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538 articles for “efficacy”
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
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A Pre-experimental Evaluation of a Structured Educational Program on Awareness of Mosquito-borne Diseases in Senior Secondary School Students in Punjab
Abstract: Introduction: Mosquitoes constitute the most important single family of insects from the standpoint of human health. They are found all over the world. The four important groups of mosquitoes in India that are related to disease transmission are the Anopheles, Culex, Aedes, and Mansonia. Aims: The aims of the study are to assess the effectiveness of structured teaching program on knowledge regarding mosquito-borne diseases among students of senior secondary schools …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 2, Issue 1, 2024 · pp. 7–14 Read article
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Time Series Sales Forecasting Using ARIMA Model
Abstract: Sales forecasting is a critical application in various industries and presents one of the most challenging problems worldwide. One method of prediction involves identifying patterns in historical data, where the outcome is known in advance and can be validated using more recent data. If a pattern consistently leads to the same outcome, it can be considered a genuine relationship. This method is highly flexible and can be utilized with diverse …
Published in International Journal of Algorithms Design and Analysis Review · Vol. 2, Issue 1, 2024 · pp. 17–27 Read article
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Using Multitarget Molecular Docking to Examine the Antiviral Potential of Clerodendrum Phlomidis against Measles
Abstract: Objective: Measles, a viral disease caused by a member of the Paramyxoviridae virus family, is highly contagious and characterized by a respiratory illness and a maculopapular rash on the skin. Children are the main victims of the illness. In the context of drug development, this study investigates the efficacy of phytocompounds derived from Clerodendrum phlomidis against the target protein of the measles virus. Methods: The 7SKS protein was retrieved from …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 32–42 Read article
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Oxadiazole Derivatives Recent Progress in Synthesis and Bioactivity
Abstract: Over the past few decades, significant advancements have been made in the development of heterocyclic derivatives, leading to the production of numerous novel agents, both synthetic and natural in origin. Because of its numerous biological properties, including antibacterial, antiviral, and antifungal properties, thiazole is a special five-membered heterocyclic motif among heterocyclic compounds. It is utilized as a fundamental building block in many pharmaceutically significant compounds. To the best of our …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 62–67 Read article
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Development of a Self-Cleaning Mechanism for Solar Panels to Enhance Efficiency
Abstract: On Earth, solar energy is the most plentiful source of energy. As it happens, the heat generated by the fusion of helium on the outermost part of the Sun additionally happens to be renewable. This energy is becoming popular because of natural advantages. In digital circuit design, AI can aid in logic synthesis and analog circuit design, AI can help in sizing transistors. The tools used to transform daylight into …
Published in Journal of Mechatronics and Automation · Vol. 11, Issue 1, 2024 · pp. 1–10 Read article
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A Study to Assess the Effectiveness of Body Mechanics Training Programme on Reducing Low Back Pain Among Nursing Officers Working in Selected Hospitals, Bangalore
Abstract: Background: Low Back Pain (LBP) is a common work related injury and costly problem among the nursing profession. Numerous studies indicate a greater occurrence of back pain and work-related back injuries among nursing officers in comparison to other occupations. Prevention of LBP is a very important technique to maintain proper body mechanics. This study aimed to assess the effectiveness of body mechanics training programme on reducing low back pain among …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 2, Issue 1, 2024 · pp. 29–62 Read article
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Development of Hybrid Detection and Alert mechanism for Women Safety using AI
Abstract: The integration of AI-based smart surveillance systems in enhancing women's safety and security has been a focal point of research and development. This literature study explores the impact of information technology advancements, particularly in the realm of mobile applications, GPS tracking, and social media platforms, on improving women's safety. Noteworthy contributions include the development of apps such as Circle of 6 and Be Safe, which offer women immediate access to …
Published in Journal of Remote Sensing & GIS · Vol. 15, Issue 1, 2024 · pp. 36–46 Read article
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Computational Exploration of Bhrijraj-derived Phytochemicals as Potential Anti-inflammatory Agents: A Molecular Docking Study with Cyclooxygenase-II Complex
Abstract: The molecular docking analysis was meticulously conducted using state-of-the-art computational tools, notably Chimera and Python. These tools were employed to unravel the complex interactions between the identified phytochemicals from Bhrijraj and the target protein, COX-II. The 3D structures of the phytochemicals were prepared with precision using ChemSketch, ensuring accuracy in the subsequent molecular docking simulations. This rigorous approach enhances the reliability and validity of the findings. This research aims to …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 31–37 Read article
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An Overview of Smart Attendance System and Communication system
Abstract: Our attendance is made more sophisticated and self-controlled by using "the smart attendance system (SAS)," which is the topic of this paper. It has an innovative QR scanner technology that makes the process accurate and simple. The system operates efficiently, saving us time and requiring less labor to maintain attendance. Previous versions of the monitoring system had problems locating students and required a tedious manual attendance method. Thanks to developments …
Published in International Journal of Radio Frequency Innovations · Vol. 1, Issue 2, 2023 · pp. 12–17 Read article
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Recent Progress in the Development of High- Efficiency Perovskite Solar Cell Using Copper Iodide (CuI) as Hole Transport Layer
Abstract: Solar cells are a practical option that could potentially require additional energy sources for developing new clean energy. A renewable source of electricity is characterized by its affordability, accessibility, and zero emissions from greenhouse gases. By converting sunlight photons into electrical power, photovoltaic cells are a viable option. The last two decades have witnessed numerous material opportunities for scientific advancements in photovoltaic technology, which have resulted in reduced costs and …
Published in Journal of Semiconductor Devices and Circuits · Vol. 11, Issue 1, 2024 Read article
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A Comprehensive Study Utilizing Patterned Fabric Images and Detection Techniques with OpenCV and Edge Detection
Abstract: This project offers a comprehensive overview of recent advancements in autonomous fabric failure detection methods, a critical aspect of quality control in the textile industry. Detecting flaws in fabric is an increasingly vital automation challenge. The project evaluates the effectiveness of a proposed method by analyzing patterned fabric images featuring typical flaws. The performance of the proposed approach is assessed across various types of fabric flaws. Additionally, the project tests …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 11, Issue 1, 2024 Read article
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Determining the Root Causes of Complications in Hemodialysis Maintenance Therapy
Abstract: As with peritoneal dialysis and kidney transplantation, hemodialysis has been considered one of the most effective therapies for the replacement of kidney function. While this helps to save patients with the disease by decreasing morbidity /mortality/ rates, this medication has some side effects. These may manifest during the dialysis process alongside the ongoing treatment. Avoiding these barriers becomes crucial for improving the patients’ prognosis in this context.We are going to …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 27–47 Read article
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Evaluating Linezolid: A Comprehensive Analysis
Abstract: Treatments for infections caused by Gram-positive bacteria, such as methicillin-resistant staphylococci and VRE, including skin and soft tissue infections, community-acquired pneumonia, and other infections treated with linezolid, an oxazolidinone antimicrobial agent that functions by specifically inhibiting protein synthesis. Even while antibiotic resistance is becoming more frequent in many nations, linezolid resistance among these pathogens is still low, typically less than 1%. Thus, the emergence of resistance in clinical isolates should …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 2, 2024 · pp. 11–16 Read article
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Unlocking Potential: Capecitabine’s Evolution as an Anticancer Wonder Drug
Abstract: Capecitabine, a precursor to 5-fluorouracil (5-FU), is Anticancer Drug in treating solid tumors like colorectal, breast, and gastric cancers. Its mechanism involves converting to 5-FU mainly within tumor cells, reducing toxicity while maximizing effectiveness. Besides being effective alone, it is also valuable in combination therapies, showcasing its versatility in cancer treatment. This review explores the transformative journey of capecitabine as a pivotal anticancer drug. Beginning with an introduction to its …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 2, 2024 · pp. 17–24 Read article
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Implementing Quality by Design (QbD): Strategies, Challenges, and Best Practices across Industries
Abstract: The present comprehensive review investigated the dynamic landscape of quality standards within the pharmaceutical sector, with a primary focus on the implementation and impact of Quality by Design principles. It illuminated the multifaceted challenges encountered by pharmaceutical companies in upholding stringent quality standards amidst evolving regulatory requirements and complex manufacturing processes. By embracing Quality by Design principles, the industry aims to foster a proactive and systematic approach to product development …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 28–36 Read article
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Ayurvedic Management of Vataja Oshtharoga Whole System Research (W.S.R.) to Pigmented Contact Cheilitis—A Case Report
Abstract: Acharya Sushruta, in his ancient text, delineated 65 types of Mukha Roga, categorizing them into seven Mukha Avayava. Among which eight Oshtha Roga was classified as Vattaja, Pittaja, Kaphaja, Sannipataja, Rakta, Mamsaja, Medaja, and Kshataja. Among these, Vataja Oshtha Roga stands out, typified by pigmented contact cheilitis in modern medical parlance. This condition manifests initially with a tingling, itching sensation accompanied by swelling of the lips. Over time, the lips …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2024 · pp. 09–13 Read article
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Switching in Bilinguals: Evidence from Forward and Backward Switching Tasks Across Visual and Auditory Modality
Abstract: Bilingualism refers to the use of two languages on a day-to-day basis. Defining bilingualism operationally is complex due to the heterogeneity associated with it. Proficiency in the second language can vary on an individual basis. Bilinguals can be classified as balanced or dominant, high proficient or low proficient based on the proficiency levels. The effect of bilingual proficiency on executive functions has been studied extensively. The current study explored the …
Published in Emerging Trends in Languages · Vol. 1, Issue 1, 2024 · pp. 19–23 Read article
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Characterization of Synthesized Heterocyclic Oxadiazole Derivatives Using Mass, UV, IR, and NMR Spectroscopy, Among other Spectroscopic Techniques: Review
Abstract: The current study synthesized and assessed 3-heteroarylazo 4-hydroxy coumarin derivatives' initial antibacterial activities in vitro against four distinct pathogenic bacterial strains, including Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli, and Staphylococcus aureus. Ampicillin, a common medication, was used to compare each compound's antibacterial properties. UV, IR, 1H NMR, mass spectroscopy, and X-ray diffraction examinations were used to analyze the compounds. By using UV–vis spectra, the solute-chromic behavior of these compounds was …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 1, Issue 1, 2023 · pp. 28–33 Read article
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Performance Analysis of Deep CNN Architectures
Abstract: A Convolutional Neural Network (CNN) is an artificial neural network renowned for its remarkable ability to handle large image datasets effectively, particularly excelling in tasks such as image recognition and classification. The fundamental structure of a CNN relies on mathematical convolution operations, comprising essential components such as convolutional layers, activation functions, pooling layers, and fully connected layers. These components work synergistically to extract and learn hierarchical features from input data, …
Published in Journal of Communication Engineering & Systems · Vol. 14, Issue 2, 2024 · pp. 1–8 Read article