Search
1953 articles for “phosphoinositol-3-kinase pathway” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
Nothing matched all of your words, so these match any of them.
-
In Silico Prediction of Multitarget Mechanism of Quinoline and Its Analogs on Phosphoinositide-3-Kinase Pathway Proteins
Abstract: Objective: Phosphoinositide 3-kinases (PI3Ks), the target of rapamycin (PI3K/Akt/mTOR, PAM), are a family of enzymes that play a role in the growth, proliferation, differentiation, motility, survival, and intracellular trafficking of cells, all of which are essential for healthy cellular function and are also connected to cancer. In this study, quinoline and its derivatives were employed to analyze its inhibition activity on the phosphoinositide-3-kinase pathway. Methods: In this work, eight phytocompounds …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 57–76 Read article
-
Effective Homoeopathic Management of Allergic Rhinitis: A Case Series Utilizing Hepar Sulph 30 and Histamine 30 with Dietary Modifications
Abstract: Background: Allergic rhinitis (AR), means our immune system intruded by some allergens which is typically a harmless substance. These allergens are found in the air we breathe, in the food we eat, in the water and fluids we drink. These allergens are attacking on our immune system and the immune system responds to the allergens by releasing histamine and chemical mediators that cause symptoms in the nose, throat, eyes, ears, …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 2, 2024 · pp. 12–16 Read article
-
Enhancing Dimensional Accuracy of Affordable 3D-Printed Objects Via Solid Model Tuning For Industrial Manufacturing
Abstract: In the industrial applications of 3D printing (3DP) technologies, achieving precise dimensional accuracy and precision as well as improving surface quality are essential goals. With a focus on cost-effective engineering applications, this experimental research examines how solid model geometry tuning improves the internal and exterior dimensional accuracy of inexpensive 3DP technologies. Dimensional errors in the X, Y, and Z directions were meticulously measured on 3D parts made using Material Extrusion/Fused …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 201–210 Read article
-
Comparative Analysis of 3D-Printed and Molded Shape-Stabilized Phase Change Composites
Abstract: Thermal energy storage (TES) has become essential for efficiently storing and utilizing thermal energy across applications like industrial heating, power plants, batteries, medical devices, food preservation, and aerospace technology. Because of their high energy density, affordability, and environmental friendliness, phase change materials, or PCMs, are employed extensively. However, challenges like poor thermal conductivity and leakage limit their performance. To address these issues, 3D printing has emerged as a powerful tool …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 184–192 Read article
-
Investigation of Residual Stress, and corrosion behavior of AA6082/Al 2 O 3 /C/ Si 3 N 4 Composite Material
Abstract: The main objective of the current study was to create AA6082/ Al2O3/C/Si3N4 Composite Material by the use of stir casting. The properties of the AA6082/ Al2O3/C/ Si3N4 Composite Material shown a significant improvement, with a micro-hardness rise of 13.5% and a residual stress decrease of 60%. As the testing parameters were increased, the residual stress of the AA6082/ Al2O3/C/ Si3N4 Composite Material rapidly decreased from -65MPa to -15MPa. An electromagnetic …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1104–1109 Read article
-
Design and Fabrication of a 3D-Printed Femur Model: Insights into Mechanical Properties and Implant Research
Abstract: This study is an attempt to analyse the 3D printing of the female femur model of the central India region and provides ample suggestions for bone implant research. This article discusses the design development and experimental validation of finite element analysis (FEA) results with the 3D-printed bone model. Using CT scan data, the FE analysis is executed on a real femur bone of a 25-year-old female of 52 kg weight …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 329–338 Read article
-
ML-Based Predictive Modeling of Mechanical Properties in 3D-Printed Polymer Composites for IoT Applications
Abstract: This study aims to develop an interpretable and high-accuracy machine learning framework for predicting the mechanical properties of 3D-printed fiber-reinforced polymer composites, with a focus on structure–property correlations relevant to polymer processing and functional performance. Composite specimens based on PLA and ABS matrices were fabricated using FDM with varying weight fractions (5–20 wt%) of carbon and glass fibers. Standardized mechanical testing (ASTM D638, D256, D790) was performed to evaluate tensile …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 61–78 Read article
-
3D-Printed Polymeric Drug Delivery Systems for Personalized Medicine
Abstract: Personalized medicine has revolutionized healthcare by tailoring treatments to individual patient needs. Among the emerging technologies, 3D printing has demonstrated immense potential in fabricating polymeric drug delivery systems with precise control over drug release, dosage, and bioavailability. These systems offer customized therapeutic solutions, improving efficacy while reducing adverse effects. This paper provides an overview of 3D-printed polymeric drug delivery systems, discussing the types of polymers used, fabrication techniques, applications in …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 313–325 Read article
-
A Comparative Study of the Structure-Property Relationships in CAD/CAM Milled vs. 3D-Printed High-Performance Polymers: Impact of Molecular Orientation on Abrasive Wear
Abstract: Background: The transition from subtractive to additive manufacturing in prosthetic dentistry has introduced significant variations in the macromolecular architecture of high-performance polymers. While CAD/CAM milling utilizes high-density, industrially polymerized blocks, 3D printing (Additive Manufacturing) relies on layer-by-layer deposition, which may induce anisotropic molecular orientation. This retrospective study investigates how these distinct manufacturing "thermal histories" influence the long-term abrasive wear resistance of PEEK and PEKK restorations.Materials and Methods: Data were retrospectively …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
-
Advancements in Metal-Plastic Hybrid Structures: Experimental Analysis and Design Optimization of 3D-Printed Honeycomb Frameworks
Abstract: The exploration of metal-plastic hybrid structures has gained significant attention due to their potential for lightweight, high-strength applications across industries such as aerospace, automotive, and construction. This study investigates the experimental and design enhancements of a metal-plastic hybrid structure utilizing a honeycomb architecture produced through 3D printing. By integrating metals with plastic polymers in a honeycomb configuration, this hybrid approach aims to combine the high strength and stiffness of metals …
Published in Trends in Machine design · Vol. 11, Issue 3, 2024 · pp. 36–43 Read article
-
The Role of 3D Modeling in Additive Manufacturing: Advances and Applications
Abstract: By making it possible to create intricate, highly functional, and customized components for a range of industries, the combination of 3D modeling and additive manufacturing (AM) has completely changed contemporary production processes. With an emphasis on both the technological advancements in digital design and its real-world applications, this paper examines the critical role that 3D modeling plays in the success of additive manufacturing. 3D modeling, the cornerstone of additive manufacturing, …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 3, Issue 2, 2025 · pp. 16–21 Read article
-
Enhancing Surface Roughness of Polylactic Acid (PLA) 3D-Printed Parts Using CO₂ Laser Scanning: An Experimental Study on Parameter Optimization
Abstract: Fused deposition modeling (FDM) of polylactic acid (PLA) often suffers from poor surface finish due to the inherent layer-by-layer deposition process, limiting its use in high-precision applications. This study investigates CO₂ laser scanning as an efficient post-processing technique to reduce the surface roughness (Ra) of PLA parts while maintaining structural integrity. Specimens (100 × 80 × 5 mm) were fabricated with varying infill densities (35%, 70%, and 100%) to assess …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 503–511 Read article
-
Mass Spectrometry–Based Phosphoproteomic Markers to Predict Kinase Inhibitor Response in Solid Tumors
Abstract: Mass spectrometry-based phosphoproteomics has emerged as a powerful tool for predicting kinase inhibitor responses in solid tumors, offering direct functional insights into signaling pathways that surpass traditional genomic profiling by capturing dynamic kinase activities and adaptive resistance mechanisms. Technological breakthroughs, including data- independent acquisition (DIA), trapped ion mobility spectrometry (timsTOF), and efficient enrichment methods like TiO2 or IMAC, now enable comprehensive profiling of over 40,000 phosphorylation sites from limited clinical …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 Read article
-
Mystic Malignant Melanoma Modalities
Abstract: Melanoma is a highly aggressive form of cancer with four recognized subtypes. In about 90% of cases, melanoma is diagnosed as a primary tumor, without signs of spreading. If caught early, the survival rate is quite high, reaching around 94%. However, for metastatic melanoma, the survival rate drops significantly to about 40%. Diagnosing melanoma can be tricky, as it shares features with benign conditions like seborrheic keratosis, benign moles, blue …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 1–10 Read article
-
Synthesis, spectroscopic, crystal structure, Hirshfeld surface, computational, and biological investigations on Isophorone derivatives: 3-(3,4-dimethoxystyryl)-5,5-dimethylcyclohex-2-en-1-one
Abstract: FT-IR, 1H NMR, and 13C NMR spectroscopy were among the spectroscopic methods used to synthesize and analyze 3-(3,4-dimethoxystyryl)-5,5-dimethylcyclohex-2-en-1-one, a new isophorone derivative. Single-crystal X-ray diffraction (SCXRD) was used to determine the crystal structure, which showed that the molecule crystallizes in a monoclinic system (space group P121/c1) with packing configurations and intermolecular interactions. To learn more about the non-covalent interactions influencing the crystal packing, Hirshfeld surface analysis was used. In order …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 2, 2025 · pp. 51–69 Read article
-
Perspectives of 3D-Printed Polylactic Acid-Based Composites Reinforced with Natural Fibers
Abstract: The growing demand for sustainable and biodegradable materials has led to the development of polylactic acid (PLA)-based composites reinforced with natural fibers. This study investigates the mechanical, thermal, printability, and environmental performance of 3D-printed PLA/Natural Fiber composites, addressing key challenges in fiber-matrix compatibility, structural integrity, and biodegradability. Natural fiber reinforcement enhanced Young’s modulus and flexural strength, but excessive fiber content led to agglomeration, reduced tensile strength, and increased brittleness. Thermal …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 649–664 Read article
-
Explainable Machine Learning for Process Parameter Optimization in Gradient 3D-Printed Polymer Composites
Abstract: The explainable machine learning-based structure may be employed to achieve a favorable process parameter of the graduate 3D-printed polymer composite structures to improve the mechanical and thermal properties without compromising the transparency of the decisions made during the fabrication process. Gradient composite specimens were made by systematically varied process parameters like nozzle temperature, raster orientation, deposition speed, gradient transition rate and fused filament fabrication. A predictive model of tensile strength …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 847–866 Read article
-
Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
-
Different Aspects and Processes in 3D Printing: An Overview
Abstract: 3D Printing or Additive manufacturing produces actual items from geometric representations by layering on materials one after the other. 3D printing is a rapidly developing technology. These days, 3D printing is employed all over the world. The application of 3D printing technology is expanding in the fields of agricultural, healthcare, automotive, locomotive, and aviation. It is utilized for mass modification and fabrication of various open-source designs. An object can be …
Published in International Journal of Manufacturing and Production Engineering · Vol. 2, Issue 1, 2024 · pp. 24–30 Read article
-
Feasibility of 3D Printed Temporal Bone for surgical simulation and practice
Abstract: Temporal bone (Ear Bone) has the most complex anatomical structure in body. ENT Surgeons need lot of practice before doing any surgery. Dissecting cadaver temporal bone is best teaching aid available with ENT surgeons, but have several constrains like legal, ethical, religious ground etc., restricts the hands-on dissection training. Availability of cadaver temporal bone is also very limited; it also houses many infectious agents and viruses. With recent advancement in …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 147–154 Read article