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22 articles for “Structural variants”
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STRUCTURAL–EPIGENOMIC ATLAS: CNV/SV- DRIVEN PROGNOSTIC REFINEMENT ACROSS CANCERS
Abstract: Structural genomic alterations, including copy number variations (CNVs) and structural variants (SVs), play a central role in cancer initiation and progression. These alterations extend beyond gene dosage effects and interact dynamically with epigenomic mechanisms such as DNA methylation, histone modifications, and three-dimensional chromatin organization. Recent pan-cancer studies have demonstrated that CNV burden and SV signatures reflect key oncogenic processes including chromothripsis, homologous recombination deficiency, enhancer hijacking, and extrachromosomal DNA (ecDNA) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 1, 2026 Read article
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Solid Lipid Nanoparticles in Medicine: Formulation, Characterization and Future prospects
Abstract: An alternative to conventional colloidal carriers such liposomes, polymeric nanoparticles, and emulsions, solid lipid nanoparticles (SLNs) were created in the early 1990s. Benefits include targeted medicine distribution, controlled drug release, and improved stability. An extensive review of the excipients utilized, the production techniques, including the membrane contractor approach, and the possible advantages and disadvantages of SLNs is given in this work. It investigates secondary stabilization techniques like freeze-drying and spray-drying, …
Published in International Journal of Membranes · Vol. 2, Issue 1, 2025 · pp. 1–15 Read article
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Targeting Papain-Like Protease of Re-Emerging Coronaviruses
Abstract: Re-emerging Corona viruses (CoVs), including SARS-CoV (S-CoVs), and SARS-CoV-2 (S-CoV-2), continue to pose a global health threat due to their high mutation rates, zoonotic spillover potential, and capacity for immune evasion. The global pandemic of year 2019, caused by S-CoV-2, has highlighted the importance for robust antiviral strategies beyond vaccines and RNA polymerase or main protease inhibitors, which are susceptible to resistance. One promising therapeutic target is the S-CoV-2 papain-like …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 3, 2025 · pp. 46–62 Read article
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Stretching Boundaries: A Comprehensive Review of Ehlers-Danlos Syndrome and its Subtypes
Abstract: The Ehlers-Danlos syndromes (EDS) encompass 13 inheritable disorders affecting connective tissue. These conditions arise from genetic alterations impacting the structure of connective tissue. Every variant of Ehlers-Danlos syndrome (EDS) exhibits distinct features and has specific diagnostic criteria. While certain traits such as joint hypermobility, skin hyperextensibility, and tissue fragility are common across all types of EDS. The range of clinical presentations spans from minor skin and joint looseness to severe …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 44–57 Read article
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Advancements in Energy-Efficient Electrical Motor Design: A Comprehensive Review
Abstract: The rapid growth in energy demand poses a fundamental challenge for the whole power industry in fulfilling the increased demand. An exhaustive energy audit recommends substituting energy-efficient gadgets with conventional ones, which function with low efficiency and waste a significant amount of electricity. Electric motors are quite common in contemporary life, providing energy to a wide range of devices, including both domestic and industrial machinery. Nevertheless, they bear the responsibility …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 1, Issue 1, 2023 · pp. 29–35 Read article
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In Silico Assessment of Demethoxycurcumin: Molecular Docking and Computational Insights into its various therapeutic Potential
Abstract: Natural compounds are increasingly explored for their therapeutic potential in medical research. Here, we focused on demethoxycurcumin (DMC), a polyphenolic bioactive compound extracted from Curcuma longa, commonly found in turmeric. DMC, with a chemical formula of C20H18O5 and a molecular weight of 340 g/mol, possesses two aromatic ring systems, each featuring a β-diketone moiety connected by a seven-carbon chain. This unique structure allows DMC to engage in tautomerism, which is …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 9–15 Read article
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Integrative Structural-Functional Genomics of Fc and Fab: Precision Models for Monoclonal Antibody Stability and Anti-Aggregation Engineering
Abstract: Monoclonal antibodies (mAbs) represent the cornerstone of biotherapeutics, yet aggregation propensity compromises up to 50% of candidates during development, driven by Fab hypervariability and Fc vulnerabilities.(1,2) This review integrates functional genomics from OAS (4B+ sequences)(5) and structural databases (SAbDab: 10K+ structures)(6) with machine learning models achieving R=0.97 for SAP prediction.(11) We dissect biophysical mechanisms, benchmark predictive tools (DeepSP, ESM2), and engineering strategies (YTE, FW mutations) that enhance Tm by 5-10°C …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Efficient Malware Detection in Cybersecurity: Leveraging Advanced Data Structures for Enhanced Threat Identification
Abstract: The cybersecurity landscape is constantly changing with more advanced malware creating major challenges for detection systems. To address these challenges effectively, advanced data structures have become essential in optimizing how data is managed, processed, and analyzed for malware detection. This review paper delves into the role of several cutting-edge data structures—bloom filters, tries, hash tables, graphs, decision trees, and suffix trees—in enhancing the efficiency and accuracy of malware detection mechanisms. …
Published in International Journal of Data Structure Studies · Vol. 2, Issue 2, 2024 · pp. 32–40 Read article
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Managed Pressure Drilling for Improved Well Control: A Cross-Case Comparative Study (2015–2025)
Abstract: Managed Pressure Drilling (MPD) has matured over the past decade from a specialist technique applied to challenging wells into a mainstream drilling capability spanning ultra-HPHT exploration, deepwater development, unconventional tight-gas multi-well campaigns, and naturally fractured sour-gas reservoirs. Despite this maturation, the operational question of which MPD variant should be applied to a given well has been addressed in the literature case-by-case rather than through structured comparative synthesis. This paper presents …
Published in Journal of Petroleum Engineering & Technology · Vol. 16, Issue 2, 2026 · pp. 07–12 Read article
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Low Velocity Impact Behaviour of Corrugated Foam Sandwich Panel
Abstract: Composite sandwich structures, renowned for their high flexural stiffness and low weight, are widely used across industries such as aerospace, automotive, and marine. However, their durability can be compromised by impact-related damages, which affect both the core and face sheets. This study explores the performance of corrugated sandwich panels compared to conventional designs under low-velocity impacts. Using a drop weight impact testing machine, panels made from polyurethane foam cores and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 79–99 Read article
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Description & Prevention of Omicron
Abstract: November 9, 2021, Botswana becomes the first country to recognise it (Nov 11 2021). The new variant (B.1.529) has been represented in 77 countries. Omicron presents 32 changes in spike protein Scribd, restricting the point of interaction with the ACE2 receptor protein. Computational shows and components’ recreation has been applied to investigate the collaboration between the SARS-CoV-2 RBD and the ACE2 receptor. The receptor-binding domain (RBD), which more barely joins …
Published in Research & Reviews: A Journal of Pharmacognosy Read article
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Importance of Thesaurus in Natural Language Processing for Scholarly Data Extraction
Abstract: The exponential growth of scholarly literature needs advanced methods for efficient data extraction and knowledge discovery. Natural Language Processing (NLP) has emerged as a crucial technology in automating the analysis and organization of academic texts. Among various linguistic resources, thesauri serve as important tool for enhancing semantic understanding by providing structured vocabularies, synonyms, and hierarchical relationships between terms. This paper examines the importance of thesauri in enhancing NLP-based scholarly data …
Published in Emerging Trends in Languages · Vol. 3, Issue 1, 2026 · pp. 19–24 Read article
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Vaccines Through Time: Conventional Foundations and Next-Gen Innovations–Part 1
Abstract: Vaccination serves as a critical pillar of global public health, markedly decreasing infection rates and associated mortality. Traditional vaccine platforms such as live attenuated, inactivated, toxoid, and subunit vaccines have demonstrated effectiveness against pathogens like Mycobacterium tuberculosis and Plasmodium spp., yet they are constrained by antigenic variability, limited immune persistence, and complex production processes. Breakthroughs in synthetic biology, structural antigen design, and computational vaccinology have driven the development of advanced …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 16, Issue 1, 2026 · pp. 53–70 Read article
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Performance Evaluation of Kevlar-Sisal-S-Glass Hybrid Composites with Ceramic Fillers for Structural Applications
Abstract: This study examines the mechanical properties of hybrid composite laminates reinforced with Kevlar, sisal, and S-glass fibers, and incorporating ceramic fillers—silicon carbide (SiC) and aluminum oxide (Al2O3)—within an epoxy matrix. The hand lay-up method was utilized to produce the laminates, ensuring a uniform fiber stacking sequence and including 10% filler material. Two composite variations were synthesized: one incorporating SiC and the other Al₂O₃, and both underwent tensile, flexural, hardness, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 Read article
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Polyurethane: Chemistry, Production, Applications, and Future Prospects—An Overview
Abstract: Polyurethane (PU), a class of versatile polymers, has emerged as one of the most significant materials in modern industry owing to its remarkable mechanical strength, elasticity, durability, and resistance to abrasion, chemicals, and environmental degradation. Its wide range of tunable properties has made PU indispensable across multiple sectors, including fashion, automotive, manufacturing, biomedical, coatings, and construction. This review emphasizes the diverse applications of polyurethane and explores how its unique chemistry …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 12, Issue 3, 2025 · pp. 17–25 Read article
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Mechanical and Morphological Analysis of Jute/Manila Hemp Hybrid Composites for Enhanced Structural Performance
Abstract: Natural fiber composites are renowned for their lightweight, strength, corrosion resistance, and high strength-to-weight ratio, often surpassing traditional metals. Despite challenges such as poor fiber-matrix adhesion and moisture susceptibility, hybridizing composites present a viable solution by enabling tailored properties for optimal performance. This study investigates hand-lay-up processed natural fiber composites, specifically woven jute/epoxy, non-woven manila hemp/epoxy, and their hybrid variants. Extensive testing was conducted on mechanical properties including hardness, flexural …
Published in Journal of Polymer & Composites · Vol. 12, Issue 8, 2024 · pp. 1–11 Read article
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Role of Carbohydrates and Herbal Plants in the Management of Diabetes Mellitus
Abstract: This extensive review explores the intricate relationship between carbohydrates and diabetes mellitus, integrating historical perspectives, biochemical foundations, and modern therapeutic approaches. The article delves into the chemistry of carbohydrates, elucidating their structural diversity and metabolic significance in relation to diabetes pathophysiology. It traces the evolution of diabetes, understanding from ancient civilizations to contemporary molecular insights, highlighting pivotal discoveries such as insulin’s identification. They critically examined various forms of diabetes, including …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 34–60 Read article
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Synergistic Effects of Hybridized Nano-Silica and Hemp Fiber Reinforcement on Bio-Epoxy Composites
Abstract: Natural fiber-reinforced bio-epoxy composites have become promising sustainable alternatives to conventional synthetic-fiber petroleum-based materials, but are often limited by low fiber-matrix interfacial bonding, low thermal stability, and high moisture absorption which limit their application in structural applications. These issues are discussed in this work, by carrying out a systematic investigation of the synergistic effects of the hybridization of nano-silica particles with alkali-treated hemp fibers in a bio-epoxy matrix the composites …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 214–228 Read article
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Study on Partial Replacement of Cement with Pinus Fiber and Nano Silica in M30 Concrete Paver Blocks: A Fiber-Reinforced Polymer-Cement Composite Approach
Abstract: This study investigates the partial replacement of cement in M30 grade concrete paver blocks using nano silica and Pinus fiber, with a primary focus on mechanical performance, sustainability, and long-term durability and promoting sustainability. Portland cement, a major contributor to global CO₂ emissions, can be partially substituted using supplementary materials to create eco-efficient construction solutions. Nano silica, due to its high pozzolanic reactivity and ultrafine size, improves the microstructure and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 63–76 Read article
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Comparative Study of BERT Variants for Sentiment Analysis with Error Analysis
Abstract: The use of media is going up fast in India, and this has led to the rise of Hinglish. Hinglish is an informal blend of Hindi and English that people commonly use in everyday conversations, especially across social media platforms such as Twitter, Facebook, and WhatsApp. People use Hinglish to talk to each other in a way that is not very formal. Hinglish blends English vocabulary with informal usage, often …
Published in International Journal of Computer Science Languages · Vol. 4, Issue 1, 2026 · pp. 39–48 Read article