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1968 articles for “AFS” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Identification of Promising Lead Compounds from Capsicum annuum Targeting BACE-1 for Alzheimer’s Disease Therapy: A Molecular Docking Study
Abstract: Background: Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions of people worldwide. Beta-secretase 1 (BACE-1) is an important therapeutic target for AD treatment. Capsicum annuum (CA) is a commonly consumed plant with potential neuroprotective properties. In this study, we aimed to identify potential lead compounds from CA that can target BACE-1 for AD therapy using molecular docking. Methods: A library of 15 compounds from CA was obtained from PubChem, …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 40–49 Read article
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A Study on Cancer Related Fatigue and Quality of Life (QOL) among Women Undergoing Treatment for Various Cancers in Selected Tertiary Care Hospitals of Ludhiana, Punjab
Abstract: Cancer is a collection of illnesses marked by irregular cell proliferation that has the potential to infiltrate or metastasize to different areas of the body. Gynecological cancer specifically refers to the abnormal cell growth in the female reproductive tract, including various organs such as the endometrium, fallopian tubes, ovaries, uterus, cervix, vagina, and breast. These cancer cells have a tendency to multiply uncontrollably. The majority of individuals diagnosed with cancer …
Published in International Journal of Oncological Nursing and Practices · Vol. 1, Issue 1, 2023 · pp. 6–11 Read article
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Identification of Secondary Metabolites from Zingiber officinale as Inhibitors for Keap 1-Nrf2 small Molecules through Molecular Docking Techniques
Abstract: Objective: Therapeutic plants aid in treating cancer-based cell signaling pathways and preventing certain risk factors. Zingiber officinale has a variety of anti-inflammatory characteristics also contributing to enhanced immunity, reducing cancer risk and used to target the KEAP NRF2. When overexpressed in response to oxidative stress and DNA damage, elevates the risk of developing multiple cancers. NRF2 cellular sensors, which also control and coordinate their expression aid in defending healthy cells …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 35–48 Read article
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A Structure-based Design Approach to Catharanthus roseus Phytoconstituents as Potential Inhibitors of B-Cell Lymphoma 6 Protein
Abstract: Objectives: Lymphoma is a cancerous disease. It develops into millions of people worldwide. Identify the naturally active compounds from Catharanthus roseus, they have multiple values in the medicinal field of Siddha, and Indian Ayurveda are used as a disease-preventing agent. Drug illness prediction, toxicity prediction, statistical information, molecular docking, as well as absorption, distribution, metabolism, and excretion (ADME) analysis are used to predict the fit ligand as a drug. Methods: …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 14–34 Read article
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In Silico Analysis and Docking Study of the Active Phyto Compounds of Ginkgo Biloba Against Alzheimer's Amyloid-Beta Protein
Abstract: Objective: Alzheimer's disease, an age-related progressive neurological condition, arises due to the accumulation of amyloid-beta protein within the brain. In this study, an attempt was made to explore the potential of natural compounds derived from Ginkgo, known for their diverse medicinal properties, in the prevention of the disorder by employing molecular docking techniques, conducting drug-likeness prediction assessments, and performing ADME analysis. Methods: Amyloid beta protein was retrieved from the PDB …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 Read article
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Understanding Tennis Elbow: Causes, Symptoms, and Available Treatments
Abstract: Tennis Elbow, clinically termed lateral epicondylitis, stands as a prevalent musculoskeletal ailment affecting the outer part of the elbow. Despite its name, this condition isn't exclusive to tennis players; it often arises due to repetitive stress or overuse of the forearm muscles and tendons, leading to micro-tears and inflammation at the elbow's lateral epicondyle. The abstract focuses on elucidating the multifaceted aspects of Tennis Elbow, exploring its causes, symptoms, and …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 1–5 Read article
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Intervertebral Disc Bulge in Young Individuals: Causes, Symptoms, and Remedies
Abstract: The prevalence of intervertebral disc bulge among younger individuals has raised concerns regarding its causes, symptoms, and potential remedies. This condition, typically associated with older age, has increasingly affected younger demographics. Understanding the causes behind this phenomenon is critical in addressing its impact on the younger population. The study delves into the key aspects related to intervertebral disc bulge among young individuals. The causes of intervertebral disc bulge in young …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 13–18 Read article
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A Study to Assess the Effectiveness of Home-based Stretching Exercises on Joint Pain Among Clients with Osteoarthritis in Selected Old Age Home, Rajkot City, Gujarat
Abstract: Osteoarthritis (OA) is a commonly encountered condition in middle-aged and older individuals, marked by its slow development. Strengthening exercises targeting the quadriceps muscles, situated in the front thigh, can mitigate knee pain, and reduce disability associated with OA. The musculoskeletal system encompasses the bones of the skeleton, the joints where these bones connect, and the muscles responsible for enabling and regulating movement. The knee, the largest and most complex joint, …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 24–28 Read article
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Representation of Post-colonial Sensibility in Chinua Achebe’s “Things Fall Apart”
Abstract: The study focuses on the post-colonial aspects of Chinua Achebe‘s famous work “Things Fall Apart.” The story develops as a delicate analysis of the colonial encounter, revealing insights into its profound effect on Igbo society in the backdrop of British colonization in Nigeria. The research navigates the intricate web of post-colonial issues such as cultural clash, identity negotiation, and resistance. Achebe‘s depiction of Igbo traditions serves as a lens through …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 14, Issue 1, 2024 · pp. 45–49 Read article
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Overview of Diabetic Neuropathy: A Comprehensive Examination
Abstract: Abstract: India has earned the unfortunate distinction of being the global epicenter for diabetes, with an alarming projection of 109 million individuals expected to be afflicted by the condition by 2035The global influence of diabetic neuropathy is significant, with an estimated 132 million individuals affected as of 2010, constituting roughly 1.9% of the global populace. Notably, within the diabetic population, there exists a significantly heightened prevalence The prevalence of sensory …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 26–36 Read article
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Mixed use settlements in a metro city: Effects on people & context
Abstract: Mixed-use settlement is a building or a combination of buildings designed to functionally and physically integrate multiple uses such as commercial, institutional, recreational, and other uses along with residential uses. In such spaces, there are more opportunities for pedestrian activities due to the presence of a majority of the daily necessities at near distances. How public spaces are designed plays a significant role in affecting one’s mental state and sense …
Published in International Journal of Urban Design and Development · Vol. 2, Issue 1, 2024 · pp. 22–35 Read article
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
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Using Multitarget Molecular Docking to Examine the Antiviral Potential of Clerodendrum Phlomidis against Measles
Abstract: Objective: Measles, a viral disease caused by a member of the Paramyxoviridae virus family, is highly contagious and characterized by a respiratory illness and a maculopapular rash on the skin. Children are the main victims of the illness. In the context of drug development, this study investigates the efficacy of phytocompounds derived from Clerodendrum phlomidis against the target protein of the measles virus. Methods: The 7SKS protein was retrieved from …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 32–42 Read article
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Natural Methods for Relieving Arthritis Pain
Abstract: Arthritis, a prevalent condition marked by joint inflammation and stiffness, can greatly affect daily activities and mobility. While medications and medical treatments are commonly used to manage arthritis pain, there is a growing interest in natural remedies to ease symptoms and enhance the quality of life for those affected. This abstract examines various natural methods for relieving arthritis pain. Firstly, engaging in regular physical activity tailored to individual abilities can …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 2, Issue 1, 2024 · pp. 16–21 Read article
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Computational Screening of Vitex negundo Compounds for Potential Arthritis Therapies in India
Abstract: Objective: Arthritis is a pervasive medical condition that manifests as inflammation and discomfort within the joints. As of September 2021, arthritis has affected an estimated 180 million people in India, making it a substantial public health concern with a considerable impact on individuals' quality of life and healthcare systems. Therefore, using molecular docking, drug-likeness prediction, and ADME analysis, an effort was made to identify natural compounds from Vitex negundo, which …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 01–18 Read article
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Development of Spanish Version of Home-Based Video Module of Balance Exercises for Peripheral Vestibular Disordered Patients
Abstract: Any disturbances affecting one or more of the balance organs lead to imbalance difficulties and as a consequence, the quality of life of the affected individuals can be seriously affected, especially if the episodes end with injuries or even fatal accidents. Bal Ex is the first home-based video guided workout that was created by Zainun and her colleagues in 2009. Ten languages are currently supported by Bal Ex, including Cantonese, …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 33–41 Read article
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Anticancer Activity of Calotropis procera by Molecular Docking Analysis
Abstract: Cyclin-dependent kinase 2 (CDK2) is a protein synthesized by Calotropis procera. It is known to be responsible for causing cancer in the human body. Studies have presented the significance of the phytochemicals to inhibit the CDK2 protein. Adsorption, distribution, metabolism, and excretion (Swiss ADME) and PubChem were the pharmacological tools which were used to check molecular weight, which should be less than 500D, acceptors less than 10, and donors less …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 01–07 Read article
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Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
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Psychotherapeutic Approaches for Enhancing Perinatal Mental Health
Abstract: Pregnancy is a life turning event in a woman's life. Many women during pregnancy and after the birth of the child face mental health issues like anxiety, depression, and stress due to varied reasons. If not addressed properly, these can affect the mother-child bond, the lady's relationship with the entire family, and the child's cognitive and emotional development. As per WHO, “Globally about 10% of pregnant women and 13% of …
Published in International Journal of Behavioral Sciences · Vol. 1, Issue 2, 2024 · pp. 26–38 Read article
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Wind’s Influence on Tall Buildings with Different Aspect Ratios
Abstract: Skyscrapers and other large buildings are being constructed worldwide these days. Because wind is so dynamic, it plays a major part in the design of these towering structures. The placement and height of such structures have a major impact on how wind affects them. The comparable static approach is used in this work to evaluate wind loads on structures with variable aspect ratios attained by altering the number of bays. …
Published in Journal of Offshore Structure and Technology · Vol. 11, Issue 2, 2024 · pp. 34–43 Read article