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412 articles for “Gene targeting”
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Multi-objective Reactive Power Planning based on MNSGA II
Abstract: Abstract This paper presents an application of modified NSGA-II (MNSGA-II) to reactive power planning (RPP) problem by minimizing the total cost (which consist of sum of annual energy cost and the installation cost of additional reactive power sources) and the load bus voltage deviations. Voltage stability index is considered as an additional constraint in order to include the system stability into account. Reference Pareto-front is generated using covariance matrix adopted. …
Published in Journal of Nuclear Engineering & Technology · Vol. 10, Issue 1, 2020 · pp. 37–45 Read article
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In- silico Design of Novel Inhibitors for 5-HT2A Receptor to Recuperate Schizophrenia
Abstract: Schizophrenia is a mental disorder characterized by positive symptoms such as disorganized speech, delusions and hallucinations and negative symptoms such as deficits of attention, affective flattening and social withdrawal in nature. There are several receptor involve in schizophrenia, one of these 5-HT2A receptor i.e. serotonin receptor. The serotonin receptor 5-HT2A has been involved in several neurological conditions and potent 5-HT2A inhibitors have therapeutic effects that use for the treatment of …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 2, 2015 · pp. 11–17 Read article
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Innovative Vaccine Technologies: Current Landscape and Future Prospects in Preventive Medicine
Abstract: This review article presents a comprehensive analysis of recent advancements and emerging trends in vaccine development, offering insights into the dynamic landscape of preventive medicine. Delving into a spectrum of infectious diseases, including influenza, HIV/AIDS, malaria, tuberculosis, respiratory syncytial virus (RSV), Group B Streptococcus (GBS), norovirus, and chikungunya, the review highlights innovative approaches and breakthroughs in vaccine technology. It explores efforts to develop universal influenza vaccines, long-awaited HIV vaccines, and …
Published in International Journal of Vaccines · Vol. 1, Issue 2, 2024 · pp. 07–15 Read article
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A Comprehensive Analysis of Novel Liposomes: Categorization, Approach, Description, and Present Formulations
Abstract: Liposomes have gained attention as a promising drug delivery system, which come with the advantages of biocompatibility, ability to load hydrophilic and hydrophobic drugs, and they can function for targeted drug delivery. In this regard, this paper offers a comprehensive overview on novel liposomes, including classification, formulation strategies, detailed structures, and current pharmaceutical applications. Recent advances in liposomal drug delivery systems includes, new liposomal architectures (i.e. stealth, targeted, stimuli-responsive, hybrid …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 15–20 Read article
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Uncontrolled Cell Growth and Human Health: A Comprehensive Exploration of Cancer
Abstract: Cancer is a diverse category of diseases defined by the uncontrolled proliferation and spread of aberrant cells. It remains the major cause of morbidity and mortality worldwide. This article presents an overview of the various forms of cancer, such as carcinomas, sarcomas, lymphomas, and leukaemia, emphasising their distinct causes, symptoms, and risks. Early detection and diagnosis are emphasized as key to enhancing treatment outcomes. The article further provides an in-depth …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 1, 2026 · pp. 1–23 Read article
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A Steady on Quality Update in New Austrian Tunneling Method (NATM) Technology for Safe Underground Shortest Path in Road Transportation Networks
Abstract: Metro train project is a combination of many related engineering fields as civil engineering, computer engineering, mechanical engineering and electrical engineering etc. But here, we discus about civil engineering and computer engineering related project report. Firstly we start from railway track/road. A railway track network can be considered as a graph (a graph is an ordered pair G=(V, E) comprising a set V of vertices or nodes or points together …
Published in Journal of Open Source Developments · Vol. 3, Issue 2, 2016 · pp. 20–26 Read article
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Transient Heat Shock Induces Oxidative Stress in Mice Testes. Amelioration by Selenium and Vitamin E
Abstract: The present study evaluated the role of Selenium (0.5 ppm selenium/kg diet) and Vitamin E (200 mg alpha-tocopherol/kg diet) (as antioxidants) in modulating the oxidative stress induced during transient heat shock (42°C-30 mins) in mice testes. Study included six different groups of male Balb/c mice; Control, Heat shock, Selenium, Selenium+heat shock, Vitamin E and Vitamin E+heat shock. Sperm parameters viz. sperm concentration and sperm motility, LPO and ROS levels, GSH, …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 2, 2019 · pp. 17–31 Read article
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IN SILICO EVALUATION OF INHIBITORY POTENTIAL OF SOME COMMERCIALLY AVAILABLE FLAVONOIDS AGAINST BETA- SECRETASE IN THE MANAGEMENT OF ALZHIEMER’S DISEASE
Abstract: In a continuing effort to develop multitargeted compounds as potential treatment agents against Alzheimer's disease (AD), a certain commercially available flavonoids were evaluated against crystal structure of beta-secretase enzyme using in silico docking studies. In this perspective, flavonoids like apigenin, galangin, gallocatechol, genistein, luteolin, myricetin, and theaflavin were selected. AutoDock 4.2 software was used for the in-silico docking studies which possess the principle of Lamarckian genetic algorithm. In the docking …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 2, 2019 · pp. 30–35 Read article
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Molecular Docking Analysis of Punica granatum Compounds as Potential Inhibitors for Colorectal Cancer-Associated Molecular Targets
Abstract: Objective: Cancer is one of the most common worldwide disease which threat the life of a person. Colorectal cancer is one of the common cause of death nowadays. As computation approach is now employed for new drug discovery, target protiens like CDK-2, matrix metalloproteinase 2 (MMP-2), cyclin A, poly (ADP- ribose) polymerase (PARP-1) and Cox2 were chosen to perform molecular docking against the derivatives of Punica granatum phtyochemicals and Food …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 28–42 Read article
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Practical studies in Vero cell and Human amnion cells for viral and stem cell applications
Abstract: Vero cells are one of the most popular mammalian continuous cells in molecular, cellular, and microbiological research. African green monkey kidneys are used to make these.One continuous cell line is the Vero cell line. This cell line is dependent on anchorage. Vero cells can be cultured in suspension because they are anchorage independent. Thought to be non-tumorigenic cells that came from a female Chlorocebus sabaeus Numerous viruses can infect vero …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 1–8 Read article
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Descriptive Study to Evaluate Attitudes Toward Teenage Pregnancy Among Nursing Students in a Selected College in Virudhunagar
Abstract: This study aimed to explore the attitudes of nursing students toward teenage pregnancy, focusing on a specific college in Virudhunagar. A purposive sampling technique was employed to select 50 participants using non-probability sampling methods. Data were gathered through a structured questionnaire based on a 5-point Likert scale, comprising 10 statements with response options ranging from "strongly disagree" to "strongly agree." The data collected were systematically organized, tabulated, and analyzed using …
Published in International Journal of Midwifery Nursing And Practices · Vol. 2, Issue 2, 2024 · pp. 22–27 Read article
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Polymer Chemistry and Composite Materials in Biomedical Applications
Abstract: The integration of polymer chemistry and composite materials has revolutionized biomedical applications. Recent advancements in polymer synthesis, functionalization, and nanotechnology have further expanded their applications, leading to significant improvements in biocompatibility, biodegradability, and mechanical performance. These polymeric carriers protect bioactive compounds from enzymatic degradation, enable controlled drug release, and improve therapeutic efficacy. The integration of polymer chemistry with nanotechnology has enabled the development of highly efficient, targeted therapeutic systems that …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 413–419 Read article
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Protein-Tyrosine Phosphatase-1B (PTP-1B) Inhibitory Perspectives of Hydroxylated Chalcones: Exploration through Docking Studies
Abstract: The current research emphasized on exploring the Protein-Tyrosine Phosphatase-1 B (PTP-1B) inhibitory potentials of hydroxylated chalcone derivatives against PDB ID: 4I8N (PTP-1B in complex with an inhibitor [(4-{(2s)-2-(1,3-benzoxazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl}phenyl)amino](oxo)acetic acid) by molecular docking approach using the iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. The current molecular docking analysis of some hydroxylated chalcone derivatives have presented a profound inhibition of the antidiabetic target PTP-1B by interacting with the amino acid residues …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 6, Issue 1, 2019 · pp. 4–8 Read article
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Exploring the Therapeutic Potential of Grapeseed Phytoconstituent Through Molecular Docking Analysis for Multiple System Atrophy Treatment
Abstract: Objective: Alpha-synuclein (α-Syn) aggregates are a common neurodegenerative disorder associated with Parkinson’s disease and multiple system atrophy (MSA). As a fruit that is extensively grown, grapes have several pharmacological advantages when it comes to reducing oxidative stress. Research has indicated that grape seed phytoconstituents have a major effect on α-Syn. The objective of this study is to inquire into the pharmacological characteristics and potential therapeutic applications of grape seed derivatives …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 14–26 Read article
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Investigating the Dynamics of Quantum Plasmas: Current Advancements and Prospective Trajectories
Abstract: Plasma is regarded as quantum if its macroscopic properties are significantly affected by the quantum nature of its constituent particles. A proper description is necessary to comprehend the importance of collective quantum plasma effects. In this entry, the field of quantum plasmas, a generic exotic state of highly ionized matter where quantum effects are relevant, is discussed, for example, by dense plasmas arising from strong laser irradiation of solid targets …
Published in Research & Reviews : Journal of Physics · Vol. 13, Issue 1, 2024 · pp. 22–34 Read article
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Proposed System: Quantum Computing Processor Based on Linear Number Relation
Abstract: This paper details the design and implementation of a specialized quantum processor tailored for efficiently evaluating custom mathematical formulas. Optimized to perform a specific set of arithmetic and logical operations, this processor delivers a stable and high-performance computing platform. Unlike general-purpose quantum processors, which are designed for versatility across a wide range of algorithms, this dedicated processor aims to enhance performance and accuracy for a targeted set of tasks. The …
Published in Recent Trends in Parallel Computing · Vol. 11, Issue 3, 2024 · pp. 24–32 Read article
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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A Study on Recent Trends in Chemical Sensors for Detecting Toxic Materials
Abstract: Poisonous materials, such as mutagenic, carcinogenic, and poisonous compounds, are widely produced as a result of industrial development. Such materials continue to be hazardous to human health despite stringent management and control procedures. As a result, practical chemical sensors—such as optical, electrochemical, nanomaterial-based, and biological system-based sensors—are needed for the monitoring of dangerous chemicals. For the detection of harmful compounds, numerous new and existing chemical sensors are being created, along …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 3, 2025 · pp. 26–35 Read article
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Greener 3D Printing: The Role of Artificial Intelligence in Sustainable Polymer and Composite Manufacturing
Abstract: The integration of sustainable materials with additive manufacturing (AM) technologies marks a significant step towards environmentally responsible production. Biodegradable polymers, recycled thermoplastics, and bio-based composites, when used in 3D printing, offer the potential to reduce the ecological footprint of manufacturing. However optimizing the interplay between material properties process parameters, and product performance remains a complex challenge. This review examines how artificial intelligence (AI) is being applied to address these challenges …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 288–300 Read article
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Scanning Electron Microscopy of Candida albicans Cell Wall on Tooth Surface after Fluconazole-Treated and Incubated with Guava (Psidium guajava L.)
Abstract: The cell wall of Candida albicans is a target of fluconazole. The content of guava (Psidium guajava L) is known to contribute factors to resistance of fluconazole.Objective: To characterize the surface alterations and the general shape changes of Candida cells after in vitro exposure to fluconazole and guava.Material and Methods: Six tooth specimen groups—Cells exposed without fungicidal doses (negative control), Positive cells exposed to maximal fungicidal doses of Fluconazole (100 …
Published in Research and Reviews: A Journal of Dentistry · Vol. 8, Issue 3, 2017 · pp. 10–17 Read article