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245 articles for “agent evaluation”
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Novel 1,3,4-Thiadiazole Derivatives: Design, Synthesis, Characterization and Anticancer Evaluation – A Review
Abstract: Cancer remains one of the leading causes of mortality worldwide despite significant advances in diagnosis and treatment. The clinical usefulness of many anticancer drugs is often restricted by toxicity, poor selectivity, and the emergence of drug resistance. These limitations have encouraged the search for novel heterocyclic compounds with improved therapeutic efficacy and safety. Among these, the 1,3,4-thiadiazole scaffold has gained considerable attention because of its favorable physicochemical characteristics, metabolic stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 42–49 Read article
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Analytical and in Vitro Evaluation of Krimighna Karma of Padumale, A Folklore Plant–Lindernia Crustacea (L) F. Muell W.S.R. To Diarrheagenic Organisms
Abstract: Traditional knowledge of medicinal plants got more importance in recent era. Hence there is a need to develop new effective traditional drugs with scientific validation. One such plant is Lindernia crustacea (L) F. Muell called as padumale in south canara district, Karnataka. It is small slender prostrate plant found in moist shady places. The local people successfully use the juice of fresh plant in few drops once in a day …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 9, Issue 03, 2022 · pp. 1–11 Read article
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Mechanistic and Catalytic Behavior of Os(VIII) for the Chlorpheniramine Maleate and Bromamine-B Redox System: A Kinetics Based Approach
Abstract: Chlorpheniramine maleate (CPM) is an important antihistamine agent. To the best of our knowledge there is no report in the literature about the oxidation of CPM with halogen + 1 oxidant from the stand point of its kinetics and mechanistic chemistry. Hence, a systematic kinetics and mechanistic study on the oxidation of CPM with bromamine-B (BAB) in the presence of NaOH and Os(VIII) catalyst has been carried out at 303 …
Published in Journal of Catalyst & Catalysis · Vol. 2, Issue 1, 2015 · pp. 18–31 Read article
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Paeonia emodi: An Ethnopharmacological and Phytochemical Review
Abstract: This review is an attempt to evaluate the phytochemical potential of the Paeonia emodi and covers the pharmacological and ethnopharmacological activities of its chemical constituents, newly isolated chemical compounds and their medicinal importance. P. emodi is used in several traditional medicinal systems in China, Korea, Pakistan, India and Thailand. Different isolated natural products like anthraquinones, terpenoids, tannins, carbohydrates, phenolics and tannins, glycosides, paeoniflorin, lactiflorin, oxypaeoniflorin, cycloartenol, cholesterol, sitosterol, campesterol, emodinol, …
Published in Research & Reviews : Journal of Herbal Science · Vol. 6, Issue 2, 2017 · pp. 11–20 Read article
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RoseRAG-Based Clinical Decision Support System for Precision Medication Safety
Abstract: Medication-related errors remain a major challenge in healthcare, contributing to adverse drug events, increased hospitalization rates, and substantial healthcare costs. Conventional Clinical Decision Support Systems (CDSS) primarily rely on rule-based mechanisms for identifying drug-related problems (DRPs), including drug–drug interactions, contraindications, dosing errors, therapeutic duplication, and medication omissions. Although effective in structured environments, these systems frequently generate excessive context-insensitive alerts, leading to alert fatigue and reduced clinical acceptance. Recent developments in …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 13, Issue 3, 2025 Read article
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Anticancer and Antioxidant Property of Bunium bulbocastanum Fruits Various Fractions
Abstract: Bunium bulbocastanum (family Apiaceae) fruits are normally used as a culinary spice for years. Since antioxidant property has a significant role in preventing oxidative stress, which has been demonstrated to be a major cause in the pathogenesis of cancer, the present study was aimed to evaluate the in vitro antioxidant and cytotoxic effect of Bunium bulbocastanum fruit extracts. Standard in vitro antioxidant assays such as reducing power, super oxide scavenging, …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 3, Issue 1, 2016 · pp. 9–13 Read article
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Computational Investigation of Phytochemicals Targeting AKT1 for Major Depressive Disorder: A Molecular Docking and ADMET Study
Abstract: Major depressive disorder (MDD) is a prevalent neuropsychiatric condition affecting approximately 280 million individuals worldwide, with women exhibiting a 50% higher likelihood of diagnosis than men. Despite significant advancements in treatment, MDD remains a chronic and relapsing disorder, necessitating the exploration of novel therapeutic interventions. This study focuses on the AKT1 gene, a key player in neuropsychiatric disorders, and investigates its interactions with natural phytochemicals as potential alternatives to conventional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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Neuro-Symbolic Agentic AI for Autonomous Scientific Discovery: Integrating Deep Reinforcement Learning, Quantum Simulation, and XAI-Audited LLM Hypothesis Generation in Drug Target Identification
Abstract: The exponential growth of multi-omics data and the increasing complexity of disease-associated protein interactomes have rendered conventional drug target identification pipelines computationally and epistemologically inadequate. This paper presents the Neuro-Symbolic Agentic AI for Scientific Discovery (NS-AASD) framework, a unified architecture that cohesively integrates deep reinforcement learning (DRL) exploration strategies, variational quantum simulation (VQS) of protein conformational dynamics, and XAI-audited large language model (LLM) hypothesis generation within an autonomous scientific discovery …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 2, 2026 · pp. 15–24 Read article
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Mechanical and Sustainable Enhancement of Epoxy Composites using Tamarind Seed Powder
Abstract: The investigation examines how tamarind seed powder affects epoxy-based materials for the development of waste-based useful products. The research examines the mechanical behavior of epoxy resin composites which contain tamarind seed powder in increasing percentages spanning from 10% to 40%. The team utilized the hand layup method to produce the composites which then fulfilled the ASTM guidelines for specimen fabrication for mechanical tests. The study examined fundamental mechanical parameters by …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 797–806 Read article
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Anti-Tumour and Anti-Bacterial Activity of Some Ethno-Medicinal Plants
Abstract: Background: Every year, millions of people are diagnosed with cancer, leading to death in a majority of the cases. Because of the high death rate associated with cancer and serious side effects of chemotherapy and radiation therapy, many cancer patients seek alternative methods of treatment. Regarding the safety and effectiveness of natural therapies, the researchers are more interested in the use of natural medicine. In the present investigation, the anti-tumour …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 3, 2017 · pp. 16–22 Read article
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In Vitro–In Vivo Correlation (IVIVC): A Strategic Tool in Drug Product Development
Abstract: In a recent era many concepts are dealing as an emerging tool for the drug delivery application like Biopharmaceutical Classification System (BCS), In vitro and In vivo study, and Bioavailability/Bioequivalence (BA/BE) study etc. To determine Therapeutic efficiency in vitro is not enough so the concept of In vitro-In vivo correlation (IVIVC) is playing as an convincing correlation with this for concept of pharmaceutical dosage forms have been a main focus …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 3, 2016 · pp. 31–54 Read article
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Preoperative Use of Midazolam vs Dexmedetomidine for Anxiolysis in Day-Care Surgery
Abstract: Surgical procedures trigger significant fear and anxiety that can adversely affect physiological responses and recovery outcomes. This prospective, randomized, double-blinded clinical trial compared the anxiolytic efficacy and safety of intravenous midazolam and dexmedetomidine in 60 patients undergoing day-care surgery. Primary outcomes included anxiety scores measured by STAI and sedation assessed by the OAAS scale at multiple perioperative time points. Secondary outcomes assessed in the study included detailed evaluation of hemodynamic …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 7–12 Read article
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Path Lab-AI: An Autonomous Framework for Error-Free Histopathology Slide Interpretation
Abstract: Path Lab-AI represents a fully autonomous platform for the analysis of histopathology slides with circumscribed structures, designed to obtain highly accurate results using diagnostic methods and avoiding the usual limitations of standard microscopy-based pathology. Leveraging recent deep learning and whole slide image (WSI) analysis innovations, our system takes advantage of automated WSI ingestion along with pre-processing steps to account for staining variability, remove artifacts, and localize tissue from background. Such …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 19–30 Read article
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Molecular Characterization of Respiratory Viral Infections and Co-Infections in Pediatric Patients Using FilmArray™ Multiplex PCR in a Tertiary-Care Hospital, South India
Abstract: Respiratory tract infections (RTIs) are a major cause of pediatric morbidity worldwide, with viruses, such as respiratory syncytial virus, rhinovirus/enterovirus, influenza virus, adenovirus, and parainfluenza virus, contribute significantly to hospitalizations. Conventional diagnostic methods often require prolonged processing times, which can delay clinical decision-making. Rapid molecular platforms, such as the FilmArray™ Panels, offer timely and comprehensive pathogen identification. This study aimed to evaluate the prevalence, seasonal trends, and co-infection patterns of …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 16, Issue 2, 2026 · pp. 57–66 Read article
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In silico analysis of Abrus precatorius L. as a potential agonist of PPARγ : A novel approach to the treatment of diabetes
Abstract: Diabetes mellitus is a chronic disorder that is characterized by a lack of insulin secretion by the pancreas or a defect in insulin action, or both. If diabetes is not controlled, over time it can cause damage to blood vessels and nerves, leading to life-threatening complications such as, kidney damage, heart disease and vision impairment. It can also weaken the immune system, making patients more prone to infection. Although treatments …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 · pp. 13–24 Read article
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Preparation, Categorization and Anticancer Study of Novel Bicyclic Compounds from Various Types for (Five and Six)- Membered Ring
Abstract: The characteristics of ring systems change in the presence of functional groups, but in some cases, elements that are considered functional groups can be classified within the same ring. Compounds that contain only carbon and hydrogen are called homogeneous rings, while those that contain other elements are called heterogeneous rings. The atom substituted in place of the carbon atom is referred to as a heteroatom. Generally, the heterocyclic atom is …
Published in Journal of Catalyst & Catalysis · Vol. 12, Issue 3, 2025 · pp. 18–30 Read article
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Development and Evaluation of a Novel Polyaniline/Polyvinyl Alcohol/Silver Nanocomposite for Antibacterial Applications: Synthesis and Characterization
Abstract: A novel nanocomposite made up of polyaniline, polyvinyl alcohol, and silver (PAL/PVA/Ag) was synthesized using the reduction of chemical technique in this study. Aniline was polymerized in situ with ammonium persulfate to create polyaniline (PAL), while Ag+ ions were employed to make an nanoparticle of Ag colloidal solution. The combination of Ag nanoparticles with the PAL/PVA composite resulted in the development of a new nanocomposite. Scanning electron microscopy (SEM) and …
Published in Journal of Polymer & Composites · Vol. 11, Issue 3, 2023 · pp. 39–47 Read article
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Continuous Thoracic Epidural Infusion: A Comparative Study of Fentanyl and Ropivacaine V/S Fentanyl and Bupivacaine in Upper Abdominal Surgery for Postoperative Analgesia
Abstract: To measure and compare the efficacy of analgesia with the both techniques with measurement of changes in hemodynamics, respiratory rate, and SPO2 with the two techniques and to compare their side effects and evaluate the patient’s satisfaction. The random selection of patients was allocated in two groups. Each group consist of 25ASA group I–II patients. Infusion was given at the rate of 0.1 ml/kg/h. Group RF: continuous thoracic epidural infusion …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 3, Issue 2, 2014 · pp. 1–10 Read article
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To Compare the Anti-Bacterial Activity of Uva Ursi 200 And Cantharis Vesicatoria 200 In Isolated E-Coli of Different Urine Samples by Kirby Bauer Disc Diffusion Method
Abstract: Background: The most common bacterial infections are Urinary Tract Infections (UTI), primarily caused by Escherichia coli (E. coli), a gram negative bacterium responsible for 80-90% of community-acquired UTIs. The rise of antibiotic-resistant E. coli strains has increased the demand for Homoeopathic remedies. This study explores the antibacterial efficacy of Uva ursi 200 and Cantharis vesicatoria 200, using Kirby-Bauer Disc Diffusion Method, by comparing the Zone of Inhibition (ZOI) of those …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 3, 2026 Read article
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Preparation of a Novel Polyherbal Hair Dye Formulation: Better Coloring and Protection Offered as Compared to Marketed Products
Abstract: Synthetic dyes contain permanent coloring agents such as aromatic diamine, amino compounds (4-amino-2-hydrosytoluene, meta-aminophenol, etc.), hydric phenols, polycompounds (para-phenylenediamine) which results in many side effects such as skin irritation, erythrema, loss or damage of hair, and even skin cancer. Dyes obtained from various plant sources are simply available, economical, safe, competent, and rarely have side-effects. In traditional systems of medicines such as Ayurveda, Unani, Siddha, and Homeopathy, the prescribed dyes …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 7, Issue 1, 2020 · pp. 11–15 Read article