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208 articles for “canny–deriche detector”
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Unearthing the Mysterious Properties of Dark Matter through Astrophysical Studies
Abstract: The nature and characteristics of dark matter, which makes up a sizeable fraction of the universe's stuff, are yet unknown.. Astrophysics plays a crucial role in understanding the mysteries surrounding dark matter, as it provides observational evidence, theoretical frameworks, and computational tools to study its effects on cosmic structures. This article reviews recent advancements in astrophysical observations and theoretical modeling aimed at unraveling the nature of dark matter. Observational investigations …
Published in Research & Reviews : Journal of Physics · Vol. 12, Issue 1, 2023 Read article
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Analytical Method Development and Validation for the Simultaneous Estimation of Elvitegravir and Cobicistat by RP-HPLC Method
Abstract: A new method was established for simultaneous estimation of Elvetigravir and Cobicistat by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Elvetigravir and Cobicistat by using Xterra C18 5 µm (4.6×150 mm) column, flow rate was 1 ml/min, mobile phase ratio was phosphate buffer (0.05 M) pH 7: MEOH (30:70%v/v) (pH was adjusted with orthophosphoric acid), and the detection wave length was 270 nm. The instrument …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 2, 2018 · pp. 1–6 Read article
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Determination of RP-HPLC Method for Safinamide: Its Bulk and Tablet Dosage Form
Abstract: A new method was established for estimation of Safinamide by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Safinamide by using Agilent C18 column (4.6×150 mm, 5 µ); flow rate was 1 ml/min, mobile phase ratio was Methnol, Acetonitril (60:40), pH 3 (pH was adjusted with orthophosphoric acid), detection wavelength was 235 nm. The instrument used was WATERS HPLC Auto Sampler, Separation module 2695, photo diode …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 3, 2018 · pp. 1–6 Read article
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Development and Validation of RP-HPLC Method for Determination of Thermal Degradation Impurity in Macrolide Immunosuppressant Substance and Drug Product
Abstract: The present study describes a simple and stability-indicating reverse phase high-performance liquid chromatography (RP-HPLC) method for the quantification of the thermal degradation impurities of Tacrolimus (FK506) namely Ally ester rearrangement impurity (Impurity R) in Tacrolimus capsules and drug substances. Successful separation of impurity R from Tacrolimus, its other related substances and its tautomers were achieved on a Zorbax XDB C8 (150×4.6 mm, 5 μm) and detector of UV at 210 …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 1, 2016 · pp. 14–19 Read article
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A New RP-HPLC Method for Simultaneous Estimation of Atorvastatin and Fenofibrate in Its Bulk and Tablet Dosage Form
Abstract: Objective: A New method was established for simultaneous estimation of Atorvastatin and Fenofibrate by RP-HPLC method. Methods: Chromatographic separations were carried using Phenomenex C18 column (4.6 × 250 mm, 5 µm) column with a mobile phase composition of 0.1 M Ammonium acetate:acetonitrile (60:40) have been delivered at a flow rate of 1ml/min and the detection was carried out using waters HPLC auto sampler, separation module 2695 with PDA detector at …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 3, 2023 · pp. 12–18 Read article
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Development and Validation of RP-HPLC Method for Estimation Ertugliflozin in Its Bulk and Tablet Dosage Form
Abstract: Background: This study developed and validated a new, sensitive, appropriate, clear, accurate, and robust reversed-phase high-performance liquid chromatography (RP-HPLC) method for determining safinamide in bulk medication and tablet formulations. An HPLC procedure using a UV detector and the Openlab EZchrome workstation programme was used to separate the samples, as well as a Kromasil C18 (250 mm × 4.6 mm i.d.) 5 μm. At a flow rate of 1.0 mL/min, methanol …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 1, 2022 · pp. 8–20 Read article
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Spectroscopic and Chromatographic Methods for Estimation of Voriconazole in Bulk and Pharmaceutical Dosage Forms
Abstract: Rapid, accurate and precise methods have been developed for estimation of voriconazole in bulk and pharmaceutical dosage forms using Ultraviolet (UV) spectroscopy and reverse phase high performance chromatography (RP-HPLC). The λmax selected in UV spectroscopy method was 255 nm and the calibration curve was linear in the concentration range of 2-50 µg/mL with correlation coefficient (r2)>0.99. In RP-HPLC method, the separation was carried out on Kromasil C18 (250 x 4.6mm, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 1, 2023 · pp. 33–39 Read article
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New RP-HPLC Method Development and Validation for Simultanious Estimation and Forced Degradation Studies of Gallic acid and Curcumin in Solid Dosage Form
Abstract: Objective: A New method was established for simultaneous estimation of Gallic acid and curcumin by RP-HPLC method. Methods: Chromatographic separations were performed on an Inspire (4.6 x 150mm, 5m) column with a mobile phase composition of 0.1 percent OPA buffer and Acetonitrile (30:70) delivered at a flow rate of 1 ml/min, and detection was performed on a waters HPLC auto sampler, separation module 2695 with PDA detector 2996 at wavelength …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 13, Issue 1, 2022 · pp. 7–15 Read article