approval was granted for this research. The study employed a time-bound prospective design; total pregnant women (900) were categorized into those suspected of having UTI (pyuria, with or without symptoms) and those not suspected. Asymptomatic bacteriuria is diagnosed through a urine specimen with an appropriate microscopic examination, followed by culture. Results: The occurrence …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 3, 2024 · pp. 13–20 Read article
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Tribological Study on SiC+Graphene Reinforced Al319 Composite andOptimization of Stir Casting Parameters
Abstract: The aluminium 319 (Al319) is a commonly used material for fabricating automobile components. Due to continuous friction and vibration, those components are subjected to significant wear. Therefore, it is necessary to improve the wear characteristics of this Al319. Hence, in this study Silicon Carbide (SiC) and Graphene nanoparticles (GNPs) are reinforce to Al319 via electro-magnetic stir casting method to optimize wear characteristics without its affecting mechanical properties. Various proposition of …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 105–123 Read article
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Ayurveda Treatment of Type 2 Diabetes Mellitus WSR Kaphaja Prameha: A Case Study
Abstract: Type 2 diabetes mellitus is highly prevalent in society nowadays. This is result of deranged lifestyle and food habits of present era. It can be corelated with Prameha in Ayurveda, that is mentioned in all ancient texts of Ayurveda. In present case study, a 45 years old obese patient visited Kayachikitsa OPD with complains of lethargy, weakness, excess sleep, lack of sexual desire and calf pain. He was diagnosed to …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 11, Issue 3, 2024 · pp. 1–4 Read article
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Fabrication and Mechanical Characterization of Hybrid Metal Matrix Composite Castings
Abstract: This work investigates and addresses the casting of a novel hybrid composite material with tungsten carbide and aluminum-silicate particles mixed at varying weight fraction rates. Production of hybrid composite has some advantages if it is processed by near net shape techniques. The simplest method for dealing with this hybrid composite is the turbulence produced by the vortex agitating technique. The vortex mixing method is used in this study to create …
Published in Journal of Experimental & Applied Mechanics · Vol. 15, Issue 3, 2024 · pp. 32–38 Read article
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CRISPR-Cas9: Revolutionizing the Genetic Frontier
Abstract: The rapid development of CRISPR/CRISPR-associated enzyme (Cas) technology has enabled truly customised treatment of human genetic disorders, paving the way for recent developments in the field of gene therapy. Because CRISPR/Cas can accurately target and edit individual genes within a genome, it has established itself as a formidable tool for genetic manipulation. CRISPR/Cas9 technology allows for precise editing of specific DNA sequences in an organism's genome. This method uses three …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
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Integrating Ayurveda in Infertility Management: A Case Study on Fimbrial Blockage
Abstract: Infertility significantly impacts a woman’s psychological and physical health, as well as that of her family. Fallopian tube blockage is one of the leading causes of female infertility, accounting for a substantial number of cases globally. Conventional medical approaches, including in vitro fertilization (IVF) and surgical procedures, often present barriers due to their high cost, invasive nature, and limited accessibility. Additionally, cultural, financial, and personal considerations can further restrict their …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 3, 2025 · pp. 12–19 Read article
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Ayurvedic Management of Vatika Pakshavadha (Hemiplegia): A Case Study
Abstract: Background: Pakshavadha, described in Ayurveda under the category of Vāta Vyādhi, is a neurological disorder caused by aggravated Vāta doṣa affecting one half of the body. Clinically, it is correlated with hemiplegia or post-stroke neurological deficits, particularly following ischemic cerebrovascular accidents. Stroke remains a leading cause of mortality and disability worldwide, often leaving patients with residual weakness, gait disturbances, and impaired speech despite modern rehabilitation. Ayurveda offers a holistic approach …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 13, Issue 2, 2026 · pp. 22–30 Read article
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A Clinical Case Study of Kaphaja Visarpa W.S.R to Pemphigus Vulgaris
Abstract: Background: Visarpa is a classical Ayurvedic dermatological condition characterised by Swift spreading of lesions across the skin involving Twak, Lasika, Rakta, and Mamsa. Kaphaja Visarpa, a subtype dominated by Kapha dosha, presents with pallor-coloured oily lesions, itching, swelling, and mild pain. Case Summary: A 58-year-old female patient, a known case of Type 2 Diabetes Mellitus, presented with shiny, oedematous, pale skin lesions across the chest, abdomen, and back, accompanied by …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 2, 2026 Read article
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Thermodynamic Analysis of Cascaded Organic Rankine Cycle for Optimizing Thermal Efficiency
Abstract: AbstractPower cycles converting medium temperature heat (~300°C) into electricity using working fluids like toluene, benzene etc. result in vacuum on condenser side operating near ambient temperatures. To overcome this, two stage cascaded power cycle is proposed with toluene in the top cycle and R- 245fa as a bottom cycle working fluid. In this scheme, condensation heat of toluene is used as a heat source for R- 245fa. A realistic analysis …
Published in Journal of Thermal Engineering and Applications · Vol. 5, Issue 3, 2018 · pp. 30–35 Read article
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Investigations on Mechanical Properties of Al 8011 Reinforced with Micro B4C/Red Mud by Stir Casting Method
Abstract: Aluminium metal matrix composites are emerging as the most versatile material for unique automotive, aviation, aerospace, defense, marine applications and other structural applications due to their excellent mixture of properties. In the present investigation, a hybrid composite of Al8011 aluminium alloy reinforced with B4C and red mud was fabricated by stir casting method. Red mud is one of the major waste material extracted from the bauxite ore of alumina during …
Published in Journal of Electronic Design Technology · Vol. 7, Issue 1, 2016 · pp. 32–38 Read article
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Design of Voltage Controlled Oscillator using GDPK 90nm CMOS Technology
Abstract: In the recent decade, there has been a major revolution in communication systems and devices. Many communication devices required a specific frequency which may range from a few Hz to several GHz by source of voltage. Voltage Control Oscillator (VCO) plays a major role in today’s modern communication system. Voltage Control Oscillator use as basic building block in communication circuits and major use in phase locked loops circuits. Due to …
Published in Journal of Electronic Design Technology · Vol. 13, Issue 1, 2022 · pp. 17–24 Read article
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A Study of Improvement of Mechanical Properties of Aluminum by Conventional Casing and Deformation Process
Abstract: Nowadays, Aluminum-Zinc alloy system are the major and rapid development in the field of automotive and aerospace industries for growing demand of efficient vehicles and aircrafts to reduce energy consumption and air pollution. Aluminum is a very soft metal by nature. Different alloying elements were added in the past to increase its strength and toughness. Zinc is considered as a major alloying element in aluminum to increase its strength and …
Published in Journal of Materials & Metallurgical Engineering · Vol. 4, Issue 2, 2014 · pp. 16–20 Read article
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Ultra Low-Power 9-Transistor Flip-Flop Design
Abstract: AbstractThe use of very large scale integration technology in high performance computing, wireless communication, consumer electronics has been rising at a very fast rate. The challenge for VLSI technology is mainly in leakage power consumption. Flip-Flops (FFs) are the basic storage elements used extensively in digital system designs. It accounts for 20%–45% of the total system power and may considerably impact the chip area. In this paper, an ultra-low-power true …
Published in Journal of Microelectronics and Solid State Devices · Vol. 5, Issue 3, 2018 · pp. 27–32 Read article
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Comparison of Central Inverter and String Inverter for Solar Power Plant: Case Study in Vietnam
Abstract: AbstractSolar power technology is developing rapidly in Vietnam and investors are interested in developing the solar power plant. Comparison of the choice of grid-tie inverter technology between central inverter and string inverter can affect the change of investment cost, operation and maintenance costs, and operation efficiency of solar power plants in the real condition. However, most of solar power plants in Vietnam are currently in the design stage, so experience …
Published in Journal of Nuclear Engineering & Technology · Vol. 9, Issue 3, 2019 · pp. 11–23 Read article
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Comparison of Symmetrical and Asymmetrical Cascaded H-Bridge Inverter with Single DC Source
Abstract: This paper presents the comparison of traditional cascaded H-bridge inverter with isolated DC sources (symmetrical arrangement) and the proposed cascaded H-bridge inverter with single DC source (asymmetrical arrangement). Also, fundamental switching strategy is used to generate the control pulses. A conventional cascaded H-bridge (CHB) inverter requires ‘n’ numbers of DC sources for 2n + 1 levels. Without requiring transformers, the scheme proposed here allows the use of a single DC …
Published in Journal of Power Electronics and Power Systems · Vol. 2, Issue 1, 2012 · pp. 8–17 Read article
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Performance Measures in Lean Production Settings: A Case Study
Abstract: The purpose of this paper is to outline how the performance measurement system of a large manufacturing unit has evolved since the implementation of a lean-based production system. In order to fulfill the purpose, this paper has been divided into four sections. The first section outlines the theoretical background and underlines the developments made in the fields of PMM and operations management over the last decades. The second part presents …
Published in Journal of Production Research & Management · Vol. 2, Issue 1-2-3, 2012 · pp. 8–17 Read article