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24 articles for “hypothesis”
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An Insilico Study of Isobutrin and Phosphorylase Kinase - A Ray of Hope for Psoriasis Patients – Clinical Hypothesis
Abstract: Psoriasis is a chronic, hyper-proliferative and inflammatory skin disease. Increased levels of the calmodulin-containing enzyme, namely, phosphorylase kinase (PhK), were observed in the human epidermis of the active psoriasis cases. Thus PhK is a potential biomarker for the diagnosis and progression of the skin disease, namely, psoriasis. The search for the potential molecules that could supress the over expression of PhK is underway and any break-through in this direction leads …
Published in International Journal of Cheminformatics · Vol. 2, Issue 1, 2024 · pp. 1–8 Read article
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Butrin Tackles Retinoblastoma – A Clinical Hypothesis †
Abstract: Breach of association of legumain protein activities to the corresponding cellular components results in over-expression of legumain, and constitutes a key biomarker for a variety of life-taxing sicknesses like cancer, Alzheimer’s/Parkinson’s and acute kidney injury. To suppress the functions of legumain, it is hypothesized that a water soluble and edible biomolecule, namely, butrin (7, 3’, 4’-trihydroxy flavanone-7, 3’-diglucoside) may have the therapeutic potential owing to its special ability to bind …
Published in International Journal of Advance in Molecular Engineering · Vol. 2, Issue 1, 2024 · pp. 26–30 Read article
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A Quasi-experimental Research Endeavor to Evaluatethe Impact of a Structured Instructional Program on Adults' Comprehension of Disaster Awareness and Management in Chosen Villages Situated in Moga,Punjab
Abstract: A quasi-experimental research was conducted to evaluate the efficiency of a structured instructional program on adults' comprehension of disasters and their management. The study involved a sample of 60 adults, divided equally into an experimental group of 30 and a control group of 30. The knowledge score of adults in experimental group regarding disaster and its management among adults was average (54%) and below average (46%) before imparting the structured …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 1, Issue 1, 2023 · pp. 25–31 Read article
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A Quasi-experimental Research Project Designed to Evaluate the Impact of a Structured Educational Program on the Awareness of Cervical Cancer Prevention Among Adolescent Girls Attending Specific Schools in Moga, Punjab
Abstract: A quasi-experimental research study aims to evaluate the efficacy of a structured educational program in enhancing the understanding of cervical cancer prevention among adolescent girls in specific schools located in Moga, Punjab. The knowledge score of adolescent girls in experimental group regarding prevention of cervical cancer was average (20%) and below average (80%), before imparting the structured teaching programme knowledge of adolescent girls were good (70%) and average (30%). The …
Published in International Journal of Oncological Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 1–9 Read article
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Unveiling the Role of Lead Molecules in CADD: A Systematic Review
Abstract: The word "medicate plan" alludes to the objective creation of modern drugs. Arbitrary screening of engineered compounds, engineered of organically dynamic compounds based on actually happening drugs, amalgamation of basic analogs of actually happening lead particles, and usage of the bioisosteric hypothesis are a few of the strategies that have been utilized. As a result, the most recent drift in medicate plan is to either completely enhance a lead or …
Published in International Journal of Membranes · Vol. 1, Issue 1, 2024 · pp. 37–43 Read article
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Examining Job Satisfaction and its Effect on Employee Productivity of a Textile Industrial Unit
Abstract: Productivity, especially the productivity of human resources, which is one of the necessities of the growth and development of every society and organization; It is not achieved by simply increasing salaries and benefits and amenities. Rather, making people productive depends on creating satisfaction and increasing job satisfaction. The current research is a descriptive-correlation method; The purpose of the research is to investigate the relationship between job satisfaction (Powell-e Specter model) …
Published in International Journal of Behavioral Sciences · Vol. 1, Issue 1, 2024 · pp. 26–38 Read article
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An Investigation into the Impact of a Structured Teaching Program on the Knowledge of Women’s Rights in India Among Working Women in Selected Government Organizations in North Gujarat
Abstract: A study was conducted to evaluate the impact of a structured teaching program on the knowledge of women’s rights in India among working women in the government sector of North Gujarat. The research used an evaluative approach, specifically a pre-experimental design with a one-group pre- test and post-test. A non-probability purposive sampling method was used to select participants from a government sector in North Gujarat. The sample included 50 women …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 23–27 Read article
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A Study to Evaluate the Effectiveness of Planned Teaching Program of Environmental Health Among Community People in Selected Rural Area of Gwalior
Abstract: Context: Environmental health is the subfield of public health that focuses on identifying and altering environmental contributors to illness and injury. The state of the environment in a certain area, especially as it relates to ecological diversity and pollution. The purpose of this research was to evaluate the efficacy of an environmental health education program for the local population. This study follows a quantitative research approach for its methodology. The …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 1, Issue 1, 2023 · pp. 23–32 Read article
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Evaluating the Efficacy of a Self-instructional Teaching Module on Home Care Management Knowledge for Renal Failure Patients Undergoing Hemodialysis in a Selected Hospital in Ambikapur, Chhattisgarh
Abstract: The kidneys, with their remarkable organization and precision in regulatory functions, exhibit a level of sophistication that can be likened to a divine quality. In a conducted study, a substantial correlation was identified between the pre-test knowledge scores of participants and specific demographic factors, particularly educational qualifications. The chi-square values calculated for educational qualifications were 18.85, and for previous knowledge, it was 6.56. In both instances, the calculated values surpassed …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 1–8 Read article
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Oral Self-examination: An Approach for Early Recognition of Oral Cancer Among Factory Workers: An Experimental Study
Abstract: Background: Cancer is a worldwide concern and ranks among the most dreaded illnesses across the globe. Oral cancers are one common cancer among all cancers. Objectives: To measure the existing knowledge concerning oral self-examination for timely recognition of oral cancer among factory workers and to develop and administer a planned health education programme of oral self-examination for early recognition of oral cancer among factory workers. 40 factory workers were selected …
Published in International Journal of Oncological Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 22–26 Read article
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Pharmacophore mapping, 3D QSAR, docking, and ADME prediction studies of novel Benzothiazinone derivatives
Abstract: Background Tuberculosis is a major public health concern worldwide which is caused by Mycobacterium tuberculosis. DprE1 (Decaprenyl Phosphoryl Ribose 2’- Epimerase) is the most challenging target for development of novel anti- tubercular agents because it is a small protein and located into cytoplasmic membrane. So, novel anti-TB drugs did not bound effectively with it. DprE1 catalyzes the oxidation of the 2’ hydroxyl group of DPR (Decaprenyl Phosphoryl D- Ribose) …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 59–82 Read article
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Review on Spirulina ( Green Alage)
Abstract: Spirulina is an edible blue-green algae that is a plant protein source. In recent years, its health benefits have attracted scientific attention, including micro-level examinations of the algae's bioactive components. As proof of concept, investigations conducted in vitro, in vivo, and ex vivo have shown how spirulina works and how it affects immunity. Spirulina has been used as a whole food and as a nutritional supplement for many years. It …
Published in International Journal of Pathogens · Vol. 1, Issue 1, 2024 · pp. 33–37 Read article
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An Exploratory Investigation into the Understanding of Keratoconjunctivitis Among Staff Nurses at SCPM Hospital in Gonda
Abstract: Background: The primary aim of the present research was to evaluate the comprehension of keratoconjunctivitis among SCPM Hospital staff nurses in Gonda. Methodologically, the study was grounded in the general system theory proposed by Ludwig von Bertalanffy in 1968. To fulfill this aim, a non-experimental descriptive research design was utilized. The study included a sample of 40 SCPM Hospital staff nurses in Gonda who met the predefined inclusion criteria. Purposive …
Published in International Journal of Community Health Nursing And Practices · Vol. 2, Issue 1, 2024 · pp. 10–14 Read article
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Evaluation of the Understanding of Home Remedies for Managing Dysmenorrhea Among Adolescent Girls in Selected School of Vaniyamkulam Panchayat
Abstract: Background: India possesses a significant adolescent population critical to its future development. Addressing the health needs of this group is imperative for progress. Dysmenorrhea, characterized by painful menstrual cramps, is prevalent among adolescent girls, and home remedies are commonly used for management. This study aimed to evaluate the knowledge of home remedies for dysmenorrhea among girls at TRK Higher Secondary School in Vaniyamkulam. Objectives: The research had two main objectives: …
Published in International Journal of Women's Health Nursing And Practices · Vol. 2, Issue 1, 2024 · pp. 52–60 Read article
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Evaluating the Impact of a Structured Teaching Programme on Knowledge About Endometriosis Among First-Year Degree Students in a Chosen College in Wayanad District
Abstract: Introduction: The primary objective of this study is to evaluate the impact of a structured teaching program on the understanding of endometriosis among female students enrolled in the first year of a chosen degree arts and science college in Wayanad district. The specific goals include evaluating the baseline knowledge about endometriosis among first-year degree students in the selected college and determining the effectiveness of the structured teaching program in enhancing …
Published in International Journal of Midwifery Nursing And Practices · Vol. 2, Issue 1, 2024 · pp. 20–24 Read article
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Global Burden of Major Depressive Disorder: Prevalence, Diagnosis, and Impact: A Comprehensive review
Abstract: In this review, we will discuss about the major depressive disorders on the basis of neurobiological changes. MDD, a prevalent psychiatric condition, manifests as a complex interplay of genetic, environmental, and physiological factors with a substantial impact on individuals and societies globally. Here the clinical assessment is fully based on diagnosis and the statistical manual for mental disorder, 5th edition (DSM-5). The pathophysiology involves Diagnosis alterations in neurotransmitter systems, dysregulation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 54–62 Read article
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Assessment of exacerbation of Depression in pulmonary tuberculosis patients by using PHQ-9 scale at Tertiary Care Hospital
Abstract: Context: Depression leads to more dysfunction and stress, which could affect the patient's life condition. Tuberculosis is a leading cause of comorbidity with depression. Those suffering from tuberculosis and depression are at higher risk of bad health-seeking nature, resulting in higher morbidities, drug resistance, and mortality. The relationship is not well established. Aims: To identify multiple variables/ dependent factors affecting depression respectively in tuberculosis patients and check the medication adherence …
Published in International Journal of Pathogens · Vol. 1, Issue 2, 2024 · pp. 24–31 Read article
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Impact of Back Massage on Anxiety Levels in Patients Undergoing Orthopedic Surgery
Abstract: Objectives: The objective of the study was to assess the pre- and post-test levels of anxiety in patients who underwent orthopaedic surgery in both the experimental and control groups, to evaluate the effectiveness of back massage in reducing anxiety among patients in the experimental group, and to explore the association between anxiety levels and selected demographic variables in these patients. Research approach: The aim of the study was to evaluate …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 35–57 Read article
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Trend Analysis of Long-Term Rainfall Data for Monsoon Season of Kharun Catchment
Abstract: This research paper investigates the trends in monsoon season rainfall over a 31-year period (1990–2021) using the non-parametric Mann–Kendall test. A range of statistical methods were utilized to analyze the rainfall data, providing valuable insights into its temporal patterns and trends. The correlation coefficient, measured by Kendall's Tau, exhibited a minimal positive correlation of 0.004 between years and their corresponding rainfall, quantities. This implies a slight tendency for increased rainfall …
Published in International Journal of Rural and Regional Development · Vol. 3, Issue 1, 2025 · pp. 12–17 Read article
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Effectiveness of Moist Heat Application on Elderly Orthopedic Clients at Selected Urban Community Area, Bengaluru
Abstract: Pain is a distressing sensory and emotional experience that arises from actual or potential tissue damage. It is a multifaceted phenomenon that extends beyond physical discomfort, encompassing emotional and psychological aspects as well. Individuals who recognize that pain management not only enhances comfort but also accelerates the healing process are more inclined to seek or administer appropriate treatment. In order to educate the elderly orthopedic clients, this study was conducted …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 18–22 Read article