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1959 articles for “Disc” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Against Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Analysis of Signal Processing Algorithms for Bio-Medical Applications
Abstract: Epilepsy is a burdensome brain disorder, in which heavy seizures will happen again and again. Sudden explosion of electrical activity during the seizures will create a blackout for patients and it will break the body equilibrium, so patients may fall down. Epilepsy affects a large population around the globe. It may begin at any age and last for generations. It can be controlled by the surgical removal of the brain …
Published in Current Trends in Signal Processing · Vol. 12, Issue 3, 2022 · pp. 24–27 Read article
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Comprehensive Analysis of Electric Scooters: Investigating Challenges, Failures And Component Optimization for Enhanced Urban Mobility.
Abstract: Renewable energy, a global topic of discussion, has made significant strides in preserving our ecosystem. Environmental pollution stands as a critical issue, necessitating proactive measures for mitigation. The emergence of electric scooters represents a positive step towards environmental conservation; however, their acceptance as urban mobility vehicles is hindered by safety apprehensions. This research delves into e-scooter design, aiming to enhance productivity and address challenges. By identifying accidents and operational failures, …
Published in Journal of Automobile Engineering and Applications · Vol. 10, Issue 1, 2023 · pp. 45–60 Read article
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Investigation of Physical Characteristics and Machining Parameters of Improved Al-SiC MMC Using Dry EDM Process for Aerospace Industries
Abstract: Aluminium-based composite is widely used in aerospace and automobile industries because it is lighter in weight; but the trouble is that it is easily worn-out and life of the components is decreased. To overcome these problems, aluminium silicon carbide composite material has been developed with good wear-resistance, hardness and lighter weight. Silicon carbide has good mechanical properties like wear resistance, hardness, toughness and high melting point. Silicon carbide weight fractions …
Published in Journal of Experimental & Applied Mechanics · Vol. 9, Issue 1, 2018 · pp. 15–32 Read article
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Review on Main Equations for Measuring Spray Properties in Centrifugal Injectors
Abstract: The method of fuel injection has a significant effect on the stability and proper mixing of fuel and oxidizer, which is done by the injector. In other words, the injector is a device that converts fluid into droplets. The faster and better the particle crushing rate, the faster the fluid particles will evaporate, resulting in higher thermal efficiency and higher thrust force. Therefore, how to inject fuel into the combustion …
Published in Journal of Industrial Safety Engineering · Vol. 8, Issue 3, 2021 · pp. 17–23 Read article
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Evaluation of Optimal Parameters for Wire EDM Machine on En45A Alloy Steel using Taguchi and Grey Relational Analysis (GRA) Method
Abstract: The core goal of this research paper is to evaluate process parameters of wire electrical discharging machining and to find out the best parameter among the multiple responses given by machine. Wire cut machine is very accurate and precise machine which is actually manufactured to cut those material which have high strength, toughness, and hardness. This machine works on melting property; here spark is generated between the work piece and …
Published in Journal of Materials & Metallurgical Engineering · Vol. 6, Issue 1, 2016 · pp. 11–21 Read article
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Processing of Magnesium Metal Matrix Composite Reinforced with Graphene Nano Platelets through Vacuum Stir Casting and Investigating its Mechanical Behaviour
Abstract: AbstractThe application of metal matrix composites (MMCs) as structural engineering materials has received increasing attention in recent years. Their high strength and toughness at elevated temperatures coupled with low-density makes them suitable for use in applications where conventional engineering materials, such as steel are used. MMCs exhibit significantly higher stiffness and mechanical strength compared to matrix alloys, but often suffer from lower ductility and interior fracture toughness. MMCs have the …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 5, Issue 3, 2018 · pp. 21–29 Read article
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Experiments to Control the Surface-Driven Microfluidic Flow of Dyed Water in Straight PMMA Microchannels Fabricated by Maskless Lithography, Hot Embossing Lithography and Direct Bonding Technique
Abstract: Total six individual straight microchannels are fabricated by maskless lithography, hot embossing lithography and direct bonding technique using author’s own hands-on completely inside the cleanroom laboratory. Polymethylmethacrylate (PMMA) is the selected polymeric material to fabricate these straight microchannels. Dyed water is prepared as working liquid to record and study the microfluidic flow characteristics inside these fabricated microchannels. Air dielectric barrier discharge (DBD) plasma processing is the surface modification technique in …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 7, Issue 1, 2020 · pp. 17–23 Read article
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Blind Image Quality Assessment using NSS Approach in the DCT Domain
Abstract: We have develop an efficient model for improving image quality using IQA and NSS based on blind image Quality Assessment.This algorithm does computation for the parameters which user expect at output. The certain extracted features approach depends on a simple Bayesian inference model to dipict image quality scores. The project features are based on statistic scenes of discrete cosine transform for images. The resultant parameters of the model are used …
Published in Recent Trends in Electronics Communication Systems · Vol. 8, Issue 3, 2021 · pp. 1–6 Read article
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Image Preprocessing And Analysis On Eye Fundus Images Segmentation By Using Density Clustering Methods
Abstract: Abstract: In order to do an automated evaluation of various retinal illnesses such as Diabetic retinopathy, Glaucoma, and Macular Edema, fundus images must be pre-processed first. For many reasons, it's difficult to accurately detect the optic disc. Many blood vessels cross the optic disc, making it difficult to discern the disc's boundaries in fundus images. Lesion regions in diabetic retinopathy look very much like an optic disc's colour and texture, …
Published in Recent Trends in Sensor Research & Technology · Vol. 8, Issue 3, 2021 · pp. 11–18 Read article
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A Review: Application of Ant Algorithm in Transport Network Design Problems
Abstract: A dependable and reliable information source for transportation route planning and ready response to traveler demand, have become a hot topic of research these days. Transportation route planning, analysis and processing of traveler demand are among most important factors affecting response to traveler demand. Because of highly dynamic networks and frequent discontinuity, it is desirable to establish routes for fast delivery of people and goods, having a low probability of …
Published in Trends in Transport Engineering and Applications · Vol. 3, Issue 3, 2016 · pp. 17–22 Read article
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The use of Genetics and Proteomics in the Finding of Therapeutic Targets
Abstract: Gene medicine is overcoming long-standing health issues that have confounded humanity. To fully comprehend and apply gene medicine, it is vital to grasp how it works at the molecular level. Currently, various technologies may be utilized to find pharmacological targets; the two most prominent are genomic and proteomic methods. In this paper, we go over how to use genomic and proteomic approaches to find pharmacological targets in depth. These materials …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 1, 2022 · pp. 9–12 Read article
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Structure based pharmacophore Modelling of compounds against Neurodegenerative disorder – Amyotrophic Lateral sclerosis
Abstract: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive degeneration of motor neurons, leading to muscle dysfunction, paralysis, and eventually death. These diseases are classified as ALS variations because autopsies reveal abnormalities in both upper and lower motor neurons. These disorders account for only 10% of all adult-onset motor neuron disease cases. Despite extensive research efforts, effective therapeutic interventions for ALS remain limited. Structure-based pharmacophore modeling …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 1–17 Read article
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Diagnostic Modalities Used for Fungal Isolates Confirmed in Clinically Suspected Cases of Otomycosis: A Screening Study
Abstract: Otomycosis is one of the most attending ailed in ENT practice. Fungal infection of external auditory canal is called otomycosis. Discomfort or pain, itching, ear blockage and ear discharge are symptoms of otomycosis. Ear discharge is seen in the cases of bacterial otitis externa (Furuncle or diffuse otitis externa), otomycosis, acute otitis media, chronic otitis media, etc. So to confirm diagnosis of otomycosis, microbiology test of ear discharge is needed. …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 3, 2018 · pp. 58–64 Read article
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Alzheimer disorders diagnosis system design using machine learning for EEG signal
Abstract: The diagnosis of Alzheimer's disorders (AD), a prevalent neurological disorder, can created by utilising a range of therapeutic methods, including the electroencephalogram (EEG), which has been especially successful in the past. The objective for this study is to develop a computer-aided diagnosis tool which may recognize AD from EEG data. The EEG information was cleaned up with a band-pass elliptic digital filter to remove any interference or disruptions. The filtered …
Published in Journal of Control & Instrumentation Read article
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Risk & Opportunities in Development of new Drugs: A New Perspective
Abstract: The procedures of drug discovery and development are briefly described in this article. Our goal is to assist researchers whose work may be pertinent to the discovery and/or development of new drugs in framing their research reports in a way that appropriately situates their findings within the drug discovery and development process and supports the efficient translation of preclinical research to humans. One overarching theme of our article is the …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 19–28 Read article
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Antibiotics – Challenges in our Post-COVID Era
Abstract: Accidental discovery of the antibiotic properties of penicillin marked a watershed moment in healthcare, transforming the landscape of medicine and saving countless lives of injured and infected. Further research and awareness on the advantages of this “miracle drug” resulted in its bulk production in the 1940s, and played a crucial role in saving lives of thousands during World War II. Subsequent discoveries especially broad-spectrum antibiotics paved the way for further …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 1–5 Read article
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Evolution of War Technology
Abstract: The continued evolution of combat technology is examined in this research study, which also discusses recent trends, historical developments, and possible future developments in this important area. Throughout history, the quest for military superiority has propelled considerable advancements in warfare technology. This study provides a succinct examination of this evolutionary process, shedding light on historical turning points, modern cutting-edge technologies, and expected future developments in combat. Important advances in the …
Published in Journal of Advancements in Robotics · Vol. 11, Issue 1, 2024 · pp. 25–32 Read article
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Computer Aided Drug Designing for Targeted Drug Delivery Systems
Abstract: The discovery and development of a contemporary sedate is widely acknowledged as an extremely difficult task that requires significant resources and effort. Therefore, computer-aided medication design techniques are widely utilized today to increase the productivity of the drug discovery and development process. Among structure-based and ligand-based drug design approaches, both recognized for their efficiency in drug discovery and development, various CADD (Computer-Aided Drug Design) techniques are evaluated based on specific …
Published in Trends in Drug Delivery · Vol. 11, Issue 2, 2024 · pp. 34–41 Read article
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Analysis of Bioinformatics Software Applied in Computer-Aided Drug Design
Abstract: The integration of bioinformatic tools with computational methods has revolutionized the field of Computer-aided Drug Design (CADD), enabling researchers to expedite the discovery and optimization of new therapeutics. This review provides an in-depth analysis of the bioinformatic tools utilized in CADD, encompassing molecular docking, molecular dynamics simulation, virtual screening, homology modelling, and molecular visualization. We go over the tenets, approaches, and uses of these instruments, emphasizing their value in expediting …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 2, 2024 · pp. 1–10 Read article