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184 articles for “Binding proteins”
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In-silico Approach of Few Selected Phytoconstituents on Newer Cancer Targets
Abstract: Background: Cancer’s high death rates are mainly due to, drug resistance and unmet medical demands. It necessitates novel anticancer medications. AI tools aid in efficient and faster drug discovery by analyzing data, modeling processes and optimizing pipeline stages. Aim: The aim of this present study is to evaluate phytoconstituents against novel and newer cancer targets. Methodology: The ligands Daidzein, Resveratrol and Genistein were targeted against the Glutamate dehydrogenase (PDB ID …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 12–17 Read article
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Samelisant, an H3 Receptor Agonist as an Anti-Alzheimer Potential – A Pilot Study on Molecular Docking
Abstract: Neurodegenerative diseases have become more prevalent and about 55 million of the population are affected by dementia globally. One of the most important neurodegenerative diseases is Alzheimer’s disease which is known for its effect on memory and cognitive impairment. Alzheimer’s disease (AD) is an area of intense scientific investigation due to its high prevalence and the lack of a definitive cure. Amyloid precursor protein plays a central role in Alzheimer’s …
Published in International Journal of Brain Sciences · Vol. 3, Issue 1, 2026 · pp. 15–26 Read article
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In silico analysis of Abrus precatorius L. as a potential agonist of PPARγ : A novel approach to the treatment of diabetes
Abstract: Diabetes mellitus is a chronic disorder that is characterized by a lack of insulin secretion by the pancreas or a defect in insulin action, or both. If diabetes is not controlled, over time it can cause damage to blood vessels and nerves, leading to life-threatening complications such as, kidney damage, heart disease and vision impairment. It can also weaken the immune system, making patients more prone to infection. Although treatments …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 · pp. 13–24 Read article
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Isolation and Characterization of “Heavy Chain Antibody” Variable Domain Gene of Indian Desert Camel (Camelus dromedarius, L.)
Abstract: Camelids have “heavy chain antibodies” (HCAbs) of IgG isotype (IgG2 and IgG3 subtypes) and lack light chains and heavy chain constant domain 1 (CH1) in their structure. The molecular biological features of VHH (i.e., antigen binding variable domain of HCAbs) gene isolated from Indian desert camel were examined as a prelude to construct VHHs-phage display library. VHH cDNA was synthesized by reverse transcription-polymerase chain reaction (RT-PCR) from B lymphocyte mRNA, …
Published in Research and Reviews : A Journal of Immunology · Vol. 3, Issue 1, 2013 · pp. 22–31 Read article